#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IXI2	uniprotkb:Q9NRI5	intact:EBI-1396430|uniprotkb:A4FVB6|uniprotkb:Q6NUR3|uniprotkb:Q6P9F8|uniprotkb:Q6PJG1|uniprotkb:Q6YMW8|uniprotkb:Q86UB0|uniprotkb:Q8IW28|uniprotkb:Q8IXJ7|uniprotkb:Q9H067|uniprotkb:Q9H9N8|uniprotkb:Q9NUZ2|uniprotkb:A6NFV0|uniprotkb:B4DG48|uniprotkb:J9JIH9|ensembl:ENSP00000334724	intact:EBI-529989|uniprotkb:O75045|uniprotkb:Q5VT44|uniprotkb:Q5VT45|uniprotkb:Q8IXJ0|uniprotkb:Q8IXJ1|uniprotkb:Q9BX19|uniprotkb:Q9NRI3|uniprotkb:Q9NRI4|uniprotkb:C9J6D0|intact:EBI-28977396|ensembl:ENSP00000403888|uniprotkb:A6NLH2|uniprotkb:C4P095|uniprotkb:C4P0A1|uniprotkb:C4P0A3|uniprotkb:C4P0B3|uniprotkb:C4P091|uniprotkb:C4P0B6|uniprotkb:C4P0C1	psi-mi:miro1_human(display_long)|uniprotkb:Ras homolog gene family member T1(gene name synonym)|uniprotkb:Rac-GTP-binding protein-like protein(gene name synonym)|uniprotkb:RHOT1(gene name)|psi-mi:RHOT1(display_short)|uniprotkb:ARHT1(gene name synonym)	psi-mi:disc1_human(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Norkett et al. (2019)	imex:IM-28852|pubmed:32637409	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26902647|imex:IM-28852-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028738.1|refseq:NP_001028740.1|refseq:NP_060777.3|refseq:NP_001028739.2|refseq:NP_001275683.1|refseq:NP_001275684.1|refseq:NP_001275687.1|dip:DIP-39114N|ensembl:ENSG00000126858(gene)|ensembl:ENST00000333942(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0034640"(establishment of mitochondrion localization by microtubule attachment)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|interpro:IPR029506|mint:Q8IXI2|rcsb pdb:5KSO|rcsb pdb:5KSP|rcsb pdb:5KSY|rcsb pdb:5KSZ|rcsb pdb:5KTY|rcsb pdb:5KU1|rcsb pdb:6D71|reactome:R-HSA-5689880|reactome:R-HSA-9013425	ensembl:ENST00000317586|ensembl:ENSP00000320784|ensembl:ENST00000366633|ensembl:ENSP00000355593|ensembl:ENST00000366636|ensembl:ENSP00000355596|ensembl:ENST00000366637|ensembl:ENSP00000355597|ensembl:ENSP00000403888|ensembl:ENST00000535983|ensembl:ENSP00000443996|ensembl:ENST00000539444|ensembl:ENSP00000440953|ensembl:ENST00000602281|ensembl:ENSP00000473425|ensembl:ENST00000602700|ensembl:ENSP00000473417|ensembl:ENST00000602713|ensembl:ENSP00000473261|ensembl:ENST00000602822|ensembl:ENSP00000473586|ensembl:ENST00000602873|ensembl:ENSP00000473386|ensembl:ENST00000628350|ensembl:ENSP00000487190|ensembl:ENSG00000162946(gene)|ensembl:ENST00000439617(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|mint:Q9NRI5|rcsb pdb:5V4B|refseq:NP_001012975.1|refseq:NP_001012976.1|refseq:NP_001012977.1|refseq:NP_061132.2|refseq:NP_001158011.1|refseq:NP_001158013.1|refseq:NP_001158017.1|refseq:NP_001158018.1|refseq:NP_001158019.1|refseq:NP_001158016.1|refseq:NP_001158027.1|refseq:NP_001158028.1|dip:DIP-33828N	-	-	-	figure legend:fig.2 e-f|comment:"We carried out GFP trap coimmunoprecipitation experiments from COS7 cells expressing untagged, WTDISC1, and GFP-tagged WT, V13, or N18 Miro1 to mimic GTP- and GDP-bound states, respectively. Interestingly, Western blot analysis revealed that more DISC1 is immunoprecipitated with V13 Miro1 compared to WT Miro1 (Figure 2E, quantified in 2F, normalized DISC1 intensity for WT Miro1 = 1.0, for V13 Miro1 = 5.2 ± 2.1, p = 0.05), indicating that DISC1 preferentially interacts with the GTP-bound Miro mimic."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2021/03/15	2021/04/07	rogid:gA6A8bgSwshvMwCO0cG66h+wwIY9606	rogid:m8e3Nji5GtYKa5m5lcFJDAUnh/89606	rigid:tpNmK+E+JCJEkuHP8DCPUrkXH04	false	green fluorescent protein tag:?-?|mutation with no effect:18-18|mutation increasing interaction:13-13	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)