#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980464|wwpdb:7JLT|imex:IM-28970-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:Table S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/05/25	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980540|imex:IM-28970-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:1B, Supp. figure 4E|comment:"The NSP7-NSP8 mixture eluted at a volume corresponding to what is expected for a 2:2 tetrameric form (∼62 kDa)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/05/25	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	sufficient binding region:74-198	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980976|imex:IM-28970-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:supp. figure 3/7B|comment:NSP7+8 tetramer;mutations on the interface II of NSP7 lead to even more severe loss of the tetrameric NSP7–NSP8 fraction than mutations on interface I.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	-	mutation decreasing interaction strength:49-49|mutation decreasing interaction strength:56-56|mutation decreasing interaction strength:52-52|mutation decreasing interaction strength:8-8|mutation decreasing interaction strength:11-11|mutation with no effect:37-37	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980994|imex:IM-28970-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:Supp. figure 3|comment:NSP7+8 tetramer.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	mutation decreasing interaction strength:90-90|mutation decreasing interaction strength:92-92|mutation decreasing interaction strength:94-94	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475871	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26981736|imex:IM-28970-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:3943|chain-seq-end:4140	figure legend:Supp. figure 7 C/D|comment:It is stated that the NSP7N37V mutation leads to a modest, but notable, disruption of the NSP7-NSP8-NSP12 complex.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/06/08	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU	false	his tag:n-n|sumo tag:n-n	his tag:n-n|sumo tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-25475871	intact:EBI-25475885	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26981736|imex:IM-28970-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:4393|chain-seq-end:5324	figure legend:Supp. figure 7 C/D|comment:It is stated that the NSP7N37V mutation leads to a modest, but notable, disruption of the NSP7-NSP8-NSP12 complex.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/05/18	2021/06/08	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	rigid:TdMBDIvOL7GW+tgRvY3boc7Q6tU	false	his tag:n-n|sumo tag:n-n	his tag:n-n|sumo tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980557|imex:IM-28970-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:1C, 3 C/E, supp. figure 1C/7A|comment:NSP7+8 tetramer|comment:"Mutations of  NSP7  F49A and NSP7  L56A (in Figure 3C) and of  NSP8 F92A (in Figure 3D) lead to an increased NSP8 dimerization, accompanied by reduction of the hetero-tetramerization of NSP7–NSP8."|comment:Mutations of NSP7, C8G and V11A, lead to an even more pronounced increase of NSP8 homodimer at the expense of NSP7-NSP8 heterotetramer.|comment:The NSP7 M52A mutation  does not appreciably affect the population of NSP8 dimer, but leads to a substantial heterotetramer-to-heterodimer shift of NSP7-NSP8.|comment:The NSP7 L71A mutant increases tetramerization of NSP7 with NSP8. Figure S1C appears to show a decrease in NSP8 dimerization and a slight increase in NSP7+8 dimerization.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	-	mutation with complex effect:49-49|mutation with complex effect:56-56|mutation with complex effect:52-52|mutation with complex effect:71-71|mutation with no effect:37-37|mutation with complex effect:8-8|mutation with complex effect:11-11	2	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980565|imex:IM-28970-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:1C, 3F|comment:NSP7+8 dimer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	mutation with no effect:90-90|mutation with no effect:92-92|mutation decreasing interaction strength:94-94	-	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475874	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980571|imex:IM-28970-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3943|chain-seq-end:4140	figure legend:1C, 3 D/F|comment:NSP8 dimer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rigid:YfH9+EduizUNu3bJ/GlfZFr5dHY	false	mutation increasing interaction strength:92-92|mutation increasing interaction strength:90-90|mutation increasing interaction strength:94-94	mutation increasing interaction strength:92-92|mutation increasing interaction strength:90-90|mutation increasing interaction strength:94-94	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475874	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980577|imex:IM-28970-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3943|chain-seq-end:4140	figure legend:1C, 3F|comment:NSP8 tetramer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rigid:YfH9+EduizUNu3bJ/GlfZFr5dHY	false	mutation increasing interaction strength:90-90|mutation increasing interaction strength:94-94	mutation increasing interaction strength:90-90|mutation increasing interaction strength:94-94	4	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980775|imex:IM-28970-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:1C, 3 C/E, Supp. figure 7A|comment:NSP7+8 dimer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	-	mutation increasing interaction strength:52-52|mutation with no effect:37-37|mutation with no effect:49-49|mutation with no effect:56-56|mutation decreasing interaction strength:8-8|mutation increasing interaction strength:11-11	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980785|imex:IM-28970-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:1C, 3 D/F|comment:NSP7+8 tetramer|comment:"Mutations of NSP7 F49A and NSP7 L56A (in Figure 3C) and of NSP8 F92A (in Figure 3D) lead to an increased NSP8 dimerization, accompanied by reduction of the hetero-tetramerization of NSP7–NSP8."|comment:Mutations M90A  and M94A, lead to an increased NSP8 dimer formation at the expense of the NSP7–NSP8 heterotetramer.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	mutation with complex effect:92-92|mutation with complex effect:90-90|mutation with complex effect:94-94	-	2	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26981677|imex:IM-28970-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:Supp. figure 4F|comment:NSP7+8 tetramer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/27	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	sufficient binding region:74-198	-	2	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25475874	intact:EBI-25475871	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26981691|imex:IM-28970-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3860|chain-seq-end:3942	figure legend:supp. figure 4F|comment:NSP7+8 dimer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/27	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rigid:9bglx2taGFlx9F8JoF9EfOktY+Y	false	sufficient binding region:74-198	-	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449626	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475874	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0030"(cross-linking study)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26981705|imex:IM-28970-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3943|chain-seq-end:4140	chain-seq-start:3943|chain-seq-end:4140	figure legend:Supp. figure 4f|comment:NSP8 dimer|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/27	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	rigid:YfH9+EduizUNu3bJ/GlfZFr5dHY	false	sufficient binding region:74-198	sufficient binding region:74-198	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475871	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980846|imex:IM-28970-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:3943|chain-seq-end:4140	figure legend:"5, (Supp. figure 8B)"|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	-	false	mutation disrupting interaction rate:49-49,52-52,56-56|mutation disrupting interaction rate:8-8|mutation decreasing interaction rate:49-49|mutation disrupting interaction rate:52-52|mutation decreasing interaction rate:56-56|mutation disrupting interaction rate:11-11|mutation disrupting interaction rate:37-37	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-25475871	intact:EBI-25475885	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980846|imex:IM-28970-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:4393|chain-seq-end:5324	figure legend:"5, (Supp. figure 8B)"|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	mutation disrupting interaction rate:49-49,52-52,56-56|mutation disrupting interaction rate:8-8|mutation decreasing interaction rate:49-49|mutation disrupting interaction rate:52-52|mutation decreasing interaction rate:56-56|mutation disrupting interaction rate:11-11|mutation disrupting interaction rate:37-37	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25620607	intact:EBI-25475871	-	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:rna_substrate(display_short)|psi-mi:EBI-25620607(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980846|imex:IM-28970-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3860|chain-seq-end:3942	-	figure legend:"5, (Supp. figure 8B)"|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	-	-	false	mutation disrupting interaction rate:49-49,52-52,56-56|mutation disrupting interaction rate:8-8|mutation decreasing interaction rate:49-49|mutation disrupting interaction rate:52-52|mutation decreasing interaction rate:56-56|mutation disrupting interaction rate:11-11|mutation disrupting interaction rate:37-37	fluorescein label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449626	intact:EBI-25475871	intact:EBI-25475874	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449626(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980855|imex:IM-28970-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:3943|chain-seq-end:4140	figure legend:5|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:Bxev1BKtZTT1Fyf+lpsPapVosnc2697049	-	false	-	mutation decreasing interaction rate:92-92|mutation disrupting interaction rate:90-90|mutation decreasing interaction rate:94-94|mutation decreasing interaction rate:58-58|mutation decreasing interaction rate:75-75|mutation decreasing interaction rate:82-82	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449625	uniprotkb:P0DTD1-PRO_0000449629	intact:EBI-25475871	intact:EBI-25475885	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449629(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980855|imex:IM-28970-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:3860|chain-seq-end:3942	chain-seq-start:4393|chain-seq-end:5324	figure legend:5|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	rogid:kbHtZYssQIRdvLv8DVwmVD7XSW02697049	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449625	intact:EBI-25620607	intact:EBI-25475871	-	psi-mi:p0dtd1-pro_0000449625(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:rna_substrate(display_short)|psi-mi:EBI-25620607(display_long)	psi-mi:"MI:0700"(rna directed rna polymerase assay)	Biswal et al. (2021)	pubmed:33999154|imex:IM-28970	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0987"(rna strand elongation)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26980855|imex:IM-28970-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2359"(ds rna)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3860|chain-seq-end:3942	-	figure legend:5|comment:"Similar results were obtained using WT bacterially optimised NSP12 and \"native\" NSP12 with sequence  from RefSeq identifier NC_045512."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/05/18	2021/05/26	rogid:3AF/ThDr7adqPPYFWsiWQE2FVyY2697049	-	-	false	-	fluorescein label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)