#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43005	uniprotkb:P43005	intact:EBI-745376|uniprotkb:O75587|uniprotkb:Q5VZ24|uniprotkb:Q8N199|uniprotkb:Q9UEW2|intact:EBI-28966902|ensembl:ENSP00000262352	intact:EBI-745376|uniprotkb:O75587|uniprotkb:Q5VZ24|uniprotkb:Q8N199|uniprotkb:Q9UEW2|intact:EBI-28966902|ensembl:ENSP00000262352	psi-mi:eaa3_human(display_long)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Neuronal and epithelial glutamate transporter(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)|uniprotkb:SLC1A1(gene name)|psi-mi:SLC1A1(display_short)|uniprotkb:EAAC1(gene name synonym)|uniprotkb:EAAT3(gene name synonym)	psi-mi:eaa3_human(display_long)|uniprotkb:Sodium-dependent glutamate/aspartate transporter 3(gene name synonym)|uniprotkb:Excitatory amino-acid carrier 1(gene name synonym)|uniprotkb:Neuronal and epithelial glutamate transporter(gene name synonym)|uniprotkb:Solute carrier family 1 member 1(gene name synonym)|uniprotkb:SLC1A1(gene name)|psi-mi:SLC1A1(display_short)|uniprotkb:EAAC1(gene name synonym)|uniprotkb:EAAT3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Qiu et al. (2021)	pubmed:33658209|imex:IM-29265	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-27094620|wwpdb:6X2L|emdb:EMD-22011|wwpdb:6X3F|emdb:EMD-22021|wwpdb:6X3E|emdb:EMD-22020|imex:IM-29265-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262352|refseq:NP_004161.4|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070633"(transepithelial transport)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0043278"(response to morphine)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0071242"(cellular response to ammonium ion)|interpro:IPR036458|rcsb pdb:6S3Q|rcsb pdb:6X2L|rcsb pdb:6X2Z|interpro:IPR018107|rcsb pdb:6X3E|rcsb pdb:6X3F|reactome:R-HSA-210500|reactome:R-HSA-425393|reactome:R-HSA-5619067|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|ensembl:ENSG00000106688(gene)|ensembl:ENST00000262352(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006811"(ion transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)	ensembl:ENSP00000262352|refseq:NP_004161.4|go:"GO:0098877"(neurotransmitter receptor transport to plasma membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0140010"(D-aspartate transmembrane transporter activity)|go:"GO:0150002"(distal dendrite)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990708"(conditioned place preference)|interpro:IPR001991("Sodium:dicarboxylate symporter")|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050808"(synapse organization)|go:"GO:0051938"(L-glutamate import)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060013"(righting reflex)|go:"GO:0060047"(heart contraction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061744"(motor behavior)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070633"(transepithelial transport)|go:"GO:0070777"(D-aspartate transport)|go:"GO:0070778"(L-aspartate transmembrane transport)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0043278"(response to morphine)|go:"GO:0042802"(identical protein binding)|go:"GO:0042883"(cysteine transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0071242"(cellular response to ammonium ion)|interpro:IPR036458|rcsb pdb:6S3Q|rcsb pdb:6X2L|rcsb pdb:6X2Z|interpro:IPR018107|rcsb pdb:6X3E|rcsb pdb:6X3F|reactome:R-HSA-210500|reactome:R-HSA-425393|reactome:R-HSA-5619067|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071944"(cell periphery)|go:"GO:0072347"(response to anesthetic)|go:"GO:0090313"(regulation of protein targeting to membrane)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097386"(glial cell projection)|go:"GO:0097440"(apical dendrite)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098793"(presynapse)|ensembl:ENSG00000106688(gene)|ensembl:ENST00000262352(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005253"(anion channel activity)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005314"(high-affinity glutamate transmembrane transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006811"(ion transport)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015501"("glutamate:sodium symporter activity")|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0022008"(neurogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033229"(cysteine transmembrane transporter activity)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036293"(response to decreased oxygen levels)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0042417"(dopamine metabolic process)	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2021/09/28	2021/10/06	rogid:jfly4MdMjJ8UjXO7nKaQx6U0vac9606	rogid:jfly4MdMjJ8UjXO7nKaQx6U0vac9606	rigid:T0sDValLWsWiQxt3OXwala2S8+4	false	-	-	3	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)