#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51946	uniprotkb:P50613	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P18074	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P19447	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P51948	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9BTT4	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394354|uniprotkb:C6G491|ensembl:ENSP00000255764	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med10_human(display_long)|uniprotkb:MED10(gene name)|psi-mi:MED10(display_short)|uniprotkb:L6(orf name)|uniprotkb:TRG17(orf name)|uniprotkb:Mediator complex subunit 10(gene name synonym)|uniprotkb:Transformation-related gene 17 protein(gene name synonym)|uniprotkb:Transformation-related gene 20 protein(gene name synonym)|uniprotkb:TRG20(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000133398(gene)|ensembl:ENST00000255764(transcript)|refseq:NP_115662.2|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019145|mint:Q9BTT4|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-31457N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:LzJW7C8kl2pWmffOjo8S/FNSS9I9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9P086	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:O60244	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394489|uniprotkb:Q4KMR7|uniprotkb:Q9UNB3|ensembl:ENSP00000323720	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med14_human(display_long)|uniprotkb:TRAP170(gene name synonym)|uniprotkb:MED14(gene name)|psi-mi:MED14(display_short)|uniprotkb:ARC150(gene name synonym)|uniprotkb:DRIP150(gene name synonym)|uniprotkb:EXLM1(gene name synonym)|uniprotkb:RGR1(gene name synonym)|uniprotkb:Mediator complex subunit 14(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 2(gene name synonym)|uniprotkb:RGR1 homolog(gene name synonym)|uniprotkb:Transcriptional coactivator CRSP150(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 150 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 170 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 150 kDa component(gene name synonym)|uniprotkb:CRSP2(gene name synonym)|uniprotkb:CXorf4(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004220.2|ensembl:ENSG00000180182(gene)|ensembl:ENST00000324817(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070847"(core mediator complex)|interpro:IPR013947(Mediator complex, subunit MED14)|mint:O60244|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-31460N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:73RBAnwmB4Lyl/kcsg7NKSUmA4c9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q96RN5	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394506|uniprotkb:O15413|uniprotkb:Q6IC31|uniprotkb:Q8NF16|uniprotkb:Q96CT0|uniprotkb:Q96IH7|uniprotkb:Q9P1T3|uniprotkb:D3DX31|uniprotkb:D3DX32|ensembl:ENSP00000263205	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med15_human(display_long)|uniprotkb:MED15(gene name)|psi-mi:MED15(display_short)|uniprotkb:ARC105(gene name synonym)|uniprotkb:CTG7A(gene name synonym)|uniprotkb:Mediator complex subunit 15(gene name synonym)|uniprotkb:Positive cofactor 2 glutamine/Q-rich-associated protein(gene name synonym)|uniprotkb:TPA-inducible gene 1 protein(gene name synonym)|uniprotkb:Activator-recruited cofactor 105 kDa component(gene name synonym)|uniprotkb:CTG repeat protein 7a(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 7 protein(gene name synonym)|uniprotkb:TIG1(gene name synonym)|uniprotkb:PCQAP(gene name synonym)|uniprotkb:TNRC7(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001280164.1|refseq:NP_001280165.1|refseq:NP_001003891.1|refseq:NP_056973.2|ensembl:ENSG00000099917(gene)|ensembl:ENST00000263205(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|interpro:IPR019087|interpro:IPR036529|mint:Q96RN5|rcsb pdb:2GUT|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-32908N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:8dqqSCXYc7Bp56sjogz0jpbTQLI9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9Y2X0	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394541|uniprotkb:Q6PJT2|uniprotkb:Q96AD4|uniprotkb:Q96I35|uniprotkb:Q9Y652|ensembl:ENSP00000325612	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med16_human(display_long)|uniprotkb:MED16(gene name)|psi-mi:MED16(display_short)|uniprotkb:Mediator complex subunit 16(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 95 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 5(gene name synonym)|uniprotkb:DRIP92(gene name synonym)|uniprotkb:THRAP5(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 92 kDa component(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_005472.2|ensembl:ENSG00000175221(gene)|ensembl:ENST00000325464(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001680(WD40 repeat)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR021665|interpro:IPR036322|mint:Q9Y2X0|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-31463N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:nMHDmIPhzAalahGVVsO++rpQE/U9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9NVC6	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394562|uniprotkb:Q9HA81|uniprotkb:Q9UNP7|uniprotkb:Q9Y2W0|uniprotkb:Q9Y660|uniprotkb:B3KN07|ensembl:ENSP00000251871	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med17_human(display_long)|uniprotkb:TRAP80(gene name synonym)|uniprotkb:MED17(gene name)|psi-mi:MED17(display_short)|uniprotkb:ARC77(gene name synonym)|uniprotkb:DRIP80(gene name synonym)|uniprotkb:Mediator complex subunit 17(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 6(gene name synonym)|uniprotkb:Transcriptional coactivator CRSP77(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 80 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 80 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 77 kDa component(gene name synonym)|uniprotkb:CRSP6(gene name synonym)|uniprotkb:DRIP77(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004259.3|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|ensembl:ENSG00000042429(gene)|ensembl:ENST00000251871(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070847"(core mediator complex)|interpro:IPR019313|mint:Q9NVC6|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-31451N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:P2hRQOjWEtjw5V+lt7J9TP3VbpU9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9BUE0	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394640|uniprotkb:Q9NXU9|uniprotkb:D3DPM1|ensembl:ENSP00000362948|ensembl:ENSP00000381963|ensembl:ENSP00000494048|ensembl:ENSP00000494184	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med18_human(display_long)|uniprotkb:MED18(gene name)|psi-mi:MED18(display_short)|uniprotkb:Mediator complex subunit 18(gene name synonym)|uniprotkb:p28b(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001120822.1|refseq:NP_060108.2|refseq:XP_005245971.1|ensembl:ENSG00000130772(gene)|ensembl:ENSG00000284944(gene)|ensembl:ENST00000373842(transcript)|ensembl:ENST00000398997(transcript)|ensembl:ENST00000645794(transcript)|ensembl:ENST00000647352(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070847"(core mediator complex)|interpro:IPR019095|mint:Q9BUE0|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:Or+Q+iu65H7u4G0WU7AsIL0DM0c9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:A0JLT2	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394430|uniprotkb:Q8IV02|intact:EBI-394763|uniprotkb:Q8IZD1	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med19_human(display_long)|uniprotkb:MED19(gene name)|psi-mi:MED19(display_short)|uniprotkb:LCMR1(gene name synonym)|uniprotkb:Lung cancer metastasis-related protein 1(gene name synonym)|uniprotkb:Mediator complex subunit 19(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001304007.1|refseq:NP_703151.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR019403|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|mint:A0JLT2|dip:DIP-31467N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:zcHhU2hQvuTpkFZz/xEKYmjrwOA9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9H944	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394644|uniprotkb:Q9Y429|uniprotkb:O95821|uniprotkb:Q5T8J4|uniprotkb:B4DE08|ensembl:ENSP00000265350	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med20_human(display_long)|uniprotkb:TRFP(gene name synonym)|uniprotkb:MED20(gene name)|psi-mi:MED20(display_short)|uniprotkb:Mediator complex subunit 20(gene name synonym)|uniprotkb:TRF-proximal protein homolog(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004266.2|refseq:NP_001292384.1|refseq:NP_001292385.1|refseq:NP_001292386.1|go:"GO:0016592"(mediator complex)|interpro:IPR013921(TATA-binding related factor)|mint:Q9H944|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENSG00000124641(gene)|ensembl:ENST00000265350(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|dip:DIP-31449N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:MpYOrONH6+0lKIlO6J+Szjzkw2A9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q13503	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394678|uniprotkb:Q6IB05|uniprotkb:Q92811|uniprotkb:B2R4I3|ensembl:ENSP00000282892	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med21_human(display_long)|uniprotkb:SRB7(gene name synonym)|uniprotkb:MED21(gene name)|psi-mi:MED21(display_short)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:RNA polymerase II holoenzyme component SRB7(gene name synonym)|uniprotkb:SURB7(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004255.2|ensembl:ENSG00000152944(gene)|ensembl:ENST00000282892(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021384|interpro:IPR037212|mint:Q13503|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|dip:DIP-31471N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:qNrBcd6tolQzcRyFK/OdD3P1Q3g9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q15528	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394687|uniprotkb:Q5T8U0|uniprotkb:O76072|uniprotkb:B3KW83|uniprotkb:B3KWX4|ensembl:ENSP00000342343|ensembl:ENSP00000482438|ensembl:ENSP00000485880|ensembl:ENSP00000487580	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med22_human(display_long)|uniprotkb:Mediator complex subunit 22(gene name synonym)|uniprotkb:MED22(gene name)|psi-mi:MED22(display_short)|uniprotkb:Surfeit locus protein 5(gene name synonym)|uniprotkb:SURF5(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_598395.1|refseq:NP_852468.1|ensembl:ENSG00000148297(gene)|ensembl:ENSG00000281022(gene)|ensembl:ENST00000343730(transcript)|ensembl:ENST00000610672(transcript)|ensembl:ENST00000629522(transcript)|ensembl:ENST00000631196(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR009332(Surfeit locus 5)|mint:Q15528|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:bAtK0Srk81ujvVt2Gj0+py7RCZY9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9ULK4	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-311161|uniprotkb:Q5JWT3|uniprotkb:Q5JWT4|uniprotkb:Q6P9H6|uniprotkb:O95403|uniprotkb:Q9H0J2|uniprotkb:Q9NTT9|uniprotkb:Q9NTU0|uniprotkb:Q9Y5P7|uniprotkb:Q9Y667|ensembl:ENSP00000357047|uniprotkb:B9TX55	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med23_human(display_long)|uniprotkb:MED23(gene name)|psi-mi:MED23(display_short)|uniprotkb:ARC130(gene name synonym)|uniprotkb:DRIP130(gene name synonym)|uniprotkb:KIAA1216(gene name synonym)|uniprotkb:SUR2(gene name synonym)|uniprotkb:CRSP3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym)|uniprotkb:Transcriptional coactivator CRSP130(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 130 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 130 kDa component(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_057063.2|refseq:NP_004821.2|ensembl:ENSG00000112282(gene)|ensembl:ENST00000368068(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016592"(mediator complex)|interpro:IPR021629|mint:Q9ULK4|rcsb pdb:6H02|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|refseq:NP_001257450.1|refseq:NP_001257451.1|dip:DIP-31461N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:gO5TvUnko3zY/83OHbeVmh7b+f89606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:O75448	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394523|uniprotkb:Q14143|uniprotkb:Q9NNY5|uniprotkb:A8K4S5|uniprotkb:B3KMR9|ensembl:ENSP00000377686	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med24_human(display_long)|uniprotkb:TRAP100(gene name synonym)|uniprotkb:MED24(gene name)|psi-mi:MED24(display_short)|uniprotkb:DRIP100(gene name synonym)|uniprotkb:KIAA0130(gene name synonym)|uniprotkb:Mediator complex subunit 24(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 100 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 4(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 100 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 100 kDa component(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 4(gene name synonym)|uniprotkb:ARC100(gene name synonym)|uniprotkb:CRSP4(gene name synonym)|uniprotkb:THRAP4(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:XP_016880955.1|refseq:NP_001072986.1|refseq:NP_055630.2|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021429|mint:O75448|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENSG00000008838(gene)|ensembl:ENST00000394128(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016592"(mediator complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|refseq:NP_001254726.1|dip:DIP-31462N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:H0iGOXcj8Qe1FOU7pOXkhaAS+pc9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q71SY5	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394558|intact:EBI-1534904|intact:EBI-399654|uniprotkb:O95783|uniprotkb:Q6P143|uniprotkb:Q6QMH5|uniprotkb:Q707U4|uniprotkb:Q8TB55|uniprotkb:Q9HB34|uniprotkb:Q9H0L5|uniprotkb:A8K095|uniprotkb:B9TX30|ensembl:ENSP00000326767	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med25_human(display_long)|uniprotkb:MED25(gene name)|psi-mi:MED25(display_short)|uniprotkb:ACID1(gene name synonym)|uniprotkb:ARC92(gene name synonym)|uniprotkb:PTOV2(gene name synonym)|uniprotkb:Mediator complex subunit 25(gene name synonym)|uniprotkb:Activator-recruited cofactor 92 kDa component(gene name synonym)|uniprotkb:Activator interaction domain-containing protein 1(gene name synonym)|uniprotkb:p78(gene name synonym)|uniprotkb:TCBAP0758(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_112235.2|ensembl:ENSG00000104973(gene)|ensembl:ENST00000312865(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016592"(mediator complex)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:2001178"(positive regulation of mediator complex assembly)|interpro:IPR021394|interpro:IPR021397|interpro:IPR021406|interpro:IPR021419|interpro:IPR036465|interpro:IPR038196|mint:Q71SY5|rcsb pdb:2KY6|rcsb pdb:2L23|rcsb pdb:2L6U|rcsb pdb:2XNF|rcsb pdb:7EMF|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENSP00000326767|ensembl:ENST00000538643|ensembl:ENSP00000437496|dip:DIP-31454N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:oh/gQ7Xo30kPBJDKME6QDW448Dg9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q6P2C8	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394603|uniprotkb:Q4F964|uniprotkb:O95401|uniprotkb:Q5VTA4|uniprotkb:Q5VTA5|uniprotkb:Q9BU57|uniprotkb:Q9NYR4|uniprotkb:V9GYV9|ensembl:ENSP00000292035	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med27_human(display_long)|uniprotkb:MED27(gene name)|psi-mi:MED27(display_short)|uniprotkb:Mediator complex subunit 27(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 8(gene name synonym)|uniprotkb:Transcriptional coactivator CRSP34(gene name synonym)|uniprotkb:P37 TRAP/SMCC/PC2 subunit(gene name synonym)|uniprotkb:CRSP34(gene name synonym)|uniprotkb:CRSP8(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001240811.1|refseq:NP_004260.2|refseq:NP_001240810.1|dip:DIP-31465N|ensembl:ENSG00000160563(gene)|ensembl:ENST00000292035(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021627|mint:Q6P2C8|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:V1clNhbtflCzCkC7OnaHGYrmQp89606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9H204	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-514199|uniprotkb:Q9BZJ5|ensembl:ENSP00000237380	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med28_human(display_long)|uniprotkb:Mediator complex subunit 28(gene name synonym)|uniprotkb:Tumor angiogenesis marker EG-1(gene name synonym)|uniprotkb:Endothelial-derived protein 1(gene name synonym)|uniprotkb:Merlin and Grb2-interacting cytoskeletal protein(gene name synonym)|uniprotkb:MED28(gene name)|psi-mi:MED28(display_short)|uniprotkb:EG1(gene name synonym)|uniprotkb:FKSG20(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_079481.2|ensembl:ENSG00000118579(gene)|ensembl:ENST00000237380(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|interpro:IPR021640|mint:Q9H204|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:1gt/0vP7vWJ+M1fU+qZPcWGj34U9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9NX70	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394656|uniprotkb:Q9NTF4|uniprotkb:Q5XX09|uniprotkb:B4DNQ6|uniprotkb:M0R2E4|ensembl:ENSP00000314343	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med29_human(display_long)|uniprotkb:MED29(gene name)|psi-mi:MED29(display_short)|uniprotkb:Mediator complex subunit 29(gene name synonym)|uniprotkb:Intersex-like protein(gene name synonym)|uniprotkb:IXL(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_060062.1|refseq:NP_001304699.1|ensembl:ENSG00000063322(gene)|ensembl:ENST00000315588(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR021018|mint:Q9NX70|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:WOrt3DAoOape6p0CwWSLIW55hVg9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q96HR3	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394659|uniprotkb:C6GKU9|intact:EBI-11137618|ensembl:ENSP00000297347	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med30_human(display_long)|uniprotkb:TRAP25(gene name synonym)|uniprotkb:MED30(gene name)|psi-mi:MED30(display_short)|uniprotkb:Mediator complex subunit 30(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 6(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 25 kDa component(gene name synonym)|uniprotkb:TRAP/Mediator complex component TRAP25(gene name synonym)|uniprotkb:THRAP6(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_542382.1|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021019|mint:Q96HR3|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|refseq:NP_001269915.1|ensembl:ENSG00000164758(gene)|ensembl:ENST00000297347(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:dUgR7zxbKAcYqPKb8teHBLgUhWY9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9Y3C7	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394707|uniprotkb:B2R4L9|ensembl:ENSP00000225728	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med31_human(display_long)|uniprotkb:CGI-125(orf name)|uniprotkb:SOH1(gene name synonym)|uniprotkb:MED31(gene name)|psi-mi:MED31(display_short)|uniprotkb:Mediator complex subunit 31(gene name synonym)|uniprotkb:Mediator complex subunit SOH1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_057144.1|ensembl:ENSG00000108590(gene)|ensembl:ENST00000225728(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070847"(core mediator complex)|interpro:IPR008831(SOH1)|interpro:IPR038089|mint:Q9Y3C7|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:QRmf6b+uoUOubBcvJbBfl9NgRTQ9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9NPJ6	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394607|uniprotkb:Q9BS95|uniprotkb:Q9NYR5|uniprotkb:Q53GB4|uniprotkb:Q53H68|uniprotkb:Q5T912|uniprotkb:Q6FHC4|uniprotkb:Q6IA79|uniprotkb:B4DX67|ensembl:ENSP00000258648	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med4_human(display_long)|uniprotkb:HSPC126(orf name)|uniprotkb:DRIP36(gene name synonym)|uniprotkb:MED4(gene name)|psi-mi:MED4(display_short)|uniprotkb:ARC36(gene name synonym)|uniprotkb:Mediator complex subunit 4(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 36 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 36 kDa component(gene name synonym)|uniprotkb:TRAP/SMCC/PC2 subunit p36 subunit(gene name synonym)|uniprotkb:VDRIP(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001257558.1|refseq:NP_054885.1|ensembl:ENSG00000136146(gene)|ensembl:ENST00000258648(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070847"(core mediator complex)|interpro:IPR019258|mint:Q9NPJ6|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:Bept2Oec50gruA9e4pf+eEUiANM9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:O75586	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394624|uniprotkb:Q6FHQ4|uniprotkb:Q9BTH1|uniprotkb:Q9UHL1|uniprotkb:O15401|uniprotkb:Q53FE3|uniprotkb:Q53HJ3|uniprotkb:B4DU17|uniprotkb:B4E2P0|ensembl:ENSP00000256379	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med6_human(display_long)|uniprotkb:ARC33(gene name synonym)|uniprotkb:MED6(gene name)|psi-mi:MED6(display_short)|uniprotkb:Mediator complex subunit 6(gene name synonym)|uniprotkb:Activator-recruited cofactor 33 kDa component(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-28(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_005457.2|refseq:NP_001271138.1|refseq:NP_001271139.1|refseq:NP_001271140.1|ensembl:ENSG00000133997(gene)|ensembl:ENST00000256379(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070847"(core mediator complex)|interpro:IPR007018(MED6 mediator)|interpro:IPR016820(Mediator complex, subunit 6, metazoa/plant)|interpro:IPR038566|mint:O75586|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-31456N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:QYK+2tX/HC1OGGPu3b3S1v/ODR89606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:O43513	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394632|ensembl:ENSP00000286317|ensembl:ENSP00000401046	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med7_human(display_long)|uniprotkb:MED7(gene name)|psi-mi:MED7(display_short)|uniprotkb:CRSP9(gene name synonym)|uniprotkb:ARC34(gene name synonym)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 9(gene name synonym)|uniprotkb:Transcriptional coactivator CRSP33(gene name synonym)|uniprotkb:RNA polymerase transcriptional regulation mediator subunit 7 homolog(gene name synonym)|uniprotkb:Activator-recruited cofactor 34 kDa component(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001094286.1|refseq:NP_004261.1|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENSG00000155868(gene)|ensembl:ENST00000286317(transcript)|ensembl:ENST00000420343(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016592"(mediator complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR009244(MED7)|interpro:IPR037212|mint:O43513|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:K6K10aETITT6OIwedZj5qvG2OmI9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q96G25	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394405|uniprotkb:A9IZ91|uniprotkb:Q96FQ4|uniprotkb:A9IZ92|uniprotkb:Q5JUY8|ensembl:ENSP00000361535	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med8_human(display_long)|uniprotkb:MED8(gene name)|psi-mi:MED8(display_short)|uniprotkb:Mediator complex subunit 8(gene name synonym)|uniprotkb:Activator-recruited cofactor 32 kDa component(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_443109.2|refseq:NP_963836.2|refseq:NP_001001653.1|ensembl:ENSG00000159479(gene)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex)|interpro:IPR019364|mint:Q96G25|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENST00000372457(transcript)	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:e/ye7rfa2E1XOPb5vVhI9Nvqmxw9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q9NWA0	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394653|ensembl:ENSP00000268711	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:med9_human(display_long)|uniprotkb:MED9(gene name)|psi-mi:MED9(display_short)|uniprotkb:Mediator complex subunit 9(gene name synonym)|uniprotkb:MED25(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_060489.1|ensembl:ENSG00000141026(gene)|ensembl:ENST00000268711(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR011425(RNA polymerase II transcription mediator)|interpro:IPR037212|interpro:IPR039242|mint:Q9NWA0|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:VSYpA1Aqh2FEaZIEF/6iCIpoPEc9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P19388	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-395189|uniprotkb:O43380|uniprotkb:Q6PIH5|uniprotkb:Q9BT06|uniprotkb:B2R6L4|uniprotkb:D6W5Y1|ensembl:ENSP00000464739|ensembl:ENSP00000478303|ensembl:ENSP00000485021	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpab1_human(display_long)|uniprotkb:POLR2E(gene name)|psi-mi:POLR2E(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit E(gene name synonym)|uniprotkb:RPB5 homolog(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 23 kDa polypeptide(gene name synonym)|uniprotkb:XAP4(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_002686.2|ensembl:ENSG00000099817(gene)|ensembl:ENST00000586746(transcript)|ensembl:ENST00000612655(transcript)|ensembl:ENST00000615234(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR000783(RNA polymerase, subunit H/Rpb5 C-terminal)|interpro:IPR005571(RNA polymerase, Rpb5, N-terminal)|interpro:IPR014381(DNA-directed RNA polymerase, RPB5 subunit)|interpro:IPR020608|interpro:IPR020609|interpro:IPR035913|interpro:IPR036710|interpro:IPR039531|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|mint:P19388|rcsb pdb:5IY6|rcsb pdb:5IY7|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-167246|dip:DIP-56N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:BIVesx7KODhdpcgjhU6CghhXNQE9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P61218	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-395180|uniprotkb:P41584|uniprotkb:Q6IAY3|ensembl:ENSP00000403852	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpab2_human(display_long)|uniprotkb:POLRF(gene name synonym)|uniprotkb:POLR2F(gene name)|psi-mi:POLR2F(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit F(gene name synonym)|uniprotkb:DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide(gene name synonym)|uniprotkb:RPABC14.4(gene name synonym)|uniprotkb:RPB6 homolog(gene name synonym)|uniprotkb:RPC15(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_068809.1|interpro:IPR036161|mint:P61218|rcsb pdb:1QKL|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|ensembl:ENSG00000100142(gene)|ensembl:ENST00000442738(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR006110(RNA polymerase Rpb6)|interpro:IPR006111(DNA-directed RNA polymerase, 14 to 18 kDa subunit)|interpro:IPR012293(RNA polymerase subunit, RPB6/omega)|interpro:IPR020708|interpro:IPR028363|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|dip:DIP-32915N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:ljFKMfBLzZ3qRT27we7Gqdh0jv89606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P52434	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-359505|uniprotkb:P53802|uniprotkb:Q969R0|ensembl:ENSP00000392913|uniprotkb:C9J413|uniprotkb:C9JBJ6|uniprotkb:C9JCU7|uniprotkb:C9JUA8	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpab3_human(display_long)|uniprotkb:POLR2H(gene name)|psi-mi:POLR2H(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit H(gene name synonym)|uniprotkb:DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide(gene name synonym)|uniprotkb:RPB17(gene name synonym)|uniprotkb:RPB8 homolog(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000163882(gene)|ensembl:ENST00000456318(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR005570(RNA polymerase, Rpb8)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P52434|rcsb pdb:2F3I|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|refseq:NP_006223.2|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|rcsb pdb:7AE3|reactome:R-HSA-1834949|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-427413|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-203927|refseq:NP_001265627.1|refseq:NP_001265628.1|refseq:NP_001265629.1|refseq:NP_001265644.1|refseq:NP_001265643.1|refseq:XP_006713729.1|refseq:XP_006713730.1|refseq:XP_016862125.1|refseq:XP_016862126.1|dip:DIP-27556N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:h7BRWDi8wRbnw/FcFo25bnlVNkE9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P53803	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-395357|uniprotkb:Q6IBD4|ensembl:ENSP00000342889	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpab4_human(display_long)|uniprotkb:POLR2K(gene name)|psi-mi:POLR2K(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit K(gene name synonym)|uniprotkb:RPB10alpha(gene name synonym)|uniprotkb:RNA polymerase II 7.0 kDa subunit(gene name synonym)|uniprotkb:ABC10-alpha(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_005025.1|ensembl:ENSG00000147669(gene)|ensembl:ENST00000353107(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006591(RNA polymerase Rbp10)|interpro:IPR029040|interpro:IPR039747|mint:P53803|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-72086|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32968N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:dVF/14F1klTHtGh1gfpkGB3YMoU9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P62875	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-359527|ensembl:ENSP00000324124|ensembl:ENSP00000432807|uniprotkb:P52436|uniprotkb:Q6FHX3	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpab5_human(display_long)|uniprotkb:POLR2L(gene name)|psi-mi:POLR2L(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit L(gene name synonym)|uniprotkb:RPB10 homolog(gene name synonym)|uniprotkb:RNA polymerase II 7.6 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000177700(gene)|ensembl:ENST00000322028(transcript)|ensembl:ENST00000534030(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR000268(RNA polymerases, N/8 Kd subunits)|interpro:IPR020789|interpro:IPR023580|mint:P62875|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|refseq:NP_066951.1|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-75955|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-203927|dip:DIP-32960N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:uDzgKgHzFTPxFaV1GeUYdYMa4Gk9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P52435	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394753|uniprotkb:O43375|uniprotkb:A5D6V8|ensembl:ENSP00000292614	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb11_human(display_long)|uniprotkb:POLR2J(gene name)|psi-mi:POLR2J(display_short)|uniprotkb:POLR2J1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit J-1(gene name synonym)|uniprotkb:RNA polymerase II 13.3 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_006225.1|ensembl:ENSG00000005075(gene)|ensembl:ENST00000292614(transcript)|go:"GO:0001055"(RNA polymerase II activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0030275"(LRR domain binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR008193(DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site)|interpro:IPR009025(DNA-directed RNA polymerase, RBP11-like)|interpro:IPR036603|interpro:IPR037685|mint:P52435|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32913N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:jK/DlwFrHHuEJ0Ns3wRoB3icmsA9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P24928	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P30876	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394712|uniprotkb:Q8IZ61|uniprotkb:A8K1A8|ensembl:ENSP00000312735|ensembl:ENSP00000370625	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb2_human(display_long)|uniprotkb:POLR2B(gene name)|psi-mi:POLR2B(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_000929.1|refseq:NP_001290197.1|refseq:NP_001290198.1|ensembl:ENSG00000047315(gene)|ensembl:ENST00000314595(transcript)|ensembl:ENST00000381227(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:P30876|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32910N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:YhEjtfLk2QnbRPefOp8ZHX0ejak9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P19387	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394729|uniprotkb:O15161|ensembl:ENSP00000219252	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb3_human(display_long)|uniprotkb:POLR2C(gene name)|psi-mi:POLR2C(display_short)|uniprotkb:A-152E5.7(orf name)|uniprotkb:DNA-directed RNA polymerase II subunit C(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 33 kDa polypeptide(gene name synonym)|uniprotkb:RPB31(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_116558.1|ensembl:ENSG00000102978(gene)|ensembl:ENST00000219252(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR036603|interpro:IPR036643|mint:P19387|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32911N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:UXFC+i+QqB2WRgL9OiYSQ66L36c9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:O15514	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-394737|uniprotkb:Q52LT4|ensembl:ENSP00000272645	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb4_human(display_long)|uniprotkb:POLR2D(gene name)|psi-mi:POLR2D(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit D(gene name synonym)|uniprotkb:RNA polymerase II 16 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004796.1|ensembl:ENSG00000144231(gene)|ensembl:ENST00000272645(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016607"(nuclear speck)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0045948"(positive regulation of translational initiation)|interpro:IPR005574(RNA polymerase II, Rpb4)|interpro:IPR006590(RNA polymerase II, Rpb4, core)|interpro:IPR010997(HRDC-like)|interpro:IPR038324|mint:O15514|rcsb pdb:2C35|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32912N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:qOGCRZ4FNc6fSBgoKUgbbCSHm889606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P62487	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-347928|ensembl:ENSP00000301788|uniprotkb:P52433|uniprotkb:Q2M1Z4|uniprotkb:B2R5C0	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb7_human(display_long)|uniprotkb:POLR2G(gene name)|psi-mi:POLR2G(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym)|uniprotkb:RPB7(gene name synonym)|uniprotkb:RNA polymerase II 19 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000168002(gene)|ensembl:ENST00000301788(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|mint:P62487|rcsb pdb:2C35|rcsb pdb:5IYA|rcsb pdb:5IY6|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|rcsb pdb:5IY7|reactome:R-HSA-167200|reactome:R-HSA-167238|rcsb pdb:5IY8|rcsb pdb:5IY9|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-5601884|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|refseq:NP_002687.1|dip:DIP-32663N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:MtnIweuhSqLFov0c40uOiwv8Eas9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P36954	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-395202|uniprotkb:Q6NW05|uniprotkb:B2R5J2|ensembl:ENSP00000221859	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:rpb9_human(display_long)|uniprotkb:POLR2I(gene name)|psi-mi:POLR2I(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit I(gene name synonym)|uniprotkb:RNA polymerase II 14.5 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_006224.1|ensembl:ENSG00000105258(gene)|ensembl:ENST00000221859(transcript)|go:"GO:0001193"(maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR001529(DNA-directed RNA polymerase, M/15 kDa subunit)|interpro:IPR012164(DNA-directed RNA polymerase, subunit C11/M/9)|interpro:IPR019761|interpro:IPR034012|mint:P36954|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32917N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:YZUW2UDzj1RhCC46iaX1LvYayNA9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P52657	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1045262|uniprotkb:A8MYQ7|intact:EBI-1570443|uniprotkb:Q6FGB5|ensembl:ENSP00000379372|ensembl:ENSP00000379373|ensembl:ENSP00000379375	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:t2ag_human(display_long)|uniprotkb:TF2A2(gene name synonym)|uniprotkb:GTF2A2(gene name)|psi-mi:GTF2A2(display_short)|uniprotkb:General transcription factor IIA subunit 2(gene name synonym)|uniprotkb:Transcription initiation factor IIA gamma chain(gene name synonym)|uniprotkb:TFIIA p12 subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004483.1|ensembl:ENSG00000140307(gene)|ensembl:ENST00000396060(transcript)|ensembl:ENST00000396061(transcript)|ensembl:ENST00000396063(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030054"(cell junction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR003194(Transcription initiation factor IIA, gamma subunit)|interpro:IPR009083(Transcription factor IIA, helical)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|interpro:IPR015871(Transcription initiation factor IIA, gamma subunit, C-terminal)|interpro:IPR015872(Transcription initiation factor IIA, gamma subunit, N-terminal)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|refseq:NP_001307858.1|refseq:NP_001307859.1|dip:DIP-40648N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:gDa6W/kUnao8AGkt3tPkATP3P2w9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P29083	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-5462215|uniprotkb:Q16103|ensembl:ENSP00000283875	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:t2ea_human(display_long)|uniprotkb:GTF2E1(gene name)|psi-mi:GTF2E1(display_short)|uniprotkb:TF2E1(gene name synonym)|uniprotkb:General transcription factor IIE 56 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor IIE subunit alpha(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:XP_011511046.1|refseq:XP_011511047.1|refseq:NP_005504.2|dip:DIP-717N|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005673"(transcription factor TFIIE complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR002853(Transcription factor TFIIE, alpha subunit)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR017919|interpro:IPR021600|interpro:IPR024550|interpro:IPR039997|mint:P29083|rcsb pdb:1VD4|rcsb pdb:2JTX|rcsb pdb:2RNQ|rcsb pdb:2RNR|rcsb pdb:5GPY|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6O9L|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|reactome:R-HSA-6807505|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|ensembl:ENSG00000153767(gene)|ensembl:ENST00000283875(transcript)|go:"GO:0001113"(transcription open complex formation at RNA polymerase II promoter)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:rk6cZKAzOOFGD4hwuTjVAB1gvEg9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P29084	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-2853321|uniprotkb:Q9H2B9|uniprotkb:D3DSV2|ensembl:ENSP00000348168	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:t2eb_human(display_long)|uniprotkb:GTF2E2(gene name)|psi-mi:GTF2E2(display_short)|uniprotkb:TF2E2(gene name synonym)|uniprotkb:General transcription factor IIE subunit 2(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_002086.1|refseq:XP_016868852.1|refseq:XP_016868853.1|dip:DIP-716N|ensembl:ENSG00000197265(gene)|ensembl:ENST00000355904(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005673"(transcription factor TFIIE complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016607"(nuclear speck)|interpro:IPR003166(Transcription factor TFIIE beta subunit, core)|interpro:IPR016656(Transcription initiation factor IIE, beta subunit)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040501|mint:P29084|rcsb pdb:1D8J|rcsb pdb:1D8K|rcsb pdb:5GPY|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6O9L|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:lTDT136qMQVOQf83W7wug9v9hw09606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P35269	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-457886|uniprotkb:Q9BWN0|ensembl:ENSP00000377969|uniprotkb:B2RCS0	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:t2fa_human(display_long)|uniprotkb:Transcription initiation factor IIF subunit alpha(gene name synonym)|uniprotkb:GTF2F1(gene name)|psi-mi:GTF2F1(display_short)|uniprotkb:RAP74(gene name synonym)|uniprotkb:Transcription initiation factor RAP74(gene name synonym)|uniprotkb:General transcription factor IIF 74 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR008851(Transcription initiation factor IIF, alpha subunit)|interpro:IPR011039(Transcription Factor IIF, Rap30/Rap74, interaction)|interpro:IPR036388|interpro:IPR036390|mint:P35269|rcsb pdb:1F3U|rcsb pdb:1I27|rcsb pdb:1J2X|rcsb pdb:1NHA|rcsb pdb:1ONV|rcsb pdb:2K7L|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009615"(response to virus)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:6O9L|refseq:NP_002087.2|go:"GO:0001096"(TFIIF-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005674"(transcription factor TFIIF complex)|go:"GO:0006366"(transcription by RNA polymerase II)|ensembl:ENSG00000125651(gene)|ensembl:ENST00000394456(transcript)|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|dip:DIP-677N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:UHTMke+O4hI3MIvpMB6opKwV3Go9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P13984	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1030560|uniprotkb:A6NNS5|uniprotkb:Q5W0H3|ensembl:ENSP00000340823	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:t2fb_human(display_long)|uniprotkb:GTF2F2(gene name)|psi-mi:GTF2F2(display_short)|uniprotkb:RAP30(gene name synonym)|uniprotkb:Transcription initiation factor IIF subunit beta(gene name synonym)|uniprotkb:ATP-dependent helicase GTF2F2(gene name synonym)|uniprotkb:Transcription initiation factor RAP30(gene name synonym)|uniprotkb:General transcription factor IIF 30 kDa subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_004119.1|ensembl:ENSG00000188342(gene)|ensembl:ENST00000340473(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005674"(transcription factor TFIIF complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003196(Transcription initiation factor IIF, beta subunit)|interpro:IPR011039(Transcription Factor IIF, Rap30/Rap74, interaction)|interpro:IPR036388|interpro:IPR040450|interpro:IPR040504|mint:P13984|interpro:IPR036390|rcsb pdb:1BBY|rcsb pdb:1F3U|rcsb pdb:2BBY|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|dip:DIP-41680N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:kAfbXXjVR1dmgs+WHBlTuG6AVTs9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P20226	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P52655	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-389518|uniprotkb:Q3KNQ9|ensembl:ENSP00000452454	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2aa_human(display_long)|uniprotkb:GTF2A1(gene name)|psi-mi:GTF2A1(display_short)|uniprotkb:TF2A1(gene name synonym)|uniprotkb:General transcription factor IIA subunit 1(gene name synonym)|uniprotkb:Transcription initiation factor TFIIA 42 kDa subunit(gene name synonym)|uniprotkb:TFIIAL(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_056943.1|refseq:NP_963889.1|refseq:NP_001265869.1|ensembl:ENSG00000165417(gene)|ensembl:ENST00000553612(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004855(Transcription factor IIA, alpha/beta subunit)|interpro:IPR009088(Transcription factor IIA, beta-barrel)|rcsb pdb:1NVP|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M4S|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-9018519|dip:DIP-33225N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:yatX/WS3e+54rhzDnTzIiI17JSY9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q00403	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-389564|uniprotkb:A8K1A7|uniprotkb:Q5JS30|ensembl:ENSP00000359531	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2b_human(display_long)|uniprotkb:GTF2B(gene name)|psi-mi:GTF2B(display_short)|uniprotkb:TF2B(gene name synonym)|uniprotkb:TFIIB(gene name synonym)|uniprotkb:General transcription factor TFIIB(gene name synonym)|uniprotkb:S300-II(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001505.1|ensembl:ENSG00000137947(gene)|ensembl:ENST00000370500(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005694"(chromosome)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019083"(viral transcription)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990114"(RNA polymerase II core complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR023486|interpro:IPR036915|mint:Q00403|rcsb pdb:1C9B|rcsb pdb:1DL6|rcsb pdb:1RLY|rcsb pdb:1RO4|rcsb pdb:1TFB|rcsb pdb:1VOL|rcsb pdb:2PHG|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5WH1|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|dip:DIP-1077N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:mVGHi0jBibSFHpBrVTGHnRm4gXw9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:P32780	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-715539|uniprotkb:Q9H5K5|uniprotkb:Q9NQD9|uniprotkb:Q6I9Y7|uniprotkb:B3KXE0|uniprotkb:D3DQY2|ensembl:ENSP00000265963|ensembl:ENSP00000393638|ensembl:ENSP00000500178|ensembl:ENSP00000500852	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2h1_human(display_long)|uniprotkb:General transcription factor IIH polypeptide 1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex p62 subunit(gene name synonym)|uniprotkb:Basic transcription factor 2 62 kDa subunit(gene name synonym)|uniprotkb:GTF2H1(gene name)|psi-mi:GTF2H1(display_short)|uniprotkb:BTF2(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001135779.1|refseq:NP_005307.1|ensembl:ENSG00000110768(gene)|ensembl:ENSG00000288114(gene)|ensembl:ENST00000265963(transcript)|ensembl:ENST00000453096(transcript)|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000672827(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|interpro:IPR005607(BSD)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013876(TFIIH p62 subunit, N-terminal)|interpro:IPR027079|interpro:IPR035925|mint:P32780|rcsb pdb:1PFJ|rcsb pdb:2DII|rcsb pdb:2RNR|rcsb pdb:2RUK|rcsb pdb:2RVB|rcsb pdb:5GOW|rcsb pdb:5XV8|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:7BUL|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|ensembl:ENST00000672527(transcript)|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|refseq:XP_006718271.1|dip:DIP-708N	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:X5tWUeZYcYgB31HZSn8Ndi9w3V89606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q13888	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1565170|uniprotkb:Q15570|uniprotkb:Q15571|uniprotkb:Q9BS41|ensembl:ENSP00000274400|ensembl:ENSP00000328901|ensembl:ENSP00000477954|ensembl:ENSP00000479262|ensembl:ENSP00000480548|ensembl:ENSP00000486014	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2h2_human(display_long)|uniprotkb:General transcription factor IIH polypeptide 2(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex p44 subunit(gene name synonym)|uniprotkb:Basic transcription factor 2 44 kDa subunit(gene name synonym)|uniprotkb:GTF2H2(gene name)|psi-mi:GTF2H2(display_short)|uniprotkb:BTF2P44(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001506.1|refseq:XP_016864894.1|refseq:XP_016864895.1|refseq:XP_016864892.1|refseq:XP_016864893.1|dip:DIP-786N|ensembl:ENSG00000145736(gene)|ensembl:ENSG00000275045(gene)|ensembl:ENSG00000276910(gene)|ensembl:ENST00000274400(transcript)|ensembl:ENST00000330280(transcript)|ensembl:ENST00000612581(transcript)|ensembl:ENST00000617228(transcript)|ensembl:ENST00000619997(transcript)|ensembl:ENST00000628423(transcript)|go:"GO:0000438"(core TFIIH complex portion of holo TFIIH complex)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009411"(response to UV)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004595(TFIIH C1-like, C-terminal)|interpro:IPR007198(Ssl1-like)|interpro:IPR012170(TFIIH basal transcription factor complex, subunit SSL1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036465|mint:Q13888|rcsb pdb:1Z60|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5O85|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:U4tPk4UlGiQz+exwhYG9kg7xGAM9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q13889	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-6380459|uniprotkb:B4DNZ6|ensembl:ENSP00000445162|uniprotkb:B2R819|uniprotkb:Q7L0G0|uniprotkb:Q96AT7	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2h3_human(display_long)|uniprotkb:GTF2H3(gene name)|psi-mi:GTF2H3(display_short)|uniprotkb:Basic transcription factor 2 34 kDa subunit(gene name synonym)|uniprotkb:General transcription factor IIH polypeptide 3(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex p34 subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000111358(gene)|ensembl:ENST00000543341(transcript)|go:"GO:0000438"(core TFIIH complex portion of holo TFIIH complex)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR004600(Transcription factor Tfb4)|interpro:IPR036465|mint:Q13889|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5O85|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-75955|dip:DIP-787N|refseq:NP_001258795.1|refseq:NP_001258796.1|refseq:NP_001258797.1|refseq:NP_001507.2	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:Ca5tFYnStJdHF1eNPEwLZtKB0+09606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q92759	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-6380495|ensembl:ENSP00000259895|ensembl:ENSP00000365493|ensembl:ENSP00000365504|ensembl:ENSP00000383300|ensembl:ENSP00000387980|ensembl:ENSP00000388227|ensembl:ENSP00000395497|ensembl:ENSP00000396251|ensembl:ENSP00000399554|ensembl:ENSP00000401105|ensembl:ENSP00000403156|ensembl:ENSP00000409483|uniprotkb:Q76KU4|uniprotkb:B4DTJ5	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2h4_human(display_long)|uniprotkb:GTF2H4(gene name)|psi-mi:GTF2H4(display_short)|uniprotkb:Basic transcription factor 2 52 kDa subunit(gene name synonym)|uniprotkb:General transcription factor IIH polypeptide 4(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex p52 subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|reactome:R-HSA-167158|rcsb pdb:7EGB|reactome:R-HSA-167160|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|reactome:R-HSA-167161|rcsb pdb:7NVR|rcsb pdb:7NVV|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|rcsb pdb:7NVW|reactome:R-HSA-73772|rcsb pdb:7NVX|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|rcsb pdb:7NVY|reactome:R-HSA-77075|rcsb pdb:7NVZ|ensembl:ENSG00000213780(gene)|ensembl:ENSG00000221974(gene)|ensembl:ENSG00000226384(gene)|ensembl:ENSG00000233149(gene)|ensembl:ENSG00000234370(gene)|ensembl:ENSG00000236895(gene)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|ensembl:ENST00000259895(transcript)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|interpro:IPR004598(Transcription factor Tfb2)|interpro:IPR040662|mint:Q92759|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|ensembl:ENST00000376316(transcript)|ensembl:ENST00000376326(transcript)|rcsb pdb:5IY8|ensembl:ENST00000400450(transcript)|ensembl:ENST00000413314(transcript)|rcsb pdb:5IY9|ensembl:ENST00000416773(transcript)|ensembl:ENST00000423881(transcript)|ensembl:ENST00000434226(transcript)|ensembl:ENST00000435498(transcript)|ensembl:ENST00000438348(transcript)|ensembl:ENST00000440824(transcript)|ensembl:ENST00000456968(transcript)|go:"GO:0000438"(core TFIIH complex portion of holo TFIIH complex)|dip:DIP-48376N|refseq:NP_001508.1	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:vQJkQt6yfTyMyQ6oYP1HpNv7hlY9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51946	uniprotkb:Q6ZYL4	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-6380438|ensembl:ENSP00000476100|uniprotkb:Q0P5V8	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:tf2h5_human(display_long)|uniprotkb:TFIIH subunit p8(gene name synonym)|uniprotkb:GTF2H5(gene name)|psi-mi:GTF2H5(display_short)|uniprotkb:C6orf175(gene name synonym)|uniprotkb:TTDA(gene name synonym)|uniprotkb:General transcription factor IIH polypeptide 5(gene name synonym)|uniprotkb:TFB5 ortholog(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex TTD-A subunit(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Abdella et al. (2021)	imex:IM-29080|pubmed:33707221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-27025560|wwpdb:7LBM|emdb:EMD-23255|imex:IM-29080-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000272047(gene)|ensembl:ENST00000607778(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006294"(nucleotide-excision repair, preincision complex assembly)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071480"(cellular response to gamma radiation)|interpro:IPR009400(Nucleotide excision repair, TFIIH, subunit TTDA)|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|interpro:IPR035935|mint:Q6ZYL4|rcsb pdb:1YDL|rcsb pdb:2JNJ|rcsb pdb:5IVW|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:7NVZ|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|rcsb pdb:6RO4|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-29188N|refseq:NP_997001.1	-	-	-	figure legend:Fig 1; Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/30	2021/07/05	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:6qEk3oQgejWFca2xqWRScoFdxNM9606	rigid:gYlTsLI1DRp+WJQ1dT4bqJGlgho	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)