#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96T52 uniprotkb:P62834 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43615 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-861737|uniprotkb:Q8N193|uniprotkb:A8K0R9|uniprotkb:D6W664|ensembl:ENSP00000270538 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tim44_human(display_long)|uniprotkb:TIMM44(gene name)|psi-mi:TIMM44(display_short)|uniprotkb:MIMT44(gene name synonym)|uniprotkb:TIM44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006342.2|ensembl:ENSG00000104980(gene)|ensembl:ENST00000270538(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|mint:O43615|rcsb pdb:2CW9|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Hwln5XuF3a9IMwVhP63Ud+LM5M09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NVH0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11324738|uniprotkb:Q8N3D3|uniprotkb:Q6AWB6|uniprotkb:G5E947|uniprotkb:B4DIH6|ensembl:ENSP00000313140|ensembl:ENSP00000387331 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:exd2_human(display_long)|uniprotkb:EXD2(gene name)|psi-mi:EXD2(display_short)|uniprotkb:C14orf114(gene name synonym)|uniprotkb:EXDL2(gene name synonym)|uniprotkb:Exonuclease 3'-5' domain-like-containing protein 2(gene name synonym)|uniprotkb:3'-5' exoribonuclease EXD2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001180289.1|refseq:NP_001180290.1|refseq:NP_001180291.1|refseq:NP_001180292.1|refseq:NP_060669.1|refseq:XP_005267874.1|refseq:XP_011535210.1|ensembl:ENSG00000081177(gene)|ensembl:ENST00000312994(transcript)|ensembl:ENST00000409018(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008852"(exodeoxyribonuclease I activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|rcsb pdb:6K17|rcsb pdb:6K18|rcsb pdb:6K19|rcsb pdb:6K1A|rcsb pdb:6K1B|rcsb pdb:6K1C|rcsb pdb:6K1D|rcsb pdb:6K1E|refseq:XP_016876910.1|dip:DIP-61996N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Id4gHPaa70qNO9LznLBjDgkMlu09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NRX2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7825154|ensembl:ENSP00000288937|uniprotkb:Q6IAH8|uniprotkb:Q9C066|uniprotkb:Q96Q53|uniprotkb:D3DQU3|intact:MINT-3064942 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm17_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein bL17m(gene name synonym)|uniprotkb:MRPL17(gene name)|psi-mi:MRPL17(display_short)|uniprotkb:LIP2(gene name synonym)|uniprotkb:LYST-interacting protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000158042(gene)|ensembl:ENST00000288937(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR000456(Ribosomal protein L17)|interpro:IPR036373|mint:Q9NRX2|rcsb pdb:2CQM|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF7|refseq:NP_071344.1 - - comment:mint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9IL43XtZbhcbaI7Gkq3X6O1M3XE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HD23 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BX68 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-8523143|intact:MINT-3063101|intact:MINT-4891407|uniprotkb:Q5TCW3|ensembl:ENSP00000259667 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hint2_human(display_long)|uniprotkb:HINT2(gene name)|psi-mi:HINT2(display_short)|uniprotkb:HINT-3(gene name synonym)|uniprotkb:HIT-17kDa(gene name synonym)|uniprotkb:PKCI-1-related HIT protein(gene name synonym)|uniprotkb:Histidine triad nucleotide-binding protein 2, mitochondrial(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_115982.1|ensembl:ENSG00000137133(gene)|ensembl:ENST00000259667(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR001310("Histidine triad (HIT) protein")|interpro:IPR011146(Histidine triad-like motif)|interpro:IPR019808|interpro:IPR036265|rcsb pdb:4INC|rcsb pdb:4INI|rcsb pdb:5KM5|rcsb pdb:5KM8|rcsb pdb:5KM9|rcsb pdb:6YI0|rcsb pdb:6YPX|rcsb pdb:6YQD|rcsb pdb:6YVP|reactome:R-HSA-9013405|rcsb pdb:6YPR - - function:Probable hydrolase|comment:mint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:DNpQta4PaPrYoOZsPdfIkLmEsFI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EY8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7825413|ensembl:ENSP00000445920|intact:UNK-5534451|uniprotkb:Q9BSH0|uniprotkb:C5HU05 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mmab_human(display_long)|uniprotkb:MMAB(gene name)|psi-mi:MMAB(display_short)|uniprotkb:Methylmalonic aciduria type B protein(gene name synonym)|uniprotkb:"Cob(II)alamin adenosyltransferase"(gene name synonym)|uniprotkb:"Cob(II)yrinic acid a,c-diamide adenosyltransferase"(gene name synonym)|uniprotkb:Cobinamide/cobalamin adenosyltransferase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENST00000545712(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008817"("cob(I)yrinic acid a,c-diamide adenosyltransferase activity")|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031419"(cobalamin binding)|interpro:IPR016030("Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like")|interpro:IPR029499|interpro:IPR036451|rcsb pdb:2IDX|rcsb pdb:6D5K|rcsb pdb:6D5X|reactome:R-HSA-196741|reactome:R-HSA-3359471|ensembl:ENSG00000139428(gene)|refseq:NP_443077.1 - - comment:mint|function:"Defects in MMAB are the cause of methylmalonic aciduria linked to the cblB complementation group (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive" figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mCC0sM9ENytksAmo6ICWkWQHbZA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8WUK0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7199479|uniprotkb:Q7Z557|uniprotkb:Q9BXV8|uniprotkb:E9PAT8|intact:MINT-8162697|intact:MINT-8247525|uniprotkb:Q96CR2|ensembl:ENSP00000325958|ensembl:ENSP00000496417 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ptpm1_human(display_long)|uniprotkb:PTPMT1(gene name)|psi-mi:PTPMT1(display_short)|uniprotkb:MOSP(gene name synonym)|uniprotkb:PLIP(gene name synonym)|uniprotkb:PTEN-like phosphatase(gene name synonym)|uniprotkb:Phosphoinositide lipid phosphatase(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase mitochondrial 1(gene name synonym)|uniprotkb:PNAS-129(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001137456.1|refseq:NP_783859.1|ensembl:ENSG00000110536(gene)|ensembl:ENSG00000285206(gene)|ensembl:ENST00000326674(transcript)|ensembl:ENST00000647378(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008962"(phosphatidylglycerophosphatase activity)|go:"GO:0032049"(cardiolipin biosynthetic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR042165|interpro:IPR044596|mint:Q8WUK0|reactome:R-HSA-1483148 - - comment:mint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:h7MaeKx6Cx3G2KpRm201THlTJqs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N5N7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7825175|uniprotkb:B7Z358|ensembl:ENSP00000363999|uniprotkb:Q9NX15|intact:UNK-5522445|uniprotkb:Q5T7E0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm50_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL50(gene name synonym)|uniprotkb:MRPL50(gene name)|psi-mi:MRPL50(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000136897(gene)|ensembl:ENST00000374865(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR018305|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF0|refseq:NP_061924.1 - - comment:mint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Qo0MGo2Bv7DnWEFNu0IPOnGXoWE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z7F7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7825445|uniprotkb:Q6UWI8|uniprotkb:Q5TBY6|uniprotkb:Q5TBY3|intact:MINT-8052096|ensembl:ENSP00000355701|ensembl:ENSP00000355702|ensembl:ENSP00000355703|ensembl:ENSP00000355705|ensembl:ENSP00000355707|ensembl:ENSP00000355708|ensembl:ENSP00000375740|ensembl:ENSP00000295008|ensembl:ENSP00000337342|ensembl:ENSP00000337361|ensembl:ENSP00000338189|ensembl:ENSP00000355694|ensembl:ENSP00000355695|ensembl:ENSP00000355696|ensembl:ENSP00000355697|ensembl:ENSP00000355700 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm55_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL55(gene name synonym)|uniprotkb:UNQ5835/PRO19675(orf name)|uniprotkb:MRPL55(gene name)|psi-mi:MRPL55(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL31m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001308213.1|refseq:XP_011542396.1|refseq:XP_011542397.1|refseq:NP_852128.1|refseq:NP_852121.1|refseq:NP_852129.1|refseq:NP_852119.1|refseq:NP_852130.1|refseq:NP_852127.2|refseq:NP_852106.1|refseq:NP_852120.1|refseq:XP_005273116.1|refseq:XP_005273118.1|refseq:XP_005273119.1|refseq:XP_005273120.1|ensembl:ENST00000295008(transcript)|ensembl:ENST00000336300(transcript)|ensembl:ENST00000336520(transcript)|ensembl:ENST00000348259(transcript)|ensembl:ENST00000366733(transcript)|ensembl:ENST00000366734(transcript)|ensembl:ENST00000366735(transcript)|ensembl:ENST00000366736(transcript)|ensembl:ENST00000366739(transcript)|ensembl:ENST00000366740(transcript)|ensembl:ENST00000366741(transcript)|ensembl:ENST00000366742(transcript)|ensembl:ENST00000366744(transcript)|ensembl:ENST00000366746(transcript)|ensembl:ENST00000366747(transcript)|ensembl:ENSG00000162910(gene)|ensembl:ENST00000391867(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR018615|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - comment:mint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:z9xjc5C0hqS/JVw11eE6AyWk3K89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6UXV4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5T1C6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7684443|ensembl:ENSP00000357804|uniprotkb:Q96KR2|uniprotkb:B2RBX2|intact:MINT-8306269 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:them4_human(display_long)|uniprotkb:THEM4(gene name)|psi-mi:THEM4(display_short)|uniprotkb:CTMP(gene name synonym)|uniprotkb:Carboxyl-terminal modulator protein(gene name synonym)|uniprotkb:Thioesterase superfamily member 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000159445(gene)|ensembl:ENST00000368814(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|rcsb pdb:4AE8|rcsb pdb:4GAH|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-199418|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-77289|refseq:NP_444283.2|dip:DIP-60764N - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:wgpknFKS1Xb9JWYSXKF/ImKoGx89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75431 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y6K0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237183|uniprotkb:Q69YJ9|uniprotkb:Q9P0Y8|ensembl:ENSP00000349696|ensembl:ENSP00000441980 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cept1_human(display_long)|uniprotkb:CEPT1(gene name)|psi-mi:CEPT1(display_short)|uniprotkb:1-alkenyl-2-acylglycerol choline phosphotransferase(gene name synonym)|uniprotkb:PRO1101(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001007795.1|refseq:NP_006081.1|refseq:NP_001317672.1|ensembl:ENSG00000134255(gene)|ensembl:ENST00000357172(transcript)|ensembl:ENST00000545121(transcript)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0004307"(ethanolaminephosphotransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0047359"(1-alkenyl-2-acylglycerol choline phosphotransferase activity)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|reactome:R-HSA-1483191|reactome:R-HSA-1483213 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:M5xOOr596HTYFySYQ0c2LgyK5Pc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y697 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y672 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11337956|uniprotkb:B3KMU2|uniprotkb:Q9H3I0|uniprotkb:Q5SXR9|ensembl:ENSP00000263440 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:alg6_human(display_long)|uniprotkb:ALG6(gene name)|psi-mi:ALG6(display_short)|uniprotkb:Asparagine-linked glycosylation protein 6 homolog(gene name synonym)|uniprotkb:"Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase"(gene name synonym)|uniprotkb:"Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase"(gene name synonym)|uniprotkb:My046(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_037471.2|ensembl:ENSG00000088035(gene)|ensembl:ENST00000263440(transcript)|go:"GO:0004583"(dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006488"(dolichol-linked oligosaccharide biosynthetic process)|go:"GO:0006490"(oligosaccharide-lipid intermediate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042281"(dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity)|go:"GO:0046527"(glucosyltransferase activity)|interpro:IPR004856(ALG6, ALG8 glycosyltransferase)|interpro:IPR039488|reactome:R-HSA-446193|reactome:R-HSA-4724289 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8dM/Kd12YNqCTrIOThU+GT0R+BE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y5L4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y512 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y4W6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y3D9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y3D5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5453854|ensembl:ENSP00000295491 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt18c_human(display_long)|uniprotkb:MRPS18C(gene name)|psi-mi:MRPS18C(display_short)|uniprotkb:28S ribosomal protein S18-1, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein bS18c(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein bS18m(gene name synonym)|uniprotkb:CGI-134(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001284698.1|refseq:NP_001284699.1|refseq:NP_057151.1|ensembl:ENSG00000163319(gene)|ensembl:ENST00000295491(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001648(Ribosomal protein S18)|interpro:IPR018275|interpro:IPR036870|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:WFVJqLIjMUdsPmYVjn7uvIxy+c49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y3D3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049319|uniprotkb:Q96Q60|ensembl:ENSP00000362036|uniprotkb:B4E032 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt16_human(display_long)|uniprotkb:MRPS16(gene name)|psi-mi:MRPS16(display_short)|uniprotkb:RPMS16(gene name synonym)|uniprotkb:CGI-132(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein bS16m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057149.1|ensembl:ENSG00000182180(gene)|ensembl:ENST00000372945(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR000307(Ribosomal protein S16)|interpro:IPR023803|mint:Q9Y3D3|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|rcsb pdb:7A5F|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7A5G - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jejigKZMzvzmWuhMXnBB3lNsShU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y399 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2880048|intact:EBI-28977422|ensembl:ENSP00000241600|ensembl:ENSP00000360850|uniprotkb:Q5T899|uniprotkb:Q9BSQ4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt02_human(display_long)|uniprotkb:MRPS2(gene name)|psi-mi:MRPS2(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS2m(gene name synonym)|uniprotkb:CGI-91(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6RW5|ensembl:ENST00000241600(transcript)|ensembl:ENST00000371785(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0061668"(mitochondrial ribosome assembly)|ensembl:ENSG00000122140(gene)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005706(Ribosomal protein S2, bacterial-type)|interpro:IPR018130|interpro:IPR023591|mint:Q9Y399|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|ensembl:ENSP00000241600|ensembl:ENSP00000360850|refseq:NP_057118.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:tlWj8Un0CmbnBQtZMYlJpvIpc/09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y375 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-741874|uniprotkb:Q9BVZ5|ensembl:ENSP00000260361|ensembl:ENSP00000453944 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cia30_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1(gene name synonym)|uniprotkb:NDUFAF1(gene name)|psi-mi:NDUFAF1(display_short)|uniprotkb:CIA30(gene name synonym)|uniprotkb:CGI-65(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057097.2|ensembl:ENSG00000137806(gene)|ensembl:ENST00000260361(transcript)|ensembl:ENST00000560978(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0010257"(NADH dehydrogenase complex assembly)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013857("NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30")|interpro:IPR039131|mint:Q9Y375|reactome:R-HSA-6799198|refseq:XP_011519960.1|refseq:XP_006720618.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:cZmtaAs6upui/PVTTBGQBEOcWvk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y2S7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y2R9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054973|uniprotkb:Q53GD6|uniprotkb:B2R9N5|ensembl:ENSP00000245539 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt07_human(display_long)|uniprotkb:bMRP-27a(gene name synonym)|uniprotkb:MRPS7(gene name)|psi-mi:MRPS7(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS7m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057055.2|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR023798|interpro:IPR036823|mint:Q9Y2R9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125445(gene)|ensembl:ENST00000245539(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:hrz2XVS38Ex1z125QFx/n9oPsys9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y276 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-719257|uniprotkb:B3KTW9|uniprotkb:Q7Z2V7|ensembl:ENSP00000352219|ensembl:ENSP00000375957|ensembl:ENSP00000375958|ensembl:ENSP00000375959|ensembl:ENSP00000404999|ensembl:ENSP00000406494|ensembl:ENSP00000413908 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:bcs1_human(display_long)|uniprotkb:BCS1-like protein(gene name synonym)|uniprotkb:BCS1L(gene name)|psi-mi:BCS1L(display_short)|uniprotkb:BCS1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001073335.1|refseq:NP_004319.1|ensembl:ENSG00000074582(gene)|ensembl:ENST00000359273(transcript)|ensembl:ENST00000392109(transcript)|ensembl:ENST00000392110(transcript)|ensembl:ENST00000392111(transcript)|ensembl:ENST00000412366(transcript)|ensembl:ENST00000431802(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR014851(BCS1 N terminal)|interpro:IPR027417|reactome:R-HSA-1268020|ensembl:ENST00000439945(transcript)|refseq:NP_001244271.1|refseq:NP_001244272.1|refseq:NP_001244273.1|refseq:NP_001305765.1|refseq:NP_001307646.1|refseq:XP_006712741.1|refseq:XP_016860120.1|refseq:XP_016860121.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:NMfoX75THfvFwzpgBcpKXGmRGcM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UI09 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UDR5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237169|uniprotkb:O95462|ensembl:ENSP00000377040|ensembl:ENSP00000403768|ensembl:ENSP00000505381|ensembl:ENSP00000505958 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:aass_human(display_long)|uniprotkb:AASS(gene name)|psi-mi:AASS(display_short)|uniprotkb:LKR/SDH(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005754.2|ensembl:ENSG00000008311(gene)|ensembl:ENST00000393376(transcript)|ensembl:ENST00000417368(transcript)|ensembl:ENST00000679511(transcript)|ensembl:ENST00000679864(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004753"(saccharopine dehydrogenase activity)|go:"GO:0004754"("saccharopine dehydrogenase (NAD+, L-lysine-forming) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006554"(lysine catabolic process)|go:"GO:0019878"(lysine biosynthetic process via aminoadipic acid)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042393"(histone binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0047130"("saccharopine dehydrogenase (NADP+, L-lysine-forming) activity")|go:"GO:0047131"("saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity")|interpro:IPR005097(Saccharopine dehydrogenase)|interpro:IPR007698(Alanine dehydrogenase/PNT, C-terminal)|interpro:IPR007886(Alanine dehydrogenase/PNT, N-terminal)|interpro:IPR032095|interpro:IPR036291|rcsb pdb:5L76|rcsb pdb:5L78|rcsb pdb:5O1N|rcsb pdb:5O1O|rcsb pdb:5O1P|reactome:R-HSA-71064 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UKSIs4pNgKcCqgLa0h1pDf1znnQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9P2R7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9P032 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9P015 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2371967|uniprotkb:Q96Q54|uniprotkb:Q9H0Y1|ensembl:ENSP00000260102 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm15_human(display_long)|uniprotkb:MRPL15(gene name)|psi-mi:MRPL15(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL15m(gene name synonym)|uniprotkb:HSPC145(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_054894.1|ensembl:ENSG00000137547(gene)|ensembl:ENST00000260102(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR005749(Ribosomal protein L15, bacterial-type)|interpro:IPR021131|interpro:IPR030878|interpro:IPR036227|mint:Q9P015|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSA - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:efJei4RFNcTx2MqyMwdu7EXO1c09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NZ45 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050885|intact:EBI-2803159|uniprotkb:Q1X902|ensembl:ENSP00000363041 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cisd1_human(display_long)|uniprotkb:C10orf70(gene name synonym)|uniprotkb:CISD1(gene name)|psi-mi:CISD1(display_short)|uniprotkb:ZCD1(gene name synonym)|uniprotkb:MitoNEET(gene name synonym)|uniprotkb:MDS029(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060934.1|ensembl:ENSG00000122873(gene)|ensembl:ENST00000333926(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR018967|interpro:IPR019610|interpro:IPR042216|mint:Q9NZ45|rcsb pdb:2QD0|rcsb pdb:2QH7|rcsb pdb:2R13|rcsb pdb:3EW0|rcsb pdb:3LPQ|rcsb pdb:3REE|rcsb pdb:4EZF|rcsb pdb:4F1E|rcsb pdb:4F28|rcsb pdb:4F2C|rcsb pdb:6DE9|dip:DIP-46446N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mrkU9Txm3hkC1rWqrPob5k7wJ3g9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NYY8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1055752|uniprotkb:Q9NVX6|uniprotkb:Q9Y2H7|ensembl:ENSP00000236980|ensembl:ENSP00000384929|ensembl:ENSP00000385990|intact:EBI-21354662 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fakd2_human(display_long)|uniprotkb:FASTKD2(gene name)|psi-mi:FASTKD2(display_short)|uniprotkb:KIAA0971(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001129665.1|refseq:NP_001129666.1|refseq:NP_055744.2|ensembl:ENST00000402774(transcript)|ensembl:ENST00000403094(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006396"(RNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0019843"(rRNA binding)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|ensembl:ENST00000236980(transcript)|ensembl:ENSG00000118246(gene) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:b7H58ZWEhq5IFl+wO3fsez1v+1U9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NYU2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NX63 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NVV4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2556166|uniprotkb:Q659E3|uniprotkb:Q9HA74|uniprotkb:Q6P7E5|uniprotkb:D3DRX0|ensembl:ENSP00000263063 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:papd1_human(display_long)|uniprotkb:PAPD1(gene name synonym)|uniprotkb:mtPAP(gene name synonym)|uniprotkb:Polynucleotide adenylyltransferase(gene name synonym)|uniprotkb:PAP-associated domain-containing protein 1(gene name synonym)|uniprotkb:Terminal uridylyltransferase 1(gene name synonym)|uniprotkb:MTPAP(gene name)|psi-mi:MTPAP(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060579.3|ensembl:ENSG00000107951(gene)|ensembl:ENST00000263063(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002134"(UTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR041252|interpro:IPR043519|rcsb pdb:3PQ1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:KUNsYSjhCHVHD8WnZbw5V60Wlec9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NVI7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NVH6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-395312|uniprotkb:Q5TZB5|uniprotkb:Q6IA90|uniprotkb:Q8TBT0|ensembl:ENSP00000335261|uniprotkb:A8K6M9|uniprotkb:B4E3R3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tmlh_human(display_long)|uniprotkb:TMLHE(gene name)|psi-mi:TMLHE(display_short)|uniprotkb:TMLH(gene name synonym)|uniprotkb:Epsilon-trimethyllysine 2-oxoglutarate dioxygenase(gene name synonym)|uniprotkb:TML-alpha-ketoglutarate dioxygenase(gene name synonym)|uniprotkb:TML hydroxylase(gene name synonym)|uniprotkb:Epsilon-trimethyllysine hydroxylase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001171726.1|refseq:NP_060666.1|go:"GO:0051354"(negative regulation of oxidoreductase activity)|interpro:IPR003819(Taurine catabolism dioxygenase TauD/TfdA)|interpro:IPR010376(Protein of unknown function DUF971)|interpro:IPR012776(Trimethyllysine dioxygenase)|interpro:IPR038492|interpro:IPR042098|reactome:R-HSA-71262|ensembl:ENSG00000185973(gene)|ensembl:ENST00000334398(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050353"(trimethyllysine dioxygenase activity) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:QJwymZVdaxmMdea5RhA7vcPCla49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NUJ1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2564608|uniprotkb:B7Z6A8|uniprotkb:C9IZX5|uniprotkb:Q8TCF9|uniprotkb:D3DN63|ensembl:ENSP00000273359 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:abhda_human(display_long)|uniprotkb:ABHD10(gene name)|psi-mi:ABHD10(display_short)|uniprotkb:Alpha/beta hydrolase domain-containing protein 10(gene name synonym)|uniprotkb:Acyl-protein thioesterase ABHD10(gene name synonym)|uniprotkb:Mycophenolic acid acyl-glucuronide esterase, mitochondrial(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060864.1|refseq:XP_011511262.1|ensembl:ENSG00000144827(gene)|ensembl:ENST00000273359(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0019391"(glucuronoside catabolic process)|go:"GO:0052695"(cellular glucuronidation)|go:"GO:0102390"(mycophenolic acid acyl-glucuronide esterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR029058|reactome:R-HSA-156588|refseq:NP_001258998.1|dip:DIP-56934N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ITjY8Sa8podE2/vmKMuwVmnTe+E9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NUB1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-10313831|uniprotkb:B3KXL2|uniprotkb:Q96JX6|uniprotkb:D3DW48|uniprotkb:B4DJZ3|uniprotkb:Q9NU28|uniprotkb:Q96JI1|uniprotkb:Q8IV99|uniprotkb:Q8N234|uniprotkb:Q5TF42|uniprotkb:F8W7Y1|uniprotkb:F5H6F4|ensembl:ENSP00000316924 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acs2l_human(display_long)|uniprotkb:ACSS1(gene name)|psi-mi:ACSS1(display_short)|uniprotkb:ACAS2L(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:KIAA1846(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001239604.1|refseq:NP_001239605.1|refseq:NP_001239606.1|refseq:NP_115890.2|ensembl:ENSG00000154930(gene)|ensembl:ENST00000323482(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006069"(ethanol oxidation)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|rcsb pdb:3GLR|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BVE|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4C78|rcsb pdb:5YTK|reactome:R-HSA-71384|rcsb pdb:5Y4H|dip:DIP-61208N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Z+A3/EcJ41rhi4xeOFci7YBP9u89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NSE4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NR09 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:/EZap+9dFkEnO5fRsbzriORwllk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NQ50 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1053902|uniprotkb:O95134|ensembl:ENSP00000333401|uniprotkb:B3KVZ7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm40_human(display_long)|uniprotkb:Nuclear localization signal-containing protein deleted in velocardiofacial syndrome(gene name synonym)|uniprotkb:Up-regulated in metastasis(gene name synonym)|uniprotkb:MRPL40(gene name)|psi-mi:MRPL40(display_short)|uniprotkb:NLVCF(gene name synonym)|uniprotkb:URIM(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL40(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000185608(gene)|ensembl:ENST00000333130(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0009653"(anatomical structure morphogenesis)|interpro:IPR019192|interpro:IPR039145|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|refseq:NP_003767.2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|rcsb pdb:6ZSG|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1puL0njSb72Xpg43i1ZEAL/l8DU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NPL8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HD26 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-349832|uniprotkb:A6NM30|uniprotkb:Q59FS4|uniprotkb:Q969U8|ensembl:ENSP00000357484 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gopc_human(display_long)|uniprotkb:CAL(gene name synonym)|uniprotkb:FIG(gene name synonym)|uniprotkb:GOPC(gene name)|psi-mi:GOPC(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym)|uniprotkb:CFTR-associated ligand(gene name synonym)|uniprotkb:Fused in glioblastoma(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001017408.1|refseq:NP_065132.1|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045176"(apical protein localization)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR038879|mint:Q9HD26|rcsb pdb:2DC2|rcsb pdb:2LOB|rcsb pdb:4E34|rcsb pdb:4E35|rcsb pdb:4JOE|rcsb pdb:4JOF|rcsb pdb:4JOG|rcsb pdb:4JOH|rcsb pdb:4JOJ|rcsb pdb:4JOK|rcsb pdb:4JOP|rcsb pdb:4JOR|rcsb pdb:4K6Y|rcsb pdb:4K72|rcsb pdb:4K75|rcsb pdb:4K76|rcsb pdb:4K78|rcsb pdb:4NMO|rcsb pdb:4NMP|rcsb pdb:4NMQ|rcsb pdb:4NMR|rcsb pdb:4NMS|rcsb pdb:4NMT|go:"GO:0042802"(identical protein binding)|rcsb pdb:4NMV|rcsb pdb:4Q6H|rcsb pdb:4Q6S|rcsb pdb:5IC3|rcsb pdb:5K4F|rcsb pdb:6OV7|rcsb pdb:6V84|rcsb pdb:6XNJ|reactome:R-HSA-5627083|reactome:R-HSA-9013406|ensembl:ENSG00000047932(gene)|ensembl:ENST00000368498(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032991"(protein-containing complex) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:bXzu5wvJifZwB+Q52cgC4tZQl/k9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HC36 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1045440|uniprotkb:Q9NVQ5|uniprotkb:Q53GN1|uniprotkb:Q86VC3|uniprotkb:Q96F76|ensembl:ENSP00000306080 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mrm3_human(display_long)|uniprotkb:MRM3(gene name)|psi-mi:MRM3(display_short)|uniprotkb:"16S rRNA (guanosine(1370)-2'-O)-methyltransferase"(gene name synonym)|uniprotkb:16S rRNA [Gm1370] 2'-O-methyltransferase(gene name synonym)|uniprotkb:RNA methyltransferase-like protein 1(gene name synonym)|uniprotkb:RNMTL1(gene name synonym)|uniprotkb:HC90(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060616.1|refseq:NP_001304876.1|ensembl:ENSG00000171861(gene)|ensembl:ENST00000304478(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0070039"("rRNA (guanosine-2'-O-)-methyltransferase activity")|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR013123(RNA 2-O ribose methyltransferase, substrate binding)|interpro:IPR029028|interpro:IPR029064|mint:Q9HC36|reactome:R-HSA-6793080 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:oOaJQgUM9tpIOv6A20UkLtAQH9c9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HC21 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6268699|ensembl:ENSP00000319574|ensembl:ENSP00000385312|ensembl:ENSP00000397818|ensembl:ENSP00000402202|ensembl:ENSP00000463795|intact:EBI-10978418|uniprotkb:E9PF74|uniprotkb:Q6V9R7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tpc_human(display_long)|uniprotkb:SLC25A19(gene name)|psi-mi:SLC25A19(display_short)|uniprotkb:DNC(gene name synonym)|uniprotkb:MUP1(gene name synonym)|uniprotkb:Mitochondrial uncoupling protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000125454(gene)|ensembl:ENST00000320362(transcript)|ensembl:ENST00000402418(transcript)|ensembl:ENST00000416858(transcript)|ensembl:ENST00000442286(transcript)|ensembl:ENST00000580994(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0030233"(deoxynucleotide transmembrane transporter activity)|go:"GO:0030302"(deoxynucleotide transport)|go:"GO:0030974"(thiamine pyrophosphate transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0090422"(thiamine pyrophosphate transmembrane transporter activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-196819|refseq:XP_005257616.1|refseq:XP_005257617.1|refseq:XP_005257618.1|refseq:XP_005257619.1|refseq:NP_001119593.1|refseq:NP_001119594.1|refseq:NP_068380.3|refseq:XP_006722070.1|refseq:XP_016880415.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+jRNNjAOfOymBAHTtdDt8p/+41Q9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HAV7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1043499|uniprotkb:Q549M6|uniprotkb:B2R783|ensembl:ENSP00000264954 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:grpe1_human(display_long)|uniprotkb:Mt-GrpE#1(gene name synonym)|uniprotkb:HMGE(gene name synonym)|uniprotkb:GRPEL1(gene name)|psi-mi:GRPEL1(display_short)|uniprotkb:GREPEL1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000109519(gene)|ensembl:ENST00000264954(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001405"(PAM complex, Tim23 associated import motor)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000740(GrpE nucleotide exchange factor)|interpro:IPR009012(GrpE nucleotide exchange factor, head)|interpro:IPR013805(GrpE nucleotide exchange factor, coiled-coil)|mint:Q9HAV7|reactome:R-HSA-1268020|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_079472.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OWuX4gnZBzxgv0arSEKY9KyZZ+o9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HA77 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2107262|uniprotkb:Q8NI84|uniprotkb:Q96IV4|ensembl:ENSP00000257347 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sycm_human(display_long)|uniprotkb:CARS2(gene name)|psi-mi:CARS2(display_short)|uniprotkb:Cysteinyl-tRNA synthetase(gene name synonym)|uniprotkb:OK/SW-cl.10(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_078813.1|ensembl:ENSG00000134905(gene)|ensembl:ENST00000257347(transcript)|go:"GO:0004817"(cysteine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006423"(cysteinyl-tRNA aminoacylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR015803(Cysteinyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR024909|interpro:IPR032678|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1YjqTFtsp39awdgDtBTL3AgJrp49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H857 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359244|uniprotkb:O95888|uniprotkb:Q96C80|uniprotkb:Q9H9Z8|uniprotkb:C9JTZ6|uniprotkb:E9PAL9|intact:EBI-11044897|ensembl:ENSP00000302468 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nt5d2_human(display_long)|uniprotkb:NT5DC2(gene name)|psi-mi:NT5DC2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001127703.1|refseq:NP_075059.1|refseq:XP_005265463.1|refseq:XP_006713368.1|ensembl:ENSG00000168268(gene)|ensembl:ENST00000307076(transcript)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:nfT/9N1bWVadX70eY1G0GS9pS9U9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H845 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H2W6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6393565|ensembl:ENSP00000312311|uniprotkb:B2RD75|uniprotkb:Q9HBU8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm46_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL46(gene name synonym)|uniprotkb:MRPL46(gene name)|psi-mi:MRPL46(display_short)|uniprotkb:C15orf4(gene name synonym)|uniprotkb:LIECG2(gene name synonym)|uniprotkb:P2ECSL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000259494(gene)|ensembl:ENST00000312475(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030054"(cell junction)|interpro:IPR015797(NUDIX)|interpro:IPR021757|interpro:IPR033650|interpro:IPR040008|mint:Q9H2W6|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|rcsb pdb:7A5K|reactome:R-HSA-5419276|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|refseq:NP_071446.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:7u4sNH/MVFnEZRMjr7ey6d8WpfM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H2U2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3957115|uniprotkb:B4DLP7|uniprotkb:Q4W5E9|uniprotkb:Q6PG51|uniprotkb:Q8TBW0|uniprotkb:Q96E55|uniprotkb:Q9H0T0|uniprotkb:Q9NX37|uniprotkb:Q9P033|uniprotkb:Q9ULX0|uniprotkb:I6L9B6|uniprotkb:F8WDN9|ensembl:ENSP00000343885 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ipyr2_human(display_long)|uniprotkb:PPA2(gene name)|psi-mi:PPA2(display_short)|uniprotkb:Pyrophosphatase SID6-306(gene name synonym)|uniprotkb:Pyrophosphate phospho-hydrolase 2(gene name synonym)|uniprotkb:HSPC124(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_008834.3|refseq:NP_789842.2|refseq:NP_789843.2|refseq:NP_789845.1|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0071344"(diphosphate metabolic process)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q9H2U2|reactome:R-HSA-379726|reactome:R-HSA-71737|ensembl:ENSG00000138777(gene)|ensembl:ENST00000341695(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:KrPc55Mf6MjN5tgxFagI03miOwY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H0R6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2856796|uniprotkb:Q5VWJ4|uniprotkb:Q9HA60|uniprotkb:Q9NV19|ensembl:ENSP00000358042 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gata_human(display_long)|uniprotkb:QRSL1(gene name)|psi-mi:QRSL1(display_short)|uniprotkb:Glutaminyl-tRNA synthase-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060762.3|dip:DIP-48970N|ensembl:ENSG00000130348(gene)|ensembl:ENST00000369046(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030956"("glutamyl-tRNA(Gln) amidotransferase complex")|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0050567"("glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity")|go:"GO:0070681"(glutaminyl-tRNAGln biosynthesis via transamidation)|interpro:IPR000120(Amidase signature enzyme)|interpro:IPR004412("Glutamyl-tRNA(Gln) amidotransferase A subunit")|interpro:IPR023631|interpro:IPR036928 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:/RVDRYFvbHttKo9WEmryGNEBR+09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H078 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9GZT3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BYN8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721378|uniprotkb:Q96Q58|ensembl:ENSP00000369682 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt26_human(display_long)|uniprotkb:28S ribosomal protein S13, mitochondrial(gene name synonym)|uniprotkb:MRPS26(gene name)|psi-mi:MRPS26(display_short)|uniprotkb:RPMS13(gene name synonym)|uniprotkb:C20orf193(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS26(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_110438.1|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125901(gene)|ensembl:ENST00000380325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR026140|mint:Q9BYN8 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ZygMazfhjHbx+aFhRkeG87c4L6E9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BXK5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BVV7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BVC6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1057733|ensembl:ENSP00000227525|ensembl:ENSP00000443990 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tm109_human(display_long)|uniprotkb:TMEM109(gene name)|psi-mi:TMEM109(display_short)|uniprotkb:Mitsugumin-23(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_076997.1|ensembl:ENSG00000110108(gene)|ensembl:ENST00000227525(transcript)|ensembl:ENST00000536171(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|interpro:IPR039492|mint:Q9BVC6 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:KsibbFWmzuiZPpo4GqJikbMMaMQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BU61 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2114801|ensembl:ENSP00000323076 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BTW9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-356005|uniprotkb:O95458|uniprotkb:Q7L8K1|uniprotkb:Q8IXP6|uniprotkb:Q8NAX0|uniprotkb:Q8WYH4|uniprotkb:Q96E74|uniprotkb:Q9UF82|uniprotkb:Q9UG46|uniprotkb:Q9Y2J3|intact:EBI-2555162|intact:EBI-2562220|ensembl:ENSP00000347719 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tbcd_human(display_long)|uniprotkb:TBCD(gene name)|psi-mi:TBCD(display_short)|uniprotkb:KIAA0988(gene name synonym)|uniprotkb:SSD1(gene name synonym)|uniprotkb:TFCD(gene name synonym)|uniprotkb:PP1096(orf name)|uniprotkb:Tubulin-folding cofactor D(gene name synonym)|uniprotkb:Beta-tubulin cofactor D(gene name synonym)|uniprotkb:SSD-1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005984.3|ensembl:ENSG00000141556(gene)|ensembl:ENST00000355528(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007023"(post-chaperonin tubulin folding pathway)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0051087"(chaperone binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022577|interpro:IPR033162|mint:Q9BTW9|reactome:R-HSA-389977 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9idLpkQy9EORh88FUMLul3LU3Yg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BSJ5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2872520|uniprotkb:A8K9X3|uniprotkb:Q9H0L9|uniprotkb:Q9NWN5|uniprotkb:Q9H5E6|uniprotkb:Q5JB45|uniprotkb:Q6YAU3|ensembl:ENSP00000351937|ensembl:ENSP00000440551 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cq080_human(display_long)|uniprotkb:C17orf80(gene name)|psi-mi:C17orf80(display_short)|uniprotkb:Cell migration-inducing gene 3 protein(gene name synonym)|uniprotkb:Human lung cancer oncogene 8 protein(gene name synonym)|uniprotkb:HLC8(orf name)|uniprotkb:MIG3(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011523263.1|refseq:XP_011523264.1|refseq:NP_001094091.1|refseq:NP_060411.2|refseq:XP_016880295.1|refseq:XP_005257544.1|ensembl:ENSG00000141219(gene)|ensembl:ENST00000359042(transcript)|ensembl:ENST00000535032(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR037694|refseq:NP_001275699.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5nHOYiWQzPdq69Zgy3moyewfalc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BSH4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-747797|uniprotkb:Q8N3N6|uniprotkb:Q9UI60|uniprotkb:B2RD21|ensembl:ENSP00000258975 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:taco1_human(display_long)|uniprotkb:PRO0477(orf name)|uniprotkb:TACO1(gene name)|psi-mi:TACO1(display_short)|uniprotkb:CCDC44(gene name synonym)|uniprotkb:Translational activator of mitochondrially-encoded cytochrome c oxidase I(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057444.2|ensembl:ENSG00000136463(gene)|ensembl:ENST00000258975(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0019843"(rRNA binding)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0061743"(motor learning)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR002876(Protein of unknown function DUF28)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR026564|interpro:IPR029072|mint:Q9BSH4|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:c/tu89NvCs3Kt8qO8e5F6hrywBo9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BS26 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BQ95 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BPX6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BPW8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-307125|uniprotkb:O43800|uniprotkb:B2RAY3|ensembl:ENSP00000216121 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nips1_human(display_long)|uniprotkb:NIPSNAP1(gene name)|psi-mi:NIPSNAP1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001189431.1|refseq:NP_003625.2|ensembl:ENSG00000184117(gene)|ensembl:ENST00000216121(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:Q9BPW8 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mOosuRNhEeYvVB5cUbkMzTJ7X7s9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q99943 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3893468|uniprotkb:A2BFI5|uniprotkb:Q5BL03|ensembl:ENSP00000337463|ensembl:ENSP00000364245|ensembl:ENSP00000364248|ensembl:ENSP00000372782|ensembl:ENSP00000378874|ensembl:ENSP00000378875|ensembl:ENSP00000378877|ensembl:ENSP00000382721|ensembl:ENSP00000382723|ensembl:ENSP00000382725|ensembl:ENSP00000382726|ensembl:ENSP00000382728|ensembl:ENSP00000387810|ensembl:ENSP00000388090|ensembl:ENSP00000388253|ensembl:ENSP00000388815|ensembl:ENSP00000388870|ensembl:ENSP00000389516|ensembl:ENSP00000390988|ensembl:ENSP00000392083|ensembl:ENSP00000392820|ensembl:ENSP00000394919|ensembl:ENSP00000395613|ensembl:ENSP00000395863|ensembl:ENSP00000397765|ensembl:ENSP00000398016|ensembl:ENSP00000401287|ensembl:ENSP00000401410|ensembl:ENSP00000404106|ensembl:ENSP00000405565|ensembl:ENSP00000405864|ensembl:ENSP00000406582|ensembl:ENSP00000406614|ensembl:ENSP00000406615|ensembl:ENSP00000387738|ensembl:ENSP00000408032|ensembl:ENSP00000408842|ensembl:ENSP00000410831|ensembl:ENSP00000412304|ensembl:ENSP00000412805|ensembl:ENSP00000415015|ensembl:ENSP00000407189 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:plca_human(display_long)|uniprotkb:AGPAT1(gene name)|psi-mi:AGPAT1(display_short)|uniprotkb:G15(gene name synonym)|uniprotkb:1-acylglycerol-3-phosphate O-acyltransferase 1(gene name synonym)|uniprotkb:Lysophosphatidic acid acyltransferase alpha(gene name synonym)|uniprotkb:Protein G15(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011512536.1|refseq:NP_006402.1|refseq:NP_116130.2|refseq:XP_005248863.1|ensembl:ENSG00000204310(gene)|ensembl:ENSG00000206324(gene)|ensembl:ENSG00000226467(gene)|ensembl:ENSG00000227642(gene)|ensembl:ENSG00000228892(gene)|ensembl:ENSG00000235758(gene)|ensembl:ENSG00000236873(gene)|ensembl:ENST00000336984(transcript)|ensembl:ENST00000375104(transcript)|ensembl:ENST00000375107(transcript)|ensembl:ENST00000383294(transcript)|ensembl:ENST00000395496(transcript)|ensembl:ENST00000395497(transcript)|ensembl:ENST00000395499(transcript)|ensembl:ENST00000399825(transcript)|ensembl:ENST00000399827(transcript)|ensembl:ENST00000399829(transcript)|ensembl:ENST00000399830(transcript)|ensembl:ENST00000399833(transcript)|ensembl:ENST00000414520(transcript)|ensembl:ENST00000414933(transcript)|ensembl:ENST00000416363(transcript)|ensembl:ENST00000417388(transcript)|ensembl:ENST00000424030(transcript)|ensembl:ENST00000425204(transcript)|ensembl:ENST00000425572(transcript)|ensembl:ENST00000427763(transcript)|ensembl:ENST00000430226(transcript)|ensembl:ENST00000430777(transcript)|ensembl:ENST00000433376(transcript)|ensembl:ENST00000433896(transcript)|ensembl:ENST00000434614(transcript)|ensembl:ENST00000436149(transcript)|ensembl:ENST00000439774(transcript)|ensembl:ENST00000440840(transcript)|ensembl:ENST00000444369(transcript)|ensembl:ENST00000446323(transcript)|ensembl:ENST00000446463(transcript)|ensembl:ENST00000448196(transcript)|ensembl:ENST00000449776(transcript)|ensembl:ENST00000451833(transcript)|ensembl:ENST00000452393(transcript)|ensembl:ENST00000452427(transcript)|ensembl:ENST00000454929(transcript)|ensembl:ENST00000455898(transcript)|ensembl:ENST00000456421(transcript)|ensembl:ENST00000456679(transcript)|ensembl:ENST00000457923(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|interpro:IPR004552(1-acyl-sn-glycerol-3-phosphate acyltransferase)|reactome:R-HSA-1483166|reactome:R-HSA-163765|ensembl:ENST00000415173(transcript) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:79aLEXZSVTqCLBYxPUnUPT5n0ME9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96TA2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96RR1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-716458|uniprotkb:Q6MZX2|uniprotkb:Q96RR0|uniprotkb:Q6PJP5|uniprotkb:B2CQL2|ensembl:ENSP00000309595 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:peo1_human(display_long)|uniprotkb:TWNK(gene name)|psi-mi:TWNK(display_short)|uniprotkb:C10orf2(gene name synonym)|uniprotkb:PEO1(gene name synonym)|uniprotkb:Progressive external ophthalmoplegia 1 protein(gene name synonym)|uniprotkb:T7 gp4-like protein with intramitochondrial nucleoid localization(gene name synonym)|uniprotkb:T7-like mitochondrial DNA helicase(gene name synonym)|uniprotkb:Twinkle protein, mitochondrial(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001157284.1|refseq:NP_068602.2|ensembl:ENST00000311916(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|ensembl:ENSG00000107815(gene)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR027417|interpro:IPR034154|mint:Q96RR1|reactome:R-HSA-2151201 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:asX2NETd8o4GZrWe8gIUntbtUpA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96RP9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2255048|uniprotkb:B3KRW1|uniprotkb:A6NCI9|uniprotkb:B2RCB9|uniprotkb:Q6GTN2|uniprotkb:Q96T39|intact:EBI-2870814|ensembl:ENSP00000419038 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:efgm_human(display_long)|uniprotkb:GFM1(gene name)|psi-mi:GFM1(display_short)|uniprotkb:EFG(gene name synonym)|uniprotkb:EFG1(gene name synonym)|uniprotkb:GFM(gene name synonym)|uniprotkb:Elongation factor G 1, mitochondrial(gene name synonym)|uniprotkb:Elongation factor G1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001295093.1|refseq:NP_001295095.1|refseq:NP_079272.4|ensembl:ENSG00000168827(gene)|ensembl:ENST00000486715(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004540(Translation elongation factor EFG/EF2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009022(Elongation factor G, III and V)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR035649|interpro:IPR041095|mint:Q96RP9|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6YDP|rcsb pdb:6YDW|rcsb pdb:7A5K|reactome:R-HSA-5389840 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:TwkylC5mlIaXRTw3hUyViUocC509606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96RL7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1752583|uniprotkb:Q5JSX9|uniprotkb:Q5JSY0|uniprotkb:Q5VYR5|uniprotkb:Q702P4|uniprotkb:Q709D0|uniprotkb:Q86YF8|uniprotkb:Q96S61|uniprotkb:Q9H995|uniprotkb:Q9Y2J1|ensembl:ENSP00000353422 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vp13a_human(display_long)|uniprotkb:VPS13A(gene name)|psi-mi:VPS13A(display_short)|uniprotkb:CHAC(gene name synonym)|uniprotkb:KIAA0986(gene name synonym)|uniprotkb:Chorein(gene name synonym)|uniprotkb:Chorea-acanthocytosis protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001018047.1|refseq:NP_001018048.1|refseq:NP_056001.1|refseq:NP_150648.2|ensembl:ENSG00000197969(gene)|ensembl:ENST00000360280(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035176"(social behavior)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0097225"(sperm midpiece)|go:"GO:0099013"(neuronal dense core vesicle lumen)|go:"GO:1905146"(lysosomal protein catabolic process)|interpro:IPR009543(Vacuolar protein sorting-associated protein)|interpro:IPR015412(ATG2, C-terminal)|interpro:IPR026847|interpro:IPR026854|interpro:IPR031642|interpro:IPR031645|interpro:IPR031646 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:GKpJsczlbPL6VtrpaPXX8K5D0xY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96QE5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96JJ7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2514069|intact:EBI-28973673|uniprotkb:B3KV75|uniprotkb:Q52LT7|uniprotkb:Q8N5J0|uniprotkb:Q9NWJ9|ensembl:ENSP00000299608 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tmx3_human(display_long)|uniprotkb:TMX3(gene name)|psi-mi:TMX3(display_short)|uniprotkb:KIAA1830(gene name synonym)|uniprotkb:TXNDC10(gene name synonym)|uniprotkb:Thioredoxin-related transmembrane protein 3(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 10(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSP00000299608|ensembl:ENST00000562706|ensembl:ENSP00000457262|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0031092"(platelet alpha granule membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|reactome:R-HSA-114608|ensembl:ENST00000299608(transcript)|ensembl:ENSG00000166479(gene)|refseq:NP_061895.3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Qber8pA1sCprlKl8Yoc5XtVEd5s9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96I99 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96HY7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11022401|uniprotkb:Q68CU5|uniprotkb:Q9HCE2|uniprotkb:Q9BUM8|ensembl:ENSP00000263035 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dhtk1_human(display_long)|uniprotkb:DHTKD1(gene name)|psi-mi:DHTKD1(display_short)|uniprotkb:Dehydrogenase E1 and transketolase domain-containing protein 1(gene name synonym)|uniprotkb:KIAA1630(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_061176.3|ensembl:ENSG00000181192(gene)|ensembl:ENST00000263035(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030976"(thiamine pyrophosphate binding)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR031717|interpro:IPR042179|rcsb pdb:5RVW|rcsb pdb:5RVX|rcsb pdb:5RVY|rcsb pdb:5RVZ|rcsb pdb:5RW0|rcsb pdb:5RW1|rcsb pdb:6SY1|rcsb pdb:6U3J|reactome:R-HSA-389661 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:YjYnA7+K+Y7Swqanvoe5pWWrguQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96GC5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5325315|ensembl:ENSP00000308717|uniprotkb:Q49AK7|uniprotkb:Q4U2Q4|uniprotkb:Q9P091|uniprotkb:Q9Y5J0|intact:EBI-10967301|uniprotkb:B4DN34 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm48_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL48(gene name synonym)|uniprotkb:CGI-118(orf name)|uniprotkb:HSPC290(orf name)|uniprotkb:MRPL48(gene name)|psi-mi:MRPL48(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000175581(gene)|ensembl:ENST00000310614(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR027486|interpro:IPR027487|mint:Q96GC5|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|interpro:IPR036838|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:6ZSG|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF6|refseq:NP_001305427.1|refseq:NP_001305428.1|refseq:NP_001305429.1|refseq:NP_057139.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xCdGuctoVF3DrDHZedpDi+IOxxQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EY7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721110|uniprotkb:A6NHD2|uniprotkb:Q597H0|uniprotkb:Q658Y9|uniprotkb:Q9BUZ8|uniprotkb:Q9NWL0|intact:EBI-2560120|uniprotkb:D6W5M1|ensembl:ENSP00000254630 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ptcd3_human(display_long)|uniprotkb:Transformation-related gene 15 protein(gene name synonym)|uniprotkb:TRG15(orf name)|uniprotkb:28S ribosomal protein S39, mitochondrial(gene name synonym)|uniprotkb:MRPS39(gene name synonym)|uniprotkb:PTCD3(gene name)|psi-mi:PTCD3(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS39(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060422.4|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR037387|mint:Q96EY7|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|go:"GO:0019843"(rRNA binding)|rcsb pdb:6ZSC|ensembl:ENSG00000132300(gene)|ensembl:ENST00000254630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSD - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:k9hyBtBrNbiBMJ5gtOQ9R6Grl9U9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EL2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1055789|uniprotkb:P82668|uniprotkb:Q96Q23|uniprotkb:Q9P047|uniprotkb:A4D1U9|ensembl:ENSP00000318158 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt24_human(display_long)|uniprotkb:bMRP-47(gene name synonym)|uniprotkb:MRPS24(gene name)|psi-mi:MRPS24(display_short)|uniprotkb:HSPC335(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS3m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_114403.1|ensembl:ENSG00000062582(gene)|ensembl:ENST00000317534(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR026146|mint:Q96EL2|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OEtFmhoLM1Sw9YVrL88HZQ5Ju0g9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EB6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96E52 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96D53 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3957978|uniprotkb:Q8TAJ1|uniprotkb:Q9HA52|ensembl:ENSP00000315118|ensembl:ENSP00000470876|ensembl:ENSP00000470916|ensembl:ENSP00000503480|ensembl:ENSP00000503944|ensembl:ENSP00000504072|ensembl:ENSP00000504085|ensembl:ENSP00000504845 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:coq8b_human(display_long)|uniprotkb:COQ8B(gene name)|psi-mi:COQ8B(display_short)|uniprotkb:ADCK4(gene name synonym)|uniprotkb:AarF domain-containing protein kinase 4(gene name synonym)|uniprotkb:Coenzyme Q protein 8B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001136027.1|refseq:NP_079152.3|ensembl:ENSG00000123815(gene)|ensembl:ENST00000324464(transcript)|ensembl:ENST00000594720(transcript)|ensembl:ENST00000601967(transcript)|ensembl:ENST00000677018(transcript)|ensembl:ENST00000678404(transcript)|ensembl:ENST00000678419(transcript)|ensembl:ENST00000678467(transcript)|ensembl:ENST00000679130(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034638|interpro:IPR034646|mint:Q96D53 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UAfHqMHShcF12Ijycxi7OWs0KFE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96CU9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-372820|uniprotkb:Q71MG0|uniprotkb:Q9BU39|uniprotkb:Q9UKY9|uniprotkb:B3KN84|uniprotkb:B4DHU2|ensembl:ENSP00000263578 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fxrd1_human(display_long)|uniprotkb:FP634(orf name)|uniprotkb:FOXRED1(gene name)|psi-mi:FOXRED1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060017.1|refseq:XP_006718944.1|refseq:XP_016873492.1|refseq:XP_016873493.1|refseq:XP_016873494.1|ensembl:ENSG00000110074(gene)|ensembl:ENST00000263578(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR036188 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:cAeSafbcQmh6XLk/IrNfsD+KHtA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96CS3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96C36 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96BR5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q969Z3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-16773897|ensembl:ENSP00000355880|uniprotkb:B2D0R5|uniprotkb:D3DTB3|uniprotkb:Q0JSK7|uniprotkb:Q5VT67|uniprotkb:Q5VXC7|uniprotkb:Q7L317|uniprotkb:Q9H066|uniprotkb:Q9NWU0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:marc2_human(display_long)|uniprotkb:MOSC2(gene name synonym)|uniprotkb:Molybdenum cofactor sulfurase C-terminal domain-containing protein 2(gene name synonym)|uniprotkb:MTARC2(gene name)|psi-mi:MTARC2(display_short)|uniprotkb:MARC2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000117791(gene)|ensembl:ENST00000366913(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042126"(nitrate metabolic process)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0051410"(detoxification of nitrogen compound)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|go:"GO:0098809"(nitrite reductase activity)|interpro:IPR005302(Molybdenum cofactor sulphurase, C-terminal)|interpro:IPR005303(MOSC, N-terminal beta barrel)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|reactome:R-HSA-211945|refseq:NP_001304267.1|refseq:NP_001317971.1|refseq:NP_060368.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ypPzLBnAlrNErXdIIuKr4LqzId09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q969Z0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q969Y2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-740290|uniprotkb:A6NKR4|uniprotkb:Q8TCY6|uniprotkb:Q8WUW9|uniprotkb:Q969G4|uniprotkb:Q9BX61|uniprotkb:A8K7B4|uniprotkb:A6NFH1|uniprotkb:A6NIG5|uniprotkb:B7Z4V8|ensembl:ENSP00000313818 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gtpb3_human(display_long)|uniprotkb:GTP-binding protein 3(gene name synonym)|uniprotkb:Mitochondrial GTP-binding protein 1(gene name synonym)|uniprotkb:GTPBP3(gene name)|psi-mi:GTPBP3(display_short)|uniprotkb:MTGP1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001122327.1|refseq:NP_001182351.1|refseq:NP_116009.2|refseq:NP_598399.2|interpro:IPR025867|interpro:IPR027266|interpro:IPR027368|interpro:IPR027417|interpro:IPR031168|reactome:R-HSA-6787450|interpro:IPR018948|ensembl:ENSG00000130299(gene)|ensembl:ENST00000324894(transcript)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030488"(tRNA methylation)|interpro:IPR004520(tRNA modification GTPase TrmE)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:DRq7ek24ZWPpvDFoB4RFO15K1k89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q969N2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-726383|uniprotkb:Q2NL69|uniprotkb:Q7Z3N7|uniprotkb:Q9BQY7|uniprotkb:Q9BQY8|uniprotkb:Q9UJG6|uniprotkb:G8JLF5|uniprotkb:Q9Y2Z5|uniprotkb:B7Z3N1|uniprotkb:B7Z7I8|uniprotkb:B2RND5|uniprotkb:E1P622|ensembl:ENSP00000279036 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pigt_human(display_long)|uniprotkb:Phosphatidylinositol-glycan biosynthesis class T protein(gene name synonym)|uniprotkb:PIGT(gene name)|psi-mi:PIGT(display_short)|uniprotkb:CGI-06(orf name)|uniprotkb:PSEC0163(orf name)|uniprotkb:UNQ716/PRO1379(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001171657.1|refseq:NP_001171658.1|refseq:NP_001171659.1|refseq:NP_057021.2|ensembl:ENSG00000124155(gene)|ensembl:ENST00000279036(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|reactome:R-HSA-162791|go:"GO:0016255"(attachment of GPI anchor to protein)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042765"(GPI-anchor transamidase complex)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR007245(Gpi16 subunit, GPI transamidase component)|mint:Q969N2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:i8lWo/nE8QDVR9IA5UpRwpVfPbQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92947 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1236978|uniprotkb:O14719|uniprotkb:A8K2Z2|ensembl:ENSP00000222214|ensembl:ENSP00000466845 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gcdh_human(display_long)|uniprotkb:GCDH(gene name)|psi-mi:GCDH(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000150.1|refseq:NP_039663.1|ensembl:ENSG00000105607(gene)|ensembl:ENST00000222214(transcript)|ensembl:ENST00000591470(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004361"(glutaryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q92947|rcsb pdb:1SIQ|rcsb pdb:1SIR|rcsb pdb:2R0M|rcsb pdb:2R0N|reactome:R-HSA-71064|go:"GO:0050660"(flavin adenine dinucleotide binding) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:W192IQEAyP1SdNxhI62Fh8C2UPU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92665 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-720602|uniprotkb:Q8WTV8|uniprotkb:Q5VYC8|uniprotkb:B2RCS3|ensembl:ENSP00000315397 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt31_human(display_long)|uniprotkb:Imogen 38(gene name synonym)|uniprotkb:MRPS31(gene name)|psi-mi:MRPS31(display_short)|uniprotkb:IMOGN38(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS31(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005821.2|ensembl:ENSG00000102738(gene)|ensembl:ENST00000323563(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR026299|mint:Q92665|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Le0Lq+WW56dP5NLuMB2eKFeg6b09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92552 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2211879|uniprotkb:Q6P1S1|uniprotkb:B4DRT2|ensembl:ENSP00000261413 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt27_human(display_long)|uniprotkb:MRPS27(gene name)|psi-mi:MRPS27(display_short)|uniprotkb:KIAA0264(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS27(gene name synonym)|uniprotkb:Mitochondrial ribosomal protein S27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001273677.1|refseq:NP_055899.2|dip:DIP-44136N|ensembl:ENSG00000113048(gene)|ensembl:ENST00000261413(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019843"(rRNA binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019266|interpro:IPR034913|mint:Q92552|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:reHIDm6Of3ERJMBRxVlVntHyRlY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8WWV3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-743502|ensembl:ENSP00000358059|uniprotkb:Q8N9B3|uniprotkb:Q8WZ66|uniprotkb:Q9BRA4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt4i1_human(display_long)|uniprotkb:NOGO-interacting mitochondrial protein(gene name synonym)|uniprotkb:RTN4IP1(gene name)|psi-mi:RTN4IP1(display_short)|uniprotkb:NIMP(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000130347(gene)|go:"GO:0007399"(nervous system development)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050773"(regulation of dendrite development)|interpro:IPR002364(Quinone oxidoreductase/zeta-crystallin, conserved site)|interpro:IPR011032(GroES-like)|interpro:IPR013154(Alcohol dehydrogenase GroES-like)|go:"GO:0008270"(zinc ion binding)|interpro:IPR020843|interpro:IPR036291|interpro:IPR037397|rcsb pdb:2VN8|ensembl:ENST00000369063(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_116119.2|refseq:NP_001305675.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8RVcy12kFri0N3iaWSGpqQYvKs89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8TCS8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052020|uniprotkb:Q53SU0|uniprotkb:Q68CN1|uniprotkb:Q7Z7D1|uniprotkb:Q8IWX1|uniprotkb:Q96T05|uniprotkb:Q9BRU3|uniprotkb:Q9BVX0|ensembl:ENSP00000393953|ensembl:ENSP00000400646 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pnpt1_human(display_long)|uniprotkb:Polynucleotide phosphorylase 1(gene name synonym)|uniprotkb:Polynucleotide phosphorylase-like protein(gene name synonym)|uniprotkb:PNPase old-35(gene name synonym)|uniprotkb:3'-5' RNA exonuclease OLD35(gene name synonym)|uniprotkb:PNPT1(gene name)|psi-mi:PNPT1(display_short)|uniprotkb:PNPASE(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_149100.2|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|go:"GO:0097222"(mitochondrial mRNA polyadenylation)|go:"GO:0097421"(liver regeneration)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR003029(S1, RNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012162(Polyribonucleotide nucleotidyltransferase)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR015848(Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type)|interpro:IPR020568|interpro:IPR022967|interpro:IPR027408|interpro:IPR036345|interpro:IPR036456|interpro:IPR036612|rcsb pdb:3U1K|rcsb pdb:5ZF6|ensembl:ENSG00000138035(gene)|ensembl:ENST00000415374(transcript)|ensembl:ENST00000447944(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000957"(mitochondrial RNA catabolic process)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0000965"(mitochondrial RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0034046"("poly(G) binding")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035927"(RNA import into mitochondrion)|go:"GO:0035928"(rRNA import into mitochondrion)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043631"(RNA polyadenylation)|go:"GO:0045025"(mitochondrial degradosome)|go:"GO:0004654"(polyribonucleotide nucleotidyltransferase activity)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060416"(response to growth hormone)|dip:DIP-50226N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:W9hr1vfWv1b0v4xfMYatfKfOMcg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NCN5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-16769589|ensembl:ENSP00000288050|ensembl:ENSP00000457916|uniprotkb:A7E298|uniprotkb:A8K8Y7|uniprotkb:B3KSE1|uniprotkb:Q6AI20|uniprotkb:Q6AWC9 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdpr_human(display_long)|uniprotkb:PDPR(gene name)|psi-mi:PDPR(display_short)|uniprotkb:KIAA1990(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000090857(gene)|ensembl:ENST00000288050(transcript)|ensembl:ENST00000568530(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR001763(Rhodanese-like)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR006222(Glycine cleavage T-protein, N-terminal)|interpro:IPR013977(Glycine cleavage T-protein, C-terminal barrel)|interpro:IPR027266|interpro:IPR029043|interpro:IPR032503|interpro:IPR036188|reactome:R-HSA-204174|refseq:NP_001309046.1|refseq:NP_060460.4|refseq:XP_005256072.1|refseq:XP_005256073.1|refseq:XP_016878876.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jKDbjPDs6wBeHVsTm8j9cZj4yAA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NC60 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-717871|uniprotkb:Q8N7L6|uniprotkb:Q9BSQ9|ensembl:ENSP00000264230 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:noa1_human(display_long)|uniprotkb:NOA1(gene name)|psi-mi:NOA1(display_short)|uniprotkb:C4orf14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_115689.1|ensembl:ENSG00000084092(gene)|ensembl:ENST00000264230(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043457"(regulation of cellular respiration)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lynfPNtWZ/q7Df9/hpwiyIjUD2Y9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N5M1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1166928|uniprotkb:A6NDE5|uniprotkb:A8K2J2|uniprotkb:Q6XYC7|ensembl:ENSP00000417190 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:atpf2_human(display_long)|uniprotkb:ATPAF2(gene name)|psi-mi:ATPAF2(display_short)|uniprotkb:ATP12(gene name synonym)|uniprotkb:LP3663(orf name)|uniprotkb:ATP12 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_663729.1|ensembl:ENSG00000171953(gene)|ensembl:ENST00000474627(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0043461"(proton-transporting ATP synthase complex assembly)|interpro:IPR011419(ATP12 ATPase)|interpro:IPR023335|interpro:IPR042272 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ifcwz4YWJr0UVp2WbqJmiqrhI809606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N5K1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1045797|uniprotkb:Q7Z3D5|ensembl:ENSP00000273986 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cisd2_human(display_long)|uniprotkb:CDGSH2(gene name synonym)|uniprotkb:ERIS(gene name synonym)|uniprotkb:ZCD2(gene name synonym)|uniprotkb:Endoplasmic reticulum intermembrane small protein(gene name synonym)|uniprotkb:MitoNEET-related 1 protein(gene name synonym)|uniprotkb:CISD2(gene name)|psi-mi:CISD2(display_short)|uniprotkb:Nutrient-deprivation autophagy factor-1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001008389.1|ensembl:ENSG00000145354(gene)|ensembl:ENST00000273986(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR018967|interpro:IPR019610|interpro:IPR042216|rcsb pdb:3FNV|rcsb pdb:4OO7|rcsb pdb:4OOA|go:"GO:0005741"(mitochondrial outer membrane) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:YxickLtFNLILnuUDAXl1QqFadD09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N442 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5460727|uniprotkb:Q5XKM8|uniprotkb:Q9H710|uniprotkb:Q9H8U4|ensembl:ENSP00000281543 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:guf1_human(display_long)|uniprotkb:GUF1(gene name)|psi-mi:GUF1(display_short)|uniprotkb:Elongation factor 4 homolog(gene name synonym)|uniprotkb:GTPase GUF1(gene name synonym)|uniprotkb:Ribosomal back-translocase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_068746.2|interpro:IPR031157|interpro:IPR035647|interpro:IPR035654|interpro:IPR038363|ensembl:ENSG00000151806(gene)|ensembl:ENST00000281543(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006412"(translation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006297(GTP-binding protein LepA)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR013842(GTP-binding protein LepA, C-terminal)|interpro:IPR027417 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8qGEN4UaBdf2SZbCrIzSU2qDugo9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N183 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2682365|uniprotkb:A8K5I1|ensembl:ENSP00000296597 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduf2_human(display_long)|uniprotkb:NDUFA12L(gene name synonym)|uniprotkb:B17.2-like(gene name synonym)|uniprotkb:Myc-induced mitochondrial protein(gene name synonym)|uniprotkb:NDUFA12-like protein(gene name synonym)|uniprotkb:NDUFAF2(gene name)|psi-mi:NDUFAF2(display_short)|uniprotkb:Mimitin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_777549.1|ensembl:ENSG00000164182(gene)|ensembl:ENST00000296597(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:sNje5xhXA48xAg0tSkOYiqBxZvk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IYU8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IYB8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2876787|ensembl:ENSP00000352678|uniprotkb:O43630|intact:EBI-3205796|uniprotkb:A8K301 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:suv3_human(display_long)|uniprotkb:SUPV3L1(gene name)|psi-mi:SUPV3L1(display_short)|uniprotkb:SUV3(gene name synonym)|uniprotkb:Suppressor of var1 3-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000156502(gene)|ensembl:ENST00000359655(transcript)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0000965"(mitochondrial RNA 3'-end processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006310"(DNA recombination)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0035945"(mitochondrial ncRNA surveillance)|go:"GO:0035946"(mitochondrial mRNA surveillance)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045025"(mitochondrial degradosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070827"(obsolete chromatin maintenance)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000827"(mitochondrial RNA surveillance)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022192|interpro:IPR027417|interpro:IPR041082|interpro:IPR041453|interpro:IPR044774|rcsb pdb:3RC3|rcsb pdb:3RC8|refseq:NP_001288612.1|refseq:NP_003162.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XmEujscj0Njj3Un62nLFTzgqr6Y9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IXJ6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-477232|uniprotkb:O95889|uniprotkb:Q924Y7|uniprotkb:Q9P0G8|uniprotkb:Q9UNT0|uniprotkb:Q9Y6E9|ensembl:ENSP00000249396|ensembl:ENSP00000489602|uniprotkb:A8K3V1|uniprotkb:B2RB45|uniprotkb:U5TP13 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sir2_human(display_long)|uniprotkb:SIR2-like protein 2(gene name synonym)|uniprotkb:SIRT2(gene name)|psi-mi:SIRT2(display_short)|uniprotkb:SIR2L(gene name synonym)|uniprotkb:SIR2L2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000068903(gene)|ensembl:ENSG00000283100(gene)|ensembl:ENST00000249396(transcript)|ensembl:ENST00000634533(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006342"|go:"GO:0006348"|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006914"(autophagy)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008134"(transcription factor binding)|rcsb pdb:6L66|rcsb pdb:6L71|rcsb pdb:6L72|rcsb pdb:6NR0|rcsb pdb:6QCN|rcsb pdb:7BOS|rcsb pdb:7BOT|reactome:R-HSA-2995383|rcsb pdb:5D7O|rcsb pdb:5D7P|rcsb pdb:5D7Q|rcsb pdb:5DY4|rcsb pdb:5DY5|rcsb pdb:5FYQ|rcsb pdb:5G4C|rcsb pdb:5MAR|rcsb pdb:5MAT|rcsb pdb:5Y0Z|rcsb pdb:5Y5N|rcsb pdb:5YQL|rcsb pdb:5YQM|rcsb pdb:5YQN|rcsb pdb:5YQO|rcsb pdb:6L65|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070446"(negative regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0097386"(glial cell projection)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000777"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q8IXJ6|rcsb pdb:1J8F|rcsb pdb:3ZGO|rcsb pdb:3ZGV|rcsb pdb:4L3O|rcsb pdb:4R8M|rcsb pdb:4RMG|rcsb pdb:4RMH|rcsb pdb:4RMI|rcsb pdb:4RMJ|rcsb pdb:4X3O|rcsb pdb:4X3P|rcsb pdb:4Y6L|rcsb pdb:4Y6O|go:"GO:0051301"(cell division)|rcsb pdb:4Y6Q|refseq:NP_001180215.1|refseq:NP_036369.2|refseq:NP_085096.1|refseq:XP_011524956.1|refseq:XP_011524957.1|refseq:XP_006723174.1|dip:DIP-33350N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:d4mOZOyT5RubJjE+a8wQhsWR6WI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IX18 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2514301|ensembl:ENSP00000251241|uniprotkb:B3KTJ5|uniprotkb:Q5JPH4|uniprotkb:Q8WY53|uniprotkb:Q8TC86|uniprotkb:Q9BXM1|uniprotkb:Q9H6M9|uniprotkb:C9JR60 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dhx40_human(display_long)|uniprotkb:DHX40(gene name)|psi-mi:DHX40(display_short)|uniprotkb:DDX40(gene name synonym)|uniprotkb:DEAH box protein 40(gene name synonym)|uniprotkb:Protein PAD(gene name synonym)|uniprotkb:ARG147(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000108406(gene)|ensembl:ENST00000251241(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_001159773.1|refseq:NP_078888.4 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jOdFhOZTjeXlSYf6zzKi/EiizXY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IUX1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2800657|uniprotkb:Q32Q09|uniprotkb:Q9NZ29|uniprotkb:Q96EP3|uniprotkb:Q8WVU3|uniprotkb:A8K535|uniprotkb:A8MSS0|ensembl:ENSP00000351737 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:t126b_human(display_long)|uniprotkb:TMEM126B(gene name)|psi-mi:TMEM126B(display_short)|uniprotkb:Transmembrane protein 126B(gene name synonym)|uniprotkb:HT007(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011543467.1|refseq:NP_001180467.1|refseq:NP_060950.3|refseq:NP_001243475.1|ensembl:ENSG00000171204(gene)|ensembl:ENST00000358867(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eQNEaTeYOl8NJlnxhrTi3R6m66I9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q86TX2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11109648|uniprotkb:Q3I5F9|uniprotkb:A1L173|ensembl:ENSP00000311224 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acot1_human(display_long)|uniprotkb:ACOT1(gene name)|psi-mi:ACOT1(display_short)|uniprotkb:CTE-I(gene name synonym)|uniprotkb:CTE-Ib(gene name synonym)|uniprotkb:CTE1(gene name synonym)|uniprotkb:Inducible cytosolic acyl-coenzyme A thioester hydrolase(gene name synonym)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Palmitoyl-coenzyme A thioesterase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001032238.1|ensembl:ENSG00000184227(gene)|ensembl:ENST00000311148(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|reactome:R-HSA-77289 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:on1deS+8E4m2ZirUewH43L1VsPc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q86SX6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049910|uniprotkb:Q3YML0|uniprotkb:Q86WY3|uniprotkb:Q8IZ54|uniprotkb:Q0X088|ensembl:ENSP00000328570 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:glrx5_human(display_long)|uniprotkb:GLRX5(gene name)|psi-mi:GLRX5(display_short)|uniprotkb:C14orf87(gene name synonym)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057501.2|ensembl:ENSG00000182512(gene)|ensembl:ENST00000331334(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|rcsb pdb:2MMZ|rcsb pdb:2WUL|reactome:R-HSA-1362409|dip:DIP-50654N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+h1VgIFt6kuH/Mc+KUxkB+w9RJI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z7H8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-723524|ensembl:ENSP00000324100|uniprotkb:Q96B80|uniprotkb:Q96Q55|uniprotkb:A6NGJ4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm10_human(display_long)|uniprotkb:MRPL8(gene name synonym)|uniprotkb:RPML8(gene name synonym)|uniprotkb:39S ribosomal protein L8, mitochondrial(gene name synonym)|uniprotkb:MRPL10(gene name)|psi-mi:MRPL10(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL10m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_660298.2|ensembl:ENSG00000159111(gene)|ensembl:ENST00000351111(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR043141|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7A5I|refseq:NP_683685.1|dip:DIP-59717N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:596vwngTyHb2gmaS48VUilgPQtw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z695 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z4W1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z2W9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6393520|ensembl:ENSP00000354580|uniprotkb:C9JPR2|uniprotkb:A6NKU0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm21_human(display_long)|uniprotkb:MRPL21(gene name)|psi-mi:MRPL21(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL21m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000197345(gene)|ensembl:ENST00000362034(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001787(Ribosomal protein L21)|interpro:IPR028909|interpro:IPR036164|mint:Q7Z2W9|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_852615.1|refseq:NP_852616.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:AtmLgjvRKsb8i5m6dl41VwqA1+Q9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7L8L6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-747570|uniprotkb:Q96JN3|uniprotkb:Q9H5D1|uniprotkb:Q9H8Y3|ensembl:ENSP00000369618 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fakd5_human(display_long)|uniprotkb:FASTKD5(gene name)|psi-mi:FASTKD5(display_short)|uniprotkb:KIAA1792(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_068598.1|ensembl:ENSG00000215251(gene)|ensembl:ENST00000380266(transcript)|go:"GO:0000963"(mitochondrial RNA processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:i48wNX7cmBCPpWXkXfnZhGnrse89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7L592 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2555519|uniprotkb:Q9P1G3|uniprotkb:Q7Z399|ensembl:ENSP00000002125 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduf7_human(display_long)|uniprotkb:NDUFAF7(gene name)|psi-mi:NDUFAF7(display_short)|uniprotkb:C2orf56(gene name synonym)|uniprotkb:NADH dehydrogenase [ubiquinone] complex I, assembly factor 7(gene name synonym)|uniprotkb:Protein midA homolog(gene name synonym)|uniprotkb:PRO1853(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001077415.1|refseq:NP_653337.1|ensembl:ENSG00000003509(gene)|ensembl:ENST00000002125(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019918"(peptidyl-arginine methylation, to symmetrical-dimethyl arginine)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|interpro:IPR003788(Protein of unknown function DUF185)|interpro:IPR029063|interpro:IPR038375|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:yPmuWj24WTnISoXS2kQzHLs/Sjs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7KZN9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q70CQ3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6UB35 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1046835|intact:EBI-28986171|ensembl:ENSP00000356290|uniprotkb:Q2TBF3|uniprotkb:Q8WVW0|uniprotkb:Q96HG8|uniprotkb:Q9H789|uniprotkb:Q9UFU8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:c1tm_human(display_long)|uniprotkb:MTHFD1L(gene name)|psi-mi:MTHFD1L(display_short)|uniprotkb:FTHFSDC1(gene name synonym)|uniprotkb:Formyltetrahydrofolate synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000120254(gene)|ensembl:ENST00000367321(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006760"(folic acid-containing compound metabolic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0015942"(formate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR027417|interpro:IPR036291|reactome:R-HSA-196757|refseq:NP_001229696.1|refseq:NP_001229697.1|refseq:NP_001229698.1|refseq:NP_056255.2|ensembl:ENST00000367307|ensembl:ENSP00000356276|ensembl:ENSP00000356290 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lJRND1kcMEF99+fT1b+X8hfuLHM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6PML9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6P1M0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052237|uniprotkb:O95186|uniprotkb:A8K2F7|uniprotkb:Q96G53|ensembl:ENSP00000300456 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:s27a4_human(display_long)|uniprotkb:Solute carrier family 27 member 4(gene name synonym)|uniprotkb:SLC27A4(gene name)|psi-mi:SLC27A4(display_short)|uniprotkb:ACSVL4(gene name synonym)|uniprotkb:FATP4(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase(gene name synonym)|uniprotkb:Very long-chain acyl-CoA synthetase 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005085.2|ensembl:ENSG00000167114(gene)|ensembl:ENST00000300456(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001579"(medium-chain fatty acid transport)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0015245"(fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0062003"(negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0090433"(palmitoyl-CoA ligase activity)|go:"GO:0090434"(oleoyl-CoA ligase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1990379"(lipid transport across blood-brain barrier)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR022272|interpro:IPR025110|interpro:IPR030304|interpro:IPR042099|reactome:R-HSA-5619108|reactome:R-HSA-804914|refseq:XP_016869711.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:0HD2kZ5IbnIpfLwEK1aFQesLQ289606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6L8Q7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2515865|ensembl:ENSP00000309142|uniprotkb:Q8IYU3|uniprotkb:Q8NDU2|uniprotkb:Q8TE78|uniprotkb:B4DTU8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pde12_human(display_long)|uniprotkb:PDE12(gene name)|psi-mi:PDE12(display_short)|uniprotkb:Mitochondrial deadenylase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENST00000311180(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034611"(oligoribonucleotidase activity)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|ensembl:ENSG00000174840(gene)|interpro:IPR036691|mint:Q6L8Q7|rcsb pdb:4Z0V|rcsb pdb:4Z2B|rcsb pdb:4ZKF|reactome:R-HSA-8983711|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|refseq:NP_808881.3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:P2ALFhSP4Qnqnd08vmkOcVoXe/I9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6DKK2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5TEU4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-10762958|uniprotkb:A8K166|uniprotkb:Q6GPH3|uniprotkb:Q9H6F4|ensembl:ENSP00000367346 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduf5_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5(gene name synonym)|uniprotkb:Putative methyltransferase NDUFAF5(gene name synonym)|uniprotkb:NDUFAF5(gene name)|psi-mi:NDUFAF5(display_short)|uniprotkb:C20orf7(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001034464.1|refseq:NP_077025.2|ensembl:ENSG00000101247(gene)|ensembl:ENST00000378106(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0030961"(peptidyl-arginine hydroxylation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032259"(methylation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR029063|mint:Q5TEU4|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:BC4jrAunVf7T4Cbrr/sZVFnkrfA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5TC12 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5T440 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-10714899|ensembl:ENSP00000355672 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:caf17_human(display_long)|uniprotkb:Iron-sulfur cluster assembly factor homolog(gene name synonym)|uniprotkb:IBA57(gene name)|psi-mi:IBA57(display_short)|uniprotkb:C1orf69(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001010867.1|ensembl:ENSG00000181873(gene)|ensembl:ENST00000366711(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016740"(transferase activity)|interpro:IPR017703(Folate-binding, YgfZ)|interpro:IPR027266|rcsb pdb:6GEU|rcsb pdb:6QE3|rcsb pdb:6QE4 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:20ToUTe4EoBuv31juWsDvsuyQY89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5ST30 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5JTZ9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-308736|uniprotkb:Q8N198|uniprotkb:Q96D02|uniprotkb:Q9ULF0|uniprotkb:A2RRN5|ensembl:ENSP00000244571 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syam_human(display_long)|uniprotkb:KIAA1270(gene name synonym)|uniprotkb:AARS2(gene name)|psi-mi:AARS2(display_short)|uniprotkb:AARSL(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_065796.1|ensembl:ENSG00000124608(gene)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:Q5JTZ9|rcsb pdb:6NLQ|rcsb pdb:6NLY|rcsb pdb:6NOW|reactome:R-HSA-379726|ensembl:ENST00000244571(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006400"(tRNA modification)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016597"(amino acid binding)|go:"GO:0070143"(mitochondrial alanyl-tRNA aminoacylation)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:RzNZMsaNjWpD4eB5AdgpjhC3vP09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5JRX3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2432778|uniprotkb:B4E0J8|uniprotkb:E7ES23|uniprotkb:B3KMJ6|uniprotkb:O95204|uniprotkb:Q2M2G6|uniprotkb:Q4VBR1|uniprotkb:Q5JRW7|uniprotkb:Q7L5Z7|uniprotkb:Q9BSI6|uniprotkb:Q9BVJ5|uniprotkb:Q9UPP8|uniprotkb:C9JSL2|ensembl:ENSP00000224949 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:prep_human(display_long)|uniprotkb:PITRM1(gene name)|psi-mi:PITRM1(display_short)|uniprotkb:KIAA1104(gene name synonym)|uniprotkb:MP1(gene name synonym)|uniprotkb:Pitrilysin metalloproteinase 1(gene name synonym)|uniprotkb:PREP(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001229236.1|refseq:NP_001229238.1|refseq:NP_055704.2|dip:DIP-52900N|ensembl:ENSG00000107959(gene)|ensembl:ENST00000224949(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR013578(Peptidase M16C associated)|mint:Q5JRX3|rcsb pdb:4L3T|rcsb pdb:4NGE|rcsb pdb:4RPU|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1kEY/XJB5fwgNRoM9u9ZGT+VrS09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5JPH6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-13943410|ensembl:ENSP00000395196|ensembl:ENSP00000501251|uniprotkb:B3KTT2|uniprotkb:D3DWF1|uniprotkb:Q86YH3|uniprotkb:Q8TF31 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syem_human(display_long)|uniprotkb:EARS2(gene name)|psi-mi:EARS2(display_short)|uniprotkb:Glutamyl-tRNA synthetase(gene name synonym)|uniprotkb:KIAA1970(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020058|interpro:IPR020751|interpro:IPR033910|reactome:R-HSA-379726|ensembl:ENSG00000103356(gene)|ensembl:ENST00000449606(transcript)|ensembl:ENST00000674054(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0050561"("glutamate-tRNA(Gln) ligase activity")|go:"GO:0070127"(tRNA aminoacylation for mitochondrial protein translation)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004527(Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial)|refseq:NP_001077083.1|refseq:NP_001295140.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Jo4TXXabhrL7bgEVz1Ffm/766PA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5HYK3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-12577722|ensembl:ENSP00000288532|uniprotkb:B2RDU9|uniprotkb:B3GK62|uniprotkb:B4DEJ4|uniprotkb:Q32Q28|uniprotkb:Q53HH0|uniprotkb:Q96LV1|uniprotkb:Q9BSP8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:coq5_human(display_long)|uniprotkb:COQ5(gene name)|psi-mi:COQ5(display_short)|uniprotkb:Ubiquinone biosynthesis methyltransferase COQ5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000110871(gene)|ensembl:ENST00000288532(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032259"(methylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043333"(2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity)|go:"GO:0043430"(2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity)|interpro:IPR004033(UbiE/COQ5 methyltransferase)|interpro:IPR023576|interpro:IPR029063|mint:Q5HYK3|reactome:R-HSA-2142789|refseq:NP_115690.3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zyV+GL8MivuqPdn5qkE6zEjYCkc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q4VC31 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q4J6C6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-949331|uniprotkb:A7E2X6|uniprotkb:O43163|uniprotkb:Q4J6C3|uniprotkb:Q4J6C4|uniprotkb:Q4ZG39|uniprotkb:Q6ZMW7|uniprotkb:Q96DW7|uniprotkb:D6W5A3|ensembl:ENSP00000260648|ensembl:ENSP00000386509|ensembl:ENSP00000386543|ensembl:ENSP00000386909|ensembl:ENSP00000391456|ensembl:ENSP00000409480 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ppcel_human(display_long)|uniprotkb:KIAA0436(gene name synonym)|uniprotkb:Prolylendopeptidase-like(gene name synonym)|uniprotkb:PREPL(gene name)|psi-mi:PREPL(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001035844.1|refseq:NP_001035845.1|refseq:NP_001165074.1|refseq:NP_001165077.1|refseq:NP_001165084.1|refseq:NP_001165088.1|refseq:NP_006027.2|refseq:XP_011531500.1|refseq:XP_011531502.1|refseq:XP_011531504.1|refseq:XP_016860873.1|refseq:XP_016860874.1|ensembl:ENSG00000138078(gene)|ensembl:ENST00000260648(transcript)|ensembl:ENST00000409272(transcript)|ensembl:ENST00000409936(transcript)|ensembl:ENST00000410081(transcript)|ensembl:ENST00000425263(transcript)|ensembl:ENST00000426481(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008233"(peptidase activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002470(Peptidase S9A, prolyl oligopeptidase)|interpro:IPR023302|interpro:IPR029058 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xn++9zR6AX/HzP4KzrriJR5IUTk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q3SY69 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6916128|ensembl:ENSP00000258494|uniprotkb:Q3SY68|uniprotkb:Q68D62|uniprotkb:Q6AI55|uniprotkb:Q8N922 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:al1l2_human(display_long)|uniprotkb:ALDH1L2(gene name)|psi-mi:ALDH1L2(display_short)|uniprotkb:Aldehyde dehydrogenase family 1 member L2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011536291.1|ensembl:ENST00000258494(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0009258"(10-formyltetrahydrofolate catabolic process)|go:"GO:0016155"(formyltetrahydrofolate dehydrogenase activity)|go:"GO:0016742"(hydroxymethyl-, formyl- and related transferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR005793(Formyl transferase, C-terminal)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011034(Formyl transferase, C-terminal-like)|interpro:IPR011407(10-formyltetrahydrofolate dehydrogenase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|ensembl:ENSG00000136010(gene)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|interpro:IPR036477|interpro:IPR036736|interpro:IPR037022|mint:Q3SY69|reactome:R-HSA-196757|refseq:NP_001029345.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Tfg9TJwXfyRvVxezABcOGaJrcas9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q16822 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2825219|uniprotkb:O43253|uniprotkb:Q9BV62|intact:EBI-3189808|uniprotkb:Q86U01|ensembl:ENSP00000216780|ensembl:ENSP00000494919|uniprotkb:B4DW73 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pckgm_human(display_long)|uniprotkb:PCK2(gene name)|psi-mi:PCK2(display_short)|uniprotkb:PEPCK2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001278485.1|refseq:NP_001294983.1|refseq:NP_001018083.2|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0042594"(response to starvation)|go:"GO:0046327"(glycerol biosynthetic process from pyruvate)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR008209(Phosphoenolpyruvate carboxykinase, GTP-utilising)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR018091|interpro:IPR035077|interpro:IPR035078|mint:Q16822|reactome:R-HSA-70263|go:"GO:0030145"(manganese ion binding)|ensembl:ENSG00000100889(gene)|ensembl:ENSG00000285241(gene)|ensembl:ENST00000216780(transcript)|ensembl:ENST00000645217(transcript)|go:"GO:0004611"(phosphoenolpyruvate carboxykinase activity)|go:"GO:0004613"("phosphoenolpyruvate carboxykinase (GTP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0019543"(propionate catabolic process)|refseq:NP_004554.3 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:gbQbu8+tVa1xs/fKesefSJlpSaM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q16795 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q16718 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15388 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-711636|uniprotkb:A8K195|uniprotkb:Q498B3|uniprotkb:Q6IBT4|ensembl:ENSP00000355566 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tom20_human(display_long)|uniprotkb:Outer mitochondrial membrane receptor Tom20(gene name synonym)|uniprotkb:TOMM20(gene name)|psi-mi:TOMM20(display_short)|uniprotkb:KIAA0016(gene name synonym)|uniprotkb:Mitochondrial 20 kDa outer membrane protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055580.1|dip:DIP-46735N|ensembl:ENSG00000173726(gene)|ensembl:ENST00000366607(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016031"(tRNA import into mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|interpro:IPR002056(Protein import receptor MAS20)|interpro:IPR022422|interpro:IPR023392|rcsb pdb:4APO|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+wNh1qTU0NtgQekYJjhfj6O3UoA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15293 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15070 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3917688|uniprotkb:B4DPA2|ensembl:ENSP00000350740 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:oxa1l_human(display_long)|uniprotkb:OXA1L(gene name)|psi-mi:OXA1L(display_short)|uniprotkb:Hsa(gene name synonym)|uniprotkb:OXA1Hs(gene name synonym)|uniprotkb:Oxidase assembly 1-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005006.3|ensembl:ENSG00000155463(gene)|ensembl:ENST00000358043(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0097177"(mitochondrial ribosome binding)|interpro:IPR001708(60 kDa inner membrane insertion protein)|interpro:IPR028055|mint:Q15070|rcsb pdb:6ZM5|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1C8BWezMWHLLnmHl7vOik3WJmKY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15031 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-13943408|ensembl:ENSP00000495093|ensembl:ENSP00000495707|ensembl:ENSP00000498867 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sylm_human(display_long)|uniprotkb:LARS2(gene name)|psi-mi:LARS2(display_short)|uniprotkb:KIAA0028(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|reactome:R-HSA-379726|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002302(Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|ensembl:ENST00000642274(transcript)|ensembl:ENST00000645846(transcript)|ensembl:ENST00000650792(transcript)|ensembl:ENSG00000011376(gene)|refseq:NP_056155.1|refseq:XP_005265063.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9yihm8Ai9McATYK+d12UMtP6A6k9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q12849 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054150|uniprotkb:Q6ZST3|uniprotkb:Q8NBD2|uniprotkb:Q4W5S5|uniprotkb:Q8IWD6|uniprotkb:B3KPW0|intact:EBI-28981368|ensembl:ENSP00000254799 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:grsf1_human(display_long)|uniprotkb:GRSF1(gene name)|psi-mi:GRSF1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002083.3|refseq:XP_011530199.1|ensembl:ENSP00000254799|ensembl:ENST00000502323|ensembl:ENSP00000425430|refseq:NP_001091947.1|ensembl:ENSG00000132463(gene)|ensembl:ENST00000254799(transcript)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033106|interpro:IPR034424|interpro:IPR034425|interpro:IPR034426|interpro:IPR035979|rcsb pdb:2LMI|rcsb pdb:4QU6|rcsb pdb:4QU7|reactome:R-HSA-192823 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:89Xul87okYruMW1PQtPMbBTqX+09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q02218 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-747213|intact:EBI-1210683|uniprotkb:Q9UDX0|uniprotkb:D3DVL0|uniprotkb:B4E2U9|uniprotkb:E9PBM1|uniprotkb:Q96DD3|ensembl:ENSP00000222673 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:odo1_human(display_long)|uniprotkb:OGDH(gene name)|psi-mi:OGDH(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002532.2|refseq:NP_001003941.1|refseq:NP_001158508.1|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0021756"(striatum development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034602"("oxoglutarate dehydrogenase (NAD+) activity")|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0106077"(histone succinylation)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|rcsb pdb:3ERY|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403|ensembl:ENSG00000105953(gene)|ensembl:ENST00000222673(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0021695"(cerebellar cortex development)|dip:DIP-39353N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:B9CSRCmhDYg7n5jSpuDlr2mrxDg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q00059 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P83111 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82933 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721385|intact:EBI-1049991|uniprotkb:Q6PG40|ensembl:ENSP00000258455 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt09_human(display_long)|uniprotkb:MRPS9(gene name)|psi-mi:MRPS9(display_short)|uniprotkb:RPMS9(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS9m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_872578.1|ensembl:ENSG00000135972(gene)|ensembl:ENST00000258455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P82933|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSE - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XNB4GL84eYgYFEB3WxOtoD3Ub989606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82932 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-716172|uniprotkb:Q96Q64|uniprotkb:Q9BSK8|uniprotkb:Q9BW89|uniprotkb:B2R573|ensembl:ENSP00000382250 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt06_human(display_long)|uniprotkb:MRPS6(gene name)|psi-mi:MRPS6(display_short)|uniprotkb:C21orf101(gene name synonym)|uniprotkb:RPMS6(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein bS6m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_115865.1|ensembl:ENSG00000243927(gene)|ensembl:ENST00000399312(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000529(Ribosomal protein S6)|interpro:IPR014717(Translation elongation factor EF1B/ribosomal protein S6)|interpro:IPR035980|mint:P82932|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZSA|rcsb pdb:6ZS9|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mMPTr45GZxT1pj2RBZvvG6TrQmo9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82930 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1048516|uniprotkb:Q9BVI7|ensembl:ENSP00000380531 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt34_human(display_long)|uniprotkb:MRPS34(gene name)|psi-mi:MRPS34(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS34(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001287829.1|refseq:NP_076425.1|ensembl:ENSG00000074071(gene)|ensembl:ENST00000397375(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR032053|mint:P82930|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UTZkYPSJqThFKwoB7D5sH6g0zuc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82912 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2371859|uniprotkb:Q969D7|uniprotkb:Q96GI3|uniprotkb:Q9BYC3|uniprotkb:B2RD52|ensembl:ENSP00000317376 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt11_human(display_long)|uniprotkb:MRPS11(gene name)|psi-mi:MRPS11(display_short)|uniprotkb:RPMS11(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCC2(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS11m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001308899.1|refseq:NP_001308901.1|refseq:NP_001308902.1|refseq:NP_001308903.1|refseq:NP_001308905.1|refseq:NP_073750.2|refseq:NP_789775.1|ensembl:ENSG00000181991(gene)|ensembl:ENST00000325844(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P82912|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:aw3XzNBYY0igd4AUE1OQyfFn8pk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82909 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11020727|uniprotkb:Q9H2H4|ensembl:ENSP00000256441|ensembl:ENSP00000482331 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt36_human(display_long)|uniprotkb:MRPS36(gene name)|psi-mi:MRPS36(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase component 4(gene name synonym)|uniprotkb:KGD4(gene name synonym)|uniprotkb:DC47(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_150597.1|ensembl:ENSG00000134056(gene)|ensembl:ENSG00000278461(gene)|ensembl:ENST00000256441(transcript)|ensembl:ENST00000613100(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006412"(translation)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|interpro:IPR020373|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:7oEY4QJNE/NCNZXlaqXftm4yTIc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82675 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054287|uniprotkb:Q96LJ6|uniprotkb:Q9BWI4|uniprotkb:Q9BYC4|uniprotkb:Q4ZFY5|ensembl:ENSP00000272418 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt05_human(display_long)|uniprotkb:MRPS5(gene name)|psi-mi:MRPS5(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS5m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_114108.1|ensembl:ENSG00000144029(gene)|ensembl:ENST00000272418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018192|interpro:IPR020568|mint:P82675|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6RW5|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:l+aZgmDVWWimuUiH4IS4FG1cwlQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82673 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2513649|ensembl:ENSP00000081029|uniprotkb:Q6P4C6|uniprotkb:Q7L1M6|uniprotkb:Q9HC14|uniprotkb:Q96AI0|uniprotkb:Q32LZ1|uniprotkb:Q9H044|uniprotkb:Q9P1R5|uniprotkb:Q8NBP4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt35_human(display_long)|uniprotkb:MRPS35(gene name)|psi-mi:MRPS35(display_short)|uniprotkb:MRPS28(gene name synonym)|uniprotkb:28S ribosomal protein S28, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS35(gene name synonym)|uniprotkb:HDCMD11P(orf name)|uniprotkb:MDS023(orf name)|uniprotkb:PSEC0213(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000061794(gene)|ensembl:ENST00000081029(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR019349|interpro:IPR039848|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_001177793.1|refseq:NP_068593.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:L7fhBRRkth1ePVbRtuVTvC5zcR09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82664 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1048271|uniprotkb:Q9H3E5|uniprotkb:Q9NVR3|uniprotkb:B2RE89|ensembl:ENSP00000053468 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt10_human(display_long)|uniprotkb:MRPS10(gene name)|psi-mi:MRPS10(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS10m(gene name synonym)|uniprotkb:MSTP040(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060611.2|ensembl:ENSG00000048544(gene)|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|ensembl:ENST00000053468(transcript)|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR027486|interpro:IPR036838|interpro:IPR040055|mint:P82664|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|dip:DIP-50902N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:D6kypsC/rbFvPq5Y1YX9/DXtwtk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82663 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1046734|uniprotkb:Q9H7P5|ensembl:ENSP00000253686|uniprotkb:B4DFJ5|uniprotkb:B4DQG6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt25_human(display_long)|uniprotkb:MRPS25(gene name)|psi-mi:MRPS25(display_short)|uniprotkb:RPMS25(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_071942.1|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000131368(gene)|ensembl:ENST00000253686(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR040049|mint:P82663|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:DQMtBaQJW2Ic025zsKJYfN4aj1I9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82650 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P80303 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2296670|uniprotkb:D3DQX5|uniprotkb:A8K642|uniprotkb:Q8NFT5|uniprotkb:V9HW75|ensembl:ENSP00000436455|ensembl:ENSP00000481959 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nucb2_human(display_long)|uniprotkb:NUCB2(gene name)|psi-mi:NUCB2(display_short)|uniprotkb:NEFA(gene name synonym)|uniprotkb:DNA-binding protein NEFA(gene name synonym)|uniprotkb:Gastric cancer antigen Zg4(gene name synonym)|uniprotkb:Prepronesfatin(gene name synonym)|uniprotkb:Epididymis secretory protein Li 109(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005004.1|refseq:XP_016873295.1|refseq:XP_016873296.1|refseq:XP_016873297.1|refseq:XP_016873298.1|refseq:XP_016873299.1|refseq:XP_016873300.1|refseq:XP_016873301.1|refseq:XP_016873302.1|refseq:XP_016873303.1|refseq:XP_016873304.1|refseq:XP_016873305.1|refseq:XP_016873306.1|refseq:XP_016873307.1|refseq:XP_016873308.1|ensembl:ENSG00000070081(gene)|ensembl:ENST00000529010(transcript)|ensembl:ENST00000622082(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028813|go:"GO:0005886"(plasma membrane)|interpro:IPR040250|mint:P80303 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:m5wJa0MtTVxrydwG9BXzjUMAlyc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P63000 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P61604 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P56556 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-714658|uniprotkb:O43675|uniprotkb:Q6IC39|uniprotkb:B2RE54|uniprotkb:Q6FGW0|uniprotkb:Q6IBT8|ensembl:ENSP00000418842|ensembl:ENSP00000475402|ensembl:ENSP00000486781|ensembl:ENSP00000487431|ensembl:ENSP00000487462 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndua6_human(display_long)|uniprotkb:LYRM6(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B14 subunit(gene name synonym)|uniprotkb:Complex I-B14(gene name synonym)|uniprotkb:LYR motif-containing protein 6(gene name synonym)|uniprotkb:NDUFA6(gene name)|psi-mi:NDUFA6(display_short)|uniprotkb:NADHB14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002481.2|ensembl:ENSG00000184983(gene)|ensembl:ENSG00000272765(gene)|ensembl:ENSG00000273397(gene)|ensembl:ENSG00000277365(gene)|ensembl:ENSG00000281013(gene)|ensembl:ENST00000498737(transcript)|ensembl:ENST00000605916(transcript)|ensembl:ENST00000628740(transcript)|ensembl:ENST00000630201(transcript)|ensembl:ENST00000630971(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR016488("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6")|mint:P56556|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rI1B6Ym+ps0tKfJIClYRtej8KcU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P56181 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P54819 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P54098 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-852624|uniprotkb:Q8NFM2|uniprotkb:Q92515|ensembl:ENSP00000268124|ensembl:ENSP00000399851 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dpog1_human(display_long)|uniprotkb:Mitochondrial DNA polymerase catalytic subunit(gene name synonym)|uniprotkb:PolG-alpha(gene name synonym)|uniprotkb:POLG(gene name)|psi-mi:POLG(display_short)|uniprotkb:MDP1(gene name synonym)|uniprotkb:POLG1(gene name synonym)|uniprotkb:POLGA(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001119603.1|refseq:NP_002684.1|ensembl:ENSG00000140521(gene)|ensembl:ENST00000268124(transcript)|ensembl:ENST00000442287(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0007568"(aging)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043195"(terminal bouton)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071333"(cellular response to glucose stimulus)|interpro:IPR001098(DNA-directed DNA polymerase, family A)|interpro:IPR002297(DNA-directed DNA-polymerase, family A, mitochondria)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR019760|interpro:IPR041336|interpro:IPR043502|mint:P54098|rcsb pdb:3IKM|rcsb pdb:4ZTU|rcsb pdb:4ZTZ|rcsb pdb:5C51|rcsb pdb:5C52|rcsb pdb:5C53 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Gt8NCLdg0R/XLyFsovnrnLrzb/A9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P51970 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P51659 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-358398|ensembl:ENSP00000424940|uniprotkb:B4DNV1|uniprotkb:B4DVS5|uniprotkb:E9PB82|uniprotkb:F5HE57 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dhb4_human(display_long)|uniprotkb:HSD17B4(gene name)|psi-mi:HSD17B4(display_short)|uniprotkb:EDH17B4(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:SDR8C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 8C member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000405.1|refseq:NP_001186220.1|refseq:NP_001186221.1|refseq:NP_001278956.1|refseq:NP_001278957.1|ensembl:ENSG00000133835(gene)|ensembl:ENST00000510025(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|rcsb pdb:1IKT|rcsb pdb:1S9C|rcsb pdb:1ZBQ|rcsb pdb:6Z1W|rcsb pdb:6Z1X|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:i3A0dh9gAO2vfrCYXvo2U6+PwJQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P51398 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-355912|uniprotkb:Q13044|uniprotkb:Q96Q20|uniprotkb:Q68CT7|uniprotkb:B4DP59|uniprotkb:E7EM60|uniprotkb:B4DY62|ensembl:ENSP00000341692|ensembl:ENSP00000357320 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt29_human(display_long)|uniprotkb:DAP3(gene name)|psi-mi:DAP3(display_short)|uniprotkb:MRPS29(gene name synonym)|uniprotkb:Death-associated protein 3(gene name synonym)|uniprotkb:Ionizing radiation resistance conferring protein(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS29(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001186778.1|refseq:NP_004623.1|refseq:NP_387506.1|refseq:NP_001186779.1|refseq:NP_001186780.1|refseq:XP_005245537.1|refseq:XP_005245538.1|ensembl:ENSG00000132676(gene)|ensembl:ENST00000343043(transcript)|ensembl:ENST00000368336(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR008092(Death associated protein 3)|interpro:IPR019368|interpro:IPR027417|mint:P51398|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_016857780.1|refseq:XP_016857781.1|refseq:XP_016857782.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xSIyqKH4F49Iu+AVuVThJWsi9EA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P50213 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P49821 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P49748 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-727618|intact:EBI-10981570|uniprotkb:O76056|uniprotkb:Q8WUL0|uniprotkb:B4DEB6|uniprotkb:F5H2A9|ensembl:ENSP00000349297 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acadv_human(display_long)|uniprotkb:ACADVL(gene name)|psi-mi:ACADVL(display_short)|uniprotkb:VLCAD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000009.1|refseq:NP_001029031.1|refseq:NP_001257376.1|ensembl:ENSG00000072778(gene)|ensembl:ENST00000356839(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:P49748|rcsb pdb:2UXW|rcsb pdb:3B96|reactome:R-HSA-381038|reactome:R-HSA-77305|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009409"(response to cold)|go:"GO:0015980"(energy derivation by oxidation of organic compounds)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0090181"(regulation of cholesterol metabolic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:3SR9FcNgkWFPGrRGTi8JaJtwiF49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P49590 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3909030|uniprotkb:B4DDY8|intact:EBI-10988212|ensembl:ENSP00000230771|ensembl:ENSP00000494296 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syhm_human(display_long)|uniprotkb:Histidyl-tRNA synthetase(gene name synonym)|uniprotkb:HARS2(gene name)|psi-mi:HARS2(display_short)|uniprotkb:HARSL(gene name synonym)|uniprotkb:HARSR(gene name synonym)|uniprotkb:HO3(gene name synonym)|uniprotkb:Histidine--tRNA ligase-like(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_036340.1|refseq:NP_001265660.1|refseq:NP_001265661.1|ensembl:ENSG00000112855(gene)|ensembl:ENST00000230771(transcript)|ensembl:ENST00000645749(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|reactome:R-HSA-379726|go:"GO:0006412"(translation)|dip:DIP-59626N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:pp4g+OJKxW3va88iXtfIAnGXMKw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P48507 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051387|uniprotkb:Q6FHC1|uniprotkb:Q9NPX9|uniprotkb:Q9NU74|uniprotkb:A8K334|uniprotkb:M5A959|uniprotkb:D3DT45|ensembl:ENSP00000359258 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gsh0_human(display_long)|uniprotkb:Gamma-glutamylcysteine synthetase regulatory subunit(gene name synonym)|uniprotkb:Gamma-ECS regulatory subunit(gene name synonym)|uniprotkb:GCS light chain(gene name synonym)|uniprotkb:Glutamate--cysteine ligase modifier subunit(gene name synonym)|uniprotkb:GCLM(gene name)|psi-mi:GCLM(display_short)|uniprotkb:GLCLR(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002052.1|refseq:NP_001295182.1|ensembl:ENSG00000023909(gene)|ensembl:ENST00000370238(transcript)|go:"GO:0004357"(glutamate-cysteine ligase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006534"(cysteine metabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0014823"(response to activity)|go:"GO:0017109"(glutamate-cysteine ligase complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0035226"(glutamate-cysteine ligase catalytic subunit binding)|go:"GO:0035229"(positive regulation of glutamate-cysteine ligase activity)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0042493"|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0097069"(cellular response to thyroxine stimulus)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR023210|interpro:IPR032963|interpro:IPR036812|reactome:R-HSA-174403|reactome:R-HSA-5578999 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:arU12Xm86K7yRxElliA31V7z5d89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P46734 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P46199 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359432|ensembl:ENSP00000263629|ensembl:ENSP00000378099|ensembl:ENSP00000384481|uniprotkb:D6W5D0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:if2m_human(display_long)|uniprotkb:MTIF2(gene name)|psi-mi:MTIF2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001307933.1|refseq:NP_001307934.1|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0070124"(mitochondrial translational initiation)|interpro:IPR000178(Initiation factor 2)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR015760(Translation initiation factor 2 related)|interpro:IPR023115|interpro:IPR027417|interpro:IPR036925|interpro:IPR044145|rcsb pdb:6GAW|rcsb pdb:6GAZ|rcsb pdb:6GB2|rcsb pdb:6RW5|reactome:R-HSA-5368286|ensembl:ENSG00000085760(gene)|ensembl:ENST00000263629(transcript)|ensembl:ENST00000394600(transcript)|ensembl:ENST00000403721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0032790"(ribosome disassembly)|refseq:NP_001005369.1|refseq:NP_002444.2|refseq:XP_011531173.1|refseq:NP_001307930.1|refseq:NP_001307931.1|refseq:NP_001307932.1|refseq:XP_005264392.1|refseq:XP_016859651.1|refseq:XP_016859652.1|dip:DIP-27596N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ThigwWzs0gInoPjmmd8DYvyrWw49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P45954 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P42704 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P40926 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P37268 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-714550|intact:EBI-1058542|uniprotkb:Q96GT0|ensembl:ENSP00000220584|ensembl:ENSP00000480828|ensembl:ENSP00000481481|uniprotkb:B3KQ95|uniprotkb:B4DJE5|uniprotkb:B4DT56|uniprotkb:B7Z1J3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fdft_human(display_long)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:FDFT1(gene name)|psi-mi:FDFT1(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENST00000618539(transcript)|refseq:NP_004453.3|ensembl:ENSG00000079459(gene)|ensembl:ENST00000220584(transcript)|ensembl:ENST00000615631(transcript)|rcsb pdb:3LEE|rcsb pdb:3Q2Z|rcsb pdb:3Q30|rcsb pdb:3V66|rcsb pdb:3VJ8|rcsb pdb:3VJ9|rcsb pdb:3VJA|rcsb pdb:3VJB|rcsb pdb:3VJC|rcsb pdb:3WC9|rcsb pdb:3WCD|rcsb pdb:3WCF|rcsb pdb:3WCH|rcsb pdb:3WCI|rcsb pdb:3WCJ|rcsb pdb:3WCL|rcsb pdb:3WCM|rcsb pdb:3WEF|rcsb pdb:3WEG|rcsb pdb:3WEH|rcsb pdb:3WEI|rcsb pdb:3WEJ|rcsb pdb:3WEK|rcsb pdb:3WSA|rcsb pdb:6PYJ|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|reactome:R-HSA-191273|reactome:R-HSA-1989781|reactome:R-HSA-2426168|rcsb pdb:3ASX|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|mint:P37268|rcsb pdb:1EZF|refseq:NP_001274671.1|refseq:NP_001274672.1|refseq:NP_001274673.1|refseq:NP_001274674.1|refseq:NP_001274676.1|refseq:NP_001274677.1|refseq:NP_001274678.1|refseq:NP_001274679.1|refseq:NP_001274680.1|refseq:NP_001274685.1|refseq:XP_016868706.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:3TjanjXw3X58/ZOEsB1xczV0/qQ9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P36957 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P36551 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P34897 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P32322 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P31327 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-536811|uniprotkb:O43774|uniprotkb:Q7Z5I5|uniprotkb:B7Z818|uniprotkb:Q53TL5|uniprotkb:J3KQL0|uniprotkb:Q59HF8|ensembl:ENSP00000233072|ensembl:ENSP00000500537|ensembl:ENSP00000501022|ensembl:ENSP00000501073 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cpsm_human(display_long)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)|uniprotkb:CPS1(gene name)|psi-mi:CPS1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001116105.1|refseq:NP_001116106.1|refseq:NP_001866.2|refseq:XP_011508943.1|refseq:XP_011508944.1|refseq:XP_011508945.1|refseq:XP_011508946.1|ensembl:ENSG00000021826(gene)|ensembl:ENST00000233072(transcript)|ensembl:ENST00000673510(transcript)|ensembl:ENST00000673630(transcript)|ensembl:ENST00000673711(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:P31327|rcsb pdb:2YVQ|rcsb pdb:4UTR|rcsb pdb:4UTV|rcsb pdb:4UTX|rcsb pdb:4UTZ|rcsb pdb:4UU7|rcsb pdb:4UU8|rcsb pdb:4UUA|rcsb pdb:4UUB|rcsb pdb:5DOT|rcsb pdb:5DOU|rcsb pdb:5OJO|rcsb pdb:6UEL|rcsb pdb:6W2J|reactome:R-HSA-70635 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:497s02igPCWuQcU4lVrMpl5SRig9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P31040 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P30405 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5544229|uniprotkb:Q2YDB7|uniprotkb:Q5W131|ensembl:ENSP00000225174 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ppif_human(display_long)|uniprotkb:PPIF(gene name)|psi-mi:PPIF(display_short)|uniprotkb:CYP3(gene name synonym)|uniprotkb:Cyclophilin F(gene name synonym)|uniprotkb:Rotamase F(gene name synonym)|uniprotkb:Cyclophilin D(gene name synonym)|uniprotkb:Mitochondrial cyclophilin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005720.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010849"(regulation of proton-transporting ATPase activity, rotational mechanism)|go:"GO:0010939"(regulation of necrotic cell death)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902686"(mitochondrial outer membrane permeabilization involved in programmed cell death)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P30405|rcsb pdb:2BIT|rcsb pdb:2BIU|rcsb pdb:2Z6W|rcsb pdb:3QYU|rcsb pdb:3R49|rcsb pdb:3R4G|rcsb pdb:3R54|rcsb pdb:3R56|rcsb pdb:3R57|rcsb pdb:3R59|rcsb pdb:3RCF|rcsb pdb:3RCG|rcsb pdb:3RCI|rcsb pdb:3RCK|rcsb pdb:3RCL|rcsb pdb:3RD9|rcsb pdb:3RDA|rcsb pdb:3RDB|rcsb pdb:3RDC|rcsb pdb:4J58|rcsb pdb:4J59|rcsb pdb:4J5A|rcsb pdb:4J5B|rcsb pdb:4J5C|rcsb pdb:4J5D|rcsb pdb:4J5E|rcsb pdb:4O8H|rcsb pdb:4O8I|rcsb pdb:4XNC|rcsb pdb:4ZSC|rcsb pdb:4ZSD|rcsb pdb:5A0E|rcsb pdb:5CBT|rcsb pdb:5CBU|rcsb pdb:5CBV|rcsb pdb:5CBW|rcsb pdb:5CCN|rcsb pdb:5CCQ|rcsb pdb:5CCR|rcsb pdb:5CCS|rcsb pdb:6R8L|rcsb pdb:6R8O|rcsb pdb:6R8W|rcsb pdb:6R9S|rcsb pdb:6R9U|rcsb pdb:6R9X|rcsb pdb:6RA1|rcsb pdb:6Y3E|rcsb pdb:6YBM|ensembl:ENSG00000108179(gene)|ensembl:ENST00000225174(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0002931"(response to ischemia)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5sa9mIaCM/Fo9PA4NgA1p4c4WIg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P30084 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P30049 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P28331 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P27797 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P24539 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P23368 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1043318|uniprotkb:Q9H4B2|uniprotkb:Q9BYG1|ensembl:ENSP00000321070|uniprotkb:B2R8J2|uniprotkb:Q9BWL6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:maom_human(display_long)|uniprotkb:Malic enzyme 2(gene name synonym)|uniprotkb:ME2(gene name)|psi-mi:ME2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001161807.1|rcsb pdb:1QR6|rcsb pdb:7BSJ|rcsb pdb:7BSK|rcsb pdb:7BSL|reactome:R-HSA-71403|ensembl:ENST00000321341(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|ensembl:ENSG00000082212(gene)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:1902031"(regulation of NADP metabolic process)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|mint:P23368|rcsb pdb:1DO8|rcsb pdb:1EFK|rcsb pdb:1EFL|rcsb pdb:1GZ3|rcsb pdb:1GZ4|rcsb pdb:1PJ2|rcsb pdb:1PJ3|rcsb pdb:1PJ4|rcsb pdb:1PJL|refseq:NP_002387.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:aJAm/VMhqHLF07K3FlystextLrc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P22830 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P21912 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P20674 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P19404 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P17655 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1028956|uniprotkb:Q16738|uniprotkb:Q6PJT3|uniprotkb:Q8WU26|uniprotkb:Q9HBB1|uniprotkb:A6NDG7|ensembl:ENSP00000295006|uniprotkb:B7ZA96|uniprotkb:E7ES58 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:can2_human(display_long)|uniprotkb:CAPN2(gene name)|psi-mi:CAPN2(display_short)|uniprotkb:CANPL2(gene name synonym)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)|uniprotkb:Calpain large polypeptide L2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001139540.1|refseq:NP_001739.2|ensembl:ENSG00000162909(gene)|ensembl:ENST00000295006(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0005634"(nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:P17655|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:2NQA|reactome:R-HSA-1474228|reactome:R-HSA-8862803|interpro:IPR002048(Calcium-binding EF-hand) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:r60XX66kihGVLaa9888soeXjc0M9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P17252 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1383528|uniprotkb:Q96RE4|uniprotkb:Q15137|uniprotkb:Q32M72|uniprotkb:B5BU22|ensembl:ENSP00000408695 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kpca_human(display_long)|uniprotkb:PRKCA(gene name)|psi-mi:PRKCA(display_short)|uniprotkb:PKCA(gene name synonym)|uniprotkb:PRKACA(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002728.1|dip:DIP-531N|ensembl:ENSG00000154229(gene)|ensembl:ENST00000413366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034663|interpro:IPR035892|mint:P17252|rcsb pdb:2ELI|rcsb pdb:3IW4|rcsb pdb:4DNL|rcsb pdb:4RA4|reactome:R-HSA-111933|reactome:R-HSA-114516|reactome:R-HSA-1250196|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2179392|reactome:R-HSA-2514859|reactome:R-HSA-3000170|reactome:R-HSA-399997|reactome:R-HSA-4086398|reactome:R-HSA-416993|reactome:R-HSA-418597|reactome:R-HSA-4419969|reactome:R-HSA-450520|reactome:R-HSA-5099900|go:"GO:0043488"(regulation of mRNA stability)|reactome:R-HSA-5668599|reactome:R-HSA-76005|reactome:R-HSA-8853659|reactome:R-HSA-9010642|reactome:R-HSA-5218921 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:VW6o9vP7DTAQT2W9hEmyCLjoEX09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P16152 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P13804 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052886|uniprotkb:B4DT43|uniprotkb:Q53XN3|ensembl:ENSP00000452762 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:etfa_human(display_long)|uniprotkb:ETFA(gene name)|psi-mi:ETFA(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000117.1|refseq:NP_001121188.1|dip:DIP-6161N|ensembl:ENSG00000140374(gene)|ensembl:ENST00000557943(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|mint:P13804|rcsb pdb:1EFV|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:2A1U|reactome:R-HSA-611105 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:J2PUTTVN+nd8eHe6TXga+37CiPw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P13667 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P13489 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P13073 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P12694 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1029053|uniprotkb:Q16034|uniprotkb:Q16472|uniprotkb:B4DP47|uniprotkb:E7EW46|ensembl:ENSP00000269980 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:odba_human(display_long)|uniprotkb:BCKDHA(gene name)|psi-mi:BCKDHA(display_short)|uniprotkb:Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000700.1|ensembl:ENSG00000248098(gene)|ensembl:ENST00000269980(transcript)|go:"GO:0003863"("3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0016831"(carboxy-lyase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR034616|rcsb pdb:1DTW|rcsb pdb:1OLS|rcsb pdb:1OLU|rcsb pdb:1OLX|rcsb pdb:1U5B|rcsb pdb:1V11|rcsb pdb:1V16|rcsb pdb:1V1M|rcsb pdb:1V1R|rcsb pdb:1WCI|rcsb pdb:1X7W|rcsb pdb:1X7X|rcsb pdb:1X7Y|rcsb pdb:1X7Z|rcsb pdb:1X80|rcsb pdb:2BEU|rcsb pdb:2BEV|rcsb pdb:2BEW|rcsb pdb:2BFB|rcsb pdb:2BFC|rcsb pdb:2BFD|rcsb pdb:2BFE|rcsb pdb:2BFF|rcsb pdb:2J9F|reactome:R-HSA-389661|reactome:R-HSA-70895|refseq:NP_001158255.1|dip:DIP-6146N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:dfjLnS4YI8gwCQljkXL3W24I/DY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P12532 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P12235 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359074|uniprotkb:D3DP59|ensembl:ENSP00000281456 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:adt1_human(display_long)|uniprotkb:SLC25A4(gene name)|psi-mi:SLC25A4(display_short)|uniprotkb:ANT1(gene name synonym)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:ADP,ATP carrier protein, heart/skeletal muscle isoform T1(gene name synonym)|uniprotkb:AAC1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001142.2|ensembl:ENST00000281456(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|ensembl:ENSG00000151729(gene)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12235|reactome:R-HSA-1268020|reactome:R-HSA-180897|reactome:R-HSA-83936|dip:DIP-33116N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:vs4XIUUUypcIHR9Lz4j1buDAnjM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P11310 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-514381|uniprotkb:Q9NYF1|uniprotkb:Q5T4U4|ensembl:ENSP00000359878 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acadm_human(display_long)|uniprotkb:Medium chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:ACADM(gene name)|psi-mi:ACADM(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000007.1|refseq:NP_001120800.1|dip:DIP-34281N|ensembl:ENSG00000117054(gene)|ensembl:ENST00000370841(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|mint:P11310|rcsb pdb:1EGC|rcsb pdb:1EGD|rcsb pdb:1EGE|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:4P13|reactome:R-HSA-1989781|reactome:R-HSA-77288|reactome:R-HSA-77346|reactome:R-HSA-77348 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rfmTmYKNQr6R6ikvfYovZIctoz49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P10606 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P08574 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1224514|uniprotkb:Q5U062|uniprotkb:Q6FHS7|ensembl:ENSP00000317159 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cy1_human(display_long)|uniprotkb:CYC1(gene name)|psi-mi:CYC1(display_short)|uniprotkb:Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit(gene name synonym)|uniprotkb:Cytochrome b-c1 complex subunit 4(gene name synonym)|uniprotkb:Complex III subunit 4(gene name synonym)|uniprotkb:Complex III subunit IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001907.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0033762"(response to glucagon)|go:"GO:0046872"(metal ion binding)|interpro:IPR002326(Cytochrome c1)|interpro:IPR021157|interpro:IPR036909|mint:P08574|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|ensembl:ENSG00000179091(gene)|ensembl:ENST00000318911(transcript)|go:"GO:0005634"(nucleus) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:WFFFejEobb6Uoum311x+fry5X+o9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P07237 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P05091 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-711703|uniprotkb:Q03639|uniprotkb:Q6IB13|uniprotkb:Q6IV71|uniprotkb:B4DW54|uniprotkb:E7EUE5|ensembl:ENSP00000261733 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:aldh2_human(display_long)|uniprotkb:ALDH class 2(gene name synonym)|uniprotkb:ALDHI(gene name synonym)|uniprotkb:ALDH-E2(gene name synonym)|uniprotkb:ALDH2(gene name)|psi-mi:ALDH2(display_short)|uniprotkb:ALDM(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000681.2|refseq:NP_001191818.1|dip:DIP-40262N|ensembl:ENSG00000111275(gene)|ensembl:ENST00000261733(transcript)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0004030"("aldehyde dehydrogenase [NAD(P)+] activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006066"(alcohol metabolic process)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P05091|rcsb pdb:1CW3|rcsb pdb:1NZW|rcsb pdb:1NZX|rcsb pdb:1NZZ|rcsb pdb:1O00|rcsb pdb:1O01|rcsb pdb:1O02|rcsb pdb:1O04|rcsb pdb:1O05|rcsb pdb:1ZUM|rcsb pdb:2ONM|rcsb pdb:2ONN|rcsb pdb:2ONO|rcsb pdb:2ONP|rcsb pdb:2VLE|rcsb pdb:3INJ|rcsb pdb:3INL|rcsb pdb:3N80|rcsb pdb:3N81|rcsb pdb:3N82|rcsb pdb:3N83|rcsb pdb:3SZ9|rcsb pdb:4FQF|rcsb pdb:4FR8|rcsb pdb:4KWF|rcsb pdb:4KWG|rcsb pdb:5L13|reactome:R-HSA-380612|reactome:R-HSA-71384 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XvszkFUJP4cXHCYokY16c+LeDEI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P03905 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O95831 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O95470 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1046170|uniprotkb:Q7Z732|uniprotkb:Q9ULG8|uniprotkb:Q9UN89|uniprotkb:B2RBD4|ensembl:ENSP00000362298 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sgpl1_human(display_long)|uniprotkb:Sphingosine-1-phosphate aldolase(gene name synonym)|uniprotkb:SGPL1(gene name)|psi-mi:SGPL1(display_short)|uniprotkb:KIAA1252(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003892.2|refseq:XP_011538618.1|refseq:XP_011538619.1|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|ensembl:ENSG00000166224(gene)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENST00000373202(transcript)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|go:"GO:0001553"(luteinization)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008117"(sphinganine-1-phosphate aldolase activity)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:4Q6R|reactome:R-HSA-1660661|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|refseq:XP_005270320.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:hGut7nnomGA7QJhsV4lHBNm+kEE9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O95202 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O95071 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O94925 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1043737|uniprotkb:Q9UL05|uniprotkb:Q9UL06|uniprotkb:Q9UL07|uniprotkb:Q9UN40|ensembl:ENSP00000317379 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:glsk_human(display_long)|uniprotkb:GLS(gene name)|psi-mi:GLS(display_short)|uniprotkb:GLS1(gene name synonym)|uniprotkb:KIAA0838(gene name synonym)|uniprotkb:L-glutamine amidohydrolase(gene name synonym)|uniprotkb:K-glutaminase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001243239.1|refseq:NP_055720.3|dip:DIP-50591N|ensembl:ENSG00000115419(gene)|ensembl:ENST00000320717(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0090461"(glutamate homeostasis)|interpro:IPR002110(Ankyrin)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR015868(Glutaminase, core)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR041541|mint:O94925|rcsb pdb:3CZD|rcsb pdb:3UNW|rcsb pdb:3UO9|rcsb pdb:3VOY|rcsb pdb:3VOZ|rcsb pdb:3VP0|rcsb pdb:3VP1|rcsb pdb:3VP2|rcsb pdb:3VP3|rcsb pdb:3VP4|rcsb pdb:5D3O|rcsb pdb:5FI2|rcsb pdb:5FI6|rcsb pdb:5FI7|rcsb pdb:5HL1|rcsb pdb:5I94|rcsb pdb:5JYO|rcsb pdb:5JYP|rcsb pdb:5U0I|rcsb pdb:5U0J|rcsb pdb:5UQE|rcsb pdb:5WJ6|rcsb pdb:6LOX|rcsb pdb:6UJG|rcsb pdb:6UJM|rcsb pdb:6UK6|rcsb pdb:6UKB|rcsb pdb:4O7D|rcsb pdb:6UL9|rcsb pdb:6ULA|rcsb pdb:6UMC|rcsb pdb:6UMD|rcsb pdb:6UME|rcsb pdb:6UMF|reactome:R-HSA-210500|reactome:R-HSA-5628897|reactome:R-HSA-8964539|rcsb pdb:6ULJ - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IV2jY1Qj63eTVPmTndDavjoUM2w9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O94826 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O76031 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75976 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3916308|uniprotkb:B7Z7T9|uniprotkb:B7ZAU4|uniprotkb:F5GZH6|uniprotkb:Q86SH9|uniprotkb:O15377|uniprotkb:Q86XE6|ensembl:ENSP00000225719 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cbpd_human(display_long)|uniprotkb:CPD(gene name)|psi-mi:CPD(display_short)|uniprotkb:Metallocarboxypeptidase D(gene name synonym)|uniprotkb:gp180(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001295.2|refseq:NP_001186704.1|interpro:IPR015567(Peptidase M14B, caboxypeptidase D unit2)|interpro:IPR033848|interpro:IPR034224|mint:O75976|rcsb pdb:5AQ0|reactome:R-HSA-432722|reactome:R-HSA-9696264|reactome:R-HSA-9696273|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|ensembl:ENSG00000108582(gene)|ensembl:ENST00000225719(transcript)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000834(Peptidase M14, carboxypeptidase A) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:PC6PFm4D7KoT4utNwyIe57VUwbY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75879 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6137441|uniprotkb:Q4W5M8|uniprotkb:Q9P0S6|uniprotkb:Q9Y2B8|uniprotkb:Q53GP4|ensembl:ENSP00000263985 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gatb_human(display_long)|uniprotkb:GATB(gene name)|psi-mi:GATB(display_short)|uniprotkb:Cytochrome c oxidase assembly factor PET112 homolog(gene name synonym)|uniprotkb:PET112(gene name synonym)|uniprotkb:PET112L(gene name synonym)|uniprotkb:HSPC199(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004555.1|dip:DIP-48968N|ensembl:ENSG00000059691(gene)|ensembl:ENST00000263985(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0030956"("glutamyl-tRNA(Gln) amidotransferase complex")|go:"GO:0032543"(mitochondrial translation)|go:"GO:0050567"("glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity")|go:"GO:0070681"(glutaminyl-tRNAGln biosynthesis via transamidation)|interpro:IPR003789(GatB/Yqey)|interpro:IPR004413("Glutamyl-tRNA(Gln) amidotransferase B subunit")|interpro:IPR006075(GatB N-terminal region)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR017958|interpro:IPR017959|interpro:IPR018027|interpro:IPR023168 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UqYWcZK5/HsUiV2AwuBgIfUDdHc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75746 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75616 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75489 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75380 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-719854|ensembl:ENSP00000274137 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus6_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-A subunit(gene name synonym)|uniprotkb:Complex I-13kD-A(gene name synonym)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004544.1|ensembl:ENSG00000145494(gene)|ensembl:ENST00000274137(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IfpFyQjgJW6a8wA2pNw14stMUL49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75306 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75251 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-719652|uniprotkb:Q2T9H7|uniprotkb:Q9BV17|ensembl:ENSP00000233627|uniprotkb:B3KRI2 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 20 kDa subunit(gene name synonym)|uniprotkb:Complex I-20kD(gene name synonym)|uniprotkb:PSST subunit(gene name synonym)|uniprotkb:NDUFS7(gene name)|psi-mi:NDUFS7(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_077718.3|ensembl:ENSG00000115286(gene)|ensembl:ENST00000233627(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006138("NADH dehydrogenase (ubiquinone), 20 kDa subunit")|mint:O75251|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:DtNXT30ApcGKwTJSdNNwHd/q3+09606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75153 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-308505|uniprotkb:Q6AHY2|uniprotkb:Q6P3X7|uniprotkb:Q6ZUG8|uniprotkb:Q8N4U7|uniprotkb:Q9BTA3|uniprotkb:Q9H979|ensembl:ENSP00000388872|ensembl:ENSP00000458986 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:clu_human(display_long)|uniprotkb:CLUH(gene name)|psi-mi:CLUH(display_short)|uniprotkb:KIAA0664(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_056044.3|ensembl:ENSG00000132361(gene)|ensembl:ENST00000435359(transcript)|ensembl:ENST00000570628(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0048312"(intracellular distribution of mitochondria)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR023231|interpro:IPR025697|interpro:IPR027523|interpro:IPR028275|interpro:IPR033646 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9605WkS82JBvT0JZ1fkpxe3SqRc9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O60313 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43852 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1171069|uniprotkb:O60456|uniprotkb:Q6FHB9|uniprotkb:Q96RL3|uniprotkb:Q9NR43|intact:EBI-2554631|uniprotkb:B3KPG9|uniprotkb:D6QS48|uniprotkb:D6QS49|uniprotkb:D6QS50|uniprotkb:D6QS51|uniprotkb:D6QS52|uniprotkb:D6QS53|uniprotkb:D6QS54|uniprotkb:D6QS55|uniprotkb:D6QS56|uniprotkb:D6QS57|uniprotkb:D6QS58|uniprotkb:D6QS59|uniprotkb:F5H1Q9|uniprotkb:F5H879|ensembl:ENSP00000249364 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:calu_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:IEF SSP 9302(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001124146.1|refseq:NP_001186602.1|refseq:NP_001210.1|refseq:NP_001186600.1|refseq:NP_001186601.1|ensembl:ENSG00000128595(gene)|ensembl:ENST00000249364(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O43852|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016868148.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43847 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2371631|uniprotkb:O15241|uniprotkb:O15242|uniprotkb:Q5VUL0|uniprotkb:Q96HB2|uniprotkb:Q9NU57|uniprotkb:A6NI41|ensembl:ENSP00000262679|intact:EBI-6137671 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nrdc_human(display_long)|uniprotkb:NRDC(gene name)|psi-mi:NRDC(display_short)|uniprotkb:N-arginine dibasic convertase(gene name synonym)|uniprotkb:NRD1(gene name synonym)|uniprotkb:Nardilysin convertase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001095132.1|refseq:NP_001229290.1|refseq:NP_002516.2|ensembl:ENSG00000078618(gene)|ensembl:ENST00000352171(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009986"(cell surface)|go:"GO:0046872"(metal ion binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:O43847 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zvZTk2Q799M8nsREOYmuYPF/x1U9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43716 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6929453|ensembl:ENSP00000446872|uniprotkb:B3KSU7|uniprotkb:Q3KNR8|uniprotkb:Q3B824 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gatc_human(display_long)|uniprotkb:15E1.2(gene name synonym)|uniprotkb:Protein 15E1.2(gene name synonym)|uniprotkb:GATC(gene name)|psi-mi:GATC(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000257218(gene)|ensembl:ENST00000551765(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0030956"("glutamyl-tRNA(Gln) amidotransferase complex")|go:"GO:0032543"(mitochondrial translation)|go:"GO:0050567"("glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity")|go:"GO:0070681"(glutaminyl-tRNAGln biosynthesis via transamidation)|interpro:IPR003837(Glu-tRNAGln amidotransferase, C subunit)|interpro:IPR036113|refseq:NP_789788.1|dip:DIP-48969N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:m/QzCxZNBt9yKuHTOG/qxQw1mL89606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43678 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43181 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1246139|uniprotkb:Q9BS69|ensembl:ENSP00000296684 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus4_human(display_long)|uniprotkb:NDUFS4(gene name)|psi-mi:NDUFS4(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 18 kDa subunit(gene name synonym)|uniprotkb:Complex I-18 kDa(gene name synonym)|uniprotkb:Complex I-AQDQ(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002486.1|ensembl:ENSG00000164258(gene)|ensembl:ENST00000296684(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007420"(brain development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR006885(ETC complex I subunit conserved region)|interpro:IPR038532|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:T/NnuQagNs7EnceU9XKo4eUdy2o9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O15269 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O15091 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2107070|ensembl:ENSP00000440915|uniprotkb:D3DS99|uniprotkb:D3DSA1|uniprotkb:B4DXD9|uniprotkb:B4E0S8|uniprotkb:B4E211|uniprotkb:Q86SZ4|uniprotkb:Q86YB5|uniprotkb:Q8N5L5|uniprotkb:C4AM93 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mrpp3_human(display_long)|uniprotkb:PRORP(gene name)|psi-mi:PRORP(display_short)|uniprotkb:KIAA0391(gene name synonym)|uniprotkb:MRPP3(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 3(gene name synonym)|uniprotkb:Protein only RNase P catalytic subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000100890(gene)|ensembl:ENST00000534898(transcript)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR031595|interpro:IPR033495|mint:O15091|refseq:XP_011535711.1|refseq:XP_011535712.1|refseq:NP_055487.2|refseq:NP_001243607.1|refseq:NP_001243608.1|refseq:NP_001243609.1|refseq:NP_001243610.1|refseq:XP_005268294.1|refseq:XP_016877324.1|refseq:XP_016877325.1|refseq:XP_016877326.1|rcsb pdb:4ROU|rcsb pdb:4XGL|rcsb pdb:4XGM|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-8868766 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ecyf1CIBRAhf7Fgt7+UfnVcNHfs9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O00746 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O00411 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-355145|uniprotkb:O60370|ensembl:ENSP00000465759 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpom_human(display_long)|uniprotkb:POLRMT(gene name)|psi-mi:POLRMT(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005026.3|ensembl:ENSG00000099821(gene)|ensembl:ENST00000588649(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034245"(mitochondrial DNA-directed RNA polymerase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR002092(DNA-directed RNA polymerase, bacteriophage type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR029262|interpro:IPR037159|interpro:IPR043502|rcsb pdb:3SPA|rcsb pdb:4BOC|rcsb pdb:5OLA|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:7A8P|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0005759"(mitochondrial matrix)|dip:DIP-56412N - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:88pltXGP9J+KpVZITuRCz2XRhHg9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O00217 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:A8MXV4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-11350801|ensembl:ENSP00000380251 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nud19_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 19(gene name synonym)|uniprotkb:NUDT19(gene name)|psi-mi:NUDT19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001099040.1|ensembl:ENSG00000213965(gene)|ensembl:ENST00000397061(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0010945"(CoA pyrophosphatase activity)|go:"GO:0015938"(coenzyme A catabolic process)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0044580"(butyryl-CoA catabolic process)|go:"GO:1901289"(succinyl-CoA catabolic process)|go:"GO:1902858"(propionyl-CoA metabolic process)|go:"GO:2001294"(malonyl-CoA catabolic process)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR039121|reactome:R-HSA-390918|reactome:R-HSA-9033241 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:nSyCFhGmUMc1wbmmLp6RZvUojaM9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:A4D1E9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5453796|uniprotkb:B4DFY6|uniprotkb:Q3B7A6|uniprotkb:Q5H9V2|uniprotkb:Q8IXG8|uniprotkb:Q8N982|uniprotkb:Q8WU16|uniprotkb:Q9BSP1|uniprotkb:Q9Y6T6|ensembl:ENSP00000222511 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gtpba_human(display_long)|uniprotkb:GTPBP10(gene name)|psi-mi:GTPBP10(display_short)|uniprotkb:OBGH2(gene name synonym)|uniprotkb:Protein obg homolog 2(gene name synonym)|uniprotkb:UG0751c10(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001036182.1|refseq:NP_149098.2|ensembl:ENSG00000105793(gene)|ensembl:ENST00000222511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006169(GTP1/OBG subdomain)|interpro:IPR027417|interpro:IPR031167|interpro:IPR035101|interpro:IPR036726 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rxJN6IWcF54XIXy3AvOt9JN9m/U9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:A3KMH1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-308657|uniprotkb:Q5JTP6|uniprotkb:Q5VW08|uniprotkb:Q7Z6I9|uniprotkb:Q86YC9|uniprotkb:Q8N3E4|uniprotkb:O60310|ensembl:ENSP00000368612 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vwa8_human(display_long)|uniprotkb:VWA8(gene name)|psi-mi:VWA8(display_short)|uniprotkb:KIAA0564(gene name synonym)|uniprotkb:PEX7-binding protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000102763(gene)|ensembl:ENST00000379310(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|refseq:NP_001009814.1|refseq:NP_055873.1|refseq:XP_016875963.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IOalBj68cHFF4BsViQ+eeXQZiRY9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:A0A0A6YYL4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-21359516|ensembl:ENSP00000460885|ensembl:ENSP00000480927 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:a0a0a6yyl4_human(display_long)|uniprotkb:CORO7-PAM16(gene name)|psi-mi:CORO7-PAM16(display_short)|uniprotkb:PAM16(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000103426(gene)|ensembl:ENSG00000278760(gene)|ensembl:ENST00000617295(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005829"(cytosol)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027331|interpro:IPR036322|interpro:IPR036869|ensembl:ENST00000572467(transcript)|refseq:NP_001188408.1 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FJcYu/wrbDW2gj/eAoKxCZam6HA9606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:A0A087X2D5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-27049058|ensembl:ENSP00000484903 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:a0a087x2d5_human(display_long)|uniprotkb:MRPL45(gene name)|psi-mi:MRPL45(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049069|imex:IM-29123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000278845(gene)|ensembl:ENST00000613675(transcript)|go:"GO:0005739"(mitochondrion)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR032710|refseq:NP_115727.5 - - - figure legend:ST1 ST2 F1|comment:the two predicted proteins present in the interactors list were not included.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:0cezsAbrbk05mOPzV1Fov73nMI49606 rigid:u9fr3So7xydVgAzbmW6fbbLmT3M false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8IY67 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2105155|uniprotkb:A6NMU4|uniprotkb:Q8IY60|uniprotkb:Q8TF24|intact:EBI-2562007|ensembl:ENSP00000479520 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ravr1_human(display_long)|uniprotkb:RAVER1(gene name)|psi-mi:RAVER1(display_short)|uniprotkb:KIAA1978(gene name synonym)|uniprotkb:Protein raver-1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_597709.2|dip:DIP-46973N|ensembl:ENSG00000161847(gene)|ensembl:ENST00000615032(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|rcsb pdb:3H2U|rcsb pdb:3H2V|rcsb pdb:3SMZ|rcsb pdb:3VF0 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:bu5ZIcFaIb6EihZAWpUflnrWL1w9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q7Z434 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O75431 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NVH0 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-11324738|uniprotkb:Q8N3D3|uniprotkb:Q6AWB6|uniprotkb:G5E947|uniprotkb:B4DIH6|ensembl:ENSP00000313140|ensembl:ENSP00000387331 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:exd2_human(display_long)|uniprotkb:EXD2(gene name)|psi-mi:EXD2(display_short)|uniprotkb:C14orf114(gene name synonym)|uniprotkb:EXDL2(gene name synonym)|uniprotkb:Exonuclease 3'-5' domain-like-containing protein 2(gene name synonym)|uniprotkb:3'-5' exoribonuclease EXD2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001180289.1|refseq:NP_001180290.1|refseq:NP_001180291.1|refseq:NP_001180292.1|refseq:NP_060669.1|refseq:XP_005267874.1|refseq:XP_011535210.1|ensembl:ENSG00000081177(gene)|ensembl:ENST00000312994(transcript)|ensembl:ENST00000409018(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008852"(exodeoxyribonuclease I activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|rcsb pdb:6K17|rcsb pdb:6K18|rcsb pdb:6K19|rcsb pdb:6K1A|rcsb pdb:6K1B|rcsb pdb:6K1C|rcsb pdb:6K1D|rcsb pdb:6K1E|refseq:XP_016876910.1|dip:DIP-61996N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Id4gHPaa70qNO9LznLBjDgkMlu09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q6UXV4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P19404 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96SK2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-10963859|ensembl:ENSP00000380747|uniprotkb:Q6PF00|uniprotkb:Q96SL6|uniprotkb:A4D1L1|uniprotkb:Q8NCH3|uniprotkb:Q49A50 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tm209_human(display_long)|uniprotkb:TMEM209(gene name)|psi-mi:TMEM209(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001288092.1|refseq:NP_116231.2|refseq:XP_005250712.1|refseq:XP_011514948.1|ensembl:ENSG00000146842(gene)|ensembl:ENST00000397622(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR019176 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LJ052UMkTP09EJVErI5qnsGxmJs9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O95831 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P20674 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96SI9 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-740355|uniprotkb:Q32NB9|uniprotkb:Q9BUE1|uniprotkb:Q9BXG4|uniprotkb:Q9H0B4|uniprotkb:Q9H7V1|uniprotkb:Q9NUK4|ensembl:ENSP00000321347|ensembl:ENSP00000415968 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:strbp_human(display_long)|uniprotkb:STRBP(gene name)|psi-mi:STRBP(display_short)|uniprotkb:SPNR(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001164608.1|refseq:NP_060857.2|ensembl:ENSG00000165209(gene)|ensembl:ENST00000348403(transcript)|ensembl:ENST00000447404(transcript)|go:"GO:0002177"(manchette)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007638"(mechanosensory behavior)|go:"GO:0008017"(microtubule binding)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR030446|interpro:IPR043519|interpro:IPR044472|rcsb pdb:2DMY|refseq:XP_016870383.1|refseq:XP_016870384.1|refseq:XP_016870385.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:xVEZqCqBcH0MBB1Ar9SU+9Yhsbs9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NSP4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-11051095|uniprotkb:B1AHQ9|uniprotkb:Q6I9W3|uniprotkb:A7LM22|ensembl:ENSP00000215980 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cenpm_human(display_long)|uniprotkb:CENPM(gene name)|psi-mi:CENPM(display_short)|uniprotkb:C22orf18(gene name synonym)|uniprotkb:ICEN39(gene name synonym)|uniprotkb:Interphase centromere complex protein 39(gene name synonym)|uniprotkb:PANE1(gene name synonym)|uniprotkb:Proliferation-associated nuclear element protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001002876.1|refseq:NP_001103685.1|refseq:NP_001291299.1|refseq:NP_001291300.1|refseq:NP_001291301.1|refseq:NP_001291302.1|refseq:NP_076958.1|ensembl:ENSG00000100162(gene)|ensembl:ENST00000215980(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020987|interpro:IPR027417|mint:Q9NSP4|rcsb pdb:4P0T|rcsb pdb:4WAU|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Ei3FrYFSQRwyweYc/yqcenf5aXg9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P09669 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q7Z695 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P49753 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1052865|uniprotkb:Q3I5F8|uniprotkb:Q9NUX4|uniprotkb:Q53EK4|ensembl:ENSP00000238651 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:acot2_human(display_long)|uniprotkb:Acyl-coenzyme A thioester hydrolase 2a(gene name synonym)|uniprotkb:Long-chain acyl-CoA thioesterase 2(gene name synonym)|uniprotkb:ZAP128(gene name synonym)|uniprotkb:CTE-Ia(gene name synonym)|uniprotkb:ACOT2(gene name)|psi-mi:ACOT2(display_short)|uniprotkb:PTE2(gene name synonym)|uniprotkb:PTE2A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006812.3|ensembl:ENSG00000119673(gene)|ensembl:ENST00000238651(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|rcsb pdb:3HLK|reactome:R-HSA-77289|reactome:R-HSA-9033241 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:3a++2vHE7Zr553F/LJ68pxvJ/289606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9GZT3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96C36 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O43678 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NX40 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2683029|uniprotkb:C9K030|uniprotkb:Q9BZE8|ensembl:ENSP00000264312|ensembl:ENSP00000370882|ensembl:ENSP00000423002|ensembl:ENSP00000423909|uniprotkb:G8JLN7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ocad1_human(display_long)|uniprotkb:OCIA(gene name synonym)|uniprotkb:Ovarian carcinoma immunoreactive antigen(gene name synonym)|uniprotkb:OCIAD1(gene name)|psi-mi:OCIAD1(display_short)|uniprotkb:ASRIJ(gene name synonym)|uniprotkb:Ovarian cancer immunoreactive antigen domain containing 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001073309.1|refseq:NP_001073311.2|refseq:NP_001073308.1|refseq:NP_001073310.1|refseq:NP_060300.1|ensembl:ENSG00000109180(gene)|ensembl:ENST00000264312(transcript)|ensembl:ENST00000381473(transcript)|ensembl:ENST00000508293(transcript)|ensembl:ENST00000513391(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187|mint:Q9NX40|refseq:XP_016863818.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:e3Ojv8LBlgj056bssUZjEC+MB+Q9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9P0J0 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-372742|uniprotkb:Q6PKI0|uniprotkb:Q9H2L3|uniprotkb:Q9Y327|uniprotkb:B4DF76|uniprotkb:K7EK58|ensembl:ENSP00000423673 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nduad_human(display_long)|uniprotkb:NDUFA13(gene name)|psi-mi:NDUFA13(display_short)|uniprotkb:CGI-39(orf name)|uniprotkb:CDA016(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase B16.6 subunit(gene name synonym)|uniprotkb:Complex I-B16.6(gene name synonym)|uniprotkb:Gene associated with retinoic and interferon-induced mortality 19 protein(gene name synonym)|uniprotkb:Cell death regulatory protein GRIM-19(gene name synonym)|uniprotkb:GRIM19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_057049.5|go:"GO:0005524"(ATP binding)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR009346(GRIM-19)|mint:Q9P0J0|rcsb pdb:5XTB|rcsb pdb:5XTC|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|ensembl:ENSG00000186010(gene)|ensembl:ENST00000507754(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|dip:DIP-31180N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:X5AsKHIxU5kpNVjY37UbZXG/Kns9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P63000 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P13073 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q15293 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O60313 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q13505 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1052588|uniprotkb:B1AVR9|uniprotkb:B1AVS0|uniprotkb:B2R9P4|uniprotkb:Q9BUU3|uniprotkb:A0A0A0MRK6|ensembl:ENSP00000357360 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mtx1_human(display_long)|uniprotkb:MTX1(gene name)|psi-mi:MTX1(display_short)|uniprotkb:MTX(gene name synonym)|uniprotkb:MTXN(gene name synonym)|uniprotkb:Mitochondrial outer membrane import complex protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_002446.3|refseq:NP_942584.2|ensembl:ENSG00000173171(gene)|ensembl:ENST00000368376(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007595"(lactation)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140275"(MIB complex)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:Q13505|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LoRdRoXuGOFmrPBEt324uUHgKos9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P82912 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2371859|uniprotkb:Q969D7|uniprotkb:Q96GI3|uniprotkb:Q9BYC3|uniprotkb:B2RD52|ensembl:ENSP00000317376 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rt11_human(display_long)|uniprotkb:MRPS11(gene name)|psi-mi:MRPS11(display_short)|uniprotkb:RPMS11(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCC2(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS11m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001308899.1|refseq:NP_001308901.1|refseq:NP_001308902.1|refseq:NP_001308903.1|refseq:NP_001308905.1|refseq:NP_073750.2|refseq:NP_789775.1|ensembl:ENSG00000181991(gene)|ensembl:ENST00000325844(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P82912|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:aw3XzNBYY0igd4AUE1OQyfFn8pk9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O94925 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1043737|uniprotkb:Q9UL05|uniprotkb:Q9UL06|uniprotkb:Q9UL07|uniprotkb:Q9UN40|ensembl:ENSP00000317379 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:glsk_human(display_long)|uniprotkb:GLS(gene name)|psi-mi:GLS(display_short)|uniprotkb:GLS1(gene name synonym)|uniprotkb:KIAA0838(gene name synonym)|uniprotkb:L-glutamine amidohydrolase(gene name synonym)|uniprotkb:K-glutaminase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001243239.1|refseq:NP_055720.3|dip:DIP-50591N|ensembl:ENSG00000115419(gene)|ensembl:ENST00000320717(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0090461"(glutamate homeostasis)|interpro:IPR002110(Ankyrin)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR015868(Glutaminase, core)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR041541|mint:O94925|rcsb pdb:3CZD|rcsb pdb:3UNW|rcsb pdb:3UO9|rcsb pdb:3VOY|rcsb pdb:3VOZ|rcsb pdb:3VP0|rcsb pdb:3VP1|rcsb pdb:3VP2|rcsb pdb:3VP3|rcsb pdb:3VP4|rcsb pdb:5D3O|rcsb pdb:5FI2|rcsb pdb:5FI6|rcsb pdb:5FI7|rcsb pdb:5HL1|rcsb pdb:5I94|rcsb pdb:5JYO|rcsb pdb:5JYP|rcsb pdb:5U0I|rcsb pdb:5U0J|rcsb pdb:5UQE|rcsb pdb:5WJ6|rcsb pdb:6LOX|rcsb pdb:6UJG|rcsb pdb:6UJM|rcsb pdb:6UK6|rcsb pdb:6UKB|rcsb pdb:4O7D|rcsb pdb:6UL9|rcsb pdb:6ULA|rcsb pdb:6UMC|rcsb pdb:6UMD|rcsb pdb:6UME|rcsb pdb:6UMF|reactome:R-HSA-210500|reactome:R-HSA-5628897|reactome:R-HSA-8964539|rcsb pdb:6ULJ - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:IV2jY1Qj63eTVPmTndDavjoUM2w9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H019 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2824497|uniprotkb:D3DPJ4|uniprotkb:A6NCB4|uniprotkb:Q63HP1|uniprotkb:B7WNV5|uniprotkb:Q9NUI7|uniprotkb:Q7Z2S7|ensembl:ENSP00000363418|ensembl:ENSP00000363419|ensembl:ENSP00000363421 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mfr1l_human(display_long)|uniprotkb:MTFR1L(gene name)|psi-mi:MTFR1L(display_short)|uniprotkb:FAM54B(gene name synonym)|uniprotkb:HYST1888(orf name)|uniprotkb:MSTP116(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001093095.1|refseq:NP_001093096.1|refseq:NP_001093097.1|refseq:NP_062457.3|interpro:IPR007972(Protein of unknown function DUF729)|ensembl:ENSG00000117640(gene)|ensembl:ENST00000374300(transcript)|ensembl:ENST00000374301(transcript)|ensembl:ENST00000374303(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0009060"(aerobic respiration) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:SVK2WRYbJLfAsZHMblHvoagnYoQ9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q5TC12 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96TA2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P98170 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q70CQ3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O95071 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q6DKK2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q12933 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O94826 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y5L4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q6PML9 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O75746 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96BR5 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P31040 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y512 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P32322 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9BSM1 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-749901|uniprotkb:Q7Z506|ensembl:ENSP00000233630 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:pcgf1_human(display_long)|uniprotkb:RING finger protein 68(gene name synonym)|uniprotkb:Nervous system Polycomb-1(gene name synonym)|uniprotkb:PCGF1(gene name)|psi-mi:PCGF1(display_short)|uniprotkb:NSPC1(gene name synonym)|uniprotkb:RNF68(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_116062.2|dip:DIP-52708N|ensembl:ENSG00000115289(gene)|ensembl:ENST00000233630(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:Q9BSM1|rcsb pdb:4HPL|rcsb pdb:4HPM|rcsb pdb:5JH5 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:wDCelsAlGM4be6FLYjSXeTkRuI09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P56181 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O00217 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O75306 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P28331 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P51970 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9UI09 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96H55 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-10983249|uniprotkb:Q59GS4|uniprotkb:Q9H5X2|ensembl:ENSP00000479518|ensembl:ENSP00000480242 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:myo19_human(display_long)|uniprotkb:MYO19(gene name)|psi-mi:MYO19(display_short)|uniprotkb:MYOHD1(gene name synonym)|uniprotkb:Myosin head domain-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001028752.1|refseq:NP_001157207.1|refseq:NP_079385.2|ensembl:ENSG00000278259(gene)|ensembl:ENSG00000278372(gene)|ensembl:ENST00000614623(transcript)|ensembl:ENST00000618519(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034642"(mitochondrion migration along actin filament)|go:"GO:0051015"(actin filament binding)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR027417|interpro:IPR036035|interpro:IPR036961|mint:Q96H55|reactome:R-HSA-9013419|reactome:R-HSA-9013425 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:coJYx89cip3wKcsCF65cbMPBt7Y9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q15390 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-724207|ensembl:ENSP00000262146|uniprotkb:Q6IB94|uniprotkb:Q86XH5|uniprotkb:Q8IVD7|uniprotkb:E7EP84|uniprotkb:Q7Z669 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mtfr1_human(display_long)|uniprotkb:Chondrocyte protein with a poly-proline region(gene name synonym)|uniprotkb:MTFR1(gene name)|psi-mi:MTFR1(display_short)|uniprotkb:CHPPR(gene name synonym)|uniprotkb:KIAA0009(gene name synonym)|uniprotkb:FAM54A2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001139310.1|refseq:NP_055452.3|ensembl:ENSG00000066855(gene)|ensembl:ENST00000262146(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0009060"(aerobic respiration)|interpro:IPR007972(Protein of unknown function DUF729) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:JVlx6NDlSs6KbMdpHuZw0rzmY2o9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96EL2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1055789|uniprotkb:P82668|uniprotkb:Q96Q23|uniprotkb:Q9P047|uniprotkb:A4D1U9|ensembl:ENSP00000318158 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rt24_human(display_long)|uniprotkb:bMRP-47(gene name synonym)|uniprotkb:MRPS24(gene name)|psi-mi:MRPS24(display_short)|uniprotkb:HSPC335(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS3m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_114403.1|ensembl:ENSG00000062582(gene)|ensembl:ENST00000317534(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR026146|mint:Q96EL2|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:OEtFmhoLM1Sw9YVrL88HZQ5Ju0g9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9GZY8 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-11420856|uniprotkb:Q567U1|uniprotkb:Q658R6|uniprotkb:Q9BVZ1|uniprotkb:Q9H690|uniprotkb:Q9NRG8|ensembl:ENSP00000302037 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mff_human(display_long)|uniprotkb:MFF(gene name)|psi-mi:MFF(display_short)|uniprotkb:C2orf33(gene name synonym)|uniprotkb:AD030(orf name)|uniprotkb:AD033(orf name)|uniprotkb:GL004(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001263990.1|refseq:NP_001263991.1|refseq:NP_001263992.1|refseq:NP_001263993.1|refseq:NP_001263994.1|refseq:NP_001263995.1|refseq:NP_001263996.1|refseq:NP_001263997.1|refseq:NP_064579.3|refseq:XP_006712701.1|refseq:XP_006712702.1|refseq:XP_011509802.1|ensembl:ENSG00000168958(gene)|ensembl:ENST00000353339(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR008518(Protein of unknown function DUF800)|interpro:IPR039433|refseq:XP_016860004.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:TwZhnkjdZZZrKu3VDUd4BvgXmRc9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q969Z3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-16773897|ensembl:ENSP00000355880|uniprotkb:B2D0R5|uniprotkb:D3DTB3|uniprotkb:Q0JSK7|uniprotkb:Q5VT67|uniprotkb:Q5VXC7|uniprotkb:Q7L317|uniprotkb:Q9H066|uniprotkb:Q9NWU0 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:marc2_human(display_long)|uniprotkb:MOSC2(gene name synonym)|uniprotkb:Molybdenum cofactor sulfurase C-terminal domain-containing protein 2(gene name synonym)|uniprotkb:MTARC2(gene name)|psi-mi:MTARC2(display_short)|uniprotkb:MARC2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000117791(gene)|ensembl:ENST00000366913(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042126"(nitrate metabolic process)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0051410"(detoxification of nitrogen compound)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|go:"GO:0098809"(nitrite reductase activity)|interpro:IPR005302(Molybdenum cofactor sulphurase, C-terminal)|interpro:IPR005303(MOSC, N-terminal beta barrel)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|reactome:R-HSA-211945|refseq:NP_001304267.1|refseq:NP_001317971.1|refseq:NP_060368.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ypPzLBnAlrNErXdIIuKr4LqzId09606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O95202 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P83111 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NSE4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O00165 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q6P444 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-10252703|uniprotkb:Q6ZUE8|uniprotkb:E1P585|uniprotkb:Q7L3U6|uniprotkb:Q5JWR7|uniprotkb:A8K8D8|uniprotkb:Q9BZ39|ensembl:ENSP00000395232|ensembl:ENSP00000407010 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mtfr2_human(display_long)|uniprotkb:MTFR2(gene name)|psi-mi:MTFR2(display_short)|uniprotkb:DUF729 domain-containing protein 1(gene name synonym)|uniprotkb:DUFD1(gene name synonym)|uniprotkb:FAM54A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001305667.1|refseq:NP_001092756.1|refseq:NP_612428.2|refseq:XP_011533712.1|refseq:XP_011533714.1|refseq:XP_011533715.1|ensembl:ENSG00000146410(gene)|ensembl:ENST00000420702(transcript)|ensembl:ENST00000451457(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0009060"(aerobic respiration)|interpro:IPR007972(Protein of unknown function DUF729) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:mH1pnDguQvenUF5V8/Nhh19brg49606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q14249 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8IYU8 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NVH1 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P36551 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P10606 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q7KZN9 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H078 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P12532 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9BRQ6 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2557895|ensembl:ENSP00000290913|uniprotkb:D6R9U0|uniprotkb:D6RIB4|uniprotkb:H8Y0Y7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mic25_human(display_long)|uniprotkb:CHCHD6(gene name)|psi-mi:CHCHD6(display_short)|uniprotkb:CHCM1(gene name synonym)|uniprotkb:Coiled-coil-helix cristae morphology protein 1(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:MIC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_115719.1|refseq:NP_001307539.1|ensembl:ENSG00000159685(gene)|ensembl:ENST00000290913(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR042860|mint:Q9BRQ6|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:6jrzreYX6MJWPfMKh2EKqiEca1s9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NX63 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q4VC31 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NWU2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1051077|uniprotkb:Q8N5M5|uniprotkb:E1P5I3|ensembl:ENSP00000266069 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:gid8_human(display_long)|uniprotkb:GID8(gene name)|psi-mi:GID8(display_short)|uniprotkb:C20orf11(gene name synonym)|uniprotkb:Two hybrid-associated protein 1 with RanBPM(gene name synonym)|uniprotkb:TWA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060366.1|ensembl:ENSG00000101193(gene)|ensembl:ENST00000266069(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR024964|mint:Q9NWU2|rcsb pdb:7NSC - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:P0HsK72KT6OPKKw7lVSJ/FiY4CU9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NR09 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:/EZap+9dFkEnO5fRsbzriORwllk9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q13490 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:FOikzyDyDtlv2l69i/WNDNq674A9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9BXK5 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q5T9A4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NVI7 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8IUR7 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NVT9 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3506974|uniprotkb:Q9H018|uniprotkb:Q9H820|uniprotkb:B4E2W7|ensembl:ENSP00000276569 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:armc1_human(display_long)|uniprotkb:ARMC1(gene name)|psi-mi:ARMC1(display_short)|uniprotkb:ARCP(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060590.1|ensembl:ENSG00000104442(gene)|ensembl:ENST00000276569(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0046872"(metal ion binding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|go:"GO:0048312"(intracellular distribution of mitochondria)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016617(Uncharacterised conserved protein UCP013899, metal binding)|interpro:IPR036163|mint:Q9NVT9|refseq:NP_001273631.1|refseq:XP_016869094.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:WP/jzUyBwj/g9TLQ38jY56DYpRI9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P54819 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y4W6 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H845 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049380|imex:IM-29123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:xBX3U+FdvgYvvL8vD3XuAUpV4eU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75431 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H6K4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-8477908|intact:MINT-8417711|uniprotkb:Q6P384|uniprotkb:Q8N784|ensembl:ENSP00000263275 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:opa3_human(display_long)|uniprotkb:OPA3(gene name)|psi-mi:OPA3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_079412.1|refseq:NP_001017989.2|ensembl:ENSG00000125741(gene)|ensembl:ENST00000263275(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0007601"(visual perception)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0050896"(response to stimulus)|interpro:IPR010754(Optic atrophy 3-like)|mint:Q9H6K4 - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:HlwZbHAbo7/jSdCOBbWhF5wKlvE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96EY8 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-7825413|ensembl:ENSP00000445920|intact:UNK-5534451|uniprotkb:Q9BSH0|uniprotkb:C5HU05 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mmab_human(display_long)|uniprotkb:MMAB(gene name)|psi-mi:MMAB(display_short)|uniprotkb:Methylmalonic aciduria type B protein(gene name synonym)|uniprotkb:"Cob(II)alamin adenosyltransferase"(gene name synonym)|uniprotkb:"Cob(II)yrinic acid a,c-diamide adenosyltransferase"(gene name synonym)|uniprotkb:Cobinamide/cobalamin adenosyltransferase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENST00000545712(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008817"("cob(I)yrinic acid a,c-diamide adenosyltransferase activity")|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031419"(cobalamin binding)|interpro:IPR016030("Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like")|interpro:IPR029499|interpro:IPR036451|rcsb pdb:2IDX|rcsb pdb:6D5K|rcsb pdb:6D5X|reactome:R-HSA-196741|reactome:R-HSA-3359471|ensembl:ENSG00000139428(gene)|refseq:NP_443077.1 - - comment:mint|function:"Defects in MMAB are the cause of methylmalonic aciduria linked to the cblB complementation group (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive" figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:mCC0sM9ENytksAmo6ICWkWQHbZA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6UXV4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5T1C6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-7684443|ensembl:ENSP00000357804|uniprotkb:Q96KR2|uniprotkb:B2RBX2|intact:MINT-8306269 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:them4_human(display_long)|uniprotkb:THEM4(gene name)|psi-mi:THEM4(display_short)|uniprotkb:CTMP(gene name synonym)|uniprotkb:Carboxyl-terminal modulator protein(gene name synonym)|uniprotkb:Thioesterase superfamily member 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000159445(gene)|ensembl:ENST00000368814(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|rcsb pdb:4AE8|rcsb pdb:4GAH|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-199418|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-77289|refseq:NP_444283.2|dip:DIP-60764N - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:wgpknFKS1Xb9JWYSXKF/ImKoGx89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P43304 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-7600203|uniprotkb:Q59FR1|intact:MINT-4530883|uniprotkb:Q9HAP9|uniprotkb:A8K4V0|uniprotkb:B3KSA9|ensembl:ENSP00000308610|ensembl:ENSP00000386425|ensembl:ENSP00000386626|ensembl:ENSP00000409708 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:gpdm_human(display_long)|uniprotkb:GPD2(gene name)|psi-mi:GPD2(display_short)|uniprotkb:mtGPD(gene name synonym)|uniprotkb:mitohondrial glycerophosphate dehydrogenase gene(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_016859319.1|refseq:XP_011509279.1|refseq:NP_001076581.2|refseq:NP_000399.3|refseq:XP_005246526.1|ensembl:ENSG00000115159(gene)|ensembl:ENST00000310454(transcript)|ensembl:ENST00000409674(transcript)|ensembl:ENST00000409861(transcript)|ensembl:ENST00000438166(transcript)|go:"GO:0004368"("glycerol-3-phosphate dehydrogenase (quinone) activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006072"(glycerol-3-phosphate metabolic process)|go:"GO:0006127"(glycerophosphate shuttle)|go:"GO:0009331"(glycerol-3-phosphate dehydrogenase complex)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0052591"("sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity")|interpro:IPR000447(FAD-dependent glycerol-3-phosphate dehydrogenase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR031656|interpro:IPR036188|interpro:IPR038299|reactome:R-HSA-1483166|reactome:R-HSA-163560 - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:PsG9Eo7dfk8l+vDJl6d4WfEST849606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P30084 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P28331 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P24539 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P22830 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P20674 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P19404 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P16152 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P13667 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P13489 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P13073 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P12532 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P10606 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P09669 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P08574 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1224514|uniprotkb:Q5U062|uniprotkb:Q6FHS7|ensembl:ENSP00000317159 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cy1_human(display_long)|uniprotkb:CYC1(gene name)|psi-mi:CYC1(display_short)|uniprotkb:Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit(gene name synonym)|uniprotkb:Cytochrome b-c1 complex subunit 4(gene name synonym)|uniprotkb:Complex III subunit 4(gene name synonym)|uniprotkb:Complex III subunit IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001907.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0033762"(response to glucagon)|go:"GO:0046872"(metal ion binding)|interpro:IPR002326(Cytochrome c1)|interpro:IPR021157|interpro:IPR036909|mint:P08574|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|ensembl:ENSG00000179091(gene)|ensembl:ENST00000318911(transcript)|go:"GO:0005634"(nucleus) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:WFFFejEobb6Uoum311x+fry5X+o9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P03915 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246343|uniprotkb:Q34773|uniprotkb:Q8WCY3|ensembl:ENSP00000354813 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nu5m_human(display_long)|uniprotkb:MT-ND5(gene name)|psi-mi:MT-ND5(display_short)|uniprotkb:MTND5(gene name synonym)|uniprotkb:NADH5(gene name synonym)|uniprotkb:ND5(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:YP_003024036.1|ensembl:ENSG00000198786(gene)|ensembl:ENST00000361567(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|interpro:IPR001516("NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal")|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003945(NADH-plastoquinone oxidoreductase, chain 5)|interpro:IPR010934(NADH dehydrogenase subunit 5, C-terminal)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qQQpmtsDu8cJSW+Re15KtO+tgNs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P03905 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P00395 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O96000 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O95831 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O95563 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-719403|uniprotkb:Q3SXR6|uniprotkb:Q6FIF3|uniprotkb:A8K261|ensembl:ENSP00000271373|ensembl:ENSP00000356820 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mpc2_human(display_long)|uniprotkb:MPC2(gene name)|psi-mi:MPC2(display_short)|uniprotkb:BRP44(gene name synonym)|uniprotkb:Brain protein 44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001137146.1|refseq:NP_056230.1|reactome:R-HSA-70268|ensembl:ENSG00000143158(gene)|ensembl:ENST00000271373(transcript)|ensembl:ENST00000367846(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006850"(mitochondrial pyruvate transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005336(Protein of unknown function UPF0041)|refseq:XP_006711329.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:smUowwyyXsnLu4q2jX26Iope4Fs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O95202 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O95169 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O94925 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1043737|uniprotkb:Q9UL05|uniprotkb:Q9UL06|uniprotkb:Q9UL07|uniprotkb:Q9UN40|ensembl:ENSP00000317379 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:glsk_human(display_long)|uniprotkb:GLS(gene name)|psi-mi:GLS(display_short)|uniprotkb:GLS1(gene name synonym)|uniprotkb:KIAA0838(gene name synonym)|uniprotkb:L-glutamine amidohydrolase(gene name synonym)|uniprotkb:K-glutaminase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001243239.1|refseq:NP_055720.3|dip:DIP-50591N|ensembl:ENSG00000115419(gene)|ensembl:ENST00000320717(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0090461"(glutamate homeostasis)|interpro:IPR002110(Ankyrin)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR015868(Glutaminase, core)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR041541|mint:O94925|rcsb pdb:3CZD|rcsb pdb:3UNW|rcsb pdb:3UO9|rcsb pdb:3VOY|rcsb pdb:3VOZ|rcsb pdb:3VP0|rcsb pdb:3VP1|rcsb pdb:3VP2|rcsb pdb:3VP3|rcsb pdb:3VP4|rcsb pdb:5D3O|rcsb pdb:5FI2|rcsb pdb:5FI6|rcsb pdb:5FI7|rcsb pdb:5HL1|rcsb pdb:5I94|rcsb pdb:5JYO|rcsb pdb:5JYP|rcsb pdb:5U0I|rcsb pdb:5U0J|rcsb pdb:5UQE|rcsb pdb:5WJ6|rcsb pdb:6LOX|rcsb pdb:6UJG|rcsb pdb:6UJM|rcsb pdb:6UK6|rcsb pdb:6UKB|rcsb pdb:4O7D|rcsb pdb:6UL9|rcsb pdb:6ULA|rcsb pdb:6UMC|rcsb pdb:6UMD|rcsb pdb:6UME|rcsb pdb:6UMF|reactome:R-HSA-210500|reactome:R-HSA-5628897|reactome:R-HSA-8964539|rcsb pdb:6ULJ - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:IV2jY1Qj63eTVPmTndDavjoUM2w9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O94826 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75880 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6656171|ensembl:ENSP00000255390|uniprotkb:B2RDM0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sco1_human(display_long)|uniprotkb:SCO1(gene name)|psi-mi:SCO1(display_short)|uniprotkb:SCOD1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000133028(gene)|ensembl:ENST00000255390(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|rcsb pdb:1WP0|rcsb pdb:2GGT|rcsb pdb:2GQK|rcsb pdb:2GQL|rcsb pdb:2GQM|rcsb pdb:2GT5|rcsb pdb:2GT6|rcsb pdb:2GVP|rcsb pdb:2HRF|rcsb pdb:2HRN|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_004580.1|dip:DIP-46086N|refseq:XP_005256808.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:oxGxX5mXuGDP5uPIW1vyOtaQHxU9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75746 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75489 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75380 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-719854|ensembl:ENSP00000274137 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus6_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-A subunit(gene name synonym)|uniprotkb:Complex I-13kD-A(gene name synonym)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004544.1|ensembl:ENSG00000145494(gene)|ensembl:ENST00000274137(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:IfpFyQjgJW6a8wA2pNw14stMUL49606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75306 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75251 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-719652|uniprotkb:Q2T9H7|uniprotkb:Q9BV17|ensembl:ENSP00000233627|uniprotkb:B3KRI2 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 20 kDa subunit(gene name synonym)|uniprotkb:Complex I-20kD(gene name synonym)|uniprotkb:PSST subunit(gene name synonym)|uniprotkb:NDUFS7(gene name)|psi-mi:NDUFS7(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_077718.3|ensembl:ENSG00000115286(gene)|ensembl:ENST00000233627(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006138("NADH dehydrogenase (ubiquinone), 20 kDa subunit")|mint:O75251|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:DtNXT30ApcGKwTJSdNNwHd/q3+09606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O60830 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2372529|uniprotkb:Q9UJV0|uniprotkb:A8K2E2|uniprotkb:J3KPV3|ensembl:ENSP00000365766 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ti17b_human(display_long)|uniprotkb:TIMM17B(gene name)|psi-mi:TIMM17B(display_short)|uniprotkb:TIM17B(gene name synonym)|uniprotkb:JM3(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001161419.1|refseq:NP_005825.1|ensembl:ENSG00000126768(gene)|ensembl:ENST00000376582(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005678(Mitochondrial import inner membrane translocase, subunit Tim17)|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2jmF1ZItisqPDfdGgX/bY9FFE9E9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O60313 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O60220 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43920 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246091|ensembl:ENSP00000362058|ensembl:ENSP00000362060 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus5_human(display_long)|uniprotkb:NDUFS5(gene name)|psi-mi:NDUFS5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 15 kDa subunit(gene name synonym)|uniprotkb:Complex I-15 kDa(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001171908.1|refseq:NP_004543.1|ensembl:ENSG00000168653(gene)|ensembl:ENST00000372967(transcript)|ensembl:ENST00000372969(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019342|mint:O43920|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:q74OuEXKdyCuxrUujwHeZjkW2gY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43852 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1171069|uniprotkb:O60456|uniprotkb:Q6FHB9|uniprotkb:Q96RL3|uniprotkb:Q9NR43|intact:EBI-2554631|uniprotkb:B3KPG9|uniprotkb:D6QS48|uniprotkb:D6QS49|uniprotkb:D6QS50|uniprotkb:D6QS51|uniprotkb:D6QS52|uniprotkb:D6QS53|uniprotkb:D6QS54|uniprotkb:D6QS55|uniprotkb:D6QS56|uniprotkb:D6QS57|uniprotkb:D6QS58|uniprotkb:D6QS59|uniprotkb:F5H1Q9|uniprotkb:F5H879|ensembl:ENSP00000249364 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:calu_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:IEF SSP 9302(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001124146.1|refseq:NP_001186602.1|refseq:NP_001210.1|refseq:NP_001186600.1|refseq:NP_001186601.1|ensembl:ENSG00000128595(gene)|ensembl:ENST00000249364(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O43852|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016868148.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43819 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357012|uniprotkb:Q3T1B5|uniprotkb:Q9UK87|ensembl:ENSP00000252785|ensembl:ENSP00000379046|ensembl:ENSP00000444242|ensembl:ENSP00000444433 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sco2_human(display_long)|uniprotkb:SCO2(gene name)|psi-mi:SCO2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001162580.1|refseq:NP_001162581.1|refseq:NP_001162582.1|refseq:NP_005129.2|dip:DIP-46088N|go:"GO:0003012"(muscle system process)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0014823"(response to activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|mint:O43819|rcsb pdb:2RLI|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000284194(gene)|ensembl:ENST00000252785(transcript)|ensembl:ENST00000395693(transcript)|ensembl:ENST00000535425(transcript)|ensembl:ENST00000543927(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001701"(in utero embryonic development) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:RaD9DPaOnFKJvwNRUK9KQdptmqc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43765 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43715 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2820212|uniprotkb:Q5RKS5|uniprotkb:Q6LCA7|uniprotkb:B2R4Z7|ensembl:ENSP00000449795 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tria1_human(display_long)|uniprotkb:TRIAP1(gene name)|psi-mi:TRIAP1(display_short)|uniprotkb:15E1.1(gene name synonym)|uniprotkb:Protein 15E1.1(gene name synonym)|uniprotkb:WF-1(gene name synonym)|uniprotkb:p53-inducible cell-survival factor(gene name synonym)|uniprotkb:HSPC132(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_057483.1|ensembl:ENSG00000170855(gene)|ensembl:ENST00000546954(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0015914"(phospholipid transport)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097035"(regulation of membrane lipid distribution)|go:"GO:0120009"(intermembrane lipid transfer)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2001140"(positive regulation of phospholipid transport)|interpro:IPR007918(Mitochondrial distribution and morphology family 35/apoptosis)|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:6I3V|rcsb pdb:6I3Y|rcsb pdb:6I4Y|reactome:R-HSA-6803204 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:LL+TOKGHJU1ng1UNFazVOxkQvmY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43678 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43676 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-718365|uniprotkb:Q6IB80|ensembl:ENSP00000237889|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000410600|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndub3_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase B12 subunit(gene name synonym)|uniprotkb:Complex I-B12(gene name synonym)|uniprotkb:NDUFB3(gene name)|psi-mi:NDUFB3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002482.1|refseq:XP_011509532.1|refseq:XP_016859675.1|refseq:NP_001244031.1|ensembl:ENSP00000237889|ensembl:ENSP00000410600|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208|ensembl:ENSG00000119013(gene)|ensembl:ENST00000237889(transcript)|ensembl:ENST00000433898(transcript)|ensembl:ENST00000450023(transcript)|ensembl:ENST00000454214(transcript)|ensembl:ENST00000682325(transcript)|ensembl:ENST00000684175(transcript)|ensembl:ENST00000684420(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR012576(NADH-ubiquinone oxidoreductase B12 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:APgw3aIZyyqiPCXMFJ9dUYPQhVE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43674 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246293|uniprotkb:Q561V6|ensembl:ENSP00000259037 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndub5_human(display_long)|uniprotkb:NDUFB5(gene name)|psi-mi:NDUFB5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase SGDH subunit(gene name synonym)|uniprotkb:Complex I-SGDH(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001186886.1|refseq:NP_001186887.1|refseq:NP_002483.1|ensembl:ENSG00000136521(gene)|ensembl:ENST00000259037(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019173|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:1UrbNq39EsuKHJ2M7tRd8ZmB6uk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O14548 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-743578|uniprotkb:Q9P118|ensembl:ENSP00000234301|ensembl:ENSP00000367938 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox7r_human(display_long)|uniprotkb:Cytochrome c oxidase subunit VIIa-related protein(gene name synonym)|uniprotkb:COX7a-related protein(gene name synonym)|uniprotkb:EB1(gene name synonym)|uniprotkb:COX7RP(gene name synonym)|uniprotkb:COX7A2L(gene name)|psi-mi:COX7A2L(display_short)|uniprotkb:COX7AR(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004709.2|refseq:NP_001305965.1|refseq:NP_001305969.1|ensembl:ENSG00000115944(gene)|ensembl:ENST00000234301(transcript)|ensembl:ENST00000378669(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR017267(Cytochrome c oxidase subunit VIIa-related, mitochondrial)|interpro:IPR036539|interpro:IPR039297|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qJHxwSXSwyenuqJmKPhQ3R76aqE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O00746 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O00217 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O00165 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:A8MXV4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-11350801|ensembl:ENSP00000380251 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nud19_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 19(gene name synonym)|uniprotkb:NUDT19(gene name)|psi-mi:NUDT19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001099040.1|ensembl:ENSG00000213965(gene)|ensembl:ENST00000397061(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0010945"(CoA pyrophosphatase activity)|go:"GO:0015938"(coenzyme A catabolic process)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0044580"(butyryl-CoA catabolic process)|go:"GO:1901289"(succinyl-CoA catabolic process)|go:"GO:1902858"(propionyl-CoA metabolic process)|go:"GO:2001294"(malonyl-CoA catabolic process)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR039121|reactome:R-HSA-390918|reactome:R-HSA-9033241 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:nSyCFhGmUMc1wbmmLp6RZvUojaM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y6M9 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y5L4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y512 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y4W6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y375 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-741874|uniprotkb:Q9BVZ5|ensembl:ENSP00000260361|ensembl:ENSP00000453944 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cia30_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1(gene name synonym)|uniprotkb:NDUFAF1(gene name)|psi-mi:NDUFAF1(display_short)|uniprotkb:CIA30(gene name synonym)|uniprotkb:CGI-65(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_057097.2|ensembl:ENSG00000137806(gene)|ensembl:ENST00000260361(transcript)|ensembl:ENST00000560978(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0010257"(NADH dehydrogenase complex assembly)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013857("NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30")|interpro:IPR039131|mint:Q9Y375|reactome:R-HSA-6799198|refseq:XP_011519960.1|refseq:XP_006720618.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:cZmtaAs6upui/PVTTBGQBEOcWvk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y2C4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-20863487|ensembl:ENSP00000287675|uniprotkb:A8K242|uniprotkb:B4DVG2|uniprotkb:Q3SXM9|uniprotkb:Q9Y2C8 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:exog_human(display_long)|uniprotkb:Endonuclease G-like 1(gene name synonym)|uniprotkb:EXOG(gene name)|psi-mi:EXOG(display_short)|uniprotkb:ENDOGL1(gene name synonym)|uniprotkb:ENDOGL2(gene name synonym)|uniprotkb:ENGL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000157036(gene)|ensembl:ENST00000287675(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR040255|interpro:IPR041003|rcsb pdb:4A1N|rcsb pdb:5T3V|rcsb pdb:5T40|rcsb pdb:5T4I|rcsb pdb:5T5C|rcsb pdb:5ZKI|rcsb pdb:5ZKJ|rcsb pdb:6IID|refseq:NP_001138936.1|refseq:NP_001305883.1|refseq:NP_001305884.1|refseq:NP_001305885.1|refseq:NP_001305886.1|refseq:NP_001305887.1|refseq:NP_001305888.1|refseq:NP_005098.2|refseq:XP_005265690.1|refseq:XP_006713507.1|refseq:XP_016863073.1|refseq:XP_016863074.1|refseq:XP_016863075.1|refseq:XP_016863076.1|refseq:XP_016863077.1|refseq:XP_016863078.1|refseq:XP_016863079.1|refseq:XP_016863080.1|refseq:XP_016863081.1|refseq:XP_016863082.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:0XFS7s10tlnzzJ7dJn+Eq2HnAKs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y276 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-719257|uniprotkb:B3KTW9|uniprotkb:Q7Z2V7|ensembl:ENSP00000352219|ensembl:ENSP00000375957|ensembl:ENSP00000375958|ensembl:ENSP00000375959|ensembl:ENSP00000404999|ensembl:ENSP00000406494|ensembl:ENSP00000413908 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:bcs1_human(display_long)|uniprotkb:BCS1-like protein(gene name synonym)|uniprotkb:BCS1L(gene name)|psi-mi:BCS1L(display_short)|uniprotkb:BCS1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001073335.1|refseq:NP_004319.1|ensembl:ENSG00000074582(gene)|ensembl:ENST00000359273(transcript)|ensembl:ENST00000392109(transcript)|ensembl:ENST00000392110(transcript)|ensembl:ENST00000392111(transcript)|ensembl:ENST00000412366(transcript)|ensembl:ENST00000431802(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR014851(BCS1 N terminal)|interpro:IPR027417|reactome:R-HSA-1268020|ensembl:ENST00000439945(transcript)|refseq:NP_001244271.1|refseq:NP_001244272.1|refseq:NP_001244273.1|refseq:NP_001305765.1|refseq:NP_001307646.1|refseq:XP_006712741.1|refseq:XP_016860120.1|refseq:XP_016860121.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:NMfoX75THfvFwzpgBcpKXGmRGcM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UJS0 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UI09 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9P0J0 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-372742|uniprotkb:Q6PKI0|uniprotkb:Q9H2L3|uniprotkb:Q9Y327|uniprotkb:B4DF76|uniprotkb:K7EK58|ensembl:ENSP00000423673 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduad_human(display_long)|uniprotkb:NDUFA13(gene name)|psi-mi:NDUFA13(display_short)|uniprotkb:CGI-39(orf name)|uniprotkb:CDA016(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase B16.6 subunit(gene name synonym)|uniprotkb:Complex I-B16.6(gene name synonym)|uniprotkb:Gene associated with retinoic and interferon-induced mortality 19 protein(gene name synonym)|uniprotkb:Cell death regulatory protein GRIM-19(gene name synonym)|uniprotkb:GRIM19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_057049.5|go:"GO:0005524"(ATP binding)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR009346(GRIM-19)|mint:Q9P0J0|rcsb pdb:5XTB|rcsb pdb:5XTC|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|ensembl:ENSG00000186010(gene)|ensembl:ENST00000507754(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|dip:DIP-31180N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:X5AsKHIxU5kpNVjY37UbZXG/Kns9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9P032 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NYU2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NX63 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NX40 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2683029|uniprotkb:C9K030|uniprotkb:Q9BZE8|ensembl:ENSP00000264312|ensembl:ENSP00000370882|ensembl:ENSP00000423002|ensembl:ENSP00000423909|uniprotkb:G8JLN7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ocad1_human(display_long)|uniprotkb:OCIA(gene name synonym)|uniprotkb:Ovarian carcinoma immunoreactive antigen(gene name synonym)|uniprotkb:OCIAD1(gene name)|psi-mi:OCIAD1(display_short)|uniprotkb:ASRIJ(gene name synonym)|uniprotkb:Ovarian cancer immunoreactive antigen domain containing 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001073309.1|refseq:NP_001073311.2|refseq:NP_001073308.1|refseq:NP_001073310.1|refseq:NP_060300.1|ensembl:ENSG00000109180(gene)|ensembl:ENST00000264312(transcript)|ensembl:ENST00000381473(transcript)|ensembl:ENST00000508293(transcript)|ensembl:ENST00000513391(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187|mint:Q9NX40|refseq:XP_016863818.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:e3Ojv8LBlgj056bssUZjEC+MB+Q9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NWH2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-10315004|uniprotkb:Q9NZ88|uniprotkb:B9EJD0|uniprotkb:Q9P094|ensembl:ENSP00000383594 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tm242_human(display_long)|uniprotkb:TMEM242(gene name)|psi-mi:TMEM242(display_short)|uniprotkb:C6orf35(gene name synonym)|uniprotkb:BM-033(orf name)|uniprotkb:HSPC287(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060922.2|ensembl:ENSG00000215712(gene)|ensembl:ENST00000400788(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009792(Protein of unknown function DUF1358) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Gt5hJPgjC+MEGeCQNxgc04W/nvk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NVI7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NSE4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NRG7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-4311855|uniprotkb:Q6ZW71|uniprotkb:Q9BVQ3|ensembl:ENSP00000382327 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:d39u1_human(display_long)|uniprotkb:SDR39U1(gene name)|psi-mi:SDR39U1(display_short)|uniprotkb:C14orf124(gene name synonym)|uniprotkb:HCDI(gene name synonym)|uniprotkb:Short-chain dehydrogenase/reductase family 39U member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_064580.2|refseq:NP_001277221.1|refseq:NP_001295004.1|ensembl:ENST00000399395(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR010099(Conserved hypothetical protein, YfcH)|interpro:IPR013549(Region of unknown function DUF1731)|interpro:IPR036291|rcsb pdb:4B4O|ensembl:ENSG00000100445(gene) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:vhowOi3rrKZnmbK1cnr+JgAzqpg9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NPL8 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9HBL7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-714824|uniprotkb:Q9NZ44|uniprotkb:B2R6W0|ensembl:ENSP00000223864 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:plrkt_human(display_long)|uniprotkb:PLGRKT(gene name)|psi-mi:PLGRKT(display_short)|uniprotkb:C9orf46(gene name synonym)|uniprotkb:AD025(orf name)|uniprotkb:MDS030(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011516262.1|ensembl:ENSG00000107020(gene)|ensembl:ENST00000223864(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010756"(positive regulation of plasminogen activation)|interpro:IPR019319|refseq:NP_060935.2|refseq:XP_005251567.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qkj3WQL8jWUfNn4aQWO8RVidNUk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H845 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H300 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H2U2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3957115|uniprotkb:B4DLP7|uniprotkb:Q4W5E9|uniprotkb:Q6PG51|uniprotkb:Q8TBW0|uniprotkb:Q96E55|uniprotkb:Q9H0T0|uniprotkb:Q9NX37|uniprotkb:Q9P033|uniprotkb:Q9ULX0|uniprotkb:I6L9B6|uniprotkb:F8WDN9|ensembl:ENSP00000343885 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ipyr2_human(display_long)|uniprotkb:PPA2(gene name)|psi-mi:PPA2(display_short)|uniprotkb:Pyrophosphatase SID6-306(gene name synonym)|uniprotkb:Pyrophosphate phospho-hydrolase 2(gene name synonym)|uniprotkb:HSPC124(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_008834.3|refseq:NP_789842.2|refseq:NP_789843.2|refseq:NP_789845.1|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0071344"(diphosphate metabolic process)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q9H2U2|reactome:R-HSA-379726|reactome:R-HSA-71737|ensembl:ENSG00000138777(gene)|ensembl:ENST00000341695(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:KrPc55Mf6MjN5tgxFagI03miOwY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H2J4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2555126|uniprotkb:Q53S68|uniprotkb:B2RA00|ensembl:ENSP00000264254 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pdcl3_human(display_long)|uniprotkb:VIAF1(gene name synonym)|uniprotkb:PhPL3(gene name synonym)|uniprotkb:Viral IAP-associated factor 1(gene name synonym)|uniprotkb:HTPHLP(gene name synonym)|uniprotkb:PDCL3(gene name)|psi-mi:PDCL3(display_short)|uniprotkb:PhLP2A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_076970.1|ensembl:ENSG00000115539(gene)|ensembl:ENST00000264254(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1903645"(negative regulation of chaperone-mediated protein folding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR024253|interpro:IPR036249|go:"GO:0006915"(apoptotic process) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:PmgvLw0EQHkGFUhm03qHPrde/v89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H078 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H061 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-10963884|ensembl:ENSP00000306887|uniprotkb:E9PI16|uniprotkb:B2R570 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:t126a_human(display_long)|uniprotkb:TMEM126A(gene name)|psi-mi:TMEM126A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001231664.1|refseq:NP_115649.1|ensembl:ENSG00000171202(gene)|ensembl:ENST00000304511(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021554"(optic nerve development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|mint:Q9H061 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eoOBOQwbptvpCACbOjdG5oQEb2I9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9GZT3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BVV7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BUR5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-10763408|uniprotkb:B2R4K9|uniprotkb:Q9H3J9|ensembl:ENSP00000368528 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mic26_human(display_long)|uniprotkb:Protein FAM121B(gene name synonym)|uniprotkb:My025(orf name)|uniprotkb:UNQ1866/PRO4302(orf name)|uniprotkb:Apolipoprotein O(gene name synonym)|uniprotkb:MIC23(gene name synonym)|uniprotkb:MIC26(gene name synonym)|uniprotkb:MICOS complex subunit MIC23(gene name synonym)|uniprotkb:APOO(gene name)|psi-mi:APOO(display_short)|uniprotkb:FAM121B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_077027.1|ensembl:ENSG00000184831(gene)|ensembl:ENST00000379226(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-HSA-8949613|refseq:XP_016885326.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:xu+C1gnPf3M63LJIPv1R57L62lc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BSH4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-747797|uniprotkb:Q8N3N6|uniprotkb:Q9UI60|uniprotkb:B2RD21|ensembl:ENSP00000258975 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:taco1_human(display_long)|uniprotkb:PRO0477(orf name)|uniprotkb:TACO1(gene name)|psi-mi:TACO1(display_short)|uniprotkb:CCDC44(gene name synonym)|uniprotkb:Translational activator of mitochondrially-encoded cytochrome c oxidase I(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_057444.2|ensembl:ENSG00000136463(gene)|ensembl:ENST00000258975(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0019843"(rRNA binding)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0061743"(motor learning)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR002876(Protein of unknown function DUF28)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR026564|interpro:IPR029072|mint:Q9BSH4|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:c/tu89NvCs3Kt8qO8e5F6hrywBo9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BSF4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-10974729|ensembl:ENSP00000270502|uniprotkb:Q96EY6|uniprotkb:Q96IT8 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tim29_human(display_long)|uniprotkb:TIMM29(gene name)|psi-mi:TIMM29(display_short)|uniprotkb:c19orf52(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_612367.1|ensembl:ENSG00000142444(gene)|ensembl:ENST00000270502(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042721"(TIM22 mitochondrial import inner membrane insertion complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0140318"(protein transporter activity)|interpro:IPR019322|rcsb pdb:7CGP - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:9RRT6AC0o31q81ETOTJgq3Gk+2E9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BRQ6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2557895|ensembl:ENSP00000290913|uniprotkb:D6R9U0|uniprotkb:D6RIB4|uniprotkb:H8Y0Y7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mic25_human(display_long)|uniprotkb:CHCHD6(gene name)|psi-mi:CHCHD6(display_short)|uniprotkb:CHCM1(gene name synonym)|uniprotkb:Coiled-coil-helix cristae morphology protein 1(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:MIC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_115719.1|refseq:NP_001307539.1|ensembl:ENSG00000159685(gene)|ensembl:ENST00000290913(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR042860|mint:Q9BRQ6|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:6jrzreYX6MJWPfMKh2EKqiEca1s9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BQ95 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BPX6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q99832 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96TA2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96T52 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96RP9 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2255048|uniprotkb:B3KRW1|uniprotkb:A6NCI9|uniprotkb:B2RCB9|uniprotkb:Q6GTN2|uniprotkb:Q96T39|intact:EBI-2870814|ensembl:ENSP00000419038 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:efgm_human(display_long)|uniprotkb:GFM1(gene name)|psi-mi:GFM1(display_short)|uniprotkb:EFG(gene name synonym)|uniprotkb:EFG1(gene name synonym)|uniprotkb:GFM(gene name synonym)|uniprotkb:Elongation factor G 1, mitochondrial(gene name synonym)|uniprotkb:Elongation factor G1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001295093.1|refseq:NP_001295095.1|refseq:NP_079272.4|ensembl:ENSG00000168827(gene)|ensembl:ENST00000486715(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004540(Translation elongation factor EFG/EF2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009022(Elongation factor G, III and V)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR035649|interpro:IPR041095|mint:Q96RP9|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6YDP|rcsb pdb:6YDW|rcsb pdb:7A5K|reactome:R-HSA-5389840 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:TwkylC5mlIaXRTw3hUyViUocC509606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96JJ7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2514069|intact:EBI-28973673|uniprotkb:B3KV75|uniprotkb:Q52LT7|uniprotkb:Q8N5J0|uniprotkb:Q9NWJ9|ensembl:ENSP00000299608 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tmx3_human(display_long)|uniprotkb:TMX3(gene name)|psi-mi:TMX3(display_short)|uniprotkb:KIAA1830(gene name synonym)|uniprotkb:TXNDC10(gene name synonym)|uniprotkb:Thioredoxin-related transmembrane protein 3(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 10(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000299608|ensembl:ENST00000562706|ensembl:ENSP00000457262|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0031092"(platelet alpha granule membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|reactome:R-HSA-114608|ensembl:ENST00000299608(transcript)|ensembl:ENSG00000166479(gene)|refseq:NP_061895.3 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Qber8pA1sCprlKl8Yoc5XtVEd5s9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96EX1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2874543|ensembl:ENSP00000428541|ensembl:ENSP00000428585|ensembl:ENSP00000428984|ensembl:ENSP00000430198|ensembl:ENSP00000430285|uniprotkb:Q52LP9|uniprotkb:Q8NCB4|uniprotkb:D3DPR5|uniprotkb:Q49AP7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sim12_human(display_long)|uniprotkb:SMIM12(gene name)|psi-mi:SMIM12(display_short)|uniprotkb:C1orf212(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000163866(gene)|ensembl:ENST00000417239(transcript)|ensembl:ENST00000423898(transcript)|ensembl:ENST00000446026(transcript)|ensembl:ENST00000456842(transcript)|ensembl:ENST00000521580(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR031933|refseq:XP_011538855.1|refseq:XP_011538857.1|refseq:NP_001307190.1|refseq:NP_001158296.1|refseq:NP_001158297.1|refseq:NP_612437.3|refseq:XP_005270460.1|refseq:XP_016855655.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qeuRSIWo2rJvSDDvexjGg07txg89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96E52 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96DB5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2564644|uniprotkb:A9UMZ8|uniprotkb:Q9Y398|ensembl:ENSP00000385927|uniprotkb:B4DNF5|uniprotkb:E7EVI2|uniprotkb:B4DZW6|uniprotkb:B5MC61|uniprotkb:C9JSC6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rmd1_human(display_long)|uniprotkb:RMDN1(gene name)|psi-mi:RMDN1(display_short)|uniprotkb:FAM82B(gene name synonym)|uniprotkb:Protein FAM82B(gene name synonym)|uniprotkb:CGI-90(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001273648.1|refseq:NP_057117.2|refseq:NP_001304736.1|ensembl:ENSG00000176623(gene)|ensembl:ENST00000406452(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q96DB5|refseq:NP_001273636.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:EAYrDAOf2NP9wZLfqd3rmwSV5uc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96C36 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96C01 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-373319|uniprotkb:Q96SS3|ensembl:ENSP00000037869 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:f136a_human(display_long)|uniprotkb:FAM136A(gene name)|psi-mi:FAM136A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_116211.2|ensembl:ENSG00000035141(gene)|ensembl:ENST00000037869(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR008560(Protein of unknown function DUF842, eukaryotic) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:i9TSWgN6JC8fuAcFrlTU3IKBDHE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96BR5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96A73 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-725897|uniprotkb:B8K1S6|uniprotkb:Q8NDU3|uniprotkb:Q9BRE5|uniprotkb:Q9H7D5|uniprotkb:Q9ULM9|uniprotkb:Q6IA24|uniprotkb:B2RD69|ensembl:ENSP00000298569|ensembl:ENSP00000421061 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:p33mx_human(display_long)|uniprotkb:KIAA1191(gene name)|psi-mi:KIAA1191(display_short)|uniprotkb:Brain-derived rescue factor p60MONOX(gene name synonym)|uniprotkb:P33MONOX(gene name synonym)|uniprotkb:Flavin monooxygenase motif-containing protein of 33 kDa(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001073152.1|refseq:NP_001073153.1|refseq:NP_065177.2|refseq:NP_001274264.1|refseq:NP_001274265.1|refseq:XP_005265998.1|refseq:XP_005266003.1|ensembl:ENSG00000122203(gene)|ensembl:ENST00000298569(transcript)|ensembl:ENST00000510164(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR026759 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ifBPsTNia/Yd27cRSNHVYm6h8H49606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96A26 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6123466|uniprotkb:Q9NRN6|uniprotkb:Q9UJX8|ensembl:ENSP00000419088 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:f162a_human(display_long)|uniprotkb:FAM162A(gene name)|psi-mi:FAM162A(display_short)|uniprotkb:C3orf28(gene name synonym)|uniprotkb:E2IG5(gene name synonym)|uniprotkb:E2-induced gene 5 protein(gene name synonym)|uniprotkb:Growth and transformation-dependent protein(gene name synonym)|uniprotkb:DC16(orf name)|uniprotkb:FWP001(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055182.3|ensembl:ENSG00000114023(gene)|ensembl:ENST00000477892(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR009432(Protein of unknown function DUF1075)|mint:Q96A26 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:CjOkqa9wFwEOorjQt5oI7/EJ6709606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8N4Q1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8N183 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2682365|uniprotkb:A8K5I1|ensembl:ENSP00000296597 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduf2_human(display_long)|uniprotkb:NDUFA12L(gene name synonym)|uniprotkb:B17.2-like(gene name synonym)|uniprotkb:Myc-induced mitochondrial protein(gene name synonym)|uniprotkb:NDUFA12-like protein(gene name synonym)|uniprotkb:NDUFAF2(gene name)|psi-mi:NDUFAF2(display_short)|uniprotkb:Mimitin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_777549.1|ensembl:ENSG00000164182(gene)|ensembl:ENST00000296597(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:sNje5xhXA48xAg0tSkOYiqBxZvk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8IYU8 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8IUX1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2800657|uniprotkb:Q32Q09|uniprotkb:Q9NZ29|uniprotkb:Q96EP3|uniprotkb:Q8WVU3|uniprotkb:A8K535|uniprotkb:A8MSS0|ensembl:ENSP00000351737 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:t126b_human(display_long)|uniprotkb:TMEM126B(gene name)|psi-mi:TMEM126B(display_short)|uniprotkb:Transmembrane protein 126B(gene name synonym)|uniprotkb:HT007(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011543467.1|refseq:NP_001180467.1|refseq:NP_060950.3|refseq:NP_001243475.1|ensembl:ENSG00000171204(gene)|ensembl:ENST00000358867(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eQNEaTeYOl8NJlnxhrTi3R6m66I9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q86TX2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-11109648|uniprotkb:Q3I5F9|uniprotkb:A1L173|ensembl:ENSP00000311224 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:acot1_human(display_long)|uniprotkb:ACOT1(gene name)|psi-mi:ACOT1(display_short)|uniprotkb:CTE-I(gene name synonym)|uniprotkb:CTE-Ib(gene name synonym)|uniprotkb:CTE1(gene name synonym)|uniprotkb:Inducible cytosolic acyl-coenzyme A thioester hydrolase(gene name synonym)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Palmitoyl-coenzyme A thioesterase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001032238.1|ensembl:ENSG00000184227(gene)|ensembl:ENST00000311148(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|reactome:R-HSA-77289 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:on1deS+8E4m2ZirUewH43L1VsPc9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q7Z695 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q7Z4W1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q7KZN9 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q70CQ3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6PML9 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6NUK1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-4289949|uniprotkb:Q705K4|uniprotkb:B7ZAI9|uniprotkb:Q5T331|uniprotkb:Q9P129|uniprotkb:Q5T485|uniprotkb:Q6PJJ9|ensembl:ENSP00000457733|ensembl:ENSP00000491572 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:scmc1_human(display_long)|uniprotkb:SLC25A24(gene name)|psi-mi:SLC25A24(display_short)|uniprotkb:APC1(gene name synonym)|uniprotkb:MCSC1(gene name synonym)|uniprotkb:SCAMC1(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 1(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 1"(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 24(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_037518.3|refseq:NP_998816.1|ensembl:ENSG00000085491(gene)|ensembl:ENSG00000284468(gene)|ensembl:ENST00000565488(transcript)|ensembl:ENST00000640416(transcript)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0015867"(ATP transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q6NUK1|rcsb pdb:4N5X|rcsb pdb:4ZCU|rcsb pdb:4ZCV - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2zVynZiDVY5UzziL6TAmqK/fkB09606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6KCM7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-11289059|uniprotkb:Q5SYW7|uniprotkb:Q5SYW8|uniprotkb:Q5SYX3|uniprotkb:Q5VWU2|uniprotkb:Q5VWU3|uniprotkb:Q5VWU4|uniprotkb:Q6KCM4|uniprotkb:Q6KCM6|uniprotkb:Q6UX48|uniprotkb:Q705K2|uniprotkb:Q96PZ1|uniprotkb:Q9BSA6|ensembl:ENSP00000362155 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:scmc2_human(display_long)|uniprotkb:SLC25A25(gene name)|psi-mi:SLC25A25(display_short)|uniprotkb:APC3(gene name synonym)|uniprotkb:KIAA1896(gene name synonym)|uniprotkb:MCSC3(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 3(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 3"(gene name synonym)|uniprotkb:SCAMC2(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 25(gene name synonym)|uniprotkb:UNQ549/PRO1106(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001006642.1|refseq:NP_001006643.1|refseq:NP_001252543.1|refseq:NP_443133.2|refseq:XP_005251746.1|ensembl:ENSG00000148339(gene)|ensembl:ENST00000373064(transcript)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032094"(response to food)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|refseq:NP_001317917.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:8scX7Hlkx6rPbDpdTtf7vNn7lqM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6DKK2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q69YU5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-16768469|ensembl:ENSP00000367330|ensembl:ENSP00000446981|ensembl:ENSP00000448771|ensembl:ENSP00000449839 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:bwnin_human(display_long)|uniprotkb:BRAWNIN(gene name)|psi-mi:BRAWNIN(display_short)|uniprotkb:BR(gene name synonym)|uniprotkb:C12orf73(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000204954(gene)|ensembl:ENST00000378090(transcript)|ensembl:ENST00000547945(transcript)|ensembl:ENST00000549478(transcript)|ensembl:ENST00000553183(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR027858|refseq:NP_001129042.1|refseq:XP_016875405.1|refseq:XP_016875406.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Qt5Oq9fK8Tp9SkleQS3p8DIeyb89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5TC12 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5T9A4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5T6V5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-14710764|ensembl:ENSP00000365522|uniprotkb:B2RPI6|uniprotkb:Q8N2B1|uniprotkb:Q9BT18 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:qspp_human(display_long)|uniprotkb:C9orf64(gene name)|psi-mi:C9orf64(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000165118(gene)|ensembl:ENST00000376344(transcript)|go:"GO:0006400"(tRNA modification)|go:"GO:0101030"(tRNA-guanine transglycosylation)|interpro:IPR019438|refseq:NP_001304926.1|refseq:NP_115683.3 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:R9r5uewNZzZlp131glK7ZtMLoKE9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5ST30 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q4VC31 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q16822 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2825219|uniprotkb:O43253|uniprotkb:Q9BV62|intact:EBI-3189808|uniprotkb:Q86U01|ensembl:ENSP00000216780|ensembl:ENSP00000494919|uniprotkb:B4DW73 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pckgm_human(display_long)|uniprotkb:PCK2(gene name)|psi-mi:PCK2(display_short)|uniprotkb:PEPCK2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001278485.1|refseq:NP_001294983.1|refseq:NP_001018083.2|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0042594"(response to starvation)|go:"GO:0046327"(glycerol biosynthetic process from pyruvate)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR008209(Phosphoenolpyruvate carboxykinase, GTP-utilising)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR018091|interpro:IPR035077|interpro:IPR035078|mint:Q16822|reactome:R-HSA-70263|go:"GO:0030145"(manganese ion binding)|ensembl:ENSG00000100889(gene)|ensembl:ENSG00000285241(gene)|ensembl:ENST00000216780(transcript)|ensembl:ENST00000645217(transcript)|go:"GO:0004611"(phosphoenolpyruvate carboxykinase activity)|go:"GO:0004613"("phosphoenolpyruvate carboxykinase (GTP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0019543"(propionate catabolic process)|refseq:NP_004554.3 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:gbQbu8+tVa1xs/fKesefSJlpSaM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q16718 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q15293 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q14249 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q13907 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6285983|ensembl:ENSP00000401879|uniprotkb:B4E155|uniprotkb:Q32Q13|uniprotkb:Q53GQ6|uniprotkb:Q86U81|uniprotkb:Q8WUX8|uniprotkb:Q96IZ4|uniprotkb:Q9BQ74 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:idi1_human(display_long)|uniprotkb:IDI1(gene name)|psi-mi:IDI1(display_short)|uniprotkb:Isopentenyl pyrophosphate isomerase 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000067064(gene)|ensembl:ENST00000429642(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004452"(isopentenyl-diphosphate delta-isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0009240"(isopentenyl diphosphate biosynthetic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050992"(dimethylallyl diphosphate biosynthetic process)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR011876(Isopentenyl-diphosphate delta-isomerase, type 1)|interpro:IPR015797(NUDIX)|mint:Q13907|rcsb pdb:2DHO|rcsb pdb:2I6K|rcsb pdb:2ICJ|rcsb pdb:2ICK|reactome:R-HSA-191273|reactome:R-HSA-2426168|refseq:NP_001304884.1|refseq:NP_001304885.1|refseq:NP_001304886.1|refseq:NP_004499.2|refseq:XP_011517759.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:UbjHfBd6yrV1Gxv+R0z56N7DVgA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q00059 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P99999 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P83111 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P61604 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P56385 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P56181 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P54819 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P53701 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P51970 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P49821 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P45954 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P42704 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P40926 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P36776 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P36551 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P35580 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P32322 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539 - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P31040 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P30101 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049466|imex:IM-29123-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N - - - figure legend:ST1 ST2 F1|comment:"the protein associated to the ID: NP_620307.1 was not included because the entry is obsolete."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/08/03 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 rigid:xS70jWtZxpq0X6JrNpIbMz3Do2E false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O75431 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NVH0 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-11324738|uniprotkb:Q8N3D3|uniprotkb:Q6AWB6|uniprotkb:G5E947|uniprotkb:B4DIH6|ensembl:ENSP00000313140|ensembl:ENSP00000387331 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:exd2_human(display_long)|uniprotkb:EXD2(gene name)|psi-mi:EXD2(display_short)|uniprotkb:C14orf114(gene name synonym)|uniprotkb:EXDL2(gene name synonym)|uniprotkb:Exonuclease 3'-5' domain-like-containing protein 2(gene name synonym)|uniprotkb:3'-5' exoribonuclease EXD2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001180289.1|refseq:NP_001180290.1|refseq:NP_001180291.1|refseq:NP_001180292.1|refseq:NP_060669.1|refseq:XP_005267874.1|refseq:XP_011535210.1|ensembl:ENSG00000081177(gene)|ensembl:ENST00000312994(transcript)|ensembl:ENST00000409018(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008852"(exodeoxyribonuclease I activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|rcsb pdb:6K17|rcsb pdb:6K18|rcsb pdb:6K19|rcsb pdb:6K1A|rcsb pdb:6K1B|rcsb pdb:6K1C|rcsb pdb:6K1D|rcsb pdb:6K1E|refseq:XP_016876910.1|dip:DIP-61996N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:Id4gHPaa70qNO9LznLBjDgkMlu09606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q6UXV4 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P20674 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P32322 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O95202 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NPL8 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9H300 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O95831 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O94826 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q96E52 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q5VT66 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-11903927|uniprotkb:A8K447|uniprotkb:B2D078|uniprotkb:Q5VVS9|uniprotkb:Q5VVT0|uniprotkb:Q5VVT1|uniprotkb:Q8N9P5|uniprotkb:Q96FN8|uniprotkb:Q9H6C7|ensembl:ENSP00000355877 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:marc1_human(display_long)|uniprotkb:MTARC1(gene name)|psi-mi:MTARC1(display_short)|uniprotkb:MARC1(gene name synonym)|uniprotkb:MOSC1(gene name synonym)|uniprotkb:Molybdenum cofactor sulfurase C-terminal domain-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_073583.3|refseq:XP_011508202.1|refseq:XP_011508206.1|ensembl:ENSG00000186205(gene)|ensembl:ENST00000366910(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042126"(nitrate metabolic process)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0051410"(detoxification of nitrogen compound)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|go:"GO:0098809"(nitrite reductase activity)|go:"GO:1903958"(nitric-oxide synthase complex)|interpro:IPR005302(Molybdenum cofactor sulphurase, C-terminal)|interpro:IPR005303(MOSC, N-terminal beta barrel)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|rcsb pdb:6FW2|reactome:R-HSA-211945 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:MVnfGK30icFS28a9p6qf739MKYs9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NVH1 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P10606 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q8N4Q1 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:A8MXV4 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-11350801|ensembl:ENSP00000380251 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:nud19_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 19(gene name synonym)|uniprotkb:NUDT19(gene name)|psi-mi:NUDT19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001099040.1|ensembl:ENSG00000213965(gene)|ensembl:ENST00000397061(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0010945"(CoA pyrophosphatase activity)|go:"GO:0015938"(coenzyme A catabolic process)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0044580"(butyryl-CoA catabolic process)|go:"GO:1901289"(succinyl-CoA catabolic process)|go:"GO:1902858"(propionyl-CoA metabolic process)|go:"GO:2001294"(malonyl-CoA catabolic process)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR039121|reactome:R-HSA-390918|reactome:R-HSA-9033241 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:nSyCFhGmUMc1wbmmLp6RZvUojaM9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P40926 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q7Z4W1 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P16152 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P17655 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1028956|uniprotkb:Q16738|uniprotkb:Q6PJT3|uniprotkb:Q8WU26|uniprotkb:Q9HBB1|uniprotkb:A6NDG7|ensembl:ENSP00000295006|uniprotkb:B7ZA96|uniprotkb:E7ES58 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:can2_human(display_long)|uniprotkb:CAPN2(gene name)|psi-mi:CAPN2(display_short)|uniprotkb:CANPL2(gene name synonym)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)|uniprotkb:Calpain large polypeptide L2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001139540.1|refseq:NP_001739.2|ensembl:ENSG00000162909(gene)|ensembl:ENST00000295006(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0005634"(nucleus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:P17655|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:2NQA|reactome:R-HSA-1474228|reactome:R-HSA-8862803|interpro:IPR002048(Calcium-binding EF-hand) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:r60XX66kihGVLaa9888soeXjc0M9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9H845 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q96TA2 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q70CQ3 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q6DKK2 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O60220 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9Y5L4 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q6PML9 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O75746 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q96BR5 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9Y512 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O60313 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O00217 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O96000 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P51970 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9BPX6 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q969Z3 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-16773897|ensembl:ENSP00000355880|uniprotkb:B2D0R5|uniprotkb:D3DTB3|uniprotkb:Q0JSK7|uniprotkb:Q5VT67|uniprotkb:Q5VXC7|uniprotkb:Q7L317|uniprotkb:Q9H066|uniprotkb:Q9NWU0 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:marc2_human(display_long)|uniprotkb:MOSC2(gene name synonym)|uniprotkb:Molybdenum cofactor sulfurase C-terminal domain-containing protein 2(gene name synonym)|uniprotkb:MTARC2(gene name)|psi-mi:MTARC2(display_short)|uniprotkb:MARC2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000117791(gene)|ensembl:ENST00000366913(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042126"(nitrate metabolic process)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0051410"(detoxification of nitrogen compound)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|go:"GO:0098809"(nitrite reductase activity)|interpro:IPR005302(Molybdenum cofactor sulphurase, C-terminal)|interpro:IPR005303(MOSC, N-terminal beta barrel)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|reactome:R-HSA-211945|refseq:NP_001304267.1|refseq:NP_001317971.1|refseq:NP_060368.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:ypPzLBnAlrNErXdIIuKr4LqzId09606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q16891 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q96T52 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NSE4 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P53701 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:O00165 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q14249 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q8IYU8 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P99999 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P36551 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P13073 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q7KZN9 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9H078 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P12532 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NX63 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q4VC31 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9BXK5 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q5TC12 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q5T9A4 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:Q9NVI7 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P83111 uniprotkb:P54819 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049642|imex:IM-29123-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:BsRdMqWf67+8uoZzT+kTfkEs890 false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O75431 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P43304 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-7600203|uniprotkb:Q59FR1|intact:MINT-4530883|uniprotkb:Q9HAP9|uniprotkb:A8K4V0|uniprotkb:B3KSA9|ensembl:ENSP00000308610|ensembl:ENSP00000386425|ensembl:ENSP00000386626|ensembl:ENSP00000409708 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:gpdm_human(display_long)|uniprotkb:GPD2(gene name)|psi-mi:GPD2(display_short)|uniprotkb:mtGPD(gene name synonym)|uniprotkb:mitohondrial glycerophosphate dehydrogenase gene(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:XP_016859319.1|refseq:XP_011509279.1|refseq:NP_001076581.2|refseq:NP_000399.3|refseq:XP_005246526.1|ensembl:ENSG00000115159(gene)|ensembl:ENST00000310454(transcript)|ensembl:ENST00000409674(transcript)|ensembl:ENST00000409861(transcript)|ensembl:ENST00000438166(transcript)|go:"GO:0004368"("glycerol-3-phosphate dehydrogenase (quinone) activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006072"(glycerol-3-phosphate metabolic process)|go:"GO:0006127"(glycerophosphate shuttle)|go:"GO:0009331"(glycerol-3-phosphate dehydrogenase complex)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0052591"("sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity")|interpro:IPR000447(FAD-dependent glycerol-3-phosphate dehydrogenase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR031656|interpro:IPR036188|interpro:IPR038299|reactome:R-HSA-1483166|reactome:R-HSA-163560 - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:PsG9Eo7dfk8l+vDJl6d4WfEST849606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q6UXV4 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NX14 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1246182|uniprotkb:Q5JRR3|uniprotkb:Q5JRR4|uniprotkb:Q6IAB6|uniprotkb:Q8WZ96|uniprotkb:Q9BXX9|ensembl:ENSP00000367042 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndubb_human(display_long)|uniprotkb:NDUFB11(gene name)|psi-mi:NDUFB11(display_short)|uniprotkb:UNQ111/PRO1064(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase ESSS subunit(gene name synonym)|uniprotkb:Complex I-ESSS(gene name synonym)|uniprotkb:Neuronal protein 17.3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001129470.1|refseq:NP_061929.2|ensembl:ENSG00000147123(gene)|ensembl:ENST00000377811(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019329|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:CAloB+PJ0fcnLukpvgNGgTFJ0zs9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96EX1 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2874543|ensembl:ENSP00000428541|ensembl:ENSP00000428585|ensembl:ENSP00000428984|ensembl:ENSP00000430198|ensembl:ENSP00000430285|uniprotkb:Q52LP9|uniprotkb:Q8NCB4|uniprotkb:D3DPR5|uniprotkb:Q49AP7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:sim12_human(display_long)|uniprotkb:SMIM12(gene name)|psi-mi:SMIM12(display_short)|uniprotkb:C1orf212(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000163866(gene)|ensembl:ENST00000417239(transcript)|ensembl:ENST00000423898(transcript)|ensembl:ENST00000446026(transcript)|ensembl:ENST00000456842(transcript)|ensembl:ENST00000521580(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR031933|refseq:XP_011538855.1|refseq:XP_011538857.1|refseq:NP_001307190.1|refseq:NP_001158296.1|refseq:NP_001158297.1|refseq:NP_612437.3|refseq:XP_005270460.1|refseq:XP_016855655.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:qeuRSIWo2rJvSDDvexjGg07txg89606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NVI7 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9Y4W6 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P28331 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P13489 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9BRQ6 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2557895|ensembl:ENSP00000290913|uniprotkb:D6R9U0|uniprotkb:D6RIB4|uniprotkb:H8Y0Y7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mic25_human(display_long)|uniprotkb:CHCHD6(gene name)|psi-mi:CHCHD6(display_short)|uniprotkb:CHCM1(gene name synonym)|uniprotkb:Coiled-coil-helix cristae morphology protein 1(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:MIC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_115719.1|refseq:NP_001307539.1|ensembl:ENSG00000159685(gene)|ensembl:ENST00000290913(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR042860|mint:Q9BRQ6|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:6jrzreYX6MJWPfMKh2EKqiEca1s9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P56181 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q16891 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9BS26 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NYU2 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P19404 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96C01 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-373319|uniprotkb:Q96SS3|ensembl:ENSP00000037869 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:f136a_human(display_long)|uniprotkb:FAM136A(gene name)|psi-mi:FAM136A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_116211.2|ensembl:ENSG00000035141(gene)|ensembl:ENST00000037869(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR008560(Protein of unknown function DUF842, eukaryotic) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:i9TSWgN6JC8fuAcFrlTU3IKBDHE9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O75880 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-6656171|ensembl:ENSP00000255390|uniprotkb:B2RDM0 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:sco1_human(display_long)|uniprotkb:SCO1(gene name)|psi-mi:SCO1(display_short)|uniprotkb:SCOD1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000133028(gene)|ensembl:ENST00000255390(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|rcsb pdb:1WP0|rcsb pdb:2GGT|rcsb pdb:2GQK|rcsb pdb:2GQL|rcsb pdb:2GQM|rcsb pdb:2GT5|rcsb pdb:2GT6|rcsb pdb:2GVP|rcsb pdb:2HRF|rcsb pdb:2HRN|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_004580.1|dip:DIP-46086N|refseq:XP_005256808.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:oxGxX5mXuGDP5uPIW1vyOtaQHxU9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O75306 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O43674 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1246293|uniprotkb:Q561V6|ensembl:ENSP00000259037 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndub5_human(display_long)|uniprotkb:NDUFB5(gene name)|psi-mi:NDUFB5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase SGDH subunit(gene name synonym)|uniprotkb:Complex I-SGDH(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001186886.1|refseq:NP_001186887.1|refseq:NP_002483.1|ensembl:ENSG00000136521(gene)|ensembl:ENST00000259037(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019173|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:1UrbNq39EsuKHJ2M7tRd8ZmB6uk9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P03905 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NSE4 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P09669 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9HBL7 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-714824|uniprotkb:Q9NZ44|uniprotkb:B2R6W0|ensembl:ENSP00000223864 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:plrkt_human(display_long)|uniprotkb:PLGRKT(gene name)|psi-mi:PLGRKT(display_short)|uniprotkb:C9orf46(gene name synonym)|uniprotkb:AD025(orf name)|uniprotkb:MDS030(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:XP_011516262.1|ensembl:ENSG00000107020(gene)|ensembl:ENST00000223864(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010756"(positive regulation of plasminogen activation)|interpro:IPR019319|refseq:NP_060935.2|refseq:XP_005251567.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:qkj3WQL8jWUfNn4aQWO8RVidNUk9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q5TC12 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96TA2 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q70CQ3 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q6DKK2 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O94826 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96B77 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-9089409|uniprotkb:B2RAY0|uniprotkb:Q9Y4T4|ensembl:ENSP00000331640 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:tm186_human(display_long)|uniprotkb:C16orf51(gene name synonym)|uniprotkb:TMEM186(gene name)|psi-mi:TMEM186(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_056236.2|ensembl:ENSG00000184857(gene)|ensembl:ENST00000333050(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026571|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:x+vajajo/J0W0DVGKWU12wFid3c9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q8IUX1 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2800657|uniprotkb:Q32Q09|uniprotkb:Q9NZ29|uniprotkb:Q96EP3|uniprotkb:Q8WVU3|uniprotkb:A8K535|uniprotkb:A8MSS0|ensembl:ENSP00000351737 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:t126b_human(display_long)|uniprotkb:TMEM126B(gene name)|psi-mi:TMEM126B(display_short)|uniprotkb:Transmembrane protein 126B(gene name synonym)|uniprotkb:HT007(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:XP_011543467.1|refseq:NP_001180467.1|refseq:NP_060950.3|refseq:NP_001243475.1|ensembl:ENSG00000171204(gene)|ensembl:ENST00000358867(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:eQNEaTeYOl8NJlnxhrTi3R6m66I9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NPL8 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O60220 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9Y5L4 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q6PML9 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q6KCM7 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-11289059|uniprotkb:Q5SYW7|uniprotkb:Q5SYW8|uniprotkb:Q5SYX3|uniprotkb:Q5VWU2|uniprotkb:Q5VWU3|uniprotkb:Q5VWU4|uniprotkb:Q6KCM4|uniprotkb:Q6KCM6|uniprotkb:Q6UX48|uniprotkb:Q705K2|uniprotkb:Q96PZ1|uniprotkb:Q9BSA6|ensembl:ENSP00000362155 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:scmc2_human(display_long)|uniprotkb:SLC25A25(gene name)|psi-mi:SLC25A25(display_short)|uniprotkb:APC3(gene name synonym)|uniprotkb:KIAA1896(gene name synonym)|uniprotkb:MCSC3(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 3(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 3"(gene name synonym)|uniprotkb:SCAMC2(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 25(gene name synonym)|uniprotkb:UNQ549/PRO1106(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001006642.1|refseq:NP_001006643.1|refseq:NP_001252543.1|refseq:NP_443133.2|refseq:XP_005251746.1|ensembl:ENSG00000148339(gene)|ensembl:ENST00000373064(transcript)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032094"(response to food)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|refseq:NP_001317917.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:8scX7Hlkx6rPbDpdTtf7vNn7lqM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q6NUK1 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-4289949|uniprotkb:Q705K4|uniprotkb:B7ZAI9|uniprotkb:Q5T331|uniprotkb:Q9P129|uniprotkb:Q5T485|uniprotkb:Q6PJJ9|ensembl:ENSP00000457733|ensembl:ENSP00000491572 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:scmc1_human(display_long)|uniprotkb:SLC25A24(gene name)|psi-mi:SLC25A24(display_short)|uniprotkb:APC1(gene name synonym)|uniprotkb:MCSC1(gene name synonym)|uniprotkb:SCAMC1(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 1(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 1"(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 24(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_037518.3|refseq:NP_998816.1|ensembl:ENSG00000085491(gene)|ensembl:ENSG00000284468(gene)|ensembl:ENST00000565488(transcript)|ensembl:ENST00000640416(transcript)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0015867"(ATP transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q6NUK1|rcsb pdb:4N5X|rcsb pdb:4ZCU|rcsb pdb:4ZCV - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:2zVynZiDVY5UzziL6TAmqK/fkB09606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O75746 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96BR5 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9Y512 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O60313 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q56VL3 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-6152758|uniprotkb:Q8N544|uniprotkb:B4DPE7|ensembl:ENSP00000423014 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ocad2_human(display_long)|uniprotkb:Ovarian carcinoma immunoreactive antigen-like protein(gene name synonym)|uniprotkb:OCIAD2(gene name)|psi-mi:OCIAD2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001014446.1|refseq:NP_689611.1|refseq:NP_001273702.1|ensembl:ENSG00000145247(gene)|ensembl:ENST00000508632(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0009617"(response to bacterium)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:z4I/nxTOVnbJ/RZhY11VYbBas0g9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NX40 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2683029|uniprotkb:C9K030|uniprotkb:Q9BZE8|ensembl:ENSP00000264312|ensembl:ENSP00000370882|ensembl:ENSP00000423002|ensembl:ENSP00000423909|uniprotkb:G8JLN7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ocad1_human(display_long)|uniprotkb:OCIA(gene name synonym)|uniprotkb:Ovarian carcinoma immunoreactive antigen(gene name synonym)|uniprotkb:OCIAD1(gene name)|psi-mi:OCIAD1(display_short)|uniprotkb:ASRIJ(gene name synonym)|uniprotkb:Ovarian cancer immunoreactive antigen domain containing 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001073309.1|refseq:NP_001073311.2|refseq:NP_001073308.1|refseq:NP_001073310.1|refseq:NP_060300.1|ensembl:ENSG00000109180(gene)|ensembl:ENST00000264312(transcript)|ensembl:ENST00000381473(transcript)|ensembl:ENST00000508293(transcript)|ensembl:ENST00000513391(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187|mint:Q9NX40|refseq:XP_016863818.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:e3Ojv8LBlgj056bssUZjEC+MB+Q9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9Y6M9 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O96000 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9P032 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P51970 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9UI09 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q13505 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1052588|uniprotkb:B1AVR9|uniprotkb:B1AVS0|uniprotkb:B2R9P4|uniprotkb:Q9BUU3|uniprotkb:A0A0A0MRK6|ensembl:ENSP00000357360 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mtx1_human(display_long)|uniprotkb:MTX1(gene name)|psi-mi:MTX1(display_short)|uniprotkb:MTX(gene name synonym)|uniprotkb:MTXN(gene name synonym)|uniprotkb:Mitochondrial outer membrane import complex protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_002446.3|refseq:NP_942584.2|ensembl:ENSG00000173171(gene)|ensembl:ENST00000368376(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007595"(lactation)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140275"(MIB complex)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:Q13505|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:LoRdRoXuGOFmrPBEt324uUHgKos9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9BPX6 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P25205 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O95202 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P83111 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P53701 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O00165 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q96A26 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-6123466|uniprotkb:Q9NRN6|uniprotkb:Q9UJX8|ensembl:ENSP00000419088 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:f162a_human(display_long)|uniprotkb:FAM162A(gene name)|psi-mi:FAM162A(display_short)|uniprotkb:C3orf28(gene name synonym)|uniprotkb:E2IG5(gene name synonym)|uniprotkb:E2-induced gene 5 protein(gene name synonym)|uniprotkb:Growth and transformation-dependent protein(gene name synonym)|uniprotkb:DC16(orf name)|uniprotkb:FWP001(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_055182.3|ensembl:ENSG00000114023(gene)|ensembl:ENST00000477892(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR009432(Protein of unknown function DUF1075)|mint:Q96A26 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:CjOkqa9wFwEOorjQt5oI7/EJ6709606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q14249 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q8IYU8 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9BQ95 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NVH1 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P99999 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P08574 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1224514|uniprotkb:Q5U062|uniprotkb:Q6FHS7|ensembl:ENSP00000317159 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cy1_human(display_long)|uniprotkb:CYC1(gene name)|psi-mi:CYC1(display_short)|uniprotkb:Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit(gene name synonym)|uniprotkb:Cytochrome b-c1 complex subunit 4(gene name synonym)|uniprotkb:Complex III subunit 4(gene name synonym)|uniprotkb:Complex III subunit IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001907.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0033762"(response to glucagon)|go:"GO:0046872"(metal ion binding)|interpro:IPR002326(Cytochrome c1)|interpro:IPR021157|interpro:IPR036909|mint:P08574|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|ensembl:ENSG00000179091(gene)|ensembl:ENST00000318911(transcript)|go:"GO:0005634"(nucleus) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:WFFFejEobb6Uoum311x+fry5X+o9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P36551 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P10606 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P20674 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P13073 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q7KZN9 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9H078 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P12532 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NX63 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q4VC31 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P16152 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q5T9A4 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9BUR5 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-10763408|uniprotkb:B2R4K9|uniprotkb:Q9H3J9|ensembl:ENSP00000368528 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mic26_human(display_long)|uniprotkb:Protein FAM121B(gene name synonym)|uniprotkb:My025(orf name)|uniprotkb:UNQ1866/PRO4302(orf name)|uniprotkb:Apolipoprotein O(gene name synonym)|uniprotkb:MIC23(gene name synonym)|uniprotkb:MIC26(gene name synonym)|uniprotkb:MICOS complex subunit MIC23(gene name synonym)|uniprotkb:APOO(gene name)|psi-mi:APOO(display_short)|uniprotkb:FAM121B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_077027.1|ensembl:ENSG00000184831(gene)|ensembl:ENST00000379226(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-HSA-8949613|refseq:XP_016885326.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:xu+C1gnPf3M63LJIPv1R57L62lc9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:P54819 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:O95831 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q7Z695 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9H845 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96E52 uniprotkb:Q9NUT2 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 intact:EBI-722515|uniprotkb:O95787|uniprotkb:A5D8W3|uniprotkb:Q53GM0|uniprotkb:B3KND2|uniprotkb:B4DG02|uniprotkb:G3XAP3|uniprotkb:B2RBL8|ensembl:ENSP00000297504 psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:mitos_human(display_long)|uniprotkb:Mitochondrial ATP-binding cassette 1(gene name synonym)|uniprotkb:ABCB8(gene name)|psi-mi:ABCB8(display_short)|uniprotkb:MABC1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 8, mitochondrial(gene name synonym)|uniprotkb:MITOSUR(gene name synonym)|uniprotkb:Mitochondrial sulfonylurea-receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049801|imex:IM-29123-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 refseq:NP_009119.2|ensembl:ENSG00000197150(gene)|ensembl:ENST00000297504(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055085"(transmembrane transport)|go:"GO:0062157"(mitochondrial ATP-gated potassium channel complex)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|rcsb pdb:5OCH|rcsb pdb:7EHL|reactome:R-HSA-1369007|refseq:NP_001269220.1|refseq:NP_001269222.1|refseq:NP_001269221.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rogid:lFgKGWIzfeFWE7DNa3Cvm5qe6Xk9606 rigid:JGeHN5uPJtmiiyZscdLGw0C0rkA false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P62834 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43615 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-861737|uniprotkb:Q8N193|uniprotkb:A8K0R9|uniprotkb:D6W664|ensembl:ENSP00000270538 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim44_human(display_long)|uniprotkb:TIMM44(gene name)|psi-mi:TIMM44(display_short)|uniprotkb:MIMT44(gene name synonym)|uniprotkb:TIM44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_006342.2|ensembl:ENSG00000104980(gene)|ensembl:ENST00000270538(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|mint:O43615|rcsb pdb:2CW9|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Hwln5XuF3a9IMwVhP63Ud+LM5M09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q5T1C6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-7684443|ensembl:ENSP00000357804|uniprotkb:Q96KR2|uniprotkb:B2RBX2|intact:MINT-8306269 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:them4_human(display_long)|uniprotkb:THEM4(gene name)|psi-mi:THEM4(display_short)|uniprotkb:CTMP(gene name synonym)|uniprotkb:Carboxyl-terminal modulator protein(gene name synonym)|uniprotkb:Thioesterase superfamily member 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000159445(gene)|ensembl:ENST00000368814(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|rcsb pdb:4AE8|rcsb pdb:4GAH|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-199418|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-77289|refseq:NP_444283.2|dip:DIP-60764N - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:wgpknFKS1Xb9JWYSXKF/ImKoGx89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8WUK0 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-7199479|uniprotkb:Q7Z557|uniprotkb:Q9BXV8|uniprotkb:E9PAT8|intact:MINT-8162697|intact:MINT-8247525|uniprotkb:Q96CR2|ensembl:ENSP00000325958|ensembl:ENSP00000496417 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ptpm1_human(display_long)|uniprotkb:PTPMT1(gene name)|psi-mi:PTPMT1(display_short)|uniprotkb:MOSP(gene name synonym)|uniprotkb:PLIP(gene name synonym)|uniprotkb:PTEN-like phosphatase(gene name synonym)|uniprotkb:Phosphoinositide lipid phosphatase(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase mitochondrial 1(gene name synonym)|uniprotkb:PNAS-129(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001137456.1|refseq:NP_783859.1|ensembl:ENSG00000110536(gene)|ensembl:ENSG00000285206(gene)|ensembl:ENST00000326674(transcript)|ensembl:ENST00000647378(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008962"(phosphatidylglycerophosphatase activity)|go:"GO:0032049"(cardiolipin biosynthetic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR042165|interpro:IPR044596|mint:Q8WUK0|reactome:R-HSA-1483148 - - comment:mint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:h7MaeKx6Cx3G2KpRm201THlTJqs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9H6K4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-8477908|intact:MINT-8417711|uniprotkb:Q6P384|uniprotkb:Q8N784|ensembl:ENSP00000263275 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:opa3_human(display_long)|uniprotkb:OPA3(gene name)|psi-mi:OPA3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_079412.1|refseq:NP_001017989.2|ensembl:ENSG00000125741(gene)|ensembl:ENST00000263275(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0007601"(visual perception)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0050896"(response to stimulus)|interpro:IPR010754(Optic atrophy 3-like)|mint:Q9H6K4 - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:HlwZbHAbo7/jSdCOBbWhF5wKlvE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75431 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96EY8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-7825413|ensembl:ENSP00000445920|intact:UNK-5534451|uniprotkb:Q9BSH0|uniprotkb:C5HU05 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mmab_human(display_long)|uniprotkb:MMAB(gene name)|psi-mi:MMAB(display_short)|uniprotkb:Methylmalonic aciduria type B protein(gene name synonym)|uniprotkb:"Cob(II)alamin adenosyltransferase"(gene name synonym)|uniprotkb:"Cob(II)yrinic acid a,c-diamide adenosyltransferase"(gene name synonym)|uniprotkb:Cobinamide/cobalamin adenosyltransferase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENST00000545712(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008817"("cob(I)yrinic acid a,c-diamide adenosyltransferase activity")|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031419"(cobalamin binding)|interpro:IPR016030("Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like")|interpro:IPR029499|interpro:IPR036451|rcsb pdb:2IDX|rcsb pdb:6D5K|rcsb pdb:6D5X|reactome:R-HSA-196741|reactome:R-HSA-3359471|ensembl:ENSG00000139428(gene)|refseq:NP_443077.1 - - comment:mint|function:"Defects in MMAB are the cause of methylmalonic aciduria linked to the cblB complementation group (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive" figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:mCC0sM9ENytksAmo6ICWkWQHbZA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BX68 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-8523143|intact:MINT-3063101|intact:MINT-4891407|uniprotkb:Q5TCW3|ensembl:ENSP00000259667 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:hint2_human(display_long)|uniprotkb:HINT2(gene name)|psi-mi:HINT2(display_short)|uniprotkb:HINT-3(gene name synonym)|uniprotkb:HIT-17kDa(gene name synonym)|uniprotkb:PKCI-1-related HIT protein(gene name synonym)|uniprotkb:Histidine triad nucleotide-binding protein 2, mitochondrial(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_115982.1|ensembl:ENSG00000137133(gene)|ensembl:ENST00000259667(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR001310("Histidine triad (HIT) protein")|interpro:IPR011146(Histidine triad-like motif)|interpro:IPR019808|interpro:IPR036265|rcsb pdb:4INC|rcsb pdb:4INI|rcsb pdb:5KM5|rcsb pdb:5KM8|rcsb pdb:5KM9|rcsb pdb:6YI0|rcsb pdb:6YPX|rcsb pdb:6YQD|rcsb pdb:6YVP|reactome:R-HSA-9013405|rcsb pdb:6YPR - - function:Probable hydrolase|comment:mint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:DNpQta4PaPrYoOZsPdfIkLmEsFI9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P43304 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-7600203|uniprotkb:Q59FR1|intact:MINT-4530883|uniprotkb:Q9HAP9|uniprotkb:A8K4V0|uniprotkb:B3KSA9|ensembl:ENSP00000308610|ensembl:ENSP00000386425|ensembl:ENSP00000386626|ensembl:ENSP00000409708 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:gpdm_human(display_long)|uniprotkb:GPD2(gene name)|psi-mi:GPD2(display_short)|uniprotkb:mtGPD(gene name synonym)|uniprotkb:mitohondrial glycerophosphate dehydrogenase gene(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:XP_016859319.1|refseq:XP_011509279.1|refseq:NP_001076581.2|refseq:NP_000399.3|refseq:XP_005246526.1|ensembl:ENSG00000115159(gene)|ensembl:ENST00000310454(transcript)|ensembl:ENST00000409674(transcript)|ensembl:ENST00000409861(transcript)|ensembl:ENST00000438166(transcript)|go:"GO:0004368"("glycerol-3-phosphate dehydrogenase (quinone) activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006072"(glycerol-3-phosphate metabolic process)|go:"GO:0006127"(glycerophosphate shuttle)|go:"GO:0009331"(glycerol-3-phosphate dehydrogenase complex)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0052591"("sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity")|interpro:IPR000447(FAD-dependent glycerol-3-phosphate dehydrogenase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR031656|interpro:IPR036188|interpro:IPR038299|reactome:R-HSA-1483166|reactome:R-HSA-163560 - - comment:mint|comment:homomint figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:PsG9Eo7dfk8l+vDJl6d4WfEST849606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6UXV4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-9641073|uniprotkb:Q3KNU7|uniprotkb:Q5H9D1|ensembl:ENSP00000362268 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mic27_human(display_long)|uniprotkb:APOOL(gene name)|psi-mi:APOOL(display_short)|uniprotkb:CXorf33(gene name synonym)|uniprotkb:FAM121A(gene name synonym)|uniprotkb:Protein FAM121A(gene name synonym)|uniprotkb:UNQ8193/PRO23204(orf name)|uniprotkb:Apolipoprotein O-like(gene name synonym)|uniprotkb:MIC27(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_940852.3|dip:DIP-47309N|ensembl:ENSG00000155008(gene)|ensembl:ENST00000373173(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|mint:Q6UXV4|reactome:R-HSA-114608|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ylhhtQDkjSpam535KFeGRCsybfE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q7L0Y3 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2107046|uniprotkb:Q9NRG5|uniprotkb:Q9NX54|uniprotkb:Q9Y596|ensembl:ENSP00000312356 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tm10c_human(display_long)|uniprotkb:TRMT10C(gene name)|psi-mi:TRMT10C(display_short)|uniprotkb:HBV pre-S2 trans-regulated protein 2(gene name synonym)|uniprotkb:MRPP1(gene name synonym)|uniprotkb:RG9MTD1(gene name synonym)|uniprotkb:"RNA (guanine-9-)-methyltransferase domain-containing protein 1"(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-49(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 1(gene name synonym)|uniprotkb:"mRNA methyladenosine-N(1)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (adenine(9)-N(1))-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (guanine(9)-N(1))-methyltransferase"(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060289.2|ensembl:ENSG00000174173(gene)|ensembl:ENST00000309922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009019"("tRNA (guanine-N1-)-methyltransferase activity")|go:"GO:0016429"("tRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0052905"("tRNA (guanine(9)-N(1))-methyltransferase activity")|go:"GO:0061953"("mRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090646"(mitochondrial tRNA processing)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR007356("tRNA (guanine-N1-)-methyltransferase, eukaryotic")|interpro:IPR016009("tRNA (guanine-N1-)-methyltransferase")|interpro:IPR025812|interpro:IPR028564|interpro:IPR038459|mint:Q7L0Y3|rcsb pdb:5NFJ|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-8868766 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ZvCWxNlWBon4eDq2zgzVTk3dI7U9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P82673 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2513649|ensembl:ENSP00000081029|uniprotkb:Q6P4C6|uniprotkb:Q7L1M6|uniprotkb:Q9HC14|uniprotkb:Q96AI0|uniprotkb:Q32LZ1|uniprotkb:Q9H044|uniprotkb:Q9P1R5|uniprotkb:Q8NBP4 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt35_human(display_long)|uniprotkb:MRPS35(gene name)|psi-mi:MRPS35(display_short)|uniprotkb:MRPS28(gene name synonym)|uniprotkb:28S ribosomal protein S28, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS35(gene name synonym)|uniprotkb:HDCMD11P(orf name)|uniprotkb:MDS023(orf name)|uniprotkb:PSEC0213(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000061794(gene)|ensembl:ENST00000081029(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR019349|interpro:IPR039848|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_001177793.1|refseq:NP_068593.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:L7fhBRRkth1ePVbRtuVTvC5zcR09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O00746 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-744871|uniprotkb:Q5U0M9|ensembl:ENSP00000219479|uniprotkb:A2IDD0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndkm_human(display_long)|uniprotkb:nm23-H4(gene name synonym)|uniprotkb:Nucleoside diphosphate kinase D(gene name synonym)|uniprotkb:NME4(gene name)|psi-mi:NME4(display_short)|uniprotkb:NM23D(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001273362.1|refseq:NP_001273364.1|refseq:NP_001273365.1|refseq:NP_001273367.1|refseq:NP_001273368.1|refseq:NP_001273369.1|refseq:NP_005000.1|ensembl:ENSG00000103202(gene)|ensembl:ENST00000219479(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:O00746|rcsb pdb:1EHW|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ybA9I8oT+oz1iuGLHT7WR1SAaKY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y2S7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P09496 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q7Z7K0 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P30101 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q5ST30 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9UJS0 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43920 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246091|ensembl:ENSP00000362058|ensembl:ENSP00000362060 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus5_human(display_long)|uniprotkb:NDUFS5(gene name)|psi-mi:NDUFS5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 15 kDa subunit(gene name synonym)|uniprotkb:Complex I-15 kDa(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001171908.1|refseq:NP_004543.1|ensembl:ENSG00000168653(gene)|ensembl:ENST00000372967(transcript)|ensembl:ENST00000372969(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019342|mint:O43920|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:q74OuEXKdyCuxrUujwHeZjkW2gY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q5T440 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10714899|ensembl:ENSP00000355672 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:caf17_human(display_long)|uniprotkb:Iron-sulfur cluster assembly factor homolog(gene name synonym)|uniprotkb:IBA57(gene name)|psi-mi:IBA57(display_short)|uniprotkb:C1orf69(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001010867.1|ensembl:ENSG00000181873(gene)|ensembl:ENST00000366711(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016740"(transferase activity)|interpro:IPR017703(Folate-binding, YgfZ)|interpro:IPR027266|rcsb pdb:6GEU|rcsb pdb:6QE3|rcsb pdb:6QE4 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:20ToUTe4EoBuv31juWsDvsuyQY89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NYY8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1055752|uniprotkb:Q9NVX6|uniprotkb:Q9Y2H7|ensembl:ENSP00000236980|ensembl:ENSP00000384929|ensembl:ENSP00000385990|intact:EBI-21354662 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:fakd2_human(display_long)|uniprotkb:FASTKD2(gene name)|psi-mi:FASTKD2(display_short)|uniprotkb:KIAA0971(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001129665.1|refseq:NP_001129666.1|refseq:NP_055744.2|ensembl:ENST00000402774(transcript)|ensembl:ENST00000403094(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006396"(RNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0019843"(rRNA binding)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|ensembl:ENST00000236980(transcript)|ensembl:ENSG00000118246(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:b7H58ZWEhq5IFl+wO3fsez1v+1U9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75380 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-719854|ensembl:ENSP00000274137 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus6_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-A subunit(gene name synonym)|uniprotkb:Complex I-13kD-A(gene name synonym)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004544.1|ensembl:ENSG00000145494(gene)|ensembl:ENST00000274137(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:IfpFyQjgJW6a8wA2pNw14stMUL49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43678 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P45954 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NVV4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2556166|uniprotkb:Q659E3|uniprotkb:Q9HA74|uniprotkb:Q6P7E5|uniprotkb:D3DRX0|ensembl:ENSP00000263063 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:papd1_human(display_long)|uniprotkb:PAPD1(gene name synonym)|uniprotkb:mtPAP(gene name synonym)|uniprotkb:Polynucleotide adenylyltransferase(gene name synonym)|uniprotkb:PAP-associated domain-containing protein 1(gene name synonym)|uniprotkb:Terminal uridylyltransferase 1(gene name synonym)|uniprotkb:MTPAP(gene name)|psi-mi:MTPAP(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060579.3|ensembl:ENSG00000107951(gene)|ensembl:ENST00000263063(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002134"(UTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR041252|interpro:IPR043519|rcsb pdb:3PQ1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:KUNsYSjhCHVHD8WnZbw5V60Wlec9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y2R9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1054973|uniprotkb:Q53GD6|uniprotkb:B2R9N5|ensembl:ENSP00000245539 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt07_human(display_long)|uniprotkb:bMRP-27a(gene name synonym)|uniprotkb:MRPS7(gene name)|psi-mi:MRPS7(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS7m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057055.2|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0019843"(rRNA binding)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR023798|interpro:IPR036823|mint:Q9Y2R9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125445(gene)|ensembl:ENST00000245539(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:hrz2XVS38Ex1z125QFx/n9oPsys9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P14927 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-743128|ensembl:ENSP00000287022|uniprotkb:Q6FGD1|uniprotkb:E5RJU0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:qcr7_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex 14 kDa protein(gene name synonym)|uniprotkb:Complex III subunit 7(gene name synonym)|uniprotkb:Complex III subunit VII(gene name synonym)|uniprotkb:QP-C(gene name synonym)|uniprotkb:UQCRB(gene name)|psi-mi:UQCRB(display_short)|uniprotkb:UQBP(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000156467(gene)|ensembl:ENST00000287022(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0009060"(aerobic respiration)|interpro:IPR003197(Cytochrome bd ubiquinol oxidase, 14 kDa subunit)|interpro:IPR036544|mint:P14927|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|refseq:NP_006285.1|refseq:NP_001186904.1|refseq:NP_001241681.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:JEa3rOlDB4nVyYDniZrcnF9b1Wg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8IWV7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-711736|uniprotkb:O60708|uniprotkb:O75492|uniprotkb:Q14D45|uniprotkb:Q68DN9|uniprotkb:Q8IWY6|uniprotkb:Q96JY4|ensembl:ENSP00000290650 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ubr1_human(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:UBR1(gene name)|psi-mi:UBR1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_777576.1|dip:DIP-47033N|ensembl:ENSG00000159459(gene)|ensembl:ENST00000290650(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV7|rcsb pdb:3NY1|rcsb pdb:5TDC|reactome:R-HSA-983168 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:BcTsfaVfIa+WpIb8EPaPca2UZN89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y5J7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1200370|uniprotkb:B2R584|ensembl:ENSP00000378588|ensembl:ENSP00000450638|ensembl:ENSP00000451006|ensembl:ENSP00000451198 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim9_human(display_long)|uniprotkb:TIMM9(gene name)|psi-mi:TIMM9(display_short)|uniprotkb:TIM9(gene name synonym)|uniprotkb:TIM9A(gene name synonym)|uniprotkb:TIMM9A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001291415.1|refseq:NP_001291414.1|refseq:NP_001291416.1|refseq:NP_001291417.1|refseq:NP_001291418.1|refseq:NP_001291419.1|refseq:NP_001291420.1|refseq:NP_036592.1|ensembl:ENSG00000100575(gene)|ensembl:ENST00000395159(transcript)|ensembl:ENST00000555061(transcript)|ensembl:ENST00000555404(transcript)|ensembl:ENST00000555593(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0051087"(chaperone binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|rcsb pdb:2BSK|rcsb pdb:7CGP|reactome:R-HSA-1268020|go:"GO:0008270"(zinc ion binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:a/L4LPXEAEVYZ54duHzDlaBt9W49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y5J9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1049085|uniprotkb:Q3KQS9|uniprotkb:Q9UN04|uniprotkb:B0YJA5|ensembl:ENSP00000422122 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim8b_human(display_long)|uniprotkb:Deafness dystonia protein 2(gene name synonym)|uniprotkb:DDP-like protein(gene name synonym)|uniprotkb:TIM8B(gene name synonym)|uniprotkb:TIMM8B(gene name)|psi-mi:TIMM8B(display_short)|uniprotkb:DDP2(gene name synonym)|uniprotkb:DDPL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_036591.2|ensembl:ENSG00000150779(gene)|ensembl:ENST00000504148(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5J9|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:7DK/1BIkwyl9KMIgEFWqRhZn2ZE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8IYB8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2876787|ensembl:ENSP00000352678|uniprotkb:O43630|intact:EBI-3205796|uniprotkb:A8K301 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:suv3_human(display_long)|uniprotkb:SUPV3L1(gene name)|psi-mi:SUPV3L1(display_short)|uniprotkb:SUV3(gene name synonym)|uniprotkb:Suppressor of var1 3-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000156502(gene)|ensembl:ENST00000359655(transcript)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0000965"(mitochondrial RNA 3'-end processing)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006310"(DNA recombination)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0035945"(mitochondrial ncRNA surveillance)|go:"GO:0035946"(mitochondrial mRNA surveillance)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045025"(mitochondrial degradosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070827"(obsolete chromatin maintenance)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000827"(mitochondrial RNA surveillance)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022192|interpro:IPR027417|interpro:IPR041082|interpro:IPR041453|interpro:IPR044774|rcsb pdb:3RC3|rcsb pdb:3RC8|refseq:NP_001288612.1|refseq:NP_003162.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:XmEujscj0Njj3Un62nLFTzgqr6Y9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43819 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-357012|uniprotkb:Q3T1B5|uniprotkb:Q9UK87|ensembl:ENSP00000252785|ensembl:ENSP00000379046|ensembl:ENSP00000444242|ensembl:ENSP00000444433 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sco2_human(display_long)|uniprotkb:SCO2(gene name)|psi-mi:SCO2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001162580.1|refseq:NP_001162581.1|refseq:NP_001162582.1|refseq:NP_005129.2|dip:DIP-46088N|go:"GO:0003012"(muscle system process)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0014823"(response to activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|mint:O43819|rcsb pdb:2RLI|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000284194(gene)|ensembl:ENST00000252785(transcript)|ensembl:ENST00000395693(transcript)|ensembl:ENST00000535425(transcript)|ensembl:ENST00000543927(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001701"(in utero embryonic development) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:RaD9DPaOnFKJvwNRUK9KQdptmqc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P63000 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P03905 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9H2W6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6393565|ensembl:ENSP00000312311|uniprotkb:B2RD75|uniprotkb:Q9HBU8 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rm46_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL46(gene name synonym)|uniprotkb:MRPL46(gene name)|psi-mi:MRPL46(display_short)|uniprotkb:C15orf4(gene name synonym)|uniprotkb:LIECG2(gene name synonym)|uniprotkb:P2ECSL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000259494(gene)|ensembl:ENST00000312475(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030054"(cell junction)|interpro:IPR015797(NUDIX)|interpro:IPR021757|interpro:IPR033650|interpro:IPR040008|mint:Q9H2W6|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|rcsb pdb:7A5K|reactome:R-HSA-5419276|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|refseq:NP_071446.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:7u4sNH/MVFnEZRMjr7ey6d8WpfM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9HAV7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1043499|uniprotkb:Q549M6|uniprotkb:B2R783|ensembl:ENSP00000264954 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:grpe1_human(display_long)|uniprotkb:Mt-GrpE#1(gene name synonym)|uniprotkb:HMGE(gene name synonym)|uniprotkb:GRPEL1(gene name)|psi-mi:GRPEL1(display_short)|uniprotkb:GREPEL1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000109519(gene)|ensembl:ENST00000264954(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001405"(PAM complex, Tim23 associated import motor)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000740(GrpE nucleotide exchange factor)|interpro:IPR009012(GrpE nucleotide exchange factor, head)|interpro:IPR013805(GrpE nucleotide exchange factor, coiled-coil)|mint:Q9HAV7|reactome:R-HSA-1268020|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_079472.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:OWuX4gnZBzxgv0arSEKY9KyZZ+o9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75616 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BRQ6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2557895|ensembl:ENSP00000290913|uniprotkb:D6R9U0|uniprotkb:D6RIB4|uniprotkb:H8Y0Y7 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mic25_human(display_long)|uniprotkb:CHCHD6(gene name)|psi-mi:CHCHD6(display_short)|uniprotkb:CHCM1(gene name synonym)|uniprotkb:Coiled-coil-helix cristae morphology protein 1(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:MIC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_115719.1|refseq:NP_001307539.1|ensembl:ENSG00000159685(gene)|ensembl:ENST00000290913(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR042860|mint:Q9BRQ6|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:6jrzreYX6MJWPfMKh2EKqiEca1s9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96TA2 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8IWV8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6DKK2 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43715 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2820212|uniprotkb:Q5RKS5|uniprotkb:Q6LCA7|uniprotkb:B2R4Z7|ensembl:ENSP00000449795 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tria1_human(display_long)|uniprotkb:TRIAP1(gene name)|psi-mi:TRIAP1(display_short)|uniprotkb:15E1.1(gene name synonym)|uniprotkb:Protein 15E1.1(gene name synonym)|uniprotkb:WF-1(gene name synonym)|uniprotkb:p53-inducible cell-survival factor(gene name synonym)|uniprotkb:HSPC132(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057483.1|ensembl:ENSG00000170855(gene)|ensembl:ENST00000546954(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0015914"(phospholipid transport)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097035"(regulation of membrane lipid distribution)|go:"GO:0120009"(intermembrane lipid transfer)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2001140"(positive regulation of phospholipid transport)|interpro:IPR007918(Mitochondrial distribution and morphology family 35/apoptosis)|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:6I3V|rcsb pdb:6I3Y|rcsb pdb:6I4Y|reactome:R-HSA-6803204 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:LL+TOKGHJU1ng1UNFazVOxkQvmY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O94826 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6PI78 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6656213|ensembl:ENSP00000297632|uniprotkb:Q8N5G8|uniprotkb:Q8WVK5 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tmm65_human(display_long)|uniprotkb:TMEM65(gene name)|psi-mi:TMEM65(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR019537|ensembl:ENSG00000164983(gene)|ensembl:ENST00000297632(transcript)|go:"GO:0003231"(cardiac ventricle development)|refseq:NP_919267.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:WPwheAbhf1OxtAf2KVEwCIPYr1o9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NWH2 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10315004|uniprotkb:Q9NZ88|uniprotkb:B9EJD0|uniprotkb:Q9P094|ensembl:ENSP00000383594 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tm242_human(display_long)|uniprotkb:TMEM242(gene name)|psi-mi:TMEM242(display_short)|uniprotkb:C6orf35(gene name synonym)|uniprotkb:BM-033(orf name)|uniprotkb:HSPC287(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060922.2|ensembl:ENSG00000215712(gene)|ensembl:ENST00000400788(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009792(Protein of unknown function DUF1358) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Gt5hJPgjC+MEGeCQNxgc04W/nvk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8IUX1 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2800657|uniprotkb:Q32Q09|uniprotkb:Q9NZ29|uniprotkb:Q96EP3|uniprotkb:Q8WVU3|uniprotkb:A8K535|uniprotkb:A8MSS0|ensembl:ENSP00000351737 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:t126b_human(display_long)|uniprotkb:TMEM126B(gene name)|psi-mi:TMEM126B(display_short)|uniprotkb:Transmembrane protein 126B(gene name synonym)|uniprotkb:HT007(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:XP_011543467.1|refseq:NP_001180467.1|refseq:NP_060950.3|refseq:NP_001243475.1|ensembl:ENSG00000171204(gene)|ensembl:ENST00000358867(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:eQNEaTeYOl8NJlnxhrTi3R6m66I9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9H061 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10963884|ensembl:ENSP00000306887|uniprotkb:E9PI16|uniprotkb:B2R570 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:t126a_human(display_long)|uniprotkb:TMEM126A(gene name)|psi-mi:TMEM126A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001231664.1|refseq:NP_115649.1|ensembl:ENSG00000171202(gene)|ensembl:ENST00000304511(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021554"(optic nerve development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009801(Protein of unknown function DUF1370)|mint:Q9H061 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:eoOBOQwbptvpCACbOjdG5oQEb2I9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NPL8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O60220 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q3ZCQ8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O60830 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2372529|uniprotkb:Q9UJV0|uniprotkb:A8K2E2|uniprotkb:J3KPV3|ensembl:ENSP00000365766 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ti17b_human(display_long)|uniprotkb:TIMM17B(gene name)|psi-mi:TIMM17B(display_short)|uniprotkb:TIM17B(gene name synonym)|uniprotkb:JM3(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001161419.1|refseq:NP_005825.1|ensembl:ENSG00000126768(gene)|ensembl:ENST00000376582(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005678(Mitochondrial import inner membrane translocase, subunit Tim17)|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:2jmF1ZItisqPDfdGgX/bY9FFE9E9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y5L4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P62072 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1200391|uniprotkb:Q9WV99|uniprotkb:Q9WVA0|uniprotkb:Q9Y5J8|uniprotkb:A8K136|ensembl:ENSP00000257245|ensembl:ENSP00000433627|ensembl:ENSP00000435678 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim10_human(display_long)|uniprotkb:TIMM10(gene name)|psi-mi:TIMM10(display_short)|uniprotkb:TIM10(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_036588.1|ensembl:ENSG00000134809(gene)|ensembl:ENST00000257245(transcript)|ensembl:ENST00000525158(transcript)|ensembl:ENST00000525587(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0051087"(chaperone binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR027100|interpro:IPR035427|rcsb pdb:2BSK|rcsb pdb:7CGP|reactome:R-HSA-1268020|go:"GO:0007605"(sensory perception of sound) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:8Ygf3Hjx342xU28Mggg7oTD6hAQ9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q00059 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BSH4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-747797|uniprotkb:Q8N3N6|uniprotkb:Q9UI60|uniprotkb:B2RD21|ensembl:ENSP00000258975 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:taco1_human(display_long)|uniprotkb:PRO0477(orf name)|uniprotkb:TACO1(gene name)|psi-mi:TACO1(display_short)|uniprotkb:CCDC44(gene name synonym)|uniprotkb:Translational activator of mitochondrially-encoded cytochrome c oxidase I(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057444.2|ensembl:ENSG00000136463(gene)|ensembl:ENST00000258975(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0019843"(rRNA binding)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0061743"(motor learning)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR002876(Protein of unknown function DUF28)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR026564|interpro:IPR029072|mint:Q9BSH4|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:c/tu89NvCs3Kt8qO8e5F6hrywBo9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9GZT3 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6PML9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2818242|uniprotkb:Q8TBB2|uniprotkb:Q7Z5I7|uniprotkb:Q4W5B6|uniprotkb:Q9Y6R2|ensembl:ENSP00000264451 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:znt9_human(display_long)|uniprotkb:SLC30A9(gene name)|psi-mi:SLC30A9(display_short)|uniprotkb:C4orf1(gene name synonym)|uniprotkb:HUEL(gene name synonym)|uniprotkb:Human embryonic lung protein(gene name synonym)|uniprotkb:Solute carrier family 30 member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_006336.3|ensembl:ENSG00000014824(gene)|ensembl:ENST00000264451(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002524(Cation efflux protein)|interpro:IPR009061(Putative DNA binding)|interpro:IPR027469|interpro:IPR037129|interpro:IPR040177|rcsb pdb:2ENK - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:FOpcvusmMSLnk+espRUTV4ijPoQ9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6KCM7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-11289059|uniprotkb:Q5SYW7|uniprotkb:Q5SYW8|uniprotkb:Q5SYX3|uniprotkb:Q5VWU2|uniprotkb:Q5VWU3|uniprotkb:Q5VWU4|uniprotkb:Q6KCM4|uniprotkb:Q6KCM6|uniprotkb:Q6UX48|uniprotkb:Q705K2|uniprotkb:Q96PZ1|uniprotkb:Q9BSA6|ensembl:ENSP00000362155 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:scmc2_human(display_long)|uniprotkb:SLC25A25(gene name)|psi-mi:SLC25A25(display_short)|uniprotkb:APC3(gene name synonym)|uniprotkb:KIAA1896(gene name synonym)|uniprotkb:MCSC3(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 3(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 3"(gene name synonym)|uniprotkb:SCAMC2(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 25(gene name synonym)|uniprotkb:UNQ549/PRO1106(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001006642.1|refseq:NP_001006643.1|refseq:NP_001252543.1|refseq:NP_443133.2|refseq:XP_005251746.1|ensembl:ENSG00000148339(gene)|ensembl:ENST00000373064(transcript)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032094"(response to food)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|refseq:NP_001317917.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:8scX7Hlkx6rPbDpdTtf7vNn7lqM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q6NUK1 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-4289949|uniprotkb:Q705K4|uniprotkb:B7ZAI9|uniprotkb:Q5T331|uniprotkb:Q9P129|uniprotkb:Q5T485|uniprotkb:Q6PJJ9|ensembl:ENSP00000457733|ensembl:ENSP00000491572 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:scmc1_human(display_long)|uniprotkb:SLC25A24(gene name)|psi-mi:SLC25A24(display_short)|uniprotkb:APC1(gene name synonym)|uniprotkb:MCSC1(gene name synonym)|uniprotkb:SCAMC1(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 1(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 1"(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 24(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_037518.3|refseq:NP_998816.1|ensembl:ENSG00000085491(gene)|ensembl:ENSG00000284468(gene)|ensembl:ENST00000565488(transcript)|ensembl:ENST00000640416(transcript)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0015867"(ATP transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q6NUK1|rcsb pdb:4N5X|rcsb pdb:4ZCU|rcsb pdb:4ZCV - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:2zVynZiDVY5UzziL6TAmqK/fkB09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75746 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P34897 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BWM7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1171999|uniprotkb:Q8NCJ0|uniprotkb:Q9NTP4|ensembl:ENSP00000377103 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sfxn3_human(display_long)|uniprotkb:SFXN3(gene name)|psi-mi:SFXN3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_112233.2|ensembl:ENST00000393459(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q9BWM7|ensembl:ENSG00000107819(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Fbem/nUN4NlpIECvuMoF8SjB7ys9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96BR5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P31040 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75880 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6656171|ensembl:ENSP00000255390|uniprotkb:B2RDM0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sco1_human(display_long)|uniprotkb:SCO1(gene name)|psi-mi:SCO1(display_short)|uniprotkb:SCOD1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000133028(gene)|ensembl:ENST00000255390(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|rcsb pdb:1WP0|rcsb pdb:2GGT|rcsb pdb:2GQK|rcsb pdb:2GQL|rcsb pdb:2GQM|rcsb pdb:2GT5|rcsb pdb:2GT6|rcsb pdb:2GVP|rcsb pdb:2HRF|rcsb pdb:2HRN|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_004580.1|dip:DIP-46086N|refseq:XP_005256808.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:oxGxX5mXuGDP5uPIW1vyOtaQHxU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y512 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9HC36 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1045440|uniprotkb:Q9NVQ5|uniprotkb:Q53GN1|uniprotkb:Q86VC3|uniprotkb:Q96F76|ensembl:ENSP00000306080 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mrm3_human(display_long)|uniprotkb:MRM3(gene name)|psi-mi:MRM3(display_short)|uniprotkb:"16S rRNA (guanosine(1370)-2'-O)-methyltransferase"(gene name synonym)|uniprotkb:16S rRNA [Gm1370] 2'-O-methyltransferase(gene name synonym)|uniprotkb:RNA methyltransferase-like protein 1(gene name synonym)|uniprotkb:RNMTL1(gene name synonym)|uniprotkb:HC90(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060616.1|refseq:NP_001304876.1|ensembl:ENSG00000171861(gene)|ensembl:ENST00000304478(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0070039"("rRNA (guanosine-2'-O-)-methyltransferase activity")|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR013123(RNA 2-O ribose methyltransferase, substrate binding)|interpro:IPR029028|interpro:IPR029064|mint:Q9HC36|reactome:R-HSA-6793080 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:oOaJQgUM9tpIOv6A20UkLtAQH9c9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P13489 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96C36 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P32322 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96EY7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-721110|uniprotkb:A6NHD2|uniprotkb:Q597H0|uniprotkb:Q658Y9|uniprotkb:Q9BUZ8|uniprotkb:Q9NWL0|intact:EBI-2560120|uniprotkb:D6W5M1|ensembl:ENSP00000254630 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ptcd3_human(display_long)|uniprotkb:Transformation-related gene 15 protein(gene name synonym)|uniprotkb:TRG15(orf name)|uniprotkb:28S ribosomal protein S39, mitochondrial(gene name synonym)|uniprotkb:MRPS39(gene name synonym)|uniprotkb:PTCD3(gene name)|psi-mi:PTCD3(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS39(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060422.4|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR037387|mint:Q96EY7|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|go:"GO:0019843"(rRNA binding)|rcsb pdb:6ZSC|ensembl:ENSG00000132300(gene)|ensembl:ENST00000254630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSD - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:k9hyBtBrNbiBMJ5gtOQ9R6Grl9U9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q4J6C6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-949331|uniprotkb:A7E2X6|uniprotkb:O43163|uniprotkb:Q4J6C3|uniprotkb:Q4J6C4|uniprotkb:Q4ZG39|uniprotkb:Q6ZMW7|uniprotkb:Q96DW7|uniprotkb:D6W5A3|ensembl:ENSP00000260648|ensembl:ENSP00000386509|ensembl:ENSP00000386543|ensembl:ENSP00000386909|ensembl:ENSP00000391456|ensembl:ENSP00000409480 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ppcel_human(display_long)|uniprotkb:KIAA0436(gene name synonym)|uniprotkb:Prolylendopeptidase-like(gene name synonym)|uniprotkb:PREPL(gene name)|psi-mi:PREPL(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001035844.1|refseq:NP_001035845.1|refseq:NP_001165074.1|refseq:NP_001165077.1|refseq:NP_001165084.1|refseq:NP_001165088.1|refseq:NP_006027.2|refseq:XP_011531500.1|refseq:XP_011531502.1|refseq:XP_011531504.1|refseq:XP_016860873.1|refseq:XP_016860874.1|ensembl:ENSG00000138078(gene)|ensembl:ENST00000260648(transcript)|ensembl:ENST00000409272(transcript)|ensembl:ENST00000409936(transcript)|ensembl:ENST00000410081(transcript)|ensembl:ENST00000425263(transcript)|ensembl:ENST00000426481(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008233"(peptidase activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002470(Peptidase S9A, prolyl oligopeptidase)|interpro:IPR023302|interpro:IPR029058 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:xn++9zR6AX/HzP4KzrriJR5IUTk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P30405 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-5544229|uniprotkb:Q2YDB7|uniprotkb:Q5W131|ensembl:ENSP00000225174 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ppif_human(display_long)|uniprotkb:PPIF(gene name)|psi-mi:PPIF(display_short)|uniprotkb:CYP3(gene name synonym)|uniprotkb:Cyclophilin F(gene name synonym)|uniprotkb:Rotamase F(gene name synonym)|uniprotkb:Cyclophilin D(gene name synonym)|uniprotkb:Mitochondrial cyclophilin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_005720.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010849"(regulation of proton-transporting ATPase activity, rotational mechanism)|go:"GO:0010939"(regulation of necrotic cell death)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902686"(mitochondrial outer membrane permeabilization involved in programmed cell death)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P30405|rcsb pdb:2BIT|rcsb pdb:2BIU|rcsb pdb:2Z6W|rcsb pdb:3QYU|rcsb pdb:3R49|rcsb pdb:3R4G|rcsb pdb:3R54|rcsb pdb:3R56|rcsb pdb:3R57|rcsb pdb:3R59|rcsb pdb:3RCF|rcsb pdb:3RCG|rcsb pdb:3RCI|rcsb pdb:3RCK|rcsb pdb:3RCL|rcsb pdb:3RD9|rcsb pdb:3RDA|rcsb pdb:3RDB|rcsb pdb:3RDC|rcsb pdb:4J58|rcsb pdb:4J59|rcsb pdb:4J5A|rcsb pdb:4J5B|rcsb pdb:4J5C|rcsb pdb:4J5D|rcsb pdb:4J5E|rcsb pdb:4O8H|rcsb pdb:4O8I|rcsb pdb:4XNC|rcsb pdb:4ZSC|rcsb pdb:4ZSD|rcsb pdb:5A0E|rcsb pdb:5CBT|rcsb pdb:5CBU|rcsb pdb:5CBV|rcsb pdb:5CBW|rcsb pdb:5CCN|rcsb pdb:5CCQ|rcsb pdb:5CCR|rcsb pdb:5CCS|rcsb pdb:6R8L|rcsb pdb:6R8O|rcsb pdb:6R8W|rcsb pdb:6R9S|rcsb pdb:6R9U|rcsb pdb:6R9X|rcsb pdb:6RA1|rcsb pdb:6Y3E|rcsb pdb:6YBM|ensembl:ENSG00000108179(gene)|ensembl:ENST00000225174(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0002931"(response to ischemia)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:5sa9mIaCM/Fo9PA4NgA1p4c4WIg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8TCS8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1052020|uniprotkb:Q53SU0|uniprotkb:Q68CN1|uniprotkb:Q7Z7D1|uniprotkb:Q8IWX1|uniprotkb:Q96T05|uniprotkb:Q9BRU3|uniprotkb:Q9BVX0|ensembl:ENSP00000393953|ensembl:ENSP00000400646 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:pnpt1_human(display_long)|uniprotkb:Polynucleotide phosphorylase 1(gene name synonym)|uniprotkb:Polynucleotide phosphorylase-like protein(gene name synonym)|uniprotkb:PNPase old-35(gene name synonym)|uniprotkb:3'-5' RNA exonuclease OLD35(gene name synonym)|uniprotkb:PNPT1(gene name)|psi-mi:PNPT1(display_short)|uniprotkb:PNPASE(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_149100.2|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|go:"GO:0097222"(mitochondrial mRNA polyadenylation)|go:"GO:0097421"(liver regeneration)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR003029(S1, RNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012162(Polyribonucleotide nucleotidyltransferase)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR015848(Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type)|interpro:IPR020568|interpro:IPR022967|interpro:IPR027408|interpro:IPR036345|interpro:IPR036456|interpro:IPR036612|rcsb pdb:3U1K|rcsb pdb:5ZF6|ensembl:ENSG00000138035(gene)|ensembl:ENST00000415374(transcript)|ensembl:ENST00000447944(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000957"(mitochondrial RNA catabolic process)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0000965"(mitochondrial RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0034046"("poly(G) binding")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035927"(RNA import into mitochondrion)|go:"GO:0035928"(rRNA import into mitochondrion)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043631"(RNA polyadenylation)|go:"GO:0045025"(mitochondrial degradosome)|go:"GO:0004654"(polyribonucleotide nucleotidyltransferase activity)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060416"(response to growth hormone)|dip:DIP-50226N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:W9hr1vfWv1b0v4xfMYatfKfOMcg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8NCN5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-16769589|ensembl:ENSP00000288050|ensembl:ENSP00000457916|uniprotkb:A7E298|uniprotkb:A8K8Y7|uniprotkb:B3KSE1|uniprotkb:Q6AI20|uniprotkb:Q6AWC9 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:pdpr_human(display_long)|uniprotkb:PDPR(gene name)|psi-mi:PDPR(display_short)|uniprotkb:KIAA1990(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000090857(gene)|ensembl:ENST00000288050(transcript)|ensembl:ENST00000568530(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR001763(Rhodanese-like)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR006222(Glycine cleavage T-protein, N-terminal)|interpro:IPR013977(Glycine cleavage T-protein, C-terminal barrel)|interpro:IPR027266|interpro:IPR029043|interpro:IPR032503|interpro:IPR036188|reactome:R-HSA-204174|refseq:NP_001309046.1|refseq:NP_060460.4|refseq:XP_005256072.1|refseq:XP_005256073.1|refseq:XP_016878876.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:jKDbjPDs6wBeHVsTm8j9cZj4yAA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y3D7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-721147|uniprotkb:Q6I9Z3|uniprotkb:Q9H5X3|ensembl:ENSP00000315693|ensembl:ENSP00000461047|ensembl:ENSP00000484240|ensembl:ENSP00000487678 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim16_human(display_long)|uniprotkb:Mitochondria-associated granulocyte macrophage CSF-signaling molecule(gene name synonym)|uniprotkb:PAM16(gene name)|psi-mi:PAM16(display_short)|uniprotkb:CGI-136(orf name)|uniprotkb:MAGMAS(gene name synonym)|uniprotkb:TIM16(gene name synonym)|uniprotkb:TIMM16(gene name synonym)|uniprotkb:Presequence translocated-associated motor subunit PAM16(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057153.8|ensembl:ENSG00000282228(gene)|ensembl:ENST00000318059(transcript)|ensembl:ENST00000576217(transcript)|ensembl:ENST00000616009(transcript)|ensembl:ENST00000634045(transcript)|go:"GO:0001405"(PAM complex, Tim23 associated import motor)|go:"GO:0001503"(ossification)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|interpro:IPR005341(Protein Transporter, Pam16)|interpro:IPR036869|reactome:R-HSA-1268020|ensembl:ENSG00000217930(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:k4Keu0mTFTL7XjWY9Ld9IKuJlhg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q15070 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-3917688|uniprotkb:B4DPA2|ensembl:ENSP00000350740 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:oxa1l_human(display_long)|uniprotkb:OXA1L(gene name)|psi-mi:OXA1L(display_short)|uniprotkb:Hsa(gene name synonym)|uniprotkb:OXA1Hs(gene name synonym)|uniprotkb:Oxidase assembly 1-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_005006.3|ensembl:ENSG00000155463(gene)|ensembl:ENST00000358043(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0097177"(mitochondrial ribosome binding)|interpro:IPR001708(60 kDa inner membrane insertion protein)|interpro:IPR028055|mint:Q15070|rcsb pdb:6ZM5|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:1C8BWezMWHLLnmHl7vOik3WJmKY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O60313 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96E52 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q56VL3 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6152758|uniprotkb:Q8N544|uniprotkb:B4DPE7|ensembl:ENSP00000423014 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ocad2_human(display_long)|uniprotkb:Ovarian carcinoma immunoreactive antigen-like protein(gene name synonym)|uniprotkb:OCIAD2(gene name)|psi-mi:OCIAD2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001014446.1|refseq:NP_689611.1|refseq:NP_001273702.1|ensembl:ENSG00000145247(gene)|ensembl:ENST00000508632(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0009617"(response to bacterium)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:z4I/nxTOVnbJ/RZhY11VYbBas0g9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NX40 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2683029|uniprotkb:C9K030|uniprotkb:Q9BZE8|ensembl:ENSP00000264312|ensembl:ENSP00000370882|ensembl:ENSP00000423002|ensembl:ENSP00000423909|uniprotkb:G8JLN7 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ocad1_human(display_long)|uniprotkb:OCIA(gene name synonym)|uniprotkb:Ovarian carcinoma immunoreactive antigen(gene name synonym)|uniprotkb:OCIAD1(gene name)|psi-mi:OCIAD1(display_short)|uniprotkb:ASRIJ(gene name synonym)|uniprotkb:Ovarian cancer immunoreactive antigen domain containing 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001073309.1|refseq:NP_001073311.2|refseq:NP_001073308.1|refseq:NP_001073310.1|refseq:NP_060300.1|ensembl:ENSG00000109180(gene)|ensembl:ENST00000264312(transcript)|ensembl:ENST00000381473(transcript)|ensembl:ENST00000508293(transcript)|ensembl:ENST00000513391(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187|mint:Q9NX40|refseq:XP_016863818.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:e3Ojv8LBlgj056bssUZjEC+MB+Q9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y697 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P56181 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P19404 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P49821 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O00217 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75251 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-719652|uniprotkb:Q2T9H7|uniprotkb:Q9BV17|ensembl:ENSP00000233627|uniprotkb:B3KRI2 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 20 kDa subunit(gene name synonym)|uniprotkb:Complex I-20kD(gene name synonym)|uniprotkb:PSST subunit(gene name synonym)|uniprotkb:NDUFS7(gene name)|psi-mi:NDUFS7(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_077718.3|ensembl:ENSG00000115286(gene)|ensembl:ENST00000233627(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006138("NADH dehydrogenase (ubiquinone), 20 kDa subunit")|mint:O75251|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:DtNXT30ApcGKwTJSdNNwHd/q3+09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43181 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246139|uniprotkb:Q9BS69|ensembl:ENSP00000296684 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus4_human(display_long)|uniprotkb:NDUFS4(gene name)|psi-mi:NDUFS4(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 18 kDa subunit(gene name synonym)|uniprotkb:Complex I-18 kDa(gene name synonym)|uniprotkb:Complex I-AQDQ(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_002486.1|ensembl:ENSG00000164258(gene)|ensembl:ENST00000296684(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007420"(brain development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR006885(ETC complex I subunit conserved region)|interpro:IPR038532|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:T/NnuQagNs7EnceU9XKo4eUdy2o9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75489 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O75306 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P28331 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y6M9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O95169 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43674 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246293|uniprotkb:Q561V6|ensembl:ENSP00000259037 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndub5_human(display_long)|uniprotkb:NDUFB5(gene name)|psi-mi:NDUFB5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase SGDH subunit(gene name synonym)|uniprotkb:Complex I-SGDH(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001186886.1|refseq:NP_001186887.1|refseq:NP_002483.1|ensembl:ENSG00000136521(gene)|ensembl:ENST00000259037(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019173|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:1UrbNq39EsuKHJ2M7tRd8ZmB6uk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O43676 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-718365|uniprotkb:Q6IB80|ensembl:ENSP00000237889|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000410600|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndub3_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase B12 subunit(gene name synonym)|uniprotkb:Complex I-B12(gene name synonym)|uniprotkb:NDUFB3(gene name)|psi-mi:NDUFB3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_002482.1|refseq:XP_011509532.1|refseq:XP_016859675.1|refseq:NP_001244031.1|ensembl:ENSP00000237889|ensembl:ENSP00000410600|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208|ensembl:ENSG00000119013(gene)|ensembl:ENST00000237889(transcript)|ensembl:ENST00000433898(transcript)|ensembl:ENST00000450023(transcript)|ensembl:ENST00000454214(transcript)|ensembl:ENST00000682325(transcript)|ensembl:ENST00000684175(transcript)|ensembl:ENST00000684420(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR012576(NADH-ubiquinone oxidoreductase B12 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:APgw3aIZyyqiPCXMFJ9dUYPQhVE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NX14 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246182|uniprotkb:Q5JRR3|uniprotkb:Q5JRR4|uniprotkb:Q6IAB6|uniprotkb:Q8WZ96|uniprotkb:Q9BXX9|ensembl:ENSP00000367042 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndubb_human(display_long)|uniprotkb:NDUFB11(gene name)|psi-mi:NDUFB11(display_short)|uniprotkb:UNQ111/PRO1064(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase ESSS subunit(gene name synonym)|uniprotkb:Complex I-ESSS(gene name synonym)|uniprotkb:Neuronal protein 17.3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001129470.1|refseq:NP_061929.2|ensembl:ENSG00000147123(gene)|ensembl:ENST00000377811(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019329|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:CAloB+PJ0fcnLukpvgNGgTFJ0zs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O96000 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9P032 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BU61 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2114801|ensembl:ENSP00000323076 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8N183 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2682365|uniprotkb:A8K5I1|ensembl:ENSP00000296597 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduf2_human(display_long)|uniprotkb:NDUFA12L(gene name synonym)|uniprotkb:B17.2-like(gene name synonym)|uniprotkb:Myc-induced mitochondrial protein(gene name synonym)|uniprotkb:NDUFA12-like protein(gene name synonym)|uniprotkb:NDUFAF2(gene name)|psi-mi:NDUFAF2(display_short)|uniprotkb:Mimitin(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_777549.1|ensembl:ENSG00000164182(gene)|ensembl:ENST00000296597(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:sNje5xhXA48xAg0tSkOYiqBxZvk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y375 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-741874|uniprotkb:Q9BVZ5|ensembl:ENSP00000260361|ensembl:ENSP00000453944 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cia30_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1(gene name synonym)|uniprotkb:NDUFAF1(gene name)|psi-mi:NDUFAF1(display_short)|uniprotkb:CIA30(gene name synonym)|uniprotkb:CGI-65(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057097.2|ensembl:ENSG00000137806(gene)|ensembl:ENST00000260361(transcript)|ensembl:ENST00000560978(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0010257"(NADH dehydrogenase complex assembly)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013857("NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30")|interpro:IPR039131|mint:Q9Y375|reactome:R-HSA-6799198|refseq:XP_011519960.1|refseq:XP_006720618.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:cZmtaAs6upui/PVTTBGQBEOcWvk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P51970 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q16718 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9P0J0 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-372742|uniprotkb:Q6PKI0|uniprotkb:Q9H2L3|uniprotkb:Q9Y327|uniprotkb:B4DF76|uniprotkb:K7EK58|ensembl:ENSP00000423673 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduad_human(display_long)|uniprotkb:NDUFA13(gene name)|psi-mi:NDUFA13(display_short)|uniprotkb:CGI-39(orf name)|uniprotkb:CDA016(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase B16.6 subunit(gene name synonym)|uniprotkb:Complex I-B16.6(gene name synonym)|uniprotkb:Gene associated with retinoic and interferon-induced mortality 19 protein(gene name synonym)|uniprotkb:Cell death regulatory protein GRIM-19(gene name synonym)|uniprotkb:GRIM19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_057049.5|go:"GO:0005524"(ATP binding)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR009346(GRIM-19)|mint:Q9P0J0|rcsb pdb:5XTB|rcsb pdb:5XTC|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|ensembl:ENSG00000186010(gene)|ensembl:ENST00000507754(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|dip:DIP-31180N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:X5AsKHIxU5kpNVjY37UbZXG/Kns9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9UI09 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P03915 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1246343|uniprotkb:Q34773|uniprotkb:Q8WCY3|ensembl:ENSP00000354813 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nu5m_human(display_long)|uniprotkb:MT-ND5(gene name)|psi-mi:MT-ND5(display_short)|uniprotkb:MTND5(gene name synonym)|uniprotkb:NADH5(gene name synonym)|uniprotkb:ND5(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 5(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:YP_003024036.1|ensembl:ENSG00000198786(gene)|ensembl:ENST00000361567(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|interpro:IPR001516("NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal")|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003945(NADH-plastoquinone oxidoreductase, chain 5)|interpro:IPR010934(NADH dehydrogenase subunit 5, C-terminal)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:qQQpmtsDu8cJSW+Re15KtO+tgNs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q92665 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-720602|uniprotkb:Q8WTV8|uniprotkb:Q5VYC8|uniprotkb:B2RCS3|ensembl:ENSP00000315397 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt31_human(display_long)|uniprotkb:Imogen 38(gene name synonym)|uniprotkb:MRPS31(gene name)|psi-mi:MRPS31(display_short)|uniprotkb:IMOGN38(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS31(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_005821.2|ensembl:ENSG00000102738(gene)|ensembl:ENST00000323563(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR026299|mint:Q92665|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Le0Lq+WW56dP5NLuMB2eKFeg6b09606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BYN8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-721378|uniprotkb:Q96Q58|ensembl:ENSP00000369682 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt26_human(display_long)|uniprotkb:28S ribosomal protein S13, mitochondrial(gene name synonym)|uniprotkb:MRPS26(gene name)|psi-mi:MRPS26(display_short)|uniprotkb:RPMS13(gene name synonym)|uniprotkb:C20orf193(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS26(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_110438.1|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125901(gene)|ensembl:ENST00000380325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR026140|mint:Q9BYN8 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ZygMazfhjHbx+aFhRkeG87c4L6E9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96EL2 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1055789|uniprotkb:P82668|uniprotkb:Q96Q23|uniprotkb:Q9P047|uniprotkb:A4D1U9|ensembl:ENSP00000318158 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt24_human(display_long)|uniprotkb:bMRP-47(gene name synonym)|uniprotkb:MRPS24(gene name)|psi-mi:MRPS24(display_short)|uniprotkb:HSPC335(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS3m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_114403.1|ensembl:ENSG00000062582(gene)|ensembl:ENST00000317534(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR026146|mint:Q96EL2|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:OEtFmhoLM1Sw9YVrL88HZQ5Ju0g9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P82912 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2371859|uniprotkb:Q969D7|uniprotkb:Q96GI3|uniprotkb:Q9BYC3|uniprotkb:B2RD52|ensembl:ENSP00000317376 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rt11_human(display_long)|uniprotkb:MRPS11(gene name)|psi-mi:MRPS11(display_short)|uniprotkb:RPMS11(gene name synonym)|uniprotkb:Cervical cancer proto-oncogene 2 protein(gene name synonym)|uniprotkb:HCC2(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS11m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001308899.1|refseq:NP_001308901.1|refseq:NP_001308902.1|refseq:NP_001308903.1|refseq:NP_001308905.1|refseq:NP_073750.2|refseq:NP_789775.1|ensembl:ENSG00000181991(gene)|ensembl:ENST00000325844(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P82912|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:aw3XzNBYY0igd4AUE1OQyfFn8pk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q7Z2W9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6393520|ensembl:ENSP00000354580|uniprotkb:C9JPR2|uniprotkb:A6NKU0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rm21_human(display_long)|uniprotkb:MRPL21(gene name)|psi-mi:MRPL21(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL21m(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000197345(gene)|ensembl:ENST00000362034(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001787(Ribosomal protein L21)|interpro:IPR028909|interpro:IPR036164|mint:Q7Z2W9|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_852615.1|refseq:NP_852616.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:AtmLgjvRKsb8i5m6dl41VwqA1+Q9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BPX6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P40926 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P42704 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O95202 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1052895|uniprotkb:Q9UF65|uniprotkb:B4DED2|ensembl:ENSP00000305653 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:letm1_human(display_long)|uniprotkb:Leucine zipper-EF-hand-containing transmembrane protein 1(gene name synonym)|uniprotkb:LETM1(gene name)|psi-mi:LETM1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_036450.1|ensembl:ENSG00000168924(gene)|ensembl:ENST00000302787(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0015369"("calcium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042407"(cristae formation)|go:"GO:0043022"(ribosome binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0099093"(calcium export from the mitochondrion)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011685(LETM1-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR033122|interpro:IPR044202|reactome:R-HSA-8949215|reactome:R-HSA-9013408 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:mDxqXWqmgCjbaZLz4JqteqjDCik9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P83111 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96T52 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96LU5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NSE4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P61604 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P53701 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O00165 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P49590 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-3909030|uniprotkb:B4DDY8|intact:EBI-10988212|ensembl:ENSP00000230771|ensembl:ENSP00000494296 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:syhm_human(display_long)|uniprotkb:Histidyl-tRNA synthetase(gene name synonym)|uniprotkb:HARS2(gene name)|psi-mi:HARS2(display_short)|uniprotkb:HARSL(gene name synonym)|uniprotkb:HARSR(gene name synonym)|uniprotkb:HO3(gene name synonym)|uniprotkb:Histidine--tRNA ligase-like(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_036340.1|refseq:NP_001265660.1|refseq:NP_001265661.1|ensembl:ENSG00000112855(gene)|ensembl:ENST00000230771(transcript)|ensembl:ENST00000645749(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|reactome:R-HSA-379726|go:"GO:0006412"(translation)|dip:DIP-59626N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:pp4g+OJKxW3va88iXtfIAnGXMKw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8N442 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-5460727|uniprotkb:Q5XKM8|uniprotkb:Q9H710|uniprotkb:Q9H8U4|ensembl:ENSP00000281543 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:guf1_human(display_long)|uniprotkb:GUF1(gene name)|psi-mi:GUF1(display_short)|uniprotkb:Elongation factor 4 homolog(gene name synonym)|uniprotkb:GTPase GUF1(gene name synonym)|uniprotkb:Ribosomal back-translocase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_068746.2|interpro:IPR031157|interpro:IPR035647|interpro:IPR035654|interpro:IPR038363|ensembl:ENSG00000151806(gene)|ensembl:ENST00000281543(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006412"(translation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006297(GTP-binding protein LepA)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR013842(GTP-binding protein LepA, C-terminal)|interpro:IPR027417 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:8qGEN4UaBdf2SZbCrIzSU2qDugo9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O94925 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1043737|uniprotkb:Q9UL05|uniprotkb:Q9UL06|uniprotkb:Q9UL07|uniprotkb:Q9UN40|ensembl:ENSP00000317379 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:glsk_human(display_long)|uniprotkb:GLS(gene name)|psi-mi:GLS(display_short)|uniprotkb:GLS1(gene name synonym)|uniprotkb:KIAA0838(gene name synonym)|uniprotkb:L-glutamine amidohydrolase(gene name synonym)|uniprotkb:K-glutaminase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001243239.1|refseq:NP_055720.3|dip:DIP-50591N|ensembl:ENSG00000115419(gene)|ensembl:ENST00000320717(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0090461"(glutamate homeostasis)|interpro:IPR002110(Ankyrin)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR015868(Glutaminase, core)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007268"(chemical synaptic transmission)|interpro:IPR041541|mint:O94925|rcsb pdb:3CZD|rcsb pdb:3UNW|rcsb pdb:3UO9|rcsb pdb:3VOY|rcsb pdb:3VOZ|rcsb pdb:3VP0|rcsb pdb:3VP1|rcsb pdb:3VP2|rcsb pdb:3VP3|rcsb pdb:3VP4|rcsb pdb:5D3O|rcsb pdb:5FI2|rcsb pdb:5FI6|rcsb pdb:5FI7|rcsb pdb:5HL1|rcsb pdb:5I94|rcsb pdb:5JYO|rcsb pdb:5JYP|rcsb pdb:5U0I|rcsb pdb:5U0J|rcsb pdb:5UQE|rcsb pdb:5WJ6|rcsb pdb:6LOX|rcsb pdb:6UJG|rcsb pdb:6UJM|rcsb pdb:6UK6|rcsb pdb:6UKB|rcsb pdb:4O7D|rcsb pdb:6UL9|rcsb pdb:6ULA|rcsb pdb:6UMC|rcsb pdb:6UMD|rcsb pdb:6UME|rcsb pdb:6UMF|reactome:R-HSA-210500|reactome:R-HSA-5628897|reactome:R-HSA-8964539|rcsb pdb:6ULJ - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:IV2jY1Qj63eTVPmTndDavjoUM2w9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96RP9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2255048|uniprotkb:B3KRW1|uniprotkb:A6NCI9|uniprotkb:B2RCB9|uniprotkb:Q6GTN2|uniprotkb:Q96T39|intact:EBI-2870814|ensembl:ENSP00000419038 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:efgm_human(display_long)|uniprotkb:GFM1(gene name)|psi-mi:GFM1(display_short)|uniprotkb:EFG(gene name synonym)|uniprotkb:EFG1(gene name synonym)|uniprotkb:GFM(gene name synonym)|uniprotkb:Elongation factor G 1, mitochondrial(gene name synonym)|uniprotkb:Elongation factor G1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001295093.1|refseq:NP_001295095.1|refseq:NP_079272.4|ensembl:ENSG00000168827(gene)|ensembl:ENST00000486715(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004540(Translation elongation factor EFG/EF2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009022(Elongation factor G, III and V)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR035649|interpro:IPR041095|mint:Q96RP9|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6YDP|rcsb pdb:6YDW|rcsb pdb:7A5K|reactome:R-HSA-5389840 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:TwkylC5mlIaXRTw3hUyViUocC509606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96DB5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2564644|uniprotkb:A9UMZ8|uniprotkb:Q9Y398|ensembl:ENSP00000385927|uniprotkb:B4DNF5|uniprotkb:E7EVI2|uniprotkb:B4DZW6|uniprotkb:B5MC61|uniprotkb:C9JSC6 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:rmd1_human(display_long)|uniprotkb:RMDN1(gene name)|psi-mi:RMDN1(display_short)|uniprotkb:FAM82B(gene name synonym)|uniprotkb:Protein FAM82B(gene name synonym)|uniprotkb:CGI-90(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001273648.1|refseq:NP_057117.2|refseq:NP_001304736.1|ensembl:ENSG00000176623(gene)|ensembl:ENST00000406452(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q96DB5|refseq:NP_001273636.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:EAYrDAOf2NP9wZLfqd3rmwSV5uc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96A26 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-6123466|uniprotkb:Q9NRN6|uniprotkb:Q9UJX8|ensembl:ENSP00000419088 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:f162a_human(display_long)|uniprotkb:FAM162A(gene name)|psi-mi:FAM162A(display_short)|uniprotkb:C3orf28(gene name synonym)|uniprotkb:E2IG5(gene name synonym)|uniprotkb:E2-induced gene 5 protein(gene name synonym)|uniprotkb:Growth and transformation-dependent protein(gene name synonym)|uniprotkb:DC16(orf name)|uniprotkb:FWP001(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_055182.3|ensembl:ENSG00000114023(gene)|ensembl:ENST00000477892(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR009432(Protein of unknown function DUF1075)|mint:Q96A26 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:CjOkqa9wFwEOorjQt5oI7/EJ6709606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96C01 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-373319|uniprotkb:Q96SS3|ensembl:ENSP00000037869 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:f136a_human(display_long)|uniprotkb:FAM136A(gene name)|psi-mi:FAM136A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_116211.2|ensembl:ENSG00000035141(gene)|ensembl:ENST00000037869(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR008560(Protein of unknown function DUF842, eukaryotic) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:i9TSWgN6JC8fuAcFrlTU3IKBDHE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y2C4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-20863487|ensembl:ENSP00000287675|uniprotkb:A8K242|uniprotkb:B4DVG2|uniprotkb:Q3SXM9|uniprotkb:Q9Y2C8 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:exog_human(display_long)|uniprotkb:Endonuclease G-like 1(gene name synonym)|uniprotkb:EXOG(gene name)|psi-mi:EXOG(display_short)|uniprotkb:ENDOGL1(gene name synonym)|uniprotkb:ENDOGL2(gene name synonym)|uniprotkb:ENGL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000157036(gene)|ensembl:ENST00000287675(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR040255|interpro:IPR041003|rcsb pdb:4A1N|rcsb pdb:5T3V|rcsb pdb:5T40|rcsb pdb:5T4I|rcsb pdb:5T5C|rcsb pdb:5ZKI|rcsb pdb:5ZKJ|rcsb pdb:6IID|refseq:NP_001138936.1|refseq:NP_001305883.1|refseq:NP_001305884.1|refseq:NP_001305885.1|refseq:NP_001305886.1|refseq:NP_001305887.1|refseq:NP_001305888.1|refseq:NP_005098.2|refseq:XP_005265690.1|refseq:XP_006713507.1|refseq:XP_016863073.1|refseq:XP_016863074.1|refseq:XP_016863075.1|refseq:XP_016863076.1|refseq:XP_016863077.1|refseq:XP_016863078.1|refseq:XP_016863079.1|refseq:XP_016863080.1|refseq:XP_016863081.1|refseq:XP_016863082.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:0XFS7s10tlnzzJ7dJn+Eq2HnAKs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q14249 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8IYU8 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BQ95 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P30084 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P99999 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P08574 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1224514|uniprotkb:Q5U062|uniprotkb:Q6FHS7|ensembl:ENSP00000317159 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cy1_human(display_long)|uniprotkb:CYC1(gene name)|psi-mi:CYC1(display_short)|uniprotkb:Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit(gene name synonym)|uniprotkb:Cytochrome b-c1 complex subunit 4(gene name synonym)|uniprotkb:Complex III subunit 4(gene name synonym)|uniprotkb:Complex III subunit IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001907.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0033762"(response to glucagon)|go:"GO:0046872"(metal ion binding)|interpro:IPR002326(Cytochrome c1)|interpro:IPR021157|interpro:IPR036909|mint:P08574|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|ensembl:ENSG00000179091(gene)|ensembl:ENST00000318911(transcript)|go:"GO:0005634"(nucleus) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:WFFFejEobb6Uoum311x+fry5X+o9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P36551 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P09669 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P14854 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P10606 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P13073 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q49B96 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-16768453|ensembl:ENSP00000342015|uniprotkb:A4FTX0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox19_human(display_long)|uniprotkb:COX19(gene name)|psi-mi:COX19(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000240230(gene)|ensembl:ENST00000344111(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR009069(MTCP1)|interpro:IPR010625(CHCH)|reactome:R-HSA-1268020|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_001026788.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:NOiFhIMs0eKlX+z1iawnCtMzzaY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q7KZN9 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9H078 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P12532 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NX63 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q4VC31 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P16152 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9HBL7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-714824|uniprotkb:Q9NZ44|uniprotkb:B2R6W0|ensembl:ENSP00000223864 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:plrkt_human(display_long)|uniprotkb:PLGRKT(gene name)|psi-mi:PLGRKT(display_short)|uniprotkb:C9orf46(gene name synonym)|uniprotkb:AD025(orf name)|uniprotkb:MDS030(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:XP_011516262.1|ensembl:ENSG00000107020(gene)|ensembl:ENST00000223864(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010756"(positive regulation of plasminogen activation)|interpro:IPR019319|refseq:NP_060935.2|refseq:XP_005251567.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:qkj3WQL8jWUfNn4aQWO8RVidNUk9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q96EX1 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2874543|ensembl:ENSP00000428541|ensembl:ENSP00000428585|ensembl:ENSP00000428984|ensembl:ENSP00000430198|ensembl:ENSP00000430285|uniprotkb:Q52LP9|uniprotkb:Q8NCB4|uniprotkb:D3DPR5|uniprotkb:Q49AP7 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:sim12_human(display_long)|uniprotkb:SMIM12(gene name)|psi-mi:SMIM12(display_short)|uniprotkb:C1orf212(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000163866(gene)|ensembl:ENST00000417239(transcript)|ensembl:ENST00000423898(transcript)|ensembl:ENST00000446026(transcript)|ensembl:ENST00000456842(transcript)|ensembl:ENST00000521580(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR031933|refseq:XP_011538855.1|refseq:XP_011538857.1|refseq:NP_001307190.1|refseq:NP_001158296.1|refseq:NP_001158297.1|refseq:NP_612437.3|refseq:XP_005270460.1|refseq:XP_016855655.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:qeuRSIWo2rJvSDDvexjGg07txg89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BSF4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10974729|ensembl:ENSP00000270502|uniprotkb:Q96EY6|uniprotkb:Q96IT8 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:tim29_human(display_long)|uniprotkb:TIMM29(gene name)|psi-mi:TIMM29(display_short)|uniprotkb:c19orf52(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_612367.1|ensembl:ENSG00000142444(gene)|ensembl:ENST00000270502(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042721"(TIM22 mitochondrial import inner membrane insertion complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0140318"(protein transporter activity)|interpro:IPR019322|rcsb pdb:7CGP - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:9RRT6AC0o31q81ETOTJgq3Gk+2E9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BSJ5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2872520|uniprotkb:A8K9X3|uniprotkb:Q9H0L9|uniprotkb:Q9NWN5|uniprotkb:Q9H5E6|uniprotkb:Q5JB45|uniprotkb:Q6YAU3|ensembl:ENSP00000351937|ensembl:ENSP00000440551 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cq080_human(display_long)|uniprotkb:C17orf80(gene name)|psi-mi:C17orf80(display_short)|uniprotkb:Cell migration-inducing gene 3 protein(gene name synonym)|uniprotkb:Human lung cancer oncogene 8 protein(gene name synonym)|uniprotkb:HLC8(orf name)|uniprotkb:MIG3(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:XP_011523263.1|refseq:XP_011523264.1|refseq:NP_001094091.1|refseq:NP_060411.2|refseq:XP_016880295.1|refseq:XP_005257544.1|ensembl:ENSG00000141219(gene)|ensembl:ENST00000359042(transcript)|ensembl:ENST00000535032(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR037694|refseq:NP_001275699.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:5nHOYiWQzPdq69Zgy3moyewfalc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q69YU5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-16768469|ensembl:ENSP00000367330|ensembl:ENSP00000446981|ensembl:ENSP00000448771|ensembl:ENSP00000449839 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:bwnin_human(display_long)|uniprotkb:BRAWNIN(gene name)|psi-mi:BRAWNIN(display_short)|uniprotkb:BR(gene name synonym)|uniprotkb:C12orf73(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000204954(gene)|ensembl:ENST00000378090(transcript)|ensembl:ENST00000547945(transcript)|ensembl:ENST00000549478(transcript)|ensembl:ENST00000553183(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR027858|refseq:NP_001129042.1|refseq:XP_016875405.1|refseq:XP_016875406.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:Qt5Oq9fK8Tp9SkleQS3p8DIeyb89606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O95563 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-719403|uniprotkb:Q3SXR6|uniprotkb:Q6FIF3|uniprotkb:A8K261|ensembl:ENSP00000271373|ensembl:ENSP00000356820 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mpc2_human(display_long)|uniprotkb:MPC2(gene name)|psi-mi:MPC2(display_short)|uniprotkb:BRP44(gene name synonym)|uniprotkb:Brain protein 44(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001137146.1|refseq:NP_056230.1|reactome:R-HSA-70268|ensembl:ENSG00000143158(gene)|ensembl:ENST00000271373(transcript)|ensembl:ENST00000367846(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006850"(mitochondrial pyruvate transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0050833"(pyruvate transmembrane transporter activity)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005336(Protein of unknown function UPF0041)|refseq:XP_006711329.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:smUowwyyXsnLu4q2jX26Iope4Fs9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q5TC12 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1166891|uniprotkb:B1AQW7|uniprotkb:Q9H6E3|uniprotkb:B7Z7D6|uniprotkb:B7Z7I6|intact:EBI-11143704|ensembl:ENSP00000459167 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:atpf1_human(display_long)|uniprotkb:ATPAF1(gene name)|psi-mi:ATPAF1(display_short)|uniprotkb:ATP11(gene name synonym)|uniprotkb:ATP11 homolog(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001036011.2|refseq:NP_001230657.1|refseq:NP_073582.3|refseq:NP_001243347.1|ensembl:ENSG00000123472(gene)|ensembl:ENST00000574428(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR010591(ATP11)|mint:Q5TC12 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:xpr/X1UE+/oYTAhgP3+EX77NNyY9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P56385 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P24539 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q5T9A4 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9NVI7 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q8N2F6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1390675|uniprotkb:Q75K91|uniprotkb:Q75MG6|uniprotkb:Q75ML8|uniprotkb:Q8IZC1|uniprotkb:Q8IZC2|uniprotkb:Q8IZC3|uniprotkb:Q9BTM6|uniprotkb:A8K703|uniprotkb:B4DWJ8|uniprotkb:F5GX65|ensembl:ENSP00000319412 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:arm10_human(display_long)|uniprotkb:Splicing variant involved in hepatocarcinogenesis protein(gene name synonym)|uniprotkb:ARMC10(gene name)|psi-mi:ARMC10(display_short)|uniprotkb:SVH(gene name synonym)|uniprotkb:PSEC0198(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001154481.1|refseq:NP_001154482.1|refseq:NP_001154484.1|refseq:NP_114111.2|refseq:NP_001154483.1|refseq:NP_001154485.1|ensembl:ENSG00000170632(gene)|ensembl:ENST00000323716(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0040008"(regulation of growth)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:iP1bkLPGuKxPCyZStXI0OIamvJ49606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9BUR5 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-10763408|uniprotkb:B2R4K9|uniprotkb:Q9H3J9|ensembl:ENSP00000368528 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:mic26_human(display_long)|uniprotkb:Protein FAM121B(gene name synonym)|uniprotkb:My025(orf name)|uniprotkb:UNQ1866/PRO4302(orf name)|uniprotkb:Apolipoprotein O(gene name synonym)|uniprotkb:MIC23(gene name synonym)|uniprotkb:MIC26(gene name synonym)|uniprotkb:MICOS complex subunit MIC23(gene name synonym)|uniprotkb:APOO(gene name)|psi-mi:APOO(display_short)|uniprotkb:FAM121B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_077027.1|ensembl:ENSG00000184831(gene)|ensembl:ENST00000379226(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001401"(SAM complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR019166|interpro:IPR033182|reactome:R-HSA-8949613|refseq:XP_016885326.1 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:xu+C1gnPf3M63LJIPv1R57L62lc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P54819 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:O95831 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9Y4W6 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q7Z695 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q86TX2 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-11109648|uniprotkb:Q3I5F9|uniprotkb:A1L173|ensembl:ENSP00000311224 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:acot1_human(display_long)|uniprotkb:ACOT1(gene name)|psi-mi:ACOT1(display_short)|uniprotkb:CTE-I(gene name synonym)|uniprotkb:CTE-Ib(gene name synonym)|uniprotkb:CTE1(gene name synonym)|uniprotkb:Inducible cytosolic acyl-coenzyme A thioester hydrolase(gene name synonym)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Palmitoyl-coenzyme A thioesterase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_001032238.1|ensembl:ENSG00000184227(gene)|ensembl:ENST00000311148(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|reactome:R-HSA-77289 - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:on1deS+8E4m2ZirUewH43L1VsPc9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:Q9H845 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H300 uniprotkb:P20674 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27049982|imex:IM-29123-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:ST1 ST2 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:pqhiI7GohcmWD793UBzOiixTHks false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:O75431 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - - comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:O60313 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9NVH1 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:O75746 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q8IV08 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-2689908|uniprotkb:Q9BW87|uniprotkb:Q92853|ensembl:ENSP00000348901|ensembl:ENSP00000386293|ensembl:ENSP00000386938|ensembl:ENSP00000387022|ensembl:ENSP00000387050 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:pld3_human(display_long)|uniprotkb:Choline phosphatase 3(gene name synonym)|uniprotkb:HindIII K4L homolog(gene name synonym)|uniprotkb:Hu-K4(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D3(gene name synonym)|uniprotkb:Phospholipase D3(gene name synonym)|uniprotkb:PLD3(gene name)|psi-mi:PLD3(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001278240.1|refseq:XP_011524994.1|refseq:XP_011524995.1|refseq:NP_001026866.1|refseq:NP_036400.2|refseq:XP_005258761.1|refseq:XP_005258764.1|refseq:XP_005258765.1|refseq:XP_005258766.1|refseq:XP_005258767.1|ensembl:ENSG00000105223(gene)|ensembl:ENST00000356508(transcript)|ensembl:ENST00000409281(transcript)|ensembl:ENST00000409419(transcript)|ensembl:ENST00000409587(transcript)|ensembl:ENST00000409735(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002376"(immune system process)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045145"(single-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR032803|reactome:R-HSA-1483148|reactome:R-HSA-2029485|refseq:XP_006723185.1|refseq:XP_016882035.1|refseq:XP_016882036.1|refseq:XP_016882037.1|refseq:XP_016882038.1 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:UAnUtENnwfOxhcqSzMmb7yOlBFI9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P53701 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P99999 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-446479|uniprotkb:A4D166|uniprotkb:P00001|uniprotkb:Q6NUR2|uniprotkb:Q6NX69|uniprotkb:Q96BV4|uniprotkb:B2R4I1|ensembl:ENSP00000307786|ensembl:ENSP00000386270|ensembl:ENSP00000387279 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cyc_human(display_long)|uniprotkb:CYCS(gene name)|psi-mi:CYCS(display_short)|uniprotkb:CYC(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_061820.1|dip:DIP-29683N|ensembl:ENSG00000172115(gene)|ensembl:ENST00000305786(transcript)|ensembl:ENST00000409409(transcript)|ensembl:ENST00000409764(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006915"(apoptotic process)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045333"(cellular respiration)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P99999|rcsb pdb:1J3S|rcsb pdb:2N3Y|rcsb pdb:2N9I|rcsb pdb:2N9J|rcsb pdb:3NWV|rcsb pdb:3ZCF|rcsb pdb:3ZOO|rcsb pdb:5EXQ|rcsb pdb:5O10|rcsb pdb:5TY3|rcsb pdb:6DUJ|rcsb pdb:6ECJ|reactome:R-HSA-111457|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-2151201|reactome:R-HSA-3299685|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9627069|reactome:R-HSA-9707564 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:vSMR7doWXd3VBP8jmhl6cUjccdY9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P63000 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q70CQ3 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:O94826 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9Y5L4 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q96BR5 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9Y512 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9H300 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-13943436|uniprotkb:Q96CQ4|uniprotkb:Q9BTJ6|uniprotkb:Q9P1E3|ensembl:ENSP00000325421 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:parl_human(display_long)|uniprotkb:PARL(gene name)|psi-mi:PARL(display_short)|uniprotkb:Mitochondrial intramembrane cleaving protease PARL(gene name synonym)|uniprotkb:PSARL(gene name synonym)|uniprotkb:PRO2207(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001032728.1|refseq:NP_061092.3|ensembl:ENSG00000175193(gene)|ensembl:ENST00000317096(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR022764|interpro:IPR035952|reactome:R-HSA-8949664 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:QQu6yLh8DBzYihAXUoVI4FiLQIw9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P51970 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P83111 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P35908 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration) - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P13645 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:z100yyq3b63P0ARy2lE2ELyJeik9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q16891 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:O00165 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q14249 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9BW60 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1050331|uniprotkb:Q53HT2|uniprotkb:Q5JUY3|uniprotkb:Q8WXU3|uniprotkb:Q9NVD9|uniprotkb:Q9Y396|uniprotkb:B4DP24|ensembl:ENSP00000361536|ensembl:ENSP00000477602 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:elov1_human(display_long)|uniprotkb:ELOVL1(gene name)|psi-mi:ELOVL1(display_short)|uniprotkb:SSC1(gene name synonym)|uniprotkb:3-keto acyl-CoA synthase ELOVL1(gene name synonym)|uniprotkb:ELOVL fatty acid elongase 1(gene name synonym)|uniprotkb:Very long chain 3-ketoacyl-CoA synthase 1(gene name synonym)|uniprotkb:Very long chain 3-oxoacyl-CoA synthase 1(gene name synonym)|uniprotkb:CGI-88(orf name) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_073732.1|refseq:NP_001243328.1|refseq:NP_001243331.1|refseq:NP_001243330.1|ensembl:ENSG00000066322(gene)|ensembl:ENST00000372458(transcript)|ensembl:ENST00000621943(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006636"(unsaturated fatty acid biosynthetic process)|go:"GO:0009922"(fatty acid elongase activity)|go:"GO:0016020"(membrane)|go:"GO:0019367"(fatty acid elongation, saturated fatty acid)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034625"(fatty acid elongation, monounsaturated fatty acid)|go:"GO:0034626"(fatty acid elongation, polyunsaturated fatty acid)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0102336"(3-oxo-arachidoyl-CoA synthase activity)|go:"GO:0102337"(3-oxo-cerotoyl-CoA synthase activity)|go:"GO:0102338"(3-oxo-lignoceronyl-CoA synthase activity)|go:"GO:0102756"(very-long-chain 3-ketoacyl-CoA synthase activity)|interpro:IPR002076(GNS1/SUR4 membrane protein)|interpro:IPR030457|interpro:IPR033681|mint:Q9BW60|reactome:R-HSA-2046105|reactome:R-HSA-2046106|reactome:R-HSA-75876 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:kiiFMKVAf2USGV2/d8VmUk6A4Cs9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P36551 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P13073 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q7KZN9 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9H078 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P12532 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q9NX63 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-743375|ensembl:ENSP00000262570 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:mic19_human(display_long)|uniprotkb:CHCHD3(gene name)|psi-mi:CHCHD3(display_short)|uniprotkb:MINOS3(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym)|uniprotkb:MIC19(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 go:"GO:0008053"(mitochondrial fusion)|refseq:NP_060282.1|refseq:NP_001304106.1|ensembl:ENSG00000106554(gene)|ensembl:ENST00000262570(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061617"(MICOS complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|mint:Q9NX63|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0019902"(phosphatase binding) - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:Ox0+PoTPYwxw8cKNqpzvSCg+Smg9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q4VC31 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P16152 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-351348|uniprotkb:Q3LHW8|uniprotkb:B2RBZ7|ensembl:ENSP00000290349|uniprotkb:B4DFK7 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:cbr1_human(display_long)|uniprotkb:SDR21C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 1(gene name synonym)|uniprotkb:CBR1(gene name)|psi-mi:CBR1(display_short)|uniprotkb:CBR(gene name synonym)|uniprotkb:CRN(gene name synonym)|uniprotkb:NADPH-dependent carbonyl reductase 1(gene name synonym)|uniprotkb:"Prostaglandin-E(2) 9-reductase"(gene name synonym)|uniprotkb:Prostaglandin 9-ketoreductase(gene name synonym)|uniprotkb:"15-hydroxyprostaglandin dehydrogenase [NADP(+)]"(gene name synonym)|uniprotkb:20-beta-hydroxysteroid dehydrogenase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001748.1|ensembl:ENSG00000159228(gene)|ensembl:ENST00000290349(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005829"(cytosol)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0017144"|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047020"("15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity")|go:"GO:0047021"("15-hydroxyprostaglandin dehydrogenase (NADP+) activity")|go:"GO:0050221"(prostaglandin-E2 9-reductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:P16152|rcsb pdb:1WMA|rcsb pdb:2PFG|rcsb pdb:3BHI|rcsb pdb:3BHJ|rcsb pdb:3BHM|rcsb pdb:4Z3D|reactome:R-HSA-2162123|refseq:NP_001273718.1|dip:DIP-33136N - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:ROzNiYne9nXfvDC9Hi3Ni6M7ILA9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:P54819 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96TA2 uniprotkb:Q7Z695 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 intact:EBI-21505425|ensembl:ENSP00000072869|uniprotkb:Q96CN6|uniprotkb:Q9Y6T5 psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:adck2_human(display_long)|uniprotkb:ADCK2(gene name)|psi-mi:ADCK2(display_short)|uniprotkb:AARF(gene name synonym) psi-mi:"MI:1314"(proximity-dependent biotin identification) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-27050177|imex:IM-29123-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 ensembl:ENSG00000133597(gene)|ensembl:ENST00000072869(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044095|refseq:NP_443085.2 - - - figure legend:ST1 ST1 F1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 rogid:VC70V5CoX0PsEV0o9CVjpAeXdlE9606 rigid:D1CfFqJ4cqhptA/3XFdKV3M5dbg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q15287 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-395959|uniprotkb:A8K1P0|uniprotkb:B4DDU8|uniprotkb:B4DZU7|uniprotkb:B7ZA17|uniprotkb:O75308|uniprotkb:Q32P25|uniprotkb:Q8WY42|uniprotkb:Q9NYG3|ensembl:ENSP00000301730|ensembl:ENSP00000315859|ensembl:ENSP00000380275|ensembl:ENSP00000457723|ensembl:ENSP00000457820 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rnps1_human(display_long)|uniprotkb:SR-related protein LDC2(gene name synonym)|uniprotkb:RNPS1(gene name)|psi-mi:RNPS1(display_short)|uniprotkb:LDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006702.1|refseq:NP_542161.1|refseq:NP_001273554.1|refseq:NP_001273555.1|refseq:NP_001273556.1|ensembl:ENSG00000205937(gene)|ensembl:ENST00000301730(transcript)|ensembl:ENST00000320225(transcript)|ensembl:ENST00000397086(transcript)|ensembl:ENST00000565678(transcript)|ensembl:ENST00000568631(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034201|interpro:IPR035979|mint:Q15287|rcsb pdb:4A8X|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|refseq:XP_005255105.1|refseq:XP_005255106.1|refseq:XP_016878363.1|dip:DIP-32943N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:nANu/nh/pD/F6dYE2Sa28OegPGs9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H0P0 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3918356|uniprotkb:Q7L3G6|uniprotkb:B8ZZC4|uniprotkb:Q6NXS6|uniprotkb:Q9UC45|uniprotkb:A8K253|uniprotkb:Q9UC42|uniprotkb:Q9UC44|uniprotkb:B2RAA5|uniprotkb:Q6IPZ1|uniprotkb:Q9UC43|uniprotkb:Q9P0P5 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:5nt3a_human(display_long)|uniprotkb:NT5C3A(gene name)|psi-mi:NT5C3A(display_short)|uniprotkb:Cytosolic 5'-nucleotidase 3(gene name synonym)|uniprotkb:Cytosolic 5'-nucleotidase III(gene name synonym)|uniprotkb:NT5C3(gene name synonym)|uniprotkb:P5N1(gene name synonym)|uniprotkb:Pyrimidine 5'-nucleotidase 1(gene name synonym)|uniprotkb:UMPH1(gene name synonym)|uniprotkb:Uridine 5'-monophosphate hydrolase 1(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:HSPC233(orf name)|uniprotkb:7-methylguanosine phosphate-specific 5'-nucleotidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN interpro:IPR036412|refseq:NP_001002010.1|refseq:NP_001159590.1|refseq:NP_057573.2|interpro:IPR023214|interpro:IPR006434(HAD-superfamily hydrolase, subfamily IE)|refseq:NP_001002009.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0000215"(tRNA 2'-phosphotransferase activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006213"(pyrimidine nucleoside metabolic process)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0051607"(defense response to virus)|rcsb pdb:2CN1|rcsb pdb:2JGA|rcsb pdb:2VKQ|reactome:R-HSA-73621|refseq:XP_011513711.1|mint:Q9H0P0 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:IMqgR3fhBBTmQWKVhLlMIhK+s4Y9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9UL42 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-302355|uniprotkb:O94959|uniprotkb:O95145|uniprotkb:Q49A18|uniprotkb:Q9UL43|ensembl:ENSP00000429344|uniprotkb:B3KNY9 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:pnma2_human(display_long)|uniprotkb:PNMA2(gene name)|psi-mi:PNMA2(display_short)|uniprotkb:KIAA0883(gene name synonym)|uniprotkb:MA2(gene name synonym)|uniprotkb:Onconeuronal antigen Ma2(gene name synonym)|uniprotkb:Paraneoplastic neuronal antigen MM2(gene name synonym)|uniprotkb:40 kDa neuronal protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_009188.1|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026525|mint:Q9UL42|ensembl:ENSG00000240694(gene)|ensembl:ENST00000522362(transcript)|go:"GO:0005730"(nucleolus)|refseq:XP_011542667.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:GeMwoq69tYJJJc5lI0/bSAGlsCQ9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P55081 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1048159|uniprotkb:Q86TG6|ensembl:ENSP00000267812 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mfap1_human(display_long)|uniprotkb:Spliceosome B complex protein MFAP1(gene name synonym)|uniprotkb:MFAP1(gene name)|psi-mi:MFAP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_005917.2|ensembl:ENSG00000140259(gene)|ensembl:ENST00000267812(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001527"(microfibril)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005813"(centrosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR009730(Micro-fibrillar-associated 1, C-terminal)|interpro:IPR033194|mint:P55081|rcsb pdb:5F5S|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-2129379 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:38SGUW2hc2ZwbmyTO52uGQRw79U9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P60510 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q16891 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9UHD2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y2S7 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96QG7 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-744593|uniprotkb:Q52LU3|uniprotkb:Q8WW11|uniprotkb:Q96QG6|uniprotkb:Q9NX50|uniprotkb:B7Z291|ensembl:ENSP00000221086|ensembl:ENSP00000495551|ensembl:ENSP00000496677 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:mtmr9_human(display_long)|uniprotkb:MTMR9(gene name)|psi-mi:MTMR9(display_short)|uniprotkb:C8orf9(gene name synonym)|uniprotkb:MTMR8(gene name synonym)|uniprotkb:Inactive phosphatidylinositol 3-phosphatase 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_056273.2|dip:DIP-54283N|ensembl:ENSG00000285032(gene)|ensembl:ENST00000221086(transcript)|ensembl:ENST00000644306(transcript)|ensembl:ENST00000646141(transcript)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029021|interpro:IPR030564|mint:Q96QG7|reactome:R-HSA-1660499|reactome:R-HSA-1660517|reactome:R-HSA-1855183|ensembl:ENSG00000104643(gene) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:CdtI/coErr0SNIsW1sz1KdGb3LA9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P67870 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q13573 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P0CG38 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-6151396|ensembl:ENSP00000392718 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:potei_human(display_long)|uniprotkb:POTEI(gene name)|psi-mi:POTEI(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001264335.1|ensembl:ENSG00000196834(gene)|ensembl:ENST00000451531(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005615"(extracellular space)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002110(Ankyrin)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020683|interpro:IPR020902|interpro:IPR036770|interpro:IPR039497|interpro:IPR043129 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:GwOezw/xl4lBr+foB8APX5SP8qc9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P24928 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P63172 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1176455|uniprotkb:Q15763|ensembl:ENSP00000356056|uniprotkb:Q5VTU4 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:dylt1_human(display_long)|uniprotkb:T-complex testis-specific protein 1 homolog(gene name synonym)|uniprotkb:Protein CW-1(gene name synonym)|uniprotkb:DYNLT1(gene name)|psi-mi:DYNLT1(display_short)|uniprotkb:TCTEL1(gene name synonym)|uniprotkb:TCTEX1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006510.1|ensembl:ENSG00000146425(gene)|ensembl:ENST00000367089(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043657"(host cell)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061564"(axon development)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)|go:"GO:0099503"(secretory vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|rcsb pdb:5JPW|reactome:R-HSA-6798695|go:"GO:0005881"(cytoplasmic microtubule)|dip:DIP-35251N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:RKVyHgf4iNjcY6GfLdIukFOFE+s9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8NB37 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-722742|uniprotkb:Q2NL76|uniprotkb:Q6ZQY0|uniprotkb:Q8NAE0|uniprotkb:B7ZKW5|ensembl:ENSP00000321691 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:gald1_human(display_long)|uniprotkb:GATD1(gene name)|psi-mi:GATD1(display_short)|uniprotkb:PDDC1(gene name synonym)|uniprotkb:Parkinson disease 7 domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_872418.1|refseq:NP_001305753.1|refseq:XP_016873156.1|ensembl:ENSG00000177225(gene)|ensembl:ENST00000319863(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR029062 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LQ3FMvZSS7oVbsX1VhtEaFlWbR49606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q86V97 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2514778|ensembl:ENSP00000368799|uniprotkb:Q96MP6|uniprotkb:Q8NDM5|uniprotkb:Q5T6Y8|uniprotkb:Q8N8L0 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:kbtb6_human(display_long)|uniprotkb:KBTBD6(gene name)|psi-mi:KBTBD6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000165572(gene)|ensembl:ENST00000379485(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4XC2|refseq:NP_690867.3 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:iMugkQiayHqkx3aiExLs32a5Bv49606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q5ST30 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P46940 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y679 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1058701|ensembl:ENSP00000366748|uniprotkb:Q9H866|uniprotkb:Q9UNQ6|uniprotkb:Q9Y685|uniprotkb:C0H5W8 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:aup1_human(display_long)|uniprotkb:AUP1(gene name)|psi-mi:AUP1(display_short)|uniprotkb:Ancient ubiquitous protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000115307(gene)|ensembl:ENST00000377526(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_853553.1|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990044"(protein localization to lipid droplet)|interpro:IPR003892(Ubiquitin system component Cue)|rcsb pdb:2EKF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:6yySfIPpRUlnm0upBDYyfBUOtIY9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8IUR7 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q12789 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-357956|uniprotkb:B2RP21|uniprotkb:Q12838|uniprotkb:Q6DKN9|uniprotkb:Q9Y4W9|ensembl:ENSP00000348510 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tf3c1_human(display_long)|uniprotkb:GTF3C1(gene name)|psi-mi:GTF3C1(display_short)|uniprotkb:Transcription factor IIIC subunit alpha(gene name synonym)|uniprotkb:TF3C-alpha(gene name synonym)|uniprotkb:Transcription factor IIIC 220 kDa subunit(gene name synonym)|uniprotkb:TFIIIC box B-binding subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001511.2|refseq:NP_001273171.1|dip:DIP-38212N|ensembl:ENSG00000077235(gene)|ensembl:ENST00000356183(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009304"(tRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007309(B-block binding subunit of TFIIIC)|interpro:IPR035625|interpro:IPR044210|mint:Q12789|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1celgxr5g9oKbPr0x1SvI6S7hNE9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8WVK2 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2512550|ensembl:ENSP00000244227|ensembl:ENSP00000395144|uniprotkb:Q15410|intact:EBI-2557655 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:snr27_human(display_long)|uniprotkb:SNRNP27(gene name)|psi-mi:SNRNP27(display_short)|uniprotkb:U4/U6.U5 tri-snRNP-associated protein 3(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP-associated 27 kDa protein(gene name synonym)|uniprotkb:Nucleic acid-binding protein RY-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000124380(gene)|ensembl:ENST00000244227(transcript)|ensembl:ENST00000450162(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR013957(Protein of unknown function DUF1777)|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_006848.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:wSOfld20fuDA9ZN9vDXLilFmmSs9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9P253 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H089 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-4402486|uniprotkb:A0JLT4|uniprotkb:A0PJK3|uniprotkb:A6NI18|uniprotkb:Q7L9H8|uniprotkb:Q9NUK8|ensembl:ENSP00000265245 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:lsg1_human(display_long)|uniprotkb:LSG1(gene name)|psi-mi:LSG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060855.2|ensembl:ENSG00000041802(gene)|ensembl:ENST00000265245(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051168"(nuclear export)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:Q9H089|rcsb pdb:6LSR - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:66YYrxhw+MOGH9+lyrsQ4JPDA3w9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P0DPB6 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-359498|uniprotkb:Q9Y2S0|ensembl:ENSP00000302478|uniprotkb:Q5TBX2|uniprotkb:Q96BR3 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rpac2_human(display_long)|uniprotkb:POLR1D(gene name)|psi-mi:POLR1D(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit D(gene name synonym)|uniprotkb:RPC16(gene name synonym)|uniprotkb:hRPA19(gene name synonym)|uniprotkb:AC19(gene name synonym)|uniprotkb:RNA polymerase I 16 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN mint:P0DPB6|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|ensembl:ENSG00000186184(gene)|ensembl:ENST00000302979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR008193(DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site)|interpro:IPR009025(DNA-directed RNA polymerase, RBP11-like)|interpro:IPR033898|interpro:IPR036603|refseq:NP_057056.1|refseq:XP_005266469.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:rDbtR47SoszVxupqkWmoxVTS4/E9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8NFH4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2563158|ensembl:ENSP00000251074|ensembl:ENSP00000448054|uniprotkb:Q9H644 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:nup37_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit Nup37(gene name synonym)|uniprotkb:NUP37(gene name)|psi-mi:NUP37(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_076962.2|ensembl:ENSG00000075188(gene)|ensembl:ENST00000251074(transcript)|ensembl:ENST00000552283(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037626|mint:Q8NFH4|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:mOkDLvRNOkSg/v6jnvOox6ZNTzo9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P82673 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2513649|ensembl:ENSP00000081029|uniprotkb:Q6P4C6|uniprotkb:Q7L1M6|uniprotkb:Q9HC14|uniprotkb:Q96AI0|uniprotkb:Q32LZ1|uniprotkb:Q9H044|uniprotkb:Q9P1R5|uniprotkb:Q8NBP4 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rt35_human(display_long)|uniprotkb:MRPS35(gene name)|psi-mi:MRPS35(display_short)|uniprotkb:MRPS28(gene name synonym)|uniprotkb:28S ribosomal protein S28, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS35(gene name synonym)|uniprotkb:HDCMD11P(orf name)|uniprotkb:MDS023(orf name)|uniprotkb:PSEC0213(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000061794(gene)|ensembl:ENST00000081029(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR019349|interpro:IPR039848|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_001177793.1|refseq:NP_068593.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:L7fhBRRkth1ePVbRtuVTvC5zcR09606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96BW9 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-13943422|uniprotkb:B4DIY7|uniprotkb:C9J2U4|ensembl:ENSP00000388598 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tam41_human(display_long)|uniprotkb:TAMM41(gene name)|psi-mi:TAMM41(display_short)|uniprotkb:C3orf31(gene name synonym)|uniprotkb:CDP-diacylglycerol synthase(gene name synonym)|uniprotkb:Mitochondrial translocator assembly and maintenance protein 41 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001271330.1|refseq:NP_001308223.1|refseq:NP_001308224.1|refseq:NP_620162.1|refseq:XP_005264930.1|ensembl:ENSG00000144559(gene)|ensembl:ENST00000444133(transcript)|go:"GO:0004605"(phosphatidate cytidylyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032049"(cardiolipin biosynthetic process)|interpro:IPR015222(Mitochondrial matrix Mmp37) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LnzB9FufQqND2kzBthGVaChZlNw9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9UHW5 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-395491|uniprotkb:Q53FS3|uniprotkb:Q6UVZ6|uniprotkb:Q7Z3D3|uniprotkb:Q8NEI2|uniprotkb:Q96HK9|uniprotkb:B2RC54|uniprotkb:D4YWV1|ensembl:ENSP00000228827|uniprotkb:F5H759 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:gpn3_human(display_long)|uniprotkb:ATPBD1C(gene name synonym)|uniprotkb:ATP-binding domain 1 family member C(gene name synonym)|uniprotkb:GPN3(gene name)|psi-mi:GPN3(display_short)|uniprotkb:AD-009(orf name)|uniprotkb:UNQ1876/PRO4319(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001157844.1|refseq:NP_001157845.1|refseq:NP_057385.3|ensembl:ENSG00000111231(gene)|ensembl:ENST00000228827(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030228|mint:Q9UHW5 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:fKBsnLcvitaM76zQUW+MQXDPxTA9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P51114 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9BYN8 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-721378|uniprotkb:Q96Q58|ensembl:ENSP00000369682 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rt26_human(display_long)|uniprotkb:28S ribosomal protein S13, mitochondrial(gene name synonym)|uniprotkb:MRPS26(gene name)|psi-mi:MRPS26(display_short)|uniprotkb:RPMS13(gene name synonym)|uniprotkb:C20orf193(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_110438.1|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125901(gene)|ensembl:ENST00000380325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR026140|mint:Q9BYN8 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:ZygMazfhjHbx+aFhRkeG87c4L6E9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q86XL3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O94826 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P62875 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-359527|ensembl:ENSP00000324124|ensembl:ENSP00000432807|uniprotkb:P52436|uniprotkb:Q6FHX3 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rpab5_human(display_long)|uniprotkb:POLR2L(gene name)|psi-mi:POLR2L(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit L(gene name synonym)|uniprotkb:RPB10 homolog(gene name synonym)|uniprotkb:RNA polymerase II 7.6 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000177700(gene)|ensembl:ENST00000322028(transcript)|ensembl:ENST00000534030(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR000268(RNA polymerases, N/8 Kd subunits)|interpro:IPR020789|interpro:IPR023580|mint:P62875|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|refseq:NP_066951.1|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-75955|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-203927|dip:DIP-32960N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:uDzgKgHzFTPxFaV1GeUYdYMa4Gk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q5VZL5 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2514659|intact:EBI-28984130|ensembl:ENSP00000322915|uniprotkb:A0JP19|uniprotkb:O43308|uniprotkb:A0JP20|uniprotkb:Q5T5E2|uniprotkb:Q7L3Q4|uniprotkb:Q5T5E1|intact:EBI-2556245 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:zmym4_human(display_long)|uniprotkb:ZMYM4(gene name)|psi-mi:ZMYM4(display_short)|uniprotkb:KIAA0425(gene name synonym)|uniprotkb:ZNF262(gene name synonym)|uniprotkb:Zinc finger protein 262(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000146463(gene)|ensembl:ENST00000314607(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|refseq:XP_016858292.1|refseq:XP_016858293.1|refseq:XP_011540725.1|refseq:XP_011540727.1|refseq:NP_005086.2|ensembl:ENSP00000322915|refseq:XP_005271388.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:jc8YwR+37J3uD08cXiUnOA2hHEI9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y6W3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1765641|ensembl:ENSP00000253693 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:can7_human(display_long)|uniprotkb:CAPN7(gene name)|psi-mi:CAPN7(display_short)|uniprotkb:PALBH(gene name synonym)|uniprotkb:PalB homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_055111.1|ensembl:ENSG00000131375(gene)|ensembl:ENST00000253693(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0097264"(self proteolysis)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR007330(MIT)|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR036181|interpro:IPR036213|interpro:IPR038765|mint:Q9Y6W3|rcsb pdb:2QFE|reactome:R-HSA-1474228 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:tRDBeVQRu1tuCDWtSrve/Y9lWsg9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H6T3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96N67 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9H269 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2655929|uniprotkb:Q5JUB1|uniprotkb:Q8WU31|uniprotkb:Q96EE7|uniprotkb:Q96N92|uniprotkb:Q9H1Q4|uniprotkb:Q9H1Q5|ensembl:ENSP00000369810 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:vps16_human(display_long)|uniprotkb:VPS16(gene name)|psi-mi:VPS16(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_072097.2|refseq:NP_536338.1|ensembl:ENSG00000215305(gene)|ensembl:ENST00000380445(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR038132|mint:Q9H269|rcsb pdb:4BX9 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:bm088LmFRv3w0wfvlPMFeottZkw9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P18077 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-353383|uniprotkb:Q08ES9|uniprotkb:Q9BVN7|ensembl:ENSP00000393393|ensembl:ENSP00000495672 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rl35a_human(display_long)|uniprotkb:RPL35A(gene name)|psi-mi:RPL35A(display_short)|uniprotkb:Cell growth-inhibiting gene 33 protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL33(gene name synonym)|uniprotkb:GIG33(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_000987.2|refseq:NP_001303240.1|ensembl:ENST00000647248(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001780(Ribosomal protein L35Ae)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR018266|interpro:IPR038661|mint:P18077|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|ensembl:ENSG00000182899(gene)|ensembl:ENST00000448864(transcript)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:fnUlL17LsiOp3lSkKNsoYO74IQQ9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9GZU8 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2371956|ensembl:ENSP00000335808|ensembl:ENSP00000374098|ensembl:ENSP00000456211|ensembl:ENSP00000457740|ensembl:ENSP00000457850 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:pip30_human(display_long)|uniprotkb:PSME3IP1(gene name)|psi-mi:PSME3IP1(display_short)|uniprotkb:C16orf94(gene name synonym)|uniprotkb:FAM192A(gene name synonym)|uniprotkb:NEFA-interacting nuclear protein NIP30(gene name synonym)|uniprotkb:NIP30(gene name synonym)|uniprotkb:PA28G-interacting protein(gene name synonym)|uniprotkb:PIP30(gene name synonym)|uniprotkb:CDA018(orf name)|uniprotkb:CDA10(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:XP_011521645.1|refseq:NP_079222.1|refseq:XP_005256217.1|refseq:XP_005256220.1|refseq:XP_005256221.1|refseq:XP_005256222.1|refseq:XP_016879171.1|refseq:XP_016879172.1|refseq:XP_016879173.1|refseq:XP_016879174.1|refseq:XP_016879175.1|refseq:XP_016879176.1|refseq:XP_016879177.1|refseq:XP_016879178.1|refseq:XP_016879179.1|refseq:XP_016879180.1|refseq:XP_016879181.1|refseq:XP_016879182.1|refseq:XP_016879183.1|refseq:XP_016879184.1|refseq:XP_016879185.1|refseq:XP_016879186.1|refseq:XP_016879187.1|refseq:XP_016879188.1|refseq:XP_016879189.1|refseq:XP_016879190.1|refseq:XP_016879191.1|refseq:XP_016879192.1|refseq:XP_016879193.1|ensembl:ENSG00000172775(gene)|ensembl:ENST00000309137(transcript)|ensembl:ENST00000389447(transcript)|ensembl:ENST00000564108(transcript)|ensembl:ENST00000567439(transcript)|ensembl:ENST00000569266(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|interpro:IPR019331|interpro:IPR039845|mint:Q9GZU8 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:L6twOcOqRARWRz4Em7oxxyLGsL09606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q5JPH6 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-13943410|ensembl:ENSP00000395196|ensembl:ENSP00000501251|uniprotkb:B3KTT2|uniprotkb:D3DWF1|uniprotkb:Q86YH3|uniprotkb:Q8TF31 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:syem_human(display_long)|uniprotkb:EARS2(gene name)|psi-mi:EARS2(display_short)|uniprotkb:Glutamyl-tRNA synthetase(gene name synonym)|uniprotkb:KIAA1970(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020058|interpro:IPR020751|interpro:IPR033910|reactome:R-HSA-379726|ensembl:ENSG00000103356(gene)|ensembl:ENST00000449606(transcript)|ensembl:ENST00000674054(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0050561"("glutamate-tRNA(Gln) ligase activity")|go:"GO:0070127"(tRNA aminoacylation for mitochondrial protein translation)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004527(Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial)|refseq:NP_001077083.1|refseq:NP_001295140.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Jo4TXXabhrL7bgEVz1Ffm/766PA9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P50336 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P19387 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-394729|uniprotkb:O15161|ensembl:ENSP00000219252 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rpb3_human(display_long)|uniprotkb:POLR2C(gene name)|psi-mi:POLR2C(display_short)|uniprotkb:A-152E5.7(orf name)|uniprotkb:DNA-directed RNA polymerase II subunit C(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 33 kDa polypeptide(gene name synonym)|uniprotkb:RPB31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_116558.1|ensembl:ENSG00000102978(gene)|ensembl:ENST00000219252(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR036603|interpro:IPR036643|mint:P19387|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32911N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:UXFC+i+QqB2WRgL9OiYSQ66L36c9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P31327 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-536811|uniprotkb:O43774|uniprotkb:Q7Z5I5|uniprotkb:B7Z818|uniprotkb:Q53TL5|uniprotkb:J3KQL0|uniprotkb:Q59HF8|ensembl:ENSP00000233072|ensembl:ENSP00000500537|ensembl:ENSP00000501022|ensembl:ENSP00000501073 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:cpsm_human(display_long)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)|uniprotkb:CPS1(gene name)|psi-mi:CPS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001116105.1|refseq:NP_001116106.1|refseq:NP_001866.2|refseq:XP_011508943.1|refseq:XP_011508944.1|refseq:XP_011508945.1|refseq:XP_011508946.1|ensembl:ENSG00000021826(gene)|ensembl:ENST00000233072(transcript)|ensembl:ENST00000673510(transcript)|ensembl:ENST00000673630(transcript)|ensembl:ENST00000673711(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:P31327|rcsb pdb:2YVQ|rcsb pdb:4UTR|rcsb pdb:4UTV|rcsb pdb:4UTX|rcsb pdb:4UTZ|rcsb pdb:4UU7|rcsb pdb:4UU8|rcsb pdb:4UUA|rcsb pdb:4UUB|rcsb pdb:5DOT|rcsb pdb:5DOU|rcsb pdb:5OJO|rcsb pdb:6UEL|rcsb pdb:6W2J|reactome:R-HSA-70635 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:497s02igPCWuQcU4lVrMpl5SRig9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q14677 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P09110 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-3926709|ensembl:ENSP00000333664|uniprotkb:G5E935|uniprotkb:Q96CA6 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:thik_human(display_long)|uniprotkb:ACAA1(gene name)|psi-mi:ACAA1(display_short)|uniprotkb:ACAA(gene name synonym)|uniprotkb:PTHIO(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001123882.1|refseq:NP_001598.1|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2IIK|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-6798695|reactome:R-HSA-9033241|reactome:R-HSA-9033500|ensembl:ENSG00000060971(gene)|ensembl:ENST00000333167(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005576"(extracellular region) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:yWp9R9bAzdied8kfDD+qVrY8Slk9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O14950 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1642165|uniprotkb:D3DUH6|intact:EBI-2826593|uniprotkb:Q7Z5Z4|uniprotkb:Q13182|ensembl:ENSP00000237500|ensembl:ENSP00000383037|ensembl:ENSP00000463559|ensembl:ENSP00000464464|ensembl:ENSP00000496809 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ml12b_human(display_long)|uniprotkb:MYL12B(gene name)|psi-mi:MYL12B(display_short)|uniprotkb:MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:MLC-2A(gene name synonym)|uniprotkb:SHUJUN-1(gene name synonym)|uniprotkb:MYLC2B(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001138416.1|refseq:NP_001138417.1|refseq:NP_291024.1|refseq:NP_001289978.1|ensembl:ENSG00000118680(gene)|ensembl:ENST00000237500(transcript)|ensembl:ENST00000400175(transcript)|ensembl:ENST00000581193(transcript)|ensembl:ENST00000584539(transcript)|ensembl:ENST00000648965(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:O14950|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P11474 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O43432 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q16540 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1046141|uniprotkb:A8MT29|uniprotkb:Q96Q71|ensembl:ENSP00000370930|ensembl:ENSP00000380466|ensembl:ENSP00000500123|ensembl:ENSP00000500896 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rm23_human(display_long)|uniprotkb:L23 mitochondrial-related protein(gene name synonym)|uniprotkb:Ribosomal protein L23-like(gene name synonym)|uniprotkb:L23MRP(gene name synonym)|uniprotkb:RPL23L(gene name synonym)|uniprotkb:MRPL23(gene name)|psi-mi:MRPL23(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL23m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_066957.3|ensembl:ENSG00000214026(gene)|ensembl:ENSG00000288141(gene)|ensembl:ENST00000381519(transcript)|ensembl:ENST00000397298(transcript)|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|ensembl:ENST00000672185(transcript)|ensembl:ENST00000672523(transcript)|go:"GO:0001650"(fibrillar center)|rcsb pdb:7ODS|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|mint:Q16540|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7ODT|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF0 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1TSlowXDlWVOW2PS1vv8Lu/e1vU9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NVH1 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q8IXM3 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-912501|uniprotkb:Q96Q49|ensembl:ENSP00000360498 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rm41_human(display_long)|uniprotkb:MRPL27(gene name synonym)|uniprotkb:39S ribosomal protein L27 homolog(gene name synonym)|uniprotkb:MRP-L27 homolog(gene name synonym)|uniprotkb:Bcl-2-interacting mitochondrial ribosomal protein L41(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 3 protein(gene name synonym)|uniprotkb:MRPL41(gene name)|psi-mi:MRPL41(display_short)|uniprotkb:BMRP(gene name synonym)|uniprotkb:RPML27(gene name synonym)|uniprotkb:PIG3(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_115866.1|ensembl:ENSG00000182154(gene)|ensembl:ENST00000371443(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019189|mint:Q8IXM3|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:1qftd9Vr6Rsymp6hgM29FeOvChA9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:A3KMH1 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-308657|uniprotkb:Q5JTP6|uniprotkb:Q5VW08|uniprotkb:Q7Z6I9|uniprotkb:Q86YC9|uniprotkb:Q8N3E4|uniprotkb:O60310|ensembl:ENSP00000368612 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:vwa8_human(display_long)|uniprotkb:VWA8(gene name)|psi-mi:VWA8(display_short)|uniprotkb:KIAA0564(gene name synonym)|uniprotkb:PEX7-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN ensembl:ENSG00000102763(gene)|ensembl:ENST00000379310(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|refseq:NP_001009814.1|refseq:NP_055873.1|refseq:XP_016875963.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:IOalBj68cHFF4BsViQ+eeXQZiRY9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q96A35 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1045743|uniprotkb:Q53G65|uniprotkb:Q53HT0|uniprotkb:Q5SYZ9|uniprotkb:Q5SZ00|uniprotkb:Q5SZ02|uniprotkb:Q96Q70|uniprotkb:Q9H7G3|uniprotkb:D3DVC8|intact:EBI-2560246|ensembl:ENSP00000354525|ensembl:ENSP00000357194 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rm24_human(display_long)|uniprotkb:MRPL24(gene name)|psi-mi:MRPL24(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL24m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_078816.2|refseq:NP_663781.1|ensembl:ENSG00000143314(gene)|ensembl:ENST00000361531(transcript)|ensembl:ENST00000368211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR003256(Ribosomal protein L24)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:Q96A35|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:6ZSE|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011508283.1|refseq:XP_011508284.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:TVDcxc2+oUe0eez+iQPW5HWBwdI9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q14157 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9HD33 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-2560181|uniprotkb:Q8N5D1|uniprotkb:Q6XRG1|ensembl:ENSP00000417602 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rm47_human(display_long)|uniprotkb:MRPL47(gene name)|psi-mi:MRPL47(display_short)|uniprotkb:NCM1(gene name synonym)|uniprotkb:Nasopharyngeal carcinoma metastasis-related protein 1(gene name synonym)|uniprotkb:CGI-204(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein uL29m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_065142.2|refseq:NP_817125.1|ensembl:ENSG00000136522(gene)|ensembl:ENST00000476781(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR010729(Ribosomal protein L47, mitochondrial)|interpro:IPR038340|mint:Q9HD33|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU3|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:Zwk2kFYyc2Efry0CU19e8o7GEW89606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O00165 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9NSE4 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q9Y2Z0 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q13084 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-723426|uniprotkb:Q4TT39|uniprotkb:Q96S26|uniprotkb:Q9BQD8|uniprotkb:Q9BR04|ensembl:ENSP00000199706|ensembl:ENSP00000374326|ensembl:ENSP00000497004|uniprotkb:B2RCM4|uniprotkb:D3DU46 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rm28_human(display_long)|uniprotkb:Melanoma antigen p15(gene name synonym)|uniprotkb:MRPL28(gene name)|psi-mi:MRPL28(display_short)|uniprotkb:MAAT1(gene name synonym)|uniprotkb:Melanoma-associated antigen recognized by T-lymphocytes(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL28m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006419.2|rcsb pdb:3J7Y|ensembl:ENSG00000086504(gene)|ensembl:ENST00000199706(transcript)|ensembl:ENST00000389675(transcript)|ensembl:ENST00000648346(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|interpro:IPR026569|interpro:IPR034704|interpro:IPR037147|mint:Q13084|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011520653.1|refseq:XP_005255098.1|dip:DIP-61135N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:rgjK24sQlABM210ZM7T9mT2wxKs9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P35580 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O95816 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P61289 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:Q07021 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:P31943 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464 uniprotkb:O75792 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 intact:EBI-9027352|uniprotkb:Q96F11|uniprotkb:B2RCY1|ensembl:ENSP00000221486 psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:rnh2a_human(display_long)|uniprotkb:RNASEH2A(gene name)|psi-mi:RNASEH2A(display_short)|uniprotkb:Aicardi-Goutieres syndrome 4 protein(gene name synonym)|uniprotkb:RNASEHI(gene name synonym)|uniprotkb:RNHIA(gene name synonym)|uniprotkb:"RNase H(35)"(gene name synonym)|uniprotkb:Ribonuclease HI large subunit(gene name synonym)|uniprotkb:Ribonuclease HI subunit A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050249|imex:IM-29123-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN refseq:NP_006388.2|ensembl:ENSG00000104889(gene)|ensembl:ENST00000221486(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006298"(mismatch repair)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0032299"(ribonuclease H2 complex)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0046872"(metal ion binding)|interpro:IPR001352(Ribonuclease HII/HIII)|interpro:IPR004649(Ribonuclease HII)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR023160|interpro:IPR024567|interpro:IPR036397|rcsb pdb:3P56|rcsb pdb:3PUF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rogid:UCK5FUsIvOKaNqxTiD2uRHyJ/ws9606 rigid:m7doQVDhtng39FFTOj53B5klaSU false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75717 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3951691|ensembl:ENSP00000353793|uniprotkb:C9JW18|uniprotkb:F6W0U7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:wdhd1_human(display_long)|uniprotkb:WDHD1(gene name)|psi-mi:WDHD1(display_short)|uniprotkb:AND1(gene name synonym)|uniprotkb:Acidic nucleoplasmic DNA-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000198554(gene)|ensembl:ENST00000360586(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0043596"(nuclear replication fork)|interpro:IPR001680(WD40 repeat)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR022100|interpro:IPR024977|interpro:IPR036322|interpro:IPR036910|rcsb pdb:2D7L|rcsb pdb:5GVA|rcsb pdb:5GVB|rcsb pdb:5OGS|rcsb pdb:6XTY|refseq:NP_001008397.1|refseq:NP_009017.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:SNbJutgOfo9kguAoOv5Hdhk5s+k9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8WXF1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q7Z7L7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1811449|uniprotkb:O00156|uniprotkb:Q5T272|uniprotkb:Q5T273|ensembl:ENSP00000291900 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:zer1_human(display_long)|uniprotkb:Zyg-11 homolog B-like protein(gene name synonym)|uniprotkb:Hzyg(gene name synonym)|uniprotkb:ZER1(gene name)|psi-mi:ZER1(display_short)|uniprotkb:C9orf60(gene name synonym)|uniprotkb:ZYG(gene name synonym)|uniprotkb:ZYG11BL(gene name synonym)|uniprotkb:Zyg11b-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_006327.2|refseq:XP_011516424.1|refseq:XP_016869674.1|refseq:XP_005251702.1|ensembl:ENSG00000160445(gene)|ensembl:ENST00000291900(transcript)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR032675|interpro:IPR040368|mint:Q7Z7L7 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:IWzURpjsw2cGVyaAkJhttRDlxzc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BTY7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O94763 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O14737 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-712290|ensembl:ENSP00000466214|uniprotkb:Q53YC9|uniprotkb:Q6IB70|uniprotkb:B4DE64 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pdcd5_human(display_long)|uniprotkb:TF-1 cell apoptosis-related protein 19(gene name synonym)|uniprotkb:PDCD5(gene name)|psi-mi:PDCD5(display_short)|uniprotkb:TFAR19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 go:"GO:0010698"(acetyltransferase activator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1903638"(positive regulation of protein insertion into mitochondrial outer membrane)|go:"GO:1903645"(negative regulation of chaperone-mediated protein folding)|mint:O14737|rcsb pdb:1YYB|rcsb pdb:2CRU|rcsb pdb:2K6B|interpro:IPR002836(DNA-binding TFAR19-related protein)|interpro:IPR036883|ensembl:ENSG00000105185(gene)|ensembl:ENST00000590247(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_004699.1|refseq:XP_005259449.1|dip:DIP-50602N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:K2DZzTWT7H8gGATfyR72aXDu5qc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q7Z4H7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2558196|uniprotkb:Q05CG1|uniprotkb:Q14CB6|uniprotkb:Q2TA91|uniprotkb:Q8IZQ4|uniprotkb:Q9H998|uniprotkb:Q96FN0|uniprotkb:Q14CD9|uniprotkb:B3KPK4|uniprotkb:Q6IQ10|uniprotkb:Q9H950|uniprotkb:Q9NXT8|uniprotkb:Q9HCJ8|uniprotkb:Q6NZX5|uniprotkb:B4DX82|ensembl:ENSP00000369871 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:haus6_human(display_long)|uniprotkb:HAUS6(gene name)|psi-mi:HAUS6(display_short)|uniprotkb:DGT6(gene name synonym)|uniprotkb:FAM29A(gene name synonym)|uniprotkb:KIAA1574(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060115.3|refseq:NP_001257819.1|dip:DIP-48830N|ensembl:ENSG00000147874(gene)|ensembl:ENST00000380502(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026797|interpro:IPR028163|mint:Q7Z4H7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:l5edu15aLS4hXrPg/lfQ2323G2o9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8WWM7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P0DPB6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-359498|uniprotkb:Q9Y2S0|ensembl:ENSP00000302478|uniprotkb:Q5TBX2|uniprotkb:Q96BR3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rpac2_human(display_long)|uniprotkb:POLR1D(gene name)|psi-mi:POLR1D(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit D(gene name synonym)|uniprotkb:RPC16(gene name synonym)|uniprotkb:hRPA19(gene name synonym)|uniprotkb:AC19(gene name synonym)|uniprotkb:RNA polymerase I 16 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 mint:P0DPB6|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|ensembl:ENSG00000186184(gene)|ensembl:ENST00000302979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR008193(DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site)|interpro:IPR009025(DNA-directed RNA polymerase, RBP11-like)|interpro:IPR033898|interpro:IPR036603|refseq:NP_057056.1|refseq:XP_005266469.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:rDbtR47SoszVxupqkWmoxVTS4/E9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96HA7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1052467|uniprotkb:Q13006|uniprotkb:Q9UGJ2|uniprotkb:B5MDP0|uniprotkb:C9JKB1|uniprotkb:C9JNV8|intact:EBI-28979102|ensembl:ENSP00000386239 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tonsl_human(display_long)|uniprotkb:IKBR(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2(gene name synonym)|uniprotkb:Inhibitor of kappa B-related protein(gene name synonym)|uniprotkb:TONSL(gene name)|psi-mi:TONSL(display_short)|uniprotkb:NFKBIL2(gene name synonym)|uniprotkb:NF-kappa-B inhibitor-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_038460.4|ensembl:ENSP00000386239|ensembl:ENSG00000160949(gene)|ensembl:ENST00000409379(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0031297"(replication fork processing)|go:"GO:0042393"(histone binding)|go:"GO:0043596"(nuclear replication fork)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020683|interpro:IPR032675|interpro:IPR036770|mint:Q96HA7|rcsb pdb:5JA4 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Y06T7HJriv692FDbQzKyimJb6z09606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O60678 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2809009|uniprotkb:B4DUC7|uniprotkb:A0A0A0MSN7|ensembl:ENSP00000331879 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:anm3_human(display_long)|uniprotkb:PRMT3(gene name)|psi-mi:PRMT3(display_short)|uniprotkb:HRMT1L3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_005779.1|ensembl:ENSG00000185238(gene)|ensembl:ENST00000331079(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1900053"(negative regulation of retinoic acid biosynthetic process)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR036236|mint:O60678|rcsb pdb:2FYT|rcsb pdb:3SMQ|rcsb pdb:4HSG|rcsb pdb:4QQN|rcsb pdb:4RYL|reactome:R-HSA-3214858|reactome:R-HSA-8876725 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:XtFHON3qMCvjDhtN8RpXJo9KODU9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6NUQ1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-726876|uniprotkb:Q75MG9|uniprotkb:Q75MH0|uniprotkb:Q96IW8|uniprotkb:Q9H229|uniprotkb:Q9HAD9|intact:EBI-28981798|ensembl:ENSP00000257700 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rint1_human(display_long)|uniprotkb:RAD50 interactor 1(gene name synonym)|uniprotkb:RINT1(gene name)|psi-mi:RINT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000135249(gene)|ensembl:ENST00000257700(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0015031"(protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0070939"(Dsl1/NZR complex)|interpro:IPR007528(RINT-1/TIP-1)|interpro:IPR042044|reactome:R-HSA-6811434|refseq:NP_068749.3|ensembl:ENSP00000257700|dip:DIP-36477N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:aUzUSBI8f6ednxeVnP97ifOMoPc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P54619 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P68400 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UPN9 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2214398|uniprotkb:O95855|uniprotkb:Q5TG72|uniprotkb:Q5TG73|uniprotkb:Q5TG74|uniprotkb:Q9C017|uniprotkb:Q9UJ79|ensembl:ENSP00000351250 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tri33_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM33(gene name synonym)|uniprotkb:TRIM33(gene name)|psi-mi:TRIM33(display_short)|uniprotkb:KIAA1113(gene name synonym)|uniprotkb:RFG7(gene name synonym)|uniprotkb:TIF1G(gene name synonym)|uniprotkb:Tripartite motif-containing protein 33(gene name synonym)|uniprotkb:Transcription intermediary factor 1-gamma(gene name synonym)|uniprotkb:Ectodermin homolog(gene name synonym)|uniprotkb:RET-fused gene 7 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_056990.3|refseq:NP_148980.2|ensembl:ENSG00000197323(gene)|ensembl:ENST00000358465(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019786|interpro:IPR019787|interpro:IPR027370|interpro:IPR036427|mint:Q9UPN9|rcsb pdb:3U5M|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3U5P|rcsb pdb:5MR8|reactome:R-HSA-2173795|dip:DIP-54262N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:DB02UIWcpeneONPdG17AS08/9/A9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43379 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-714790|uniprotkb:Q63HP9|uniprotkb:Q659D7|uniprotkb:Q8NBF7|uniprotkb:Q96AD9|intact:EBI-2563293|ensembl:ENSP00000270301 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:wdr62_human(display_long)|uniprotkb:WDR62(gene name)|psi-mi:WDR62(display_short)|uniprotkb:C19orf14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0034451"(centriolar satellite)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR036322|mint:O43379|go:"GO:0005813"(centrosome)|ensembl:ENSG00000075702(gene)|ensembl:ENST00000270301(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|refseq:NP_001077430.1|refseq:NP_775907.4|refseq:XP_016882154.1|dip:DIP-56792N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:bKUivd80luQPFZHsU9mDdwyGwi89606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P46939 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:metWqbqGtzonNZ1mgNjlFrenuI89606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O94927 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2558224|uniprotkb:B2RXK1|uniprotkb:Q6P2P7|uniprotkb:Q96CT8|uniprotkb:Q7L3D5|ensembl:ENSP00000439056 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:haus5_human(display_long)|uniprotkb:HAUS5(gene name)|psi-mi:HAUS5(display_short)|uniprotkb:KIAA0841(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_056117.1|ensembl:ENSG00000249115(gene)|ensembl:ENST00000203166(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026215|interpro:IPR029131|mint:O94927|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|dip:DIP-48831N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ChAZl+X89FxK08LHh2+lYDqQZn09606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BUK6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2340176|uniprotkb:Q7LBZ8|uniprotkb:Q5T717|uniprotkb:Q7Z3M7|uniprotkb:Q53GR8|uniprotkb:Q9NQX2|uniprotkb:Q9NVU4|uniprotkb:Q7Z558|uniprotkb:Q5CZ69|uniprotkb:Q8TE05|uniprotkb:Q68CT6|ensembl:ENSP00000245564 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:msto1_human(display_long)|uniprotkb:MSTO1(gene name)|psi-mi:MSTO1(display_short)|uniprotkb:LST005(orf name)|uniprotkb:SLTP005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011508010.1|refseq:NP_060586.2|refseq:NP_001243461.1|refseq:NP_001243462.1|refseq:XP_016857098.1|ensembl:ENSG00000125459(gene)|ensembl:ENST00000245564(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0048311"(mitochondrion distribution)|interpro:IPR019605|interpro:IPR029209|interpro:IPR036525 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:aZOmttCfkLs7GpgtF2DEp2gPrwQ9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q13620 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O14950 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1642165|uniprotkb:D3DUH6|intact:EBI-2826593|uniprotkb:Q7Z5Z4|uniprotkb:Q13182|ensembl:ENSP00000237500|ensembl:ENSP00000383037|ensembl:ENSP00000463559|ensembl:ENSP00000464464|ensembl:ENSP00000496809 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ml12b_human(display_long)|uniprotkb:MYL12B(gene name)|psi-mi:MYL12B(display_short)|uniprotkb:MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:MLC-2A(gene name synonym)|uniprotkb:SHUJUN-1(gene name synonym)|uniprotkb:MYLC2B(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001138416.1|refseq:NP_001138417.1|refseq:NP_291024.1|refseq:NP_001289978.1|ensembl:ENSG00000118680(gene)|ensembl:ENST00000237500(transcript)|ensembl:ENST00000400175(transcript)|ensembl:ENST00000581193(transcript)|ensembl:ENST00000584539(transcript)|ensembl:ENST00000648965(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:O14950|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5VUJ6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2659666|uniprotkb:Q9P233|uniprotkb:Q9HA88|uniprotkb:F5H2T1|uniprotkb:Q08AD5|ensembl:ENSP00000325091 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:lrch2_human(display_long)|uniprotkb:KIAA1495(gene name synonym)|uniprotkb:LRCH2(gene name)|psi-mi:LRCH2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_065922.3|refseq:NP_001230892.1|ensembl:ENSG00000130224(gene)|ensembl:ENST00000317135(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:hjJwBxAeVmoDWTtcKK5NzCIDnBo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y3R5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-4403087|uniprotkb:D3DSG5|uniprotkb:Q6PJQ7|uniprotkb:Q9UEZ3|ensembl:ENSP00000382104 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dop2_human(display_long)|uniprotkb:DOP1B(gene name)|psi-mi:DOP1B(display_short)|uniprotkb:C21orf5(gene name synonym)|uniprotkb:DOPEY2(gene name synonym)|uniprotkb:KIAA0933(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_005119.2|refseq:NP_001307643.1|ensembl:ENSG00000142197(gene)|ensembl:ENST00000399151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0015031"(protein transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007249(Dopey, N-terminal)|interpro:IPR040314 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Xi6Ahb2aiWOCLFMvGusvCKLXtCo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UJX3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1384164|uniprotkb:Q96AC4|uniprotkb:Q96GF4|uniprotkb:Q9BU24|uniprotkb:Q9NT16|ensembl:ENSP00000394394|ensembl:ENSP00000402314 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:apc7_human(display_long)|uniprotkb:ANAPC7(gene name)|psi-mi:ANAPC7(display_short)|uniprotkb:APC7(gene name synonym)|uniprotkb:Cyclosome subunit 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001131136.1|refseq:NP_057322.2|dip:DIP-39765N|ensembl:ENSG00000196510(gene)|ensembl:ENST00000450008(transcript)|ensembl:ENST00000455511(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX3|rcsb pdb:3FFL|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2q+llvuIzK2MOWjPuOUxmyN782E9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q12955 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2691178|uniprotkb:Q5VXD5|intact:EBI-7224084|intact:MINT-1182900|uniprotkb:Q13484|uniprotkb:B4DIL1|uniprotkb:E9PE32|uniprotkb:Q5CZH9|uniprotkb:Q7Z3G4|uniprotkb:B1AQT2|uniprotkb:Q9H0P5|ensembl:ENSP00000280772 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ank3_human(display_long)|uniprotkb:Ankyrin-G(gene name synonym)|uniprotkb:ANK3(gene name)|psi-mi:ANK3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000280772|ensembl:ENST00000355288|ensembl:ENSP00000347436|ensembl:ENST00000373827|ensembl:ENSP00000362933|ensembl:ENST00000503366|ensembl:ENSP00000425236|refseq:NP_066267.2|refseq:NP_001191332.1|refseq:NP_001191333.1|refseq:NP_001140.2|ensembl:ENSG00000151150(gene)|ensembl:ENST00000280772(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010650"(positive regulation of cell communication by electrical coupling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014704"(intercalated disc)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042383"(sarcolemma)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043034"(costamere)|go:"GO:0043194"(axon initial segment)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072660"(maintenance of protein location in plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0099612"(protein localization to axon)|go:"GO:1900827"(positive regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR002110(Ankyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037971|interpro:IPR040745|rcsb pdb:4O6X|reactome:R-HSA-445095|reactome:R-HSA-6807878|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-49017N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:k03Sz+VxForOlnJt8P9i8KAFzss9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O15027 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357515|intact:EBI-1384174|uniprotkb:A1YCA4|uniprotkb:Q5SXP0|uniprotkb:Q5SXP1|uniprotkb:Q8N347|uniprotkb:Q96HP1|uniprotkb:J3KNL6|uniprotkb:Q4G0D7|intact:EBI-28968206|ensembl:ENSP00000325827|intact:EBI-10967582|intact:EBI-21024388 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sc16a_human(display_long)|uniprotkb:KIAA0310(gene name synonym)|uniprotkb:SEC16(gene name synonym)|uniprotkb:SEC16L(gene name synonym)|uniprotkb:SEC16 homolog A(gene name synonym)|uniprotkb:SEC16A(gene name)|psi-mi:SEC16A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011517562.1|refseq:XP_005266191.1|refseq:XP_011517548.1|refseq:XP_011517549.1|refseq:XP_011517550.1|refseq:XP_011517557.1|refseq:XP_011517559.1|refseq:XP_011517561.1|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR024298|interpro:IPR024340|interpro:IPR024880|mint:O15027|reactome:R-HSA-204005|ensembl:ENSG00000148396(gene)|ensembl:ENST00000313050(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031090"(organelle membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|ensembl:ENSP00000325827|refseq:NP_055681.1|refseq:XP_011517554.1|refseq:NP_001263347.1|dip:DIP-27588N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:yB65QJbL+WBjtWO5UXAx2DCRbwI9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y6W3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1765641|ensembl:ENSP00000253693 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:can7_human(display_long)|uniprotkb:CAPN7(gene name)|psi-mi:CAPN7(display_short)|uniprotkb:PALBH(gene name synonym)|uniprotkb:PalB homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055111.1|ensembl:ENSG00000131375(gene)|ensembl:ENST00000253693(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:0097264"(self proteolysis)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR007330(MIT)|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR036181|interpro:IPR036213|interpro:IPR038765|mint:Q9Y6W3|rcsb pdb:2QFE|reactome:R-HSA-1474228 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:tRDBeVQRu1tuCDWtSrve/Y9lWsg9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O43432 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O14974 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P63172 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1176455|uniprotkb:Q15763|ensembl:ENSP00000356056|uniprotkb:Q5VTU4 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dylt1_human(display_long)|uniprotkb:T-complex testis-specific protein 1 homolog(gene name synonym)|uniprotkb:Protein CW-1(gene name synonym)|uniprotkb:DYNLT1(gene name)|psi-mi:DYNLT1(display_short)|uniprotkb:TCTEL1(gene name synonym)|uniprotkb:TCTEX1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_006510.1|ensembl:ENSG00000146425(gene)|ensembl:ENST00000367089(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043657"(host cell)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061564"(axon development)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)|go:"GO:0099503"(secretory vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|rcsb pdb:5JPW|reactome:R-HSA-6798695|go:"GO:0005881"(cytoplasmic microtubule)|dip:DIP-35251N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:RKVyHgf4iNjcY6GfLdIukFOFE+s9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q99567 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-726178|uniprotkb:Q9BWE5|uniprotkb:D3DTM2|intact:EBI-28967918|ensembl:ENSP00000458954 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nup88_human(display_long)|uniprotkb:Nucleoporin Nup88(gene name synonym)|uniprotkb:88 kDa nucleoporin(gene name synonym)|uniprotkb:NUP88(gene name)|psi-mi:NUP88(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000458954|refseq:NP_002523.2|refseq:NP_001307582.1|ensembl:ENSG00000108559(gene)|ensembl:ENST00000573584(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005215"(transporter activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|interpro:IPR019321|interpro:IPR037700|mint:Q99567|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:4e7YTurNWkXUn9zj0JiD2muc94A9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P24468 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2795198|uniprotkb:B6ZGU1|uniprotkb:Q03754|uniprotkb:B4DQJ2|uniprotkb:Q3KQR7|ensembl:ENSP00000377721 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cot2_human(display_long)|uniprotkb:NR2F2(gene name)|psi-mi:NR2F2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:TFCOUP2(gene name synonym)|uniprotkb:COUP transcription factor II(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 2(gene name synonym)|uniprotkb:Apolipoprotein A-I regulatory protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_066285.1|refseq:NP_001138627.1|refseq:NP_001138628.1|refseq:NP_001138629.1|ensembl:ENSG00000185551(gene)|ensembl:ENST00000394166(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0009956"(radial pattern formation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0032355"(response to estradiol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060173"(limb development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:3CJW|reactome:R-HSA-381340|dip:DIP-29713N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:XsZyqUr06sQQaD3oXAA3IEa6Dug9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P36957 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O94826 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q14677 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P11474 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O95477 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75616 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P24928 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H840 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-715455|uniprotkb:Q6IA34|ensembl:ENSP00000375813|ensembl:ENSP00000465704|ensembl:ENSP00000466342|ensembl:ENSP00000270257 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:gemi7_human(display_long)|uniprotkb:SIP3(gene name synonym)|uniprotkb:GEMIN7(gene name)|psi-mi:GEMIN7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_005259319.1|refseq:XP_005259320.1|refseq:NP_001007270.1|refseq:NP_001007271.1|refseq:NP_078983.1|ensembl:ENSG00000142252(gene)|ensembl:ENST00000270257(transcript)|ensembl:ENST00000391951(transcript)|ensembl:ENST00000591607(transcript)|ensembl:ENST00000591747(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0120114"(Sm-like protein family complex)|interpro:IPR020338|interpro:IPR024642|mint:Q9H840|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859|refseq:NP_001305983.1|refseq:NP_001305984.1|refseq:XP_016882801.1|dip:DIP-41750N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:jnNKbzuQxiIWKDmv7+je9B5U81Q9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NVH1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1055336|uniprotkb:Q4VWF5|uniprotkb:Q5VZN0|uniprotkb:Q6PK20|uniprotkb:Q6PK70|uniprotkb:Q8NDM2|uniprotkb:Q96CL7|ensembl:ENSP00000366800 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:djc11_human(display_long)|uniprotkb:DNAJC11(gene name)|psi-mi:DNAJC11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060668.2|ensembl:ENSG00000007923(gene)|ensembl:ENST00000377577(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0042407"(cristae formation)|go:"GO:0140275"(MIB complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR024586|interpro:IPR036869|mint:Q9NVH1|reactome:R-HSA-8949613 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:+I9CW/QUSn5NIkn2CRTFzq50c/I9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O14602 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-286439|uniprotkb:Q9BS77|ensembl:ENSP00000354722 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:if1ay_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 4C(gene name synonym)|uniprotkb:EIF1AY(gene name)|psi-mi:EIF1AY(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004672.2|refseq:NP_001265541.1|ensembl:ENSG00000198692(gene)|ensembl:ENST00000361365(transcript)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR001253("Eukaryotic initiation factor 1A (eIF-1A)")|interpro:IPR006196(S1, IF1 type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018104 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:8nbys9cgdyGlFgYev/Ws9Q0cu6s9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P37198 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q99615 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H857 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-359244|uniprotkb:O95888|uniprotkb:Q96C80|uniprotkb:Q9H9Z8|uniprotkb:C9JTZ6|uniprotkb:E9PAL9|intact:EBI-11044897|ensembl:ENSP00000302468 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nt5d2_human(display_long)|uniprotkb:NT5DC2(gene name)|psi-mi:NT5DC2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001127703.1|refseq:NP_075059.1|refseq:XP_005265463.1|refseq:XP_006713368.1|ensembl:ENSG00000168268(gene)|ensembl:ENST00000307076(transcript)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:nfT/9N1bWVadX70eY1G0GS9pS9U9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P54098 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-852624|uniprotkb:Q8NFM2|uniprotkb:Q92515|ensembl:ENSP00000268124|ensembl:ENSP00000399851 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dpog1_human(display_long)|uniprotkb:Mitochondrial DNA polymerase catalytic subunit(gene name synonym)|uniprotkb:PolG-alpha(gene name synonym)|uniprotkb:POLG(gene name)|psi-mi:POLG(display_short)|uniprotkb:MDP1(gene name synonym)|uniprotkb:POLG1(gene name synonym)|uniprotkb:POLGA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001119603.1|refseq:NP_002684.1|ensembl:ENSG00000140521(gene)|ensembl:ENST00000268124(transcript)|ensembl:ENST00000442287(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0007568"(aging)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043195"(terminal bouton)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071333"(cellular response to glucose stimulus)|interpro:IPR001098(DNA-directed DNA polymerase, family A)|interpro:IPR002297(DNA-directed DNA-polymerase, family A, mitochondria)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR019760|interpro:IPR041336|interpro:IPR043502|mint:P54098|rcsb pdb:3IKM|rcsb pdb:4ZTU|rcsb pdb:4ZTZ|rcsb pdb:5C51|rcsb pdb:5C52|rcsb pdb:5C53 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Gt8NCLdg0R/XLyFsovnrnLrzb/A9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y5V3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q6DKK2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8NFF5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5TA45 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q15370 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P60510 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8NB37 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-722742|uniprotkb:Q2NL76|uniprotkb:Q6ZQY0|uniprotkb:Q8NAE0|uniprotkb:B7ZKW5|ensembl:ENSP00000321691 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:gald1_human(display_long)|uniprotkb:GATD1(gene name)|psi-mi:GATD1(display_short)|uniprotkb:PDDC1(gene name synonym)|uniprotkb:Parkinson disease 7 domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_872418.1|refseq:NP_001305753.1|refseq:XP_016873156.1|ensembl:ENSG00000177225(gene)|ensembl:ENST00000319863(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR029062 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:LQ3FMvZSS7oVbsX1VhtEaFlWbR49606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UHW5 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-395491|uniprotkb:Q53FS3|uniprotkb:Q6UVZ6|uniprotkb:Q7Z3D3|uniprotkb:Q8NEI2|uniprotkb:Q96HK9|uniprotkb:B2RC54|uniprotkb:D4YWV1|ensembl:ENSP00000228827|uniprotkb:F5H759 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:gpn3_human(display_long)|uniprotkb:ATPBD1C(gene name synonym)|uniprotkb:ATP-binding domain 1 family member C(gene name synonym)|uniprotkb:GPN3(gene name)|psi-mi:GPN3(display_short)|uniprotkb:AD-009(orf name)|uniprotkb:UNQ1876/PRO4319(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001157844.1|refseq:NP_001157845.1|refseq:NP_057385.3|ensembl:ENSG00000111231(gene)|ensembl:ENST00000228827(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030228|mint:Q9UHW5 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:fKBsnLcvitaM76zQUW+MQXDPxTA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q14181 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-712752|ensembl:ENSP00000265465|uniprotkb:Q9BPV3|uniprotkb:B4DNB4 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dpoa2_human(display_long)|uniprotkb:DNA polymerase alpha 70 kDa subunit(gene name synonym)|uniprotkb:POLA2(gene name)|psi-mi:POLA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 reactome:R-HSA-69183|reactome:R-HSA-69166|reactome:R-HSA-9710421|ensembl:ENSG00000014138(gene)|ensembl:ENST00000265465(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR013627(DNA polymerase alpha, subunit B N-terminal)|interpro:IPR016722(DNA polymerase alpha, subunit B)|interpro:IPR043034|rcsb pdb:2KEB|rcsb pdb:4E2I|rcsb pdb:4Y97|rcsb pdb:5EXR|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|refseq:NP_002680.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:cPvK8qerkbSbnl1+TAIlBqTuEFU9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75828 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-714504|ensembl:ENSP00000290354|uniprotkb:Q6FHP2 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cbr3_human(display_long)|uniprotkb:NADPH-dependent carbonyl reductase 3(gene name synonym)|uniprotkb:CBR3(gene name)|psi-mi:CBR3(display_short)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000159231(gene)|ensembl:ENST00000290354(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0042376"(phylloquinone catabolic process)|go:"GO:0050890"(cognition)|go:"GO:0070402"(NADPH binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:2HRB|reactome:R-HSA-211945|refseq:NP_001227.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:31QYceUdGN2HanRmiei1aR9f8MI9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NWS0 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P62875 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-359527|ensembl:ENSP00000324124|ensembl:ENSP00000432807|uniprotkb:P52436|uniprotkb:Q6FHX3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rpab5_human(display_long)|uniprotkb:POLR2L(gene name)|psi-mi:POLR2L(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit L(gene name synonym)|uniprotkb:RPB10 homolog(gene name synonym)|uniprotkb:RNA polymerase II 7.6 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000177700(gene)|ensembl:ENST00000322028(transcript)|ensembl:ENST00000534030(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR000268(RNA polymerases, N/8 Kd subunits)|interpro:IPR020789|interpro:IPR023580|mint:P62875|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|refseq:NP_066951.1|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-75955|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-203927|dip:DIP-32960N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:uDzgKgHzFTPxFaV1GeUYdYMa4Gk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BVL4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-16811833|ensembl:ENSP00000370288|uniprotkb:Q2TAL2|uniprotkb:Q5JZ81|uniprotkb:Q8WUI0 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:selo_human(display_long)|uniprotkb:Selenoprotein O(gene name synonym)|uniprotkb:SELENOO(gene name)|psi-mi:SELENOO(display_short)|uniprotkb:SELO(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000073169(gene)|ensembl:ENST00000380903(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0018117"(protein adenylylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070733"(protein adenylyltransferase activity)|interpro:IPR003846(Protein of unknown function UPF0061)|refseq:NP_113642.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Rfwzqq4U1s+f8ugyECwJWlWKD1Y9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q86TG7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2858265|uniprotkb:Q9UPV1|uniprotkb:Q96A68 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:peg10_human(display_long)|uniprotkb:PEG10(gene name)|psi-mi:PEG10(display_short)|uniprotkb:EDR(gene name synonym)|uniprotkb:KIAA1051(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:MART2(gene name synonym)|uniprotkb:MEF3L1(gene name synonym)|uniprotkb:RGAG3(gene name synonym)|uniprotkb:Embryonal carcinoma differentiation-regulated protein(gene name synonym)|uniprotkb:Mammalian retrotransposon-derived protein 2(gene name synonym)|uniprotkb:Myelin expression factor 3-like protein 1(gene name synonym)|uniprotkb:Paternally expressed gene 10 protein(gene name synonym)|uniprotkb:Retrotransposon gag domain-containing protein 3(gene name synonym)|uniprotkb:Retrotransposon-derived gag-like polyprotein(gene name synonym)|uniprotkb:Ty3/Gypsy-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 interpro:IPR032549|interpro:IPR032567|refseq:NP_001035242.1|refseq:NP_001171890.1|refseq:NP_001171891.1|refseq:NP_055883.2|interpro:IPR021109|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR043128|interpro:IPR043502 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:wkCBsH9/PsFMwJFu/qOwZcn63D49606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9UHD2 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96QG7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-744593|uniprotkb:Q52LU3|uniprotkb:Q8WW11|uniprotkb:Q96QG6|uniprotkb:Q9NX50|uniprotkb:B7Z291|ensembl:ENSP00000221086|ensembl:ENSP00000495551|ensembl:ENSP00000496677 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mtmr9_human(display_long)|uniprotkb:MTMR9(gene name)|psi-mi:MTMR9(display_short)|uniprotkb:C8orf9(gene name synonym)|uniprotkb:MTMR8(gene name synonym)|uniprotkb:Inactive phosphatidylinositol 3-phosphatase 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_056273.2|dip:DIP-54283N|ensembl:ENSG00000285032(gene)|ensembl:ENST00000221086(transcript)|ensembl:ENST00000644306(transcript)|ensembl:ENST00000646141(transcript)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029021|interpro:IPR030564|mint:Q96QG7|reactome:R-HSA-1660499|reactome:R-HSA-1660517|reactome:R-HSA-1855183|ensembl:ENSG00000104643(gene) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:CdtI/coErr0SNIsW1sz1KdGb3LA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P51114 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H0A8 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9P253 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q96N67 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75600 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2959690|ensembl:ENSP00000248924|uniprotkb:Q96CA9|uniprotkb:E2QC23|uniprotkb:Q6ZWF1 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:kbl_human(display_long)|uniprotkb:GCAT(gene name)|psi-mi:GCAT(display_short)|uniprotkb:KBL(gene name synonym)|uniprotkb:Aminoacetone synthase(gene name synonym)|uniprotkb:Glycine acetyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000100116(gene)|ensembl:ENST00000248924(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0008890"(glycine C-acetyltransferase activity)|go:"GO:0009058"(biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019518"(L-threonine catabolic process to glycine)|go:"GO:0030170"(pyridoxal phosphate binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR011282(2-amino-3-ketobutyrate coenzyme A ligase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|reactome:R-HSA-8849175|refseq:NP_055106.1|refseq:NP_001165161.1|refseq:XP_005261467.1|refseq:XP_016884166.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:JcxSdpqnWgMx3m5s6nO38OjqO+I9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P55010 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-286450|uniprotkb:Q9H5N2|uniprotkb:Q9UG48|uniprotkb:Q53XB3|ensembl:ENSP00000216554|ensembl:ENSP00000376477|ensembl:ENSP00000453743 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:if5_human(display_long)|uniprotkb:EIF5(gene name)|psi-mi:EIF5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001960.2|refseq:NP_892116.2|ensembl:ENSG00000100664(gene)|ensembl:ENST00000216554(transcript)|ensembl:ENST00000392715(transcript)|ensembl:ENST00000558506(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P55010|rcsb pdb:2E9H|rcsb pdb:2G2K|rcsb pdb:2IU1|reactome:R-HSA-72702|reactome:R-HSA-72706 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lM5AZJWJOQGbxADfl8MGCx3JAXc9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y679 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1058701|ensembl:ENSP00000366748|uniprotkb:Q9H866|uniprotkb:Q9UNQ6|uniprotkb:Q9Y685|uniprotkb:C0H5W8 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:aup1_human(display_long)|uniprotkb:AUP1(gene name)|psi-mi:AUP1(display_short)|uniprotkb:Ancient ubiquitous protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000115307(gene)|ensembl:ENST00000377526(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_853553.1|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990044"(protein localization to lipid droplet)|interpro:IPR003892(Ubiquitin system component Cue)|rcsb pdb:2EKF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:6yySfIPpRUlnm0upBDYyfBUOtIY9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H269 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2655929|uniprotkb:Q5JUB1|uniprotkb:Q8WU31|uniprotkb:Q96EE7|uniprotkb:Q96N92|uniprotkb:Q9H1Q4|uniprotkb:Q9H1Q5|ensembl:ENSP00000369810 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:vps16_human(display_long)|uniprotkb:VPS16(gene name)|psi-mi:VPS16(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_072097.2|refseq:NP_536338.1|ensembl:ENSG00000215305(gene)|ensembl:ENST00000380445(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR038132|mint:Q9H269|rcsb pdb:4BX9 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:bm088LmFRv3w0wfvlPMFeottZkw9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P30048 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:+J/zV8u0jGCSzTGXafxgecTv/149606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q13555 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9Y2S7 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q2TAL8 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2798044|uniprotkb:Q8TEA5|uniprotkb:Q4G0F7|uniprotkb:Q7L621|ensembl:ENSP00000350094|ensembl:ENSP00000378830|ensembl:ENSP00000412890 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:qric1_human(display_long)|uniprotkb:QRICH1(gene name)|psi-mi:QRICH1(display_short)|uniprotkb:Glutamine-rich protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001307509.1|refseq:NP_001307510.1|refseq:NP_001307511.1|refseq:NP_001307512.1|refseq:NP_001307513.1|refseq:NP_001307514.1|refseq:XP_011532165.1|refseq:NP_060200.2|refseq:NP_942581.1|ensembl:ENSG00000198218(gene)|ensembl:ENST00000357496(transcript)|ensembl:ENST00000395443(transcript)|ensembl:ENST00000424300(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0140467"(integrated stress response signaling)|interpro:IPR021893 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:lZutsiEMc3Fpej5M2vhosiQZnoA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9BZE1 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-5325218|ensembl:ENSP00000354086|uniprotkb:Q96Q67|uniprotkb:Q9BWR1|uniprotkb:Q9P0P3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rm37_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL37(gene name synonym)|uniprotkb:MRPL37(gene name)|psi-mi:MRPL37(display_short)|uniprotkb:MRPL2(gene name synonym)|uniprotkb:RPML2(gene name synonym)|uniprotkb:39S ribosomal protein L2, mitochondrial(gene name synonym)|uniprotkb:HSPC235(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000116221(gene)|ensembl:ENST00000360840(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR010793(Ribosomal protein S30, mitochondrial)|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:3J7Y|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:3J9M|rcsb pdb:7ODR|rcsb pdb:5OOL|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:5OOM|rcsb pdb:7OF0|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OG4|refseq:NP_057575.2|dip:DIP-59718N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:rYwNelB9BJA4STHaD5AlJjUxCpM9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q8NFH4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2563158|ensembl:ENSP00000251074|ensembl:ENSP00000448054|uniprotkb:Q9H644 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nup37_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit Nup37(gene name synonym)|uniprotkb:NUP37(gene name)|psi-mi:NUP37(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_076962.2|ensembl:ENSG00000075188(gene)|ensembl:ENST00000251074(transcript)|ensembl:ENST00000552283(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037626|mint:Q8NFH4|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:mOkDLvRNOkSg/v6jnvOox6ZNTzo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P19387 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-394729|uniprotkb:O15161|ensembl:ENSP00000219252 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rpb3_human(display_long)|uniprotkb:POLR2C(gene name)|psi-mi:POLR2C(display_short)|uniprotkb:A-152E5.7(orf name)|uniprotkb:DNA-directed RNA polymerase II subunit C(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 33 kDa polypeptide(gene name synonym)|uniprotkb:RPB31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_116558.1|ensembl:ENSG00000102978(gene)|ensembl:ENST00000219252(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR036603|interpro:IPR036643|mint:P19387|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32911N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:UXFC+i+QqB2WRgL9OiYSQ66L36c9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P84085 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-4289908|uniprotkb:P26437|ensembl:ENSP00000000233 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:arf5_human(display_long)|uniprotkb:ARF5(gene name)|psi-mi:ARF5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSG00000004059(gene)|ensembl:ENST00000000233(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84085|rcsb pdb:2B6H|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001653.1|dip:DIP-61289N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P31327 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-536811|uniprotkb:O43774|uniprotkb:Q7Z5I5|uniprotkb:B7Z818|uniprotkb:Q53TL5|uniprotkb:J3KQL0|uniprotkb:Q59HF8|ensembl:ENSP00000233072|ensembl:ENSP00000500537|ensembl:ENSP00000501022|ensembl:ENSP00000501073 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:cpsm_human(display_long)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)|uniprotkb:CPS1(gene name)|psi-mi:CPS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001116105.1|refseq:NP_001116106.1|refseq:NP_001866.2|refseq:XP_011508943.1|refseq:XP_011508944.1|refseq:XP_011508945.1|refseq:XP_011508946.1|ensembl:ENSG00000021826(gene)|ensembl:ENST00000233072(transcript)|ensembl:ENST00000673510(transcript)|ensembl:ENST00000673630(transcript)|ensembl:ENST00000673711(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:P31327|rcsb pdb:2YVQ|rcsb pdb:4UTR|rcsb pdb:4UTV|rcsb pdb:4UTX|rcsb pdb:4UTZ|rcsb pdb:4UU7|rcsb pdb:4UU8|rcsb pdb:4UUA|rcsb pdb:4UUB|rcsb pdb:5DOT|rcsb pdb:5DOU|rcsb pdb:5OJO|rcsb pdb:6UEL|rcsb pdb:6W2J|reactome:R-HSA-70635 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:497s02igPCWuQcU4lVrMpl5SRig9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NP81 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1049768|uniprotkb:A6NHW7|uniprotkb:Q9BVP3|uniprotkb:B4DE10|ensembl:ENSP00000221431|ensembl:ENSP00000489539 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:sysm_human(display_long)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)|uniprotkb:SerRSmt(gene name synonym)|uniprotkb:SARS2(gene name)|psi-mi:SARS2(display_short)|uniprotkb:SARSM(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001139373.1|refseq:NP_060297.1|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR033729|interpro:IPR042103|mint:Q9NP81|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|reactome:R-HSA-379726|ensembl:ENSG00000104835(gene)|ensembl:ENSG00000283104(gene)|ensembl:ENST00000221431(transcript)|ensembl:ENST00000634687(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0070158"(mitochondrial seryl-tRNA aminoacylation)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process") - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:xYa2ZQIifKicNHV/6vlcUGaN9q49606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q13418 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NVH6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-395312|uniprotkb:Q5TZB5|uniprotkb:Q6IA90|uniprotkb:Q8TBT0|ensembl:ENSP00000335261|uniprotkb:A8K6M9|uniprotkb:B4E3R3 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:tmlh_human(display_long)|uniprotkb:TMLHE(gene name)|psi-mi:TMLHE(display_short)|uniprotkb:TMLH(gene name synonym)|uniprotkb:Epsilon-trimethyllysine 2-oxoglutarate dioxygenase(gene name synonym)|uniprotkb:TML-alpha-ketoglutarate dioxygenase(gene name synonym)|uniprotkb:TML hydroxylase(gene name synonym)|uniprotkb:Epsilon-trimethyllysine hydroxylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001171726.1|refseq:NP_060666.1|go:"GO:0051354"(negative regulation of oxidoreductase activity)|interpro:IPR003819(Taurine catabolism dioxygenase TauD/TfdA)|interpro:IPR010376(Protein of unknown function DUF971)|interpro:IPR012776(Trimethyllysine dioxygenase)|interpro:IPR038492|interpro:IPR042098|reactome:R-HSA-71262|ensembl:ENSG00000185973(gene)|ensembl:ENST00000334398(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050353"(trimethyllysine dioxygenase activity) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:QJwymZVdaxmMdea5RhA7vcPCla49606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q92882 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P35658 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9H6T3 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P50336 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q92900 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P09110 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-3926709|ensembl:ENSP00000333664|uniprotkb:G5E935|uniprotkb:Q96CA6 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:thik_human(display_long)|uniprotkb:ACAA1(gene name)|psi-mi:ACAA1(display_short)|uniprotkb:ACAA(gene name synonym)|uniprotkb:PTHIO(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001123882.1|refseq:NP_001598.1|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2IIK|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-6798695|reactome:R-HSA-9033241|reactome:R-HSA-9033500|ensembl:ENSG00000060971(gene)|ensembl:ENST00000333167(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005576"(extracellular region) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:yWp9R9bAzdied8kfDD+qVrY8Slk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5JPH6 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-13943410|ensembl:ENSP00000395196|ensembl:ENSP00000501251|uniprotkb:B3KTT2|uniprotkb:D3DWF1|uniprotkb:Q86YH3|uniprotkb:Q8TF31 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:syem_human(display_long)|uniprotkb:EARS2(gene name)|psi-mi:EARS2(display_short)|uniprotkb:Glutamyl-tRNA synthetase(gene name synonym)|uniprotkb:KIAA1970(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020058|interpro:IPR020751|interpro:IPR033910|reactome:R-HSA-379726|ensembl:ENSG00000103356(gene)|ensembl:ENST00000449606(transcript)|ensembl:ENST00000674054(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0050561"("glutamate-tRNA(Gln) ligase activity")|go:"GO:0070127"(tRNA aminoacylation for mitochondrial protein translation)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004527(Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial)|refseq:NP_001077083.1|refseq:NP_001295140.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:Jo4TXXabhrL7bgEVz1Ffm/766PA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q16740 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1056029|uniprotkb:B2R4W5|ensembl:ENSP00000245816 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:clpp_human(display_long)|uniprotkb:CLPP(gene name)|psi-mi:CLPP(display_short)|uniprotkb:Endopeptidase Clp(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_006003.1|ensembl:ENSG00000125656(gene)|ensembl:ENST00000245816(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:1TG6|rcsb pdb:6BBA|rcsb pdb:6DL7|rcsb pdb:6H23|dip:DIP-50384N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:HTSz7OgKpaMKvoab6xXG0i4ZcBk9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O60282 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-717170|uniprotkb:O95079|uniprotkb:Q2YDC5|ensembl:ENSP00000393379|ensembl:ENSP00000503013 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:kif5c_human(display_long)|uniprotkb:Kinesin heavy chain neuron-specific 2(gene name synonym)|uniprotkb:KIF5C(gene name)|psi-mi:KIF5C(display_short)|uniprotkb:KIAA0531(gene name synonym)|uniprotkb:NKHC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_004513.1|refseq:XP_011509459.1|refseq:XP_016859551.1|ensembl:ENSG00000168280(gene)|ensembl:ENST00000435030(transcript)|ensembl:ENST00000677891(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006996"(organelle organization)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0150034"(distal axon)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|mint:O60282|reactome:R-HSA-264876|interpro:IPR036961 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:4TqyBBhm1/nyaCSyz66oisPiwpA9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q14157 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q5ST30 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NU22 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1050480|uniprotkb:O15019|uniprotkb:Q5T794|ensembl:ENSP00000358400|ensembl:ENSP00000486270|ensembl:ENSP00000499843|ensembl:ENSP00000499895 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:mdn1_human(display_long)|uniprotkb:MIDAS-containing protein(gene name synonym)|uniprotkb:Dynein-related AAA-ATPase MDN1(gene name synonym)|uniprotkb:MDN1(gene name)|psi-mi:MDN1(display_short)|uniprotkb:KIAA0301(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_055426.1|ensembl:ENSG00000112159(gene)|ensembl:ENSG00000288121(gene)|ensembl:ENST00000369393(transcript)|ensembl:ENST00000629399(transcript)|ensembl:ENST00000672983(transcript)|ensembl:ENST00000673332(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR012099(Midasin)|interpro:IPR027417|interpro:IPR036465|interpro:IPR040848|interpro:IPR041190|mint:Q9NU22|go:"GO:0005829"(cytosol) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:/LVYhffZVpP0pYVM6hLNltoc6pY9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:Q9NSE4 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:P10809 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LU5 uniprotkb:O75792 intact:EBI-21619007|ensembl:ENSP00000278200|ensembl:ENSP00000435576|uniprotkb:D3DQZ7|uniprotkb:Q96SH9 intact:EBI-9027352|uniprotkb:Q96F11|uniprotkb:B2RCY1|ensembl:ENSP00000221486 psi-mi:imp1l_human(display_long)|uniprotkb:IMP1-like protein(gene name synonym)|uniprotkb:IMMP1L(gene name)|psi-mi:IMMP1L(display_short) psi-mi:rnh2a_human(display_long)|uniprotkb:RNASEH2A(gene name)|psi-mi:RNASEH2A(display_short)|uniprotkb:Aicardi-Goutieres syndrome 4 protein(gene name synonym)|uniprotkb:RNASEHI(gene name synonym)|uniprotkb:RNHIA(gene name synonym)|uniprotkb:"RNase H(35)"(gene name synonym)|uniprotkb:Ribonuclease HI large subunit(gene name synonym)|uniprotkb:Ribonuclease HI subunit A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050332|imex:IM-29123-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148950(gene)|ensembl:ENST00000278200(transcript)|ensembl:ENST00000532287(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR036286|refseq:XP_011518245.1|refseq:NP_001291203.1|refseq:NP_659418.1|refseq:XP_005252869.1|refseq:XP_011518244.1|refseq:XP_011518246.1|refseq:XP_011518247.1|refseq:XP_011518248.1|refseq:XP_011518249.1|refseq:XP_016872794.1 refseq:NP_006388.2|ensembl:ENSG00000104889(gene)|ensembl:ENST00000221486(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006298"(mismatch repair)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0032299"(ribonuclease H2 complex)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0046872"(metal ion binding)|interpro:IPR001352(Ribonuclease HII/HIII)|interpro:IPR004649(Ribonuclease HII)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR023160|interpro:IPR024567|interpro:IPR036397|rcsb pdb:3P56|rcsb pdb:3PUF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:Ksp9iEfki1yzeEpGRBHNGLTgBFA9606 rogid:UCK5FUsIvOKaNqxTiD2uRHyJ/ws9606 rigid:GIcmC8OLu7H8ATVCNX9+cJJlKKg false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5VZM2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8WXF1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NB46 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1996119|uniprotkb:B1Q2K2|uniprotkb:A6NE79|ensembl:ENSP00000267116 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:anr52_human(display_long)|uniprotkb:ANKRD52(gene name)|psi-mi:ANKRD52(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 52(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_775866.2|ensembl:ENSG00000139645(gene)|ensembl:ENST00000267116(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:yDxfgyMLVZlGwQW0OSokGlMkmPo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75717 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3951691|ensembl:ENSP00000353793|uniprotkb:C9JW18|uniprotkb:F6W0U7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:wdhd1_human(display_long)|uniprotkb:WDHD1(gene name)|psi-mi:WDHD1(display_short)|uniprotkb:AND1(gene name synonym)|uniprotkb:Acidic nucleoplasmic DNA-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000198554(gene)|ensembl:ENST00000360586(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0043596"(nuclear replication fork)|interpro:IPR001680(WD40 repeat)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR022100|interpro:IPR024977|interpro:IPR036322|interpro:IPR036910|rcsb pdb:2D7L|rcsb pdb:5GVA|rcsb pdb:5GVB|rcsb pdb:5OGS|rcsb pdb:6XTY|refseq:NP_001008397.1|refseq:NP_009017.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:SNbJutgOfo9kguAoOv5Hdhk5s+k9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NEC7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-8469616|intact:MINT-6779113|uniprotkb:Q9H8S3|uniprotkb:A8MVD3|uniprotkb:A8K8J0|uniprotkb:H9KV97|ensembl:ENSP00000353695|ensembl:ENSP00000378216|ensembl:ENSP00000422354 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gstcd_human(display_long)|uniprotkb:GSTCD(gene name)|psi-mi:GSTCD(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011530550.1|refseq:XP_011530551.1|refseq:XP_011530554.1|refseq:NP_001026890.2|refseq:NP_079027.2|refseq:XP_005263279.1|ensembl:ENSG00000138780(gene)|ensembl:ENST00000360505(transcript)|ensembl:ENST00000394728(transcript)|ensembl:ENST00000515279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR025714|interpro:IPR029063|interpro:IPR036282|mint:Q8NEC7 - - comment:mint|comment:homomint figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jg34D624i8iGCgGTedM+tfGgmRQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H6K4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-8477908|intact:MINT-8417711|uniprotkb:Q6P384|uniprotkb:Q8N784|ensembl:ENSP00000263275 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:opa3_human(display_long)|uniprotkb:OPA3(gene name)|psi-mi:OPA3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_079412.1|refseq:NP_001017989.2|ensembl:ENSG00000125741(gene)|ensembl:ENST00000263275(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0007601"(visual perception)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0050896"(response to stimulus)|interpro:IPR010754(Optic atrophy 3-like)|mint:Q9H6K4 - - comment:mint|comment:homomint figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:HlwZbHAbo7/jSdCOBbWhF5wKlvE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BTY7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BW61 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y3D9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054270|uniprotkb:Q96Q24|uniprotkb:Q9BWH8|uniprotkb:Q9P053|uniprotkb:B2R6V3|ensembl:ENSP00000320184 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt23_human(display_long)|uniprotkb:MRPS23(gene name)|psi-mi:MRPS23(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS23(gene name synonym)|uniprotkb:CGI-138(orf name)|uniprotkb:HSPC329(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057154.2|ensembl:ENSG00000181610(gene)|ensembl:ENST00000313608(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0031965"(nuclear membrane)|interpro:IPR019520|interpro:IPR023611|mint:Q9Y3D9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:6Iyu6KkT1Y0+n0LKWy5Gf0DkhHw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P53582 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051435|uniprotkb:B4E2E6|ensembl:ENSP00000296411 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:map11_human(display_long)|uniprotkb:Peptidase M 1(gene name synonym)|uniprotkb:METAP1(gene name)|psi-mi:METAP1(display_short)|uniprotkb:KIAA0094(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055958.2|ensembl:ENSG00000164024(gene)|ensembl:ENST00000296411(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0031365"(N-terminal protein amino acid modification)|go:"GO:0046872"(metal ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070084"(protein initiator methionine removal)|go:"GO:0070527"(platelet aggregation)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR001714(Peptidase M24, methionine aminopeptidase)|interpro:IPR002467(Peptidase M24A, methionine aminopeptidase, subfamily 1)|interpro:IPR031615|interpro:IPR036005|rcsb pdb:2B3H|rcsb pdb:2B3K|rcsb pdb:2B3L|rcsb pdb:2G6P|rcsb pdb:2GZ5|rcsb pdb:2NQ6|rcsb pdb:2NQ7|rcsb pdb:4FLI|rcsb pdb:4FLJ|rcsb pdb:4FLK|rcsb pdb:4FLL|rcsb pdb:4HXX|rcsb pdb:4IKR|rcsb pdb:4IKS|rcsb pdb:4IKT|rcsb pdb:4IKU|rcsb pdb:4IU6|rcsb pdb:4U1B|rcsb pdb:4U69|rcsb pdb:4U6C|rcsb pdb:4U6E|rcsb pdb:4U6J|rcsb pdb:4U6W|rcsb pdb:4U6Z|rcsb pdb:4U70|rcsb pdb:4U71|rcsb pdb:4U73|rcsb pdb:4U75|rcsb pdb:4U76|rcsb pdb:5YKP|rcsb pdb:5YR4|rcsb pdb:5YR5|rcsb pdb:5YR6|rcsb pdb:5YR7|rcsb pdb:6LZB|rcsb pdb:6LZC|reactome:R-HSA-2514859 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rjlwnLqFUpQLlzyigVWlNAQ9XUw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96DA6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-9679081|uniprotkb:B2R4B1|uniprotkb:C9JBV1|ensembl:ENSP00000372005 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tim14_human(display_long)|uniprotkb:DNAJC19(gene name)|psi-mi:DNAJC19(display_short)|uniprotkb:TIM14(gene name synonym)|uniprotkb:TIMM14(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001177162.1|refseq:NP_660304.1|dip:DIP-62091N|ensembl:ENSG00000205981(gene)|ensembl:ENST00000382564(transcript)|go:"GO:0001405"(PAM complex, Tim23 associated import motor)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0048806"(genitalia development)|go:"GO:0098800"(inner mitochondrial membrane protein complex)|go:"GO:0099617"(matrix side of mitochondrial inner membrane)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR036869|reactome:R-HSA-1268020 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:D4F4Zp25GxZQckdl1pJaBwciYik9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8TD30 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2512017|ensembl:ENSP00000345282|uniprotkb:Q8N9E2 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:alat2_human(display_long)|uniprotkb:GPT2(gene name)|psi-mi:GPT2(display_short)|uniprotkb:AAT2(gene name synonym)|uniprotkb:ALT2(gene name synonym)|uniprotkb:Glutamic--pyruvic transaminase 2(gene name synonym)|uniprotkb:Glutamate pyruvate transaminase 2(gene name synonym)|uniprotkb:Glutamic--alanine transaminase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000166123(gene)|ensembl:ENST00000340124(transcript)|go:"GO:0004021"("L-alanine:2-oxoglutarate aminotransferase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042851"(L-alanine metabolic process)|go:"GO:0042853"(L-alanine catabolic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:3IHJ|reactome:R-HSA-8964540|refseq:NP_001135938.1|refseq:NP_597700.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:y1b6AvLMwS7WNYKP9r2gwU2BeR49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P68400 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P24928 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O15084 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359567|uniprotkb:Q6ULS0|uniprotkb:Q6ZT57|uniprotkb:B4DES5|uniprotkb:Q1WWL4|uniprotkb:Q29RW6|uniprotkb:Q3B857|ensembl:ENSP00000382379|ensembl:ENSP00000397341 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:anr28_human(display_long)|uniprotkb:ANKRD28(gene name)|psi-mi:ANKRD28(display_short)|uniprotkb:KIAA0379(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001182027.1|refseq:NP_001182028.1|refseq:NP_056014.2|refseq:XP_011531842.1|refseq:XP_005265053.1|refseq:XP_016861515.1|refseq:XP_016861516.1|dip:DIP-27583N|ensembl:ENSG00000206560(gene)|ensembl:ENST00000399451(transcript)|ensembl:ENST00000412318(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:O15084|reactome:R-HSA-171319|reactome:R-HSA-204005 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:YLJtZR7PWrGejJ8EFI093KRtb2Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6R327 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1387196|uniprotkb:Q68DT5|uniprotkb:Q86UB7|uniprotkb:Q8N3A0|uniprotkb:Q8NCM6|uniprotkb:B2RNX0|uniprotkb:B7ZMF7|ensembl:ENSP00000349959 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rictr_human(display_long)|uniprotkb:RICTOR(gene name)|psi-mi:RICTOR(display_short)|uniprotkb:KIAA1999(gene name synonym)|uniprotkb:AVO3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001272368.1|refseq:NP_001272369.1|refseq:NP_689969.2|dip:DIP-39479N|ensembl:ENST00000357387(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043022"(ribosome binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029259|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|mint:Q6R327|rcsb pdb:5ZCS|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5674400|reactome:R-HSA-6804757|ensembl:ENSG00000164327(gene) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:LlVf8U/ZLBh0fYyzx8RzSpm+1sc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UBW8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-712982|ensembl:ENSP00000229251|ensembl:ENSP00000438115|ensembl:ENSP00000438363|ensembl:ENSP00000441852|ensembl:ENSP00000446039|uniprotkb:Q9NVX3|uniprotkb:Q9UJW4|uniprotkb:A8K9A6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:csn7a_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 7a(gene name synonym)|uniprotkb:Dermal papilla-derived protein 10(gene name synonym)|uniprotkb:COPS7A(gene name)|psi-mi:COPS7A(display_short)|uniprotkb:CSN7A(gene name synonym)|uniprotkb:DERP10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000111652(gene)|ensembl:ENST00000229251(transcript)|ensembl:ENST00000534877(transcript)|ensembl:ENST00000534947(transcript)|ensembl:ENST00000539735(transcript)|ensembl:ENST00000543155(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR037757|interpro:IPR041481|mint:Q9UBW8|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|refseq:NP_001157565.1|refseq:NP_001157566.1|refseq:NP_001157567.1|refseq:NP_057403.1|refseq:XP_005253751.1|dip:DIP-53412N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:KT1zw5OuZthyscvNa/4lW1iJz2Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UBN7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NZ32 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2559426|uniprotkb:Q9H9Y5|uniprotkb:Q9NWY2|ensembl:ENSP00000254286 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:arp10_human(display_long)|uniprotkb:ACTR10(gene name)|psi-mi:ACTR10(display_short)|uniprotkb:ACTR11(gene name synonym)|uniprotkb:ARP11(gene name synonym)|uniprotkb:Actin-related protein 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060947.1|ensembl:ENSG00000131966(gene)|ensembl:ENST00000254286(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0098958"(retrograde axonal transport of mitochondrion)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004000(Actin/actin-like)|interpro:IPR027127|interpro:IPR043129|mint:Q9NZ32|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zP8oC2X4zksg1YC89SF2yerpa6I9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P0DPB6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359498|uniprotkb:Q9Y2S0|ensembl:ENSP00000302478|uniprotkb:Q5TBX2|uniprotkb:Q96BR3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpac2_human(display_long)|uniprotkb:POLR1D(gene name)|psi-mi:POLR1D(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit D(gene name synonym)|uniprotkb:RPC16(gene name synonym)|uniprotkb:hRPA19(gene name synonym)|uniprotkb:AC19(gene name synonym)|uniprotkb:RNA polymerase I 16 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 mint:P0DPB6|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|ensembl:ENSG00000186184(gene)|ensembl:ENST00000302979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR008193(DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site)|interpro:IPR009025(DNA-directed RNA polymerase, RBP11-like)|interpro:IPR033898|interpro:IPR036603|refseq:NP_057056.1|refseq:XP_005266469.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rDbtR47SoszVxupqkWmoxVTS4/E9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y3P9 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1057545|uniprotkb:Q05CW2|uniprotkb:Q6ZMY1|uniprotkb:Q9HA28|uniprotkb:Q9P0E2|uniprotkb:Q9UG67|intact:EBI-2948690|uniprotkb:B9A6L2|ensembl:ENSP00000362751 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rbgp1_human(display_long)|uniprotkb:RABGAP1(gene name)|psi-mi:RABGAP1(display_short)|uniprotkb:HSPC094(orf name)|uniprotkb:Rab6 GTPase-activating protein GAPCenA(gene name synonym)|uniprotkb:GAP and centrosome-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011516742.1|refseq:XP_011516743.1|refseq:NP_036329.3|ensembl:ENSG00000011454(gene)|ensembl:ENST00000373647(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022164|interpro:IPR033185|interpro:IPR035969|mint:Q9Y3P9|rcsb pdb:4NC6|reactome:R-HSA-8854214|refseq:XP_016870056.1|refseq:XP_016870057.1|refseq:XP_016870058.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:yGnx7q5tyqYfpbeVDwZ8IKI1o+k9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P54098 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-852624|uniprotkb:Q8NFM2|uniprotkb:Q92515|ensembl:ENSP00000268124|ensembl:ENSP00000399851 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dpog1_human(display_long)|uniprotkb:Mitochondrial DNA polymerase catalytic subunit(gene name synonym)|uniprotkb:PolG-alpha(gene name synonym)|uniprotkb:POLG(gene name)|psi-mi:POLG(display_short)|uniprotkb:MDP1(gene name synonym)|uniprotkb:POLG1(gene name synonym)|uniprotkb:POLGA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001119603.1|refseq:NP_002684.1|ensembl:ENSG00000140521(gene)|ensembl:ENST00000268124(transcript)|ensembl:ENST00000442287(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0007568"(aging)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043195"(terminal bouton)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071333"(cellular response to glucose stimulus)|interpro:IPR001098(DNA-directed DNA polymerase, family A)|interpro:IPR002297(DNA-directed DNA-polymerase, family A, mitochondria)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR019760|interpro:IPR041336|interpro:IPR043502|mint:P54098|rcsb pdb:3IKM|rcsb pdb:4ZTU|rcsb pdb:4ZTZ|rcsb pdb:5C51|rcsb pdb:5C52|rcsb pdb:5C53 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Gt8NCLdg0R/XLyFsovnrnLrzb/A9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96D53 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3957978|uniprotkb:Q8TAJ1|uniprotkb:Q9HA52|ensembl:ENSP00000315118|ensembl:ENSP00000470876|ensembl:ENSP00000470916|ensembl:ENSP00000503480|ensembl:ENSP00000503944|ensembl:ENSP00000504072|ensembl:ENSP00000504085|ensembl:ENSP00000504845 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:coq8b_human(display_long)|uniprotkb:COQ8B(gene name)|psi-mi:COQ8B(display_short)|uniprotkb:ADCK4(gene name synonym)|uniprotkb:AarF domain-containing protein kinase 4(gene name synonym)|uniprotkb:Coenzyme Q protein 8B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001136027.1|refseq:NP_079152.3|ensembl:ENSG00000123815(gene)|ensembl:ENST00000324464(transcript)|ensembl:ENST00000594720(transcript)|ensembl:ENST00000601967(transcript)|ensembl:ENST00000677018(transcript)|ensembl:ENST00000678404(transcript)|ensembl:ENST00000678419(transcript)|ensembl:ENST00000678467(transcript)|ensembl:ENST00000679130(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008289"(lipid binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0021692"(cerebellar Purkinje cell layer morphogenesis)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|interpro:IPR004147(ABC-1)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034638|interpro:IPR034646|mint:Q96D53 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UAfHqMHShcF12Ijycxi7OWs0KFE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P49753 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052865|uniprotkb:Q3I5F8|uniprotkb:Q9NUX4|uniprotkb:Q53EK4|ensembl:ENSP00000238651 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:acot2_human(display_long)|uniprotkb:Acyl-coenzyme A thioester hydrolase 2a(gene name synonym)|uniprotkb:Long-chain acyl-CoA thioesterase 2(gene name synonym)|uniprotkb:ZAP128(gene name synonym)|uniprotkb:CTE-Ia(gene name synonym)|uniprotkb:ACOT2(gene name)|psi-mi:ACOT2(display_short)|uniprotkb:PTE2(gene name synonym)|uniprotkb:PTE2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006812.3|ensembl:ENSG00000119673(gene)|ensembl:ENST00000238651(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490|rcsb pdb:3HLK|reactome:R-HSA-77289|reactome:R-HSA-9033241 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:3a++2vHE7Zr553F/LJ68pxvJ/289606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IUR7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P27986 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UPY3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-395506|uniprotkb:O95943|uniprotkb:Q9UQ02|uniprotkb:A7E2D3|ensembl:ENSP00000343745|ensembl:ENSP00000376783|ensembl:ENSP00000435681|ensembl:ENSP00000437256|uniprotkb:E0AD28|uniprotkb:B3KRG4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dicer_human(display_long)|uniprotkb:DICER1(gene name)|psi-mi:DICER1(display_short)|uniprotkb:DICER(gene name synonym)|uniprotkb:HERNA(gene name synonym)|uniprotkb:KIAA0928(gene name synonym)|uniprotkb:Helicase with RNase motif(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_085124.2|refseq:NP_803187.1|refseq:NP_001182502.1|refseq:XP_011534901.1|refseq:XP_011534902.1|refseq:XP_011534903.1|refseq:XP_011534904.1|ensembl:ENSG00000100697(gene)|ensembl:ENST00000343455(transcript)|ensembl:ENST00000393063(transcript)|ensembl:ENST00000526495(transcript)|ensembl:ENST00000527414(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|mint:Q9UPY3|rcsb pdb:2EB1|rcsb pdb:4NGB|rcsb pdb:4NGC|rcsb pdb:4NGD|rcsb pdb:4NGF|rcsb pdb:4NGG|rcsb pdb:4NH3|rcsb pdb:4NH5|rcsb pdb:4NH6|rcsb pdb:4NHA|rcsb pdb:4WYQ|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|reactome:R-HSA-203927|reactome:R-HSA-426486|go:"GO:0035280"(miRNA loading onto RISC)|reactome:R-HSA-9708296|refseq:NP_001258211.1|refseq:NP_001278557.1|refseq:XP_016876609.1|refseq:XP_016876610.1|dip:DIP-29664N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:RhSXQEEvS9b0IOvnrPYhRd0MzI09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P54619 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15370 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5SY16 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1055462|uniprotkb:Q4VBY3|uniprotkb:Q6P472|uniprotkb:Q7L4D6|uniprotkb:Q96EE0|uniprotkb:Q9H5L4|uniprotkb:Q2NL84|ensembl:ENSP00000366934 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nol9_human(display_long)|uniprotkb:NOL9(gene name)|psi-mi:NOL9(display_short)|uniprotkb:Nucleolar protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_078930.3|refseq:XP_011540449.1|ensembl:ENST00000377705(transcript)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051731"(polynucleotide 5'-hydroxyl-kinase activity)|interpro:IPR027417|interpro:IPR032319|mint:Q5SY16|reactome:R-HSA-6791226|ensembl:ENSG00000162408(gene)|refseq:XP_016857827.1|refseq:XP_016857828.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IWGhuh/G+MlTxlSXEcIml8tvK7Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EL2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1055789|uniprotkb:P82668|uniprotkb:Q96Q23|uniprotkb:Q9P047|uniprotkb:A4D1U9|ensembl:ENSP00000318158 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt24_human(display_long)|uniprotkb:bMRP-47(gene name synonym)|uniprotkb:MRPS24(gene name)|psi-mi:MRPS24(display_short)|uniprotkb:HSPC335(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS3m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_114403.1|ensembl:ENSG00000062582(gene)|ensembl:ENST00000317534(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR026146|mint:Q96EL2|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OEtFmhoLM1Sw9YVrL88HZQ5Ju0g9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q99797 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3893060|uniprotkb:Q5JV15|uniprotkb:Q5T9Q9|uniprotkb:Q96G65|ensembl:ENSP00000371607 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mipep_human(display_long)|uniprotkb:MIPEP(gene name)|psi-mi:MIPEP(display_short)|uniprotkb:MIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005923.2|ensembl:ENSG00000027001(gene)|ensembl:ENST00000382172(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001567(Peptidase M3A and M3B, thimet/oligopeptidase F)|interpro:IPR024077|interpro:IPR024079 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:vAXeDaFEEGzQGvsfOQUknrfD74Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8TEW0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-81968|uniprotkb:Q5T2U1|uniprotkb:Q5VWV0|uniprotkb:Q5VWV4|uniprotkb:Q5VWV5|uniprotkb:Q8TEW1|uniprotkb:Q8TEW2|uniprotkb:Q8TEW3|uniprotkb:Q96K28|uniprotkb:Q96RM6|uniprotkb:Q96RM7|uniprotkb:Q9BY57|uniprotkb:Q9BY58|uniprotkb:Q9HC48|uniprotkb:Q9NWL4|uniprotkb:Q9NYE6|uniprotkb:Q5VWV3|uniprotkb:Q5VUA2|uniprotkb:Q5VUA3|uniprotkb:Q5VWV1|intact:EBI-1221123|uniprotkb:Q8TCZ9|ensembl:ENSP00000363921|intact:EBI-10975849|uniprotkb:F5H5T0|uniprotkb:Q6IQ47 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pard3_human(display_long)|uniprotkb:PARD3(gene name)|psi-mi:PARD3(display_short)|uniprotkb:PAR3(gene name synonym)|uniprotkb:PAR3A(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:CTCL tumor antigen se2-5(gene name synonym)|uniprotkb:PAR3-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:Q8TEW0|rcsb pdb:2KOM|reactome:R-HSA-2173791|reactome:R-HSA-420029|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSG00000148498(gene)|go:"GO:0006612"(protein targeting to membrane)|ensembl:ENST00000374789(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|refseq:NP_001171714.1|refseq:NP_001171716.1|refseq:NP_001171717.1|refseq:NP_001171718.1|refseq:NP_001171719.1|refseq:NP_001171720.1|refseq:NP_001171721.1|refseq:NP_001171722.1|refseq:NP_001171723.1|refseq:NP_062565.2|refseq:NP_001171715.1|dip:DIP-31315N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FdOAcXyXE7jKSBJdlPcabwbnq5k9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43933 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-988601|uniprotkb:Q96S71|uniprotkb:Q96S72|uniprotkb:Q96S73|uniprotkb:Q99994|ensembl:ENSP00000248633|uniprotkb:A8KA90|uniprotkb:A4D1G3|uniprotkb:B4DIM7|uniprotkb:E9PE75 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pex1_human(display_long)|uniprotkb:Peroxin-1(gene name synonym)|uniprotkb:Peroxisome biogenesis disorder protein 1(gene name synonym)|uniprotkb:PEX1(gene name)|psi-mi:PEX1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001269606.1|refseq:NP_001269607.1|refseq:NP_000457.1|ensembl:ENSG00000127980(gene)|ensembl:ENST00000248633(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060152"(microtubule-based peroxisome localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015342(Peroxisome biogenesis factor 1, N-terminal)|interpro:IPR015343(Peroxisome biogenesis factor 1, alpha/beta)|interpro:IPR025653|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:O43933|reactome:R-HSA-9033241|go:"GO:0070062"(extracellular exosome) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:tc6YxVhySlqqv5/zhBkZ5pvv6/M9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q12894 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O14950 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1642165|uniprotkb:D3DUH6|intact:EBI-2826593|uniprotkb:Q7Z5Z4|uniprotkb:Q13182|ensembl:ENSP00000237500|ensembl:ENSP00000383037|ensembl:ENSP00000463559|ensembl:ENSP00000464464|ensembl:ENSP00000496809 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ml12b_human(display_long)|uniprotkb:MYL12B(gene name)|psi-mi:MYL12B(display_short)|uniprotkb:MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:MLC-2A(gene name synonym)|uniprotkb:SHUJUN-1(gene name synonym)|uniprotkb:MYLC2B(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001138416.1|refseq:NP_001138417.1|refseq:NP_291024.1|refseq:NP_001289978.1|ensembl:ENSG00000118680(gene)|ensembl:ENST00000237500(transcript)|ensembl:ENST00000400175(transcript)|ensembl:ENST00000581193(transcript)|ensembl:ENST00000584539(transcript)|ensembl:ENST00000648965(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:O14950|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q14677 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UBS8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2130308|uniprotkb:B7ZLV2|uniprotkb:A0AV26|uniprotkb:A6NMR2|uniprotkb:B3KN72|uniprotkb:O94793|uniprotkb:Q6IBV0|uniprotkb:A8MTW5|uniprotkb:D3DQE4|ensembl:ENSP00000324956|ensembl:ENSP00000348462|ensembl:ENSP00000378027|ensembl:ENSP00000378028 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rnf14_human(display_long)|uniprotkb:RNF14(gene name)|psi-mi:RNF14(display_short)|uniprotkb:ARA54(gene name synonym)|uniprotkb:RING finger protein 14(gene name synonym)|uniprotkb:Androgen receptor-associated protein 54(gene name synonym)|uniprotkb:Triad2 protein(gene name synonym)|uniprotkb:HFB30(gene name synonym)|uniprotkb:HRIHFB2038(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011536016.1|refseq:NP_001188294.1|refseq:NP_004281.1|refseq:NP_899645.1|refseq:NP_899646.1|refseq:NP_899647.1|refseq:NP_899648.1|refseq:XP_016865559.1|refseq:XP_016865560.1|refseq:XP_016865561.1|refseq:XP_005268593.1|refseq:XP_005268594.1|refseq:XP_005268596.1|refseq:XP_005268597.1|refseq:XP_005268598.1|ensembl:ENSG00000013561(gene)|ensembl:ENST00000347642(transcript)|ensembl:ENST00000356143(transcript)|ensembl:ENST00000394519(transcript)|ensembl:ENST00000394520(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR006575(RWD)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017907|interpro:IPR031127|interpro:IPR031128|interpro:IPR044066|mint:Q9UBS8|reactome:R-HSA-983168 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zCNZ6kHw7XNUvpVBRQSgZ7ffJ9U9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96QG7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-744593|uniprotkb:Q52LU3|uniprotkb:Q8WW11|uniprotkb:Q96QG6|uniprotkb:Q9NX50|uniprotkb:B7Z291|ensembl:ENSP00000221086|ensembl:ENSP00000495551|ensembl:ENSP00000496677 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mtmr9_human(display_long)|uniprotkb:MTMR9(gene name)|psi-mi:MTMR9(display_short)|uniprotkb:C8orf9(gene name synonym)|uniprotkb:MTMR8(gene name synonym)|uniprotkb:Inactive phosphatidylinositol 3-phosphatase 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_056273.2|dip:DIP-54283N|ensembl:ENSG00000285032(gene)|ensembl:ENST00000221086(transcript)|ensembl:ENST00000644306(transcript)|ensembl:ENST00000646141(transcript)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029021|interpro:IPR030564|mint:Q96QG7|reactome:R-HSA-1660499|reactome:R-HSA-1660517|reactome:R-HSA-1855183|ensembl:ENSG00000104643(gene) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:CdtI/coErr0SNIsW1sz1KdGb3LA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6P158 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051531|uniprotkb:Q53SI4|uniprotkb:Q6P9G1|uniprotkb:Q7Z6H3|uniprotkb:Q8NG17|uniprotkb:Q96M33|uniprotkb:A2RRC7|ensembl:ENSP00000405111 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dhx57_human(display_long)|uniprotkb:DEAH box protein 57(gene name synonym)|uniprotkb:DHX57(gene name)|psi-mi:DHX57(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_945314.1|refseq:XP_011531456.1|refseq:XP_011531457.1|ensembl:ENSG00000163214(gene)|ensembl:ENST00000457308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR041367|interpro:IPR042615|mint:Q6P158 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+srrYp6+3YKAvSOr8wkq0Vcjsvo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P63172 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1176455|uniprotkb:Q15763|ensembl:ENSP00000356056|uniprotkb:Q5VTU4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dylt1_human(display_long)|uniprotkb:T-complex testis-specific protein 1 homolog(gene name synonym)|uniprotkb:Protein CW-1(gene name synonym)|uniprotkb:DYNLT1(gene name)|psi-mi:DYNLT1(display_short)|uniprotkb:TCTEL1(gene name synonym)|uniprotkb:TCTEX1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006510.1|ensembl:ENSG00000146425(gene)|ensembl:ENST00000367089(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043657"(host cell)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061564"(axon development)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)|go:"GO:0099503"(secretory vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|rcsb pdb:5JPW|reactome:R-HSA-6798695|go:"GO:0005881"(cytoplasmic microtubule)|dip:DIP-35251N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:RKVyHgf4iNjcY6GfLdIukFOFE+s9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8WUA4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237062|uniprotkb:D6W557|ensembl:ENSP00000264720|ensembl:ENSP00000352536|uniprotkb:Q16632|uniprotkb:Q9BWI7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tf3c2_human(display_long)|uniprotkb:GTF3C2(gene name)|psi-mi:GTF3C2(display_short)|uniprotkb:KIAA0011(gene name synonym)|uniprotkb:Transcription factor IIIC subunit beta(gene name synonym)|uniprotkb:TF3C-beta(gene name synonym)|uniprotkb:Transcription factor IIIC 110 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000115207(gene)|ensembl:ENST00000264720(transcript)|ensembl:ENST00000359541(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q8WUA4|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|refseq:NP_001030598.1|refseq:NP_001512.1|refseq:NP_001305838.1|dip:DIP-38213N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:D2SnUgtDMoh8axZsIMskwjmNW1c9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9P0J7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6870925|ensembl:ENSP00000386738|uniprotkb:Q9UFE8|uniprotkb:Q9H8P5|uniprotkb:Q4ZG04|uniprotkb:Q9BWK2|uniprotkb:Q53SC7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kcmf1_human(display_long)|uniprotkb:FGF-induced in gastric cancer(gene name synonym)|uniprotkb:FIGC(gene name synonym)|uniprotkb:Potassium channel modulatory factor(gene name synonym)|uniprotkb:ZZ-type zinc finger-containing protein 1(gene name synonym)|uniprotkb:ZZZ1(gene name synonym)|uniprotkb:KCMF1(gene name)|psi-mi:KCMF1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase KCMF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000176407(gene)|ensembl:ENST00000409785(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045202"(synapse)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0099536"(synaptic signaling)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR039858|interpro:IPR043145|mint:Q9P0J7|reactome:R-HSA-6798695|refseq:NP_064507.3|dip:DIP-47300N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:g6qsAzE28YlXOJVmsfX8cXe2XUU9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EY7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721110|uniprotkb:A6NHD2|uniprotkb:Q597H0|uniprotkb:Q658Y9|uniprotkb:Q9BUZ8|uniprotkb:Q9NWL0|intact:EBI-2560120|uniprotkb:D6W5M1|ensembl:ENSP00000254630 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ptcd3_human(display_long)|uniprotkb:Transformation-related gene 15 protein(gene name synonym)|uniprotkb:TRG15(orf name)|uniprotkb:28S ribosomal protein S39, mitochondrial(gene name synonym)|uniprotkb:MRPS39(gene name synonym)|uniprotkb:PTCD3(gene name)|psi-mi:PTCD3(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060422.4|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR037387|mint:Q96EY7|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|go:"GO:0019843"(rRNA binding)|rcsb pdb:6ZSC|ensembl:ENSG00000132300(gene)|ensembl:ENST00000254630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSD - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:k9hyBtBrNbiBMJ5gtOQ9R6Grl9U9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O60610 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NFF5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H0A8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9ULT8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-310559|uniprotkb:Q6P445|uniprotkb:Q86VJ1|uniprotkb:Q96F34|uniprotkb:Q9UFZ7|uniprotkb:D3DS86|ensembl:ENSP00000382269|ensembl:ENSP00000450697 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:hecd1_human(display_long)|uniprotkb:HECTD1(gene name)|psi-mi:HECTD1(display_short)|uniprotkb:KIAA1131(gene name synonym)|uniprotkb:HECT domain-containing protein 1(gene name synonym)|uniprotkb:E3 ligase for inhibin receptor(gene name synonym)|uniprotkb:EULIR(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECTD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000092148(gene)|ensembl:ENST00000399332(transcript)|ensembl:ENST00000553700(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR000569(HECT)|interpro:IPR002110(Ankyrin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010606(Mib-herc2)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020683|interpro:IPR035983|interpro:IPR036770|interpro:IPR037252|interpro:IPR041200|mint:Q9ULT8|rcsb pdb:2DK3|rcsb pdb:3DKM|reactome:R-HSA-983168|rcsb pdb:2LC3|refseq:XP_005267559.2|ensembl:ENSP00000382269|ensembl:ENSP00000450697|refseq:NP_056197.3|dip:DIP-31669N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:/l60ZSm+P4Vlc8B79wS7+T1Zvzk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H2G2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1022272|uniprotkb:O00211|uniprotkb:Q6P1Z4|uniprotkb:Q86WU7|uniprotkb:Q86WW1|uniprotkb:Q92603|uniprotkb:Q9NQL0|uniprotkb:Q9NQL1|uniprotkb:D3DRA0|uniprotkb:D3DRA1|ensembl:ENSP00000358770 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:slk_human(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 2(gene name synonym)|uniprotkb:CTCL tumor antigen se20-9(gene name synonym)|uniprotkb:SLK(gene name)|psi-mi:SLK(display_short)|uniprotkb:KIAA0204(gene name synonym)|uniprotkb:STK2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055535.2|refseq:NP_001291672.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|mint:Q9H2G2|rcsb pdb:2J51|rcsb pdb:2JFL|rcsb pdb:2JFM|rcsb pdb:2UV2|rcsb pdb:4USF|rcsb pdb:6HVD|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000065613(gene)|ensembl:ENST00000369755(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:T9Ej6CkWUmqEmPLcptvF2/f1Q+09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q29RF7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1175454|uniprotkb:Q2TTR5|uniprotkb:Q68DF7|uniprotkb:Q8N7J4|uniprotkb:Q8NG14|uniprotkb:Q9Y4D4|intact:EBI-2554552|ensembl:ENSP00000303427 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pds5a_human(display_long)|uniprotkb:Sister chromatid cohesion protein 112(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 54 protein(gene name synonym)|uniprotkb:PDS5A(gene name)|psi-mi:PDS5A(display_short)|uniprotkb:KIAA0648(gene name synonym)|uniprotkb:PDS5(gene name synonym)|uniprotkb:PIG54(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000121892(gene)|ensembl:ENST00000303538(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039776|mint:Q29RF7|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|go:"GO:0005829"(cytosol)|refseq:NP_001093869.1|refseq:NP_001093870.1|refseq:XP_011511974.1|refseq:XP_016863417.1|dip:DIP-35419N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:PaZZmQCIaSIoxVpMuuERQbDLMpY9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q02153 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6911707|ensembl:ENSP00000264424|uniprotkb:B7Z426|uniprotkb:Q86WY5 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gcyb1_human(display_long)|uniprotkb:GUCY1B1(gene name)|psi-mi:GUCY1B1(display_short)|uniprotkb:GUC1B3(gene name synonym)|uniprotkb:GUCSB3(gene name synonym)|uniprotkb:GUCY1B3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000061918(gene)|ensembl:ENST00000264424(transcript)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047805"(cytidylate cyclase activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:2WZ1|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:5MNW|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:NP_000848.1|refseq:NP_001278881.1|refseq:NP_001278882.1|refseq:NP_001278883.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XG3K0TurvMfAZcp1KXRsltIvuS49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NWS0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5VIR6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2850511|uniprotkb:Q9BY02|uniprotkb:A8K2S8|uniprotkb:Q9BRR2|uniprotkb:Q9NV25|uniprotkb:Q8WYW3|uniprotkb:B3FH42|ensembl:ENSP00000401435|ensembl:ENSP00000492761|ensembl:ENSP00000505997 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vps53_human(display_long)|uniprotkb:PP13624(orf name)|uniprotkb:VPS53(gene name)|psi-mi:VPS53(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001121631.1|refseq:NP_060759.2|dip:DIP-59352N|ensembl:ENSG00000141252(gene)|ensembl:ENSG00000283883(gene)|ensembl:ENST00000437048(transcript)|ensembl:ENST00000639801(transcript)|ensembl:ENST00000680465(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007234(Vps53-like, N-terminal)|interpro:IPR038260|interpro:IPR039766|reactome:R-HSA-6811440 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:gnrMqPquSOGNPQYESYuA7ztMI0Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92890 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P46199 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359432|ensembl:ENSP00000263629|ensembl:ENSP00000378099|ensembl:ENSP00000384481|uniprotkb:D6W5D0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:if2m_human(display_long)|uniprotkb:MTIF2(gene name)|psi-mi:MTIF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001307933.1|refseq:NP_001307934.1|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0070124"(mitochondrial translational initiation)|interpro:IPR000178(Initiation factor 2)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR015760(Translation initiation factor 2 related)|interpro:IPR023115|interpro:IPR027417|interpro:IPR036925|interpro:IPR044145|rcsb pdb:6GAW|rcsb pdb:6GAZ|rcsb pdb:6GB2|rcsb pdb:6RW5|reactome:R-HSA-5368286|ensembl:ENSG00000085760(gene)|ensembl:ENST00000263629(transcript)|ensembl:ENST00000394600(transcript)|ensembl:ENST00000403721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0032790"(ribosome disassembly)|refseq:NP_001005369.1|refseq:NP_002444.2|refseq:XP_011531173.1|refseq:NP_001307930.1|refseq:NP_001307931.1|refseq:NP_001307932.1|refseq:XP_005264392.1|refseq:XP_016859651.1|refseq:XP_016859652.1|dip:DIP-27596N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ThigwWzs0gInoPjmmd8DYvyrWw49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UGJ1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052544|uniprotkb:Q969X3|uniprotkb:Q9NVF0|uniprotkb:B3KNK6|ensembl:ENSP00000260383 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gcp4_human(display_long)|uniprotkb:Gamma-ring complex protein 76 kDa(gene name synonym)|uniprotkb:TUBGCP4(gene name)|psi-mi:TUBGCP4(display_short)|uniprotkb:76P(gene name synonym)|uniprotkb:GCP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055259.2|refseq:NP_001273343.1|refseq:XP_011519757.1|ensembl:ENSG00000137822(gene)|ensembl:ENST00000260383(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9UGJ1|rcsb pdb:3RIP|rcsb pdb:6V69|rcsb pdb:6V6S|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|dip:DIP-50536N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:5pAlGB03qeX0CJ0etjcLInwgaZQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q6DKK2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-948354|ensembl:ENSP00000261647|uniprotkb:Q7L3U8|uniprotkb:Q9NXB2|uniprotkb:A8MZ52|uniprotkb:B3KP62|uniprotkb:B4DN65|uniprotkb:Q9H6G3|uniprotkb:Q2M248 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ttc19_human(display_long)|uniprotkb:TTC19(gene name)|psi-mi:TTC19(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000011295(gene)|ensembl:ENST00000261647(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005813"(centrosome)|go:"GO:0030496"(midbody)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0070469"(respirasome)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040395|mint:Q6DKK2|refseq:NP_001258349.1|refseq:NP_060245.3 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:skTQJ+iUoHBb06IqVhoprLMYEtA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q86TG7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2858265|uniprotkb:Q9UPV1|uniprotkb:Q96A68 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:peg10_human(display_long)|uniprotkb:PEG10(gene name)|psi-mi:PEG10(display_short)|uniprotkb:EDR(gene name synonym)|uniprotkb:KIAA1051(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:MART2(gene name synonym)|uniprotkb:MEF3L1(gene name synonym)|uniprotkb:RGAG3(gene name synonym)|uniprotkb:Embryonal carcinoma differentiation-regulated protein(gene name synonym)|uniprotkb:Mammalian retrotransposon-derived protein 2(gene name synonym)|uniprotkb:Myelin expression factor 3-like protein 1(gene name synonym)|uniprotkb:Paternally expressed gene 10 protein(gene name synonym)|uniprotkb:Retrotransposon gag domain-containing protein 3(gene name synonym)|uniprotkb:Retrotransposon-derived gag-like polyprotein(gene name synonym)|uniprotkb:Ty3/Gypsy-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR032549|interpro:IPR032567|refseq:NP_001035242.1|refseq:NP_001171890.1|refseq:NP_001171891.1|refseq:NP_055883.2|interpro:IPR021109|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|interpro:IPR043128|interpro:IPR043502 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:wkCBsH9/PsFMwJFu/qOwZcn63D49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q4J6C6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-949331|uniprotkb:A7E2X6|uniprotkb:O43163|uniprotkb:Q4J6C3|uniprotkb:Q4J6C4|uniprotkb:Q4ZG39|uniprotkb:Q6ZMW7|uniprotkb:Q96DW7|uniprotkb:D6W5A3|ensembl:ENSP00000260648|ensembl:ENSP00000386509|ensembl:ENSP00000386543|ensembl:ENSP00000386909|ensembl:ENSP00000391456|ensembl:ENSP00000409480 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ppcel_human(display_long)|uniprotkb:KIAA0436(gene name synonym)|uniprotkb:Prolylendopeptidase-like(gene name synonym)|uniprotkb:PREPL(gene name)|psi-mi:PREPL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001035844.1|refseq:NP_001035845.1|refseq:NP_001165074.1|refseq:NP_001165077.1|refseq:NP_001165084.1|refseq:NP_001165088.1|refseq:NP_006027.2|refseq:XP_011531500.1|refseq:XP_011531502.1|refseq:XP_011531504.1|refseq:XP_016860873.1|refseq:XP_016860874.1|ensembl:ENSG00000138078(gene)|ensembl:ENST00000260648(transcript)|ensembl:ENST00000409272(transcript)|ensembl:ENST00000409936(transcript)|ensembl:ENST00000410081(transcript)|ensembl:ENST00000425263(transcript)|ensembl:ENST00000426481(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008233"(peptidase activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002470(Peptidase S9A, prolyl oligopeptidase)|interpro:IPR023302|interpro:IPR029058 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xn++9zR6AX/HzP4KzrriJR5IUTk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y4P8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-719396|uniprotkb:Q5MNZ8|uniprotkb:Q6FI96|uniprotkb:Q75L50|uniprotkb:Q96IE4|uniprotkb:Q9Y364|uniprotkb:B3KNC2|ensembl:ENSP00000288828 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:wipi2_human(display_long)|uniprotkb:WIPI49-like protein 2(gene name synonym)|uniprotkb:WIPI2(gene name)|psi-mi:WIPI2(display_short)|uniprotkb:CGI-50(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001028690.1|refseq:NP_001028691.1|refseq:NP_001028692.1|refseq:NP_056425.1|refseq:NP_057087.2|ensembl:ENSG00000157954(gene)|ensembl:ENST00000288828(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0098792"(xenophagy)|interpro:IPR001680(WD40 repeat)|interpro:IPR032911|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001265228.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IKOg7KzZAI2jyK5KsGAz6SOd4XM9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8WVB6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P24468 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2795198|uniprotkb:B6ZGU1|uniprotkb:Q03754|uniprotkb:B4DQJ2|uniprotkb:Q3KQR7|ensembl:ENSP00000377721 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cot2_human(display_long)|uniprotkb:NR2F2(gene name)|psi-mi:NR2F2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:TFCOUP2(gene name synonym)|uniprotkb:COUP transcription factor II(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 2(gene name synonym)|uniprotkb:Apolipoprotein A-I regulatory protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_066285.1|refseq:NP_001138627.1|refseq:NP_001138628.1|refseq:NP_001138629.1|ensembl:ENSG00000185551(gene)|ensembl:ENST00000394166(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0009956"(radial pattern formation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0032355"(response to estradiol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060173"(limb development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:3CJW|reactome:R-HSA-381340|dip:DIP-29713N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XsZyqUr06sQQaD3oXAA3IEa6Dug9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P62875 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-359527|ensembl:ENSP00000324124|ensembl:ENSP00000432807|uniprotkb:P52436|uniprotkb:Q6FHX3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpab5_human(display_long)|uniprotkb:POLR2L(gene name)|psi-mi:POLR2L(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit L(gene name synonym)|uniprotkb:RPB10 homolog(gene name synonym)|uniprotkb:RNA polymerase II 7.6 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000177700(gene)|ensembl:ENST00000322028(transcript)|ensembl:ENST00000534030(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR000268(RNA polymerases, N/8 Kd subunits)|interpro:IPR020789|interpro:IPR023580|mint:P62875|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|refseq:NP_066951.1|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-75955|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-203927|dip:DIP-32960N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:uDzgKgHzFTPxFaV1GeUYdYMa4Gk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NSV4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1050601|uniprotkb:A2A3B8|uniprotkb:A2A3B9|uniprotkb:A2A3C0|uniprotkb:Q18P99|uniprotkb:Q18PA0|uniprotkb:Q18PA1|uniprotkb:Q2KPB6|uniprotkb:Q3ZK23|uniprotkb:Q5JTP8|uniprotkb:Q5T2S7|uniprotkb:Q5XKF6|uniprotkb:Q6MZF0|uniprotkb:Q6NUP0|uniprotkb:Q86VS4|uniprotkb:Q8NAV4|ensembl:ENSP00000383178 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:diap3_human(display_long)|uniprotkb:Diaphanous-related formin-3(gene name synonym)|uniprotkb:DIAPH3(gene name)|psi-mi:DIAPH3(display_short)|uniprotkb:DIAP3(gene name synonym)|uniprotkb:MDia2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001035982.1|refseq:NP_112194.2|refseq:NP_001245295.1|refseq:NP_001245296.1|refseq:NP_001245297.1|refseq:NP_001245298.1|refseq:NP_001245299.1|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSG00000139734(gene)|ensembl:ENST00000400324(transcript)|go:"GO:0045296"(cadherin binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027654|interpro:IPR042201|interpro:IPR010465(DRF autoregulatory)|mint:Q9NSV4|rcsb pdb:5UWP|rcsb pdb:6X2Y|reactome:R-HSA-5663220|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:noy8LGt6F+8an19X1WyEqSqpAYk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q04837 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O94826 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75828 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-714504|ensembl:ENSP00000290354|uniprotkb:Q6FHP2 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cbr3_human(display_long)|uniprotkb:NADPH-dependent carbonyl reductase 3(gene name synonym)|uniprotkb:CBR3(gene name)|psi-mi:CBR3(display_short)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000159231(gene)|ensembl:ENST00000290354(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0042376"(phylloquinone catabolic process)|go:"GO:0050890"(cognition)|go:"GO:0070402"(NADPH binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:2HRB|reactome:R-HSA-211945|refseq:NP_001227.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:31QYceUdGN2HanRmiei1aR9f8MI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q13418 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H0P0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3918356|uniprotkb:Q7L3G6|uniprotkb:B8ZZC4|uniprotkb:Q6NXS6|uniprotkb:Q9UC45|uniprotkb:A8K253|uniprotkb:Q9UC42|uniprotkb:Q9UC44|uniprotkb:B2RAA5|uniprotkb:Q6IPZ1|uniprotkb:Q9UC43|uniprotkb:Q9P0P5 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:5nt3a_human(display_long)|uniprotkb:NT5C3A(gene name)|psi-mi:NT5C3A(display_short)|uniprotkb:Cytosolic 5'-nucleotidase 3(gene name synonym)|uniprotkb:Cytosolic 5'-nucleotidase III(gene name synonym)|uniprotkb:NT5C3(gene name synonym)|uniprotkb:P5N1(gene name synonym)|uniprotkb:Pyrimidine 5'-nucleotidase 1(gene name synonym)|uniprotkb:UMPH1(gene name synonym)|uniprotkb:Uridine 5'-monophosphate hydrolase 1(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:HSPC233(orf name)|uniprotkb:7-methylguanosine phosphate-specific 5'-nucleotidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR036412|refseq:NP_001002010.1|refseq:NP_001159590.1|refseq:NP_057573.2|interpro:IPR023214|interpro:IPR006434(HAD-superfamily hydrolase, subfamily IE)|refseq:NP_001002009.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0000215"(tRNA 2'-phosphotransferase activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006213"(pyrimidine nucleoside metabolic process)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0051607"(defense response to virus)|rcsb pdb:2CN1|rcsb pdb:2JGA|rcsb pdb:2VKQ|reactome:R-HSA-73621|refseq:XP_011513711.1|mint:Q9H0P0 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:IMqgR3fhBBTmQWKVhLlMIhK+s4Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z4H7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2558196|uniprotkb:Q05CG1|uniprotkb:Q14CB6|uniprotkb:Q2TA91|uniprotkb:Q8IZQ4|uniprotkb:Q9H998|uniprotkb:Q96FN0|uniprotkb:Q14CD9|uniprotkb:B3KPK4|uniprotkb:Q6IQ10|uniprotkb:Q9H950|uniprotkb:Q9NXT8|uniprotkb:Q9HCJ8|uniprotkb:Q6NZX5|uniprotkb:B4DX82|ensembl:ENSP00000369871 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:haus6_human(display_long)|uniprotkb:HAUS6(gene name)|psi-mi:HAUS6(display_short)|uniprotkb:DGT6(gene name synonym)|uniprotkb:FAM29A(gene name synonym)|uniprotkb:KIAA1574(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060115.3|refseq:NP_001257819.1|dip:DIP-48830N|ensembl:ENSG00000147874(gene)|ensembl:ENST00000380502(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026797|interpro:IPR028163|mint:Q7Z4H7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:l5edu15aLS4hXrPg/lfQ2323G2o9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5TA45 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q4G0F5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6151831|uniprotkb:Q96A55|ensembl:ENSP00000281187|ensembl:ENSP00000434162 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vp26b_human(display_long)|uniprotkb:Vesicle protein sorting 26B(gene name synonym)|uniprotkb:VPS26B(gene name)|psi-mi:VPS26B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_443107.1|ensembl:ENSG00000151502(gene)|ensembl:ENST00000281187(transcript)|ensembl:ENST00000525095(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8NQBMiFKQXjWM4/Vy7swv2pW0V89606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UHD2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P55010 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-286450|uniprotkb:Q9H5N2|uniprotkb:Q9UG48|uniprotkb:Q53XB3|ensembl:ENSP00000216554|ensembl:ENSP00000376477|ensembl:ENSP00000453743 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:if5_human(display_long)|uniprotkb:EIF5(gene name)|psi-mi:EIF5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001960.2|refseq:NP_892116.2|ensembl:ENSG00000100664(gene)|ensembl:ENST00000216554(transcript)|ensembl:ENST00000392715(transcript)|ensembl:ENST00000558506(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P55010|rcsb pdb:2E9H|rcsb pdb:2G2K|rcsb pdb:2IU1|reactome:R-HSA-72702|reactome:R-HSA-72706 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lM5AZJWJOQGbxADfl8MGCx3JAXc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z4Q2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051903|uniprotkb:Q8N525|uniprotkb:Q8WV56|uniprotkb:Q96CC9|uniprotkb:Q9NWN7|uniprotkb:A8K1N4|ensembl:ENSP00000299192 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:heat3_human(display_long)|uniprotkb:HEATR3(gene name)|psi-mi:HEATR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_891552.1|ensembl:ENSG00000155393(gene)|ensembl:ENST00000299192(transcript)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR016024(Armadillo-type fold)|mint:Q7Z4Q2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:CjdYLKIHc/A29+XYy4VjNNHJSRU9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43432 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O15075 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2684263|uniprotkb:Q5VZZ1|uniprotkb:B7Z3E9|uniprotkb:Q5VZY8|uniprotkb:Q5VZZ0|ensembl:ENSP00000353846 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dclk1_human(display_long)|uniprotkb:DCAMKL1(gene name synonym)|uniprotkb:DCDC3A(gene name synonym)|uniprotkb:KIAA0369(gene name synonym)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)|uniprotkb:Doublecortin domain-containing protein 3A(gene name synonym)|uniprotkb:DCLK1(gene name)|psi-mi:DCLK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001182344.1|refseq:NP_001182345.1|refseq:NP_004725.1|ensembl:ENSG00000133083(gene)|ensembl:ENST00000360631(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003533(Doublecortin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036572|mint:O15075|rcsb pdb:1MFW|rcsb pdb:1MG4|rcsb pdb:1UF0|rcsb pdb:5JZJ|rcsb pdb:5JZN|rcsb pdb:6KYQ|rcsb pdb:6KYR|refseq:NP_001317000.1|refseq:NP_001317001.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:zCZrL4FeF69gU85zd6h/LE0nDI49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5T5X7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1211496|uniprotkb:A2RRH2|uniprotkb:Q9HCL9|ensembl:ENSP00000358038|ensembl:ENSP00000411268 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:bend3_human(display_long)|uniprotkb:BEND3(gene name)|psi-mi:BEND3(display_short)|uniprotkb:KIAA1553(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_005267136.1|refseq:XP_005267137.1|refseq:NP_001073919.1|refseq:XP_011534307.1|refseq:XP_016866627.1|ensembl:ENSG00000178409(gene)|ensembl:ENST00000369042(transcript)|ensembl:ENST00000429433(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000792"(heterochromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1903580"(positive regulation of ATP metabolic process)|interpro:IPR018379|interpro:IPR033583|rcsb pdb:5JNO - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:W+UmsinDpvnD5wV9MZI5YWywK6U9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:H7C0V5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-27050435|ensembl:ENSP00000396882 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:h7c0v5_human(display_long)|uniprotkb:ANKHD1-EIF4EBP3(gene name)|psi-mi:ANKHD1-EIF4EBP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000254996(gene)|ensembl:ENST00000437495(transcript) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Mz78glSXPoObWRXGmmUz/wlvEIk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92900 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96JM3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2560420|uniprotkb:Q8NC88|uniprotkb:B3KU06|uniprotkb:Q6P181|uniprotkb:Q9BST0|ensembl:ENSP00000354730|ensembl:ENSP00000496699 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:chap1_human(display_long)|uniprotkb:CHAMP(gene name synonym)|uniprotkb:CHAMP1(gene name)|psi-mi:CHAMP1(display_short)|uniprotkb:C13orf8(gene name synonym)|uniprotkb:CAMP(gene name synonym)|uniprotkb:KIAA1802(gene name synonym)|uniprotkb:ZNF828(gene name synonym)|uniprotkb:Zinc finger protein 828(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001157616.1|refseq:NP_001157617.1|refseq:NP_115812.1|ensembl:ENSG00000198824(gene)|ensembl:ENST00000361283(transcript)|ensembl:ENST00000643483(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0016604"(nuclear body)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0090543"(Flemming body)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR039330|mint:Q96JM3|rcsb pdb:6EKJ|rcsb pdb:6EKL|rcsb pdb:5XPT|rcsb pdb:5XPU - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Di1yMiufHKsy384vPjOgdncmQXw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q7Z5K2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1022242|uniprotkb:Q5VSK5|uniprotkb:Q8IX10|uniprotkb:Q92549|uniprotkb:A7E2B5|ensembl:ENSP00000298767 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:wapl_human(display_long)|uniprotkb:WAPL(gene name)|psi-mi:WAPL(display_short)|uniprotkb:FOE(gene name synonym)|uniprotkb:Friend of EBNA2 protein(gene name synonym)|uniprotkb:KIAA0261(gene name synonym)|uniprotkb:WAPAL(gene name synonym)|uniprotkb:WAPL cohesin release factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055860.1|refseq:NP_001305257.1|ensembl:ENSG00000062650(gene)|ensembl:ENST00000298767(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009636"(response to toxic substance)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045875"(negative regulation of sister chromatid cohesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0072686"(mitotic spindle)|interpro:IPR012502(Wings apart-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022771|interpro:IPR039874|mint:Q7Z5K2|rcsb pdb:4K6J|go:"GO:0071922"(regulation of cohesin loading)|rcsb pdb:5HDT|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|dip:DIP-31176N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:3i6RKmQTqtFexq/ZVxKQCgNHbZw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q12849 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054150|uniprotkb:Q6ZST3|uniprotkb:Q8NBD2|uniprotkb:Q4W5S5|uniprotkb:Q8IWD6|uniprotkb:B3KPW0|intact:EBI-28981368|ensembl:ENSP00000254799 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:grsf1_human(display_long)|uniprotkb:GRSF1(gene name)|psi-mi:GRSF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002083.3|refseq:XP_011530199.1|ensembl:ENSP00000254799|ensembl:ENST00000502323|ensembl:ENSP00000425430|refseq:NP_001091947.1|ensembl:ENSG00000132463(gene)|ensembl:ENST00000254799(transcript)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033106|interpro:IPR034424|interpro:IPR034425|interpro:IPR034426|interpro:IPR035979|rcsb pdb:2LMI|rcsb pdb:4QU6|rcsb pdb:4QU7|reactome:R-HSA-192823 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:89Xul87okYruMW1PQtPMbBTqX+09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P23921 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-717006|uniprotkb:Q9UNN2|ensembl:ENSP00000300738 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rir1_human(display_long)|uniprotkb:Ribonucleoside-diphosphate reductase subunit M1(gene name synonym)|uniprotkb:Ribonucleotide reductase large subunit(gene name synonym)|uniprotkb:RRM1(gene name)|psi-mi:RRM1(display_short)|uniprotkb:RR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001024.1|refseq:NP_001304993.1|refseq:NP_001304994.1|ensembl:ENSG00000167325(gene)|ensembl:ENST00000300738(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006206"(pyrimidine nucleobase metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0008584"(male gonad development)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061731"(ribonucleoside-diphosphate reductase activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:2WGH|rcsb pdb:3HNC|rcsb pdb:3HND|rcsb pdb:3HNE|rcsb pdb:3HNF|rcsb pdb:4X3V|rcsb pdb:5D1Y|rcsb pdb:5TUS|rcsb pdb:6AUI|rcsb pdb:6L3R|rcsb pdb:6L7L|rcsb pdb:6LKM|reactome:R-HSA-499943|dip:DIP-24233N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:3+XYBQzGh1wi495ZTSvHbYvUXZQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O15530 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-717097|uniprotkb:Q8IV52|uniprotkb:Q9BRD5|uniprotkb:Q6FI20|uniprotkb:H0Y4Z0|uniprotkb:Q59EH6|intact:EBI-28968232|ensembl:ENSP00000344220 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdpk1_human(display_long)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short)|uniprotkb:PDK1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002604.1|refseq:NP_112558.2|ensembl:ENST00000268673|ensembl:ENSP00000268673|ensembl:ENSP00000344220|ensembl:ENST00000441549|ensembl:ENSP00000395357|refseq:NP_001248745.1|ensembl:ENSG00000140992(gene)|ensembl:ENST00000342085(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|rcsb pdb:1H1W|rcsb pdb:1OKY|rcsb pdb:1OKZ|rcsb pdb:1UU3|rcsb pdb:1UU7|rcsb pdb:1UU8|rcsb pdb:1UU9|rcsb pdb:1UVR|rcsb pdb:1W1G|rcsb pdb:1W1H|rcsb pdb:1Z5M|rcsb pdb:2BIY|rcsb pdb:2PE0|rcsb pdb:2PE1|rcsb pdb:2PE2|rcsb pdb:2R7B|rcsb pdb:2VKI|rcsb pdb:2XCH|rcsb pdb:2XCK|rcsb pdb:3H9O|rcsb pdb:3HRC|rcsb pdb:3HRF|rcsb pdb:3ION|rcsb pdb:3IOP|rcsb pdb:3NAX|rcsb pdb:3NAY|rcsb pdb:3NUN|rcsb pdb:3NUS|rcsb pdb:3NUU|rcsb pdb:3NUY|rcsb pdb:3ORX|rcsb pdb:3ORZ|rcsb pdb:3OTU|rcsb pdb:1W1D|rcsb pdb:3PWY|rcsb pdb:3QC4|rcsb pdb:3QCQ|rcsb pdb:3QCS|rcsb pdb:3QCX|rcsb pdb:3QCY|rcsb pdb:3QD0|rcsb pdb:3QD3|rcsb pdb:3QD4|rcsb pdb:3RCJ|rcsb pdb:3RWP|rcsb pdb:3RWQ|rcsb pdb:3SC1|rcsb pdb:4A06|rcsb pdb:4A07|rcsb pdb:4AW0|rcsb pdb:4AW1|rcsb pdb:4CT1|rcsb pdb:4CT2|rcsb pdb:4RQK|rcsb pdb:4RQV|rcsb pdb:4RRV|rcsb pdb:4XX9|rcsb pdb:5ACK|rcsb pdb:5HKM|rcsb pdb:5HNG|rcsb pdb:5HO7|rcsb pdb:5HO8|rcsb pdb:5LVL|rcsb pdb:5LVM|rcsb pdb:5LVN|rcsb pdb:5LVO|rcsb pdb:5LVP|rcsb pdb:5MRD|rcsb pdb:6WJQ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-165158|reactome:R-HSA-202424|reactome:R-HSA-2730905|reactome:R-HSA-2871837|reactome:R-HSA-354192|reactome:R-HSA-389357|reactome:R-HSA-392451|reactome:R-HSA-444257|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5625740|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-9634635|dip:DIP-38372N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1Uf7b8GptL7XBfEZm43zB3ho6ZQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P32019 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-10963917|uniprotkb:Q5VSH0|uniprotkb:Q86YE1|uniprotkb:Q5VSG9|uniprotkb:Q658Q5|uniprotkb:Q5VSH1|uniprotkb:C9J6U5|uniprotkb:Q6PD53|uniprotkb:Q6P6D4|ensembl:ENSP00000362114|ensembl:ENSP00000362117 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:i5p2_human(display_long)|uniprotkb:INPP5B(gene name)|psi-mi:INPP5B(display_short)|uniprotkb:75 kDa inositol polyphosphate-5-phosphatase(gene name synonym)|uniprotkb:OCRL2(gene name synonym)|uniprotkb:Phosphoinositide 5-phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001284363.1|refseq:NP_005531.2|ensembl:ENSG00000204084(gene)|ensembl:ENST00000373023(transcript)|ensembl:ENST00000373026(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0070613"(regulation of protein processing)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031896|interpro:IPR036691|interpro:IPR037793|rcsb pdb:3MTC|rcsb pdb:3N9V|rcsb pdb:4CML|rcsb pdb:5A7I|rcsb pdb:5A7J|reactome:R-HSA-1855183|reactome:R-HSA-1855204 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:0JIiNz1Bp56ZqscGeMQUXu8w4Fc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y2X0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-394541|uniprotkb:Q6PJT2|uniprotkb:Q96AD4|uniprotkb:Q96I35|uniprotkb:Q9Y652|ensembl:ENSP00000325612 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:med16_human(display_long)|uniprotkb:MED16(gene name)|psi-mi:MED16(display_short)|uniprotkb:Mediator complex subunit 16(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 95 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 5(gene name synonym)|uniprotkb:DRIP92(gene name synonym)|uniprotkb:THRAP5(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 92 kDa component(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005472.2|ensembl:ENSG00000175221(gene)|ensembl:ENST00000325464(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001680(WD40 repeat)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR021665|interpro:IPR036322|mint:Q9Y2X0|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|dip:DIP-31463N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:nMHDmIPhzAalahGVVsO++rpQE/U9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P18077 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-353383|uniprotkb:Q08ES9|uniprotkb:Q9BVN7|ensembl:ENSP00000393393|ensembl:ENSP00000495672 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rl35a_human(display_long)|uniprotkb:RPL35A(gene name)|psi-mi:RPL35A(display_short)|uniprotkb:Cell growth-inhibiting gene 33 protein(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL33(gene name synonym)|uniprotkb:GIG33(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000987.2|refseq:NP_001303240.1|ensembl:ENST00000647248(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001780(Ribosomal protein L35Ae)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR018266|interpro:IPR038661|mint:P18077|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|ensembl:ENSG00000182899(gene)|ensembl:ENST00000448864(transcript)|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:fnUlL17LsiOp3lSkKNsoYO74IQQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BVL4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-16811833|ensembl:ENSP00000370288|uniprotkb:Q2TAL2|uniprotkb:Q5JZ81|uniprotkb:Q8WUI0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:selo_human(display_long)|uniprotkb:Selenoprotein O(gene name synonym)|uniprotkb:SELENOO(gene name)|psi-mi:SELENOO(display_short)|uniprotkb:SELO(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000073169(gene)|ensembl:ENST00000380903(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0018117"(protein adenylylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070733"(protein adenylyltransferase activity)|interpro:IPR003846(Protein of unknown function UPF0061)|refseq:NP_113642.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Rfwzqq4U1s+f8ugyECwJWlWKD1Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y679 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1058701|ensembl:ENSP00000366748|uniprotkb:Q9H866|uniprotkb:Q9UNQ6|uniprotkb:Q9Y685|uniprotkb:C0H5W8 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:aup1_human(display_long)|uniprotkb:AUP1(gene name)|psi-mi:AUP1(display_short)|uniprotkb:Ancient ubiquitous protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000115307(gene)|ensembl:ENST00000377526(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_853553.1|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990044"(protein localization to lipid droplet)|interpro:IPR003892(Ubiquitin system component Cue)|rcsb pdb:2EKF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:6yySfIPpRUlnm0upBDYyfBUOtIY9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q86XL3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1773621|uniprotkb:O75176|uniprotkb:Q6P6A5|uniprotkb:Q96DH4|uniprotkb:Q8TAZ9|uniprotkb:A8KAG3|uniprotkb:B3KN97|uniprotkb:B3KSF8|ensembl:ENSP00000350686 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ankl2_human(display_long)|uniprotkb:ANKLE2(gene name)|psi-mi:ANKLE2(display_short)|uniprotkb:KIAA0692(gene name synonym)|uniprotkb:LEM domain-containing protein 4(gene name synonym)|uniprotkb:LEM4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011533089.1|refseq:XP_011533090.1|refseq:NP_055929.1|ensembl:ENSG00000176915(gene)|ensembl:ENST00000357997(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR011320(Ribonuclease HI, N-terminal)|interpro:IPR035006|interpro:IPR035007|interpro:IPR036770|interpro:IPR037056|reactome:R-HSA-2995383|reactome:R-HSA-9013404|reactome:R-HSA-9013408 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Gaa+XAC6xNVobxZhMlzCHvVDFgk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75600 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2959690|ensembl:ENSP00000248924|uniprotkb:Q96CA9|uniprotkb:E2QC23|uniprotkb:Q6ZWF1 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kbl_human(display_long)|uniprotkb:GCAT(gene name)|psi-mi:GCAT(display_short)|uniprotkb:KBL(gene name synonym)|uniprotkb:Aminoacetone synthase(gene name synonym)|uniprotkb:Glycine acetyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000100116(gene)|ensembl:ENST00000248924(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0008890"(glycine C-acetyltransferase activity)|go:"GO:0009058"(biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019518"(L-threonine catabolic process to glycine)|go:"GO:0030170"(pyridoxal phosphate binding)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR011282(2-amino-3-ketobutyrate coenzyme A ligase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|reactome:R-HSA-8849175|refseq:NP_055106.1|refseq:NP_001165161.1|refseq:XP_005261467.1|refseq:XP_016884166.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:JcxSdpqnWgMx3m5s6nO38OjqO+I9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q13555 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BUK6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2340176|uniprotkb:Q7LBZ8|uniprotkb:Q5T717|uniprotkb:Q7Z3M7|uniprotkb:Q53GR8|uniprotkb:Q9NQX2|uniprotkb:Q9NVU4|uniprotkb:Q7Z558|uniprotkb:Q5CZ69|uniprotkb:Q8TE05|uniprotkb:Q68CT6|ensembl:ENSP00000245564 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:msto1_human(display_long)|uniprotkb:MSTO1(gene name)|psi-mi:MSTO1(display_short)|uniprotkb:LST005(orf name)|uniprotkb:SLTP005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011508010.1|refseq:NP_060586.2|refseq:NP_001243461.1|refseq:NP_001243462.1|refseq:XP_016857098.1|ensembl:ENSG00000125459(gene)|ensembl:ENST00000245564(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0048311"(mitochondrion distribution)|interpro:IPR019605|interpro:IPR029209|interpro:IPR036525 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:aZOmttCfkLs7GpgtF2DEp2gPrwQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q13620 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O14974 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NB37 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-722742|uniprotkb:Q2NL76|uniprotkb:Q6ZQY0|uniprotkb:Q8NAE0|uniprotkb:B7ZKW5|ensembl:ENSP00000321691 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gald1_human(display_long)|uniprotkb:GATD1(gene name)|psi-mi:GATD1(display_short)|uniprotkb:PDDC1(gene name synonym)|uniprotkb:Parkinson disease 7 domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_872418.1|refseq:NP_001305753.1|refseq:XP_016873156.1|ensembl:ENSG00000177225(gene)|ensembl:ENST00000319863(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR029062 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:LQ3FMvZSS7oVbsX1VhtEaFlWbR49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y2S7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96EB6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O60645 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1052278|uniprotkb:Q8TEN6|uniprotkb:Q8WUW0|uniprotkb:Q96DI4|uniprotkb:Q6P2E8|ensembl:ENSP00000323377|ensembl:ENSP00000425587|intact:EBI-11944037 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:exoc3_human(display_long)|uniprotkb:Exocyst complex component Sec6(gene name synonym)|uniprotkb:EXOC3(gene name)|psi-mi:EXOC3(display_short)|uniprotkb:SEC6(gene name synonym)|uniprotkb:SEC6L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_016864492.1|refseq:XP_016864493.1|ensembl:ENSG00000180104(gene)|ensembl:ENST00000315013(transcript)|ensembl:ENST00000512944(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000149"(SNARE binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051601"(exocyst localization)|interpro:IPR010326(Exocyst complex component Sec6)|interpro:IPR042532|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0030426"(growth cone)|refseq:NP_009208.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:7nhIGGYkkrej3iW0UKDqP5BwUz09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H840 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-715455|uniprotkb:Q6IA34|ensembl:ENSP00000375813|ensembl:ENSP00000465704|ensembl:ENSP00000466342|ensembl:ENSP00000270257 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gemi7_human(display_long)|uniprotkb:SIP3(gene name synonym)|uniprotkb:GEMIN7(gene name)|psi-mi:GEMIN7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_005259319.1|refseq:XP_005259320.1|refseq:NP_001007270.1|refseq:NP_001007271.1|refseq:NP_078983.1|ensembl:ENSG00000142252(gene)|ensembl:ENST00000270257(transcript)|ensembl:ENST00000391951(transcript)|ensembl:ENST00000591607(transcript)|ensembl:ENST00000591747(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0120114"(Sm-like protein family complex)|interpro:IPR020338|interpro:IPR024642|mint:Q9H840|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859|refseq:NP_001305983.1|refseq:NP_001305984.1|refseq:XP_016882801.1|dip:DIP-41750N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jnNKbzuQxiIWKDmv7+je9B5U81Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P60510 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96A35 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1045743|uniprotkb:Q53G65|uniprotkb:Q53HT0|uniprotkb:Q5SYZ9|uniprotkb:Q5SZ00|uniprotkb:Q5SZ02|uniprotkb:Q96Q70|uniprotkb:Q9H7G3|uniprotkb:D3DVC8|intact:EBI-2560246|ensembl:ENSP00000354525|ensembl:ENSP00000357194 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm24_human(display_long)|uniprotkb:MRPL24(gene name)|psi-mi:MRPL24(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL24m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_078816.2|refseq:NP_663781.1|ensembl:ENSG00000143314(gene)|ensembl:ENST00000361531(transcript)|ensembl:ENST00000368211(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR003256(Ribosomal protein L24)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:Q96A35|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:6ZSE|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011508283.1|refseq:XP_011508284.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:TVDcxc2+oUe0eez+iQPW5HWBwdI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96GX5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2556114|uniprotkb:Q5T8D5|uniprotkb:Q5T8D7|uniprotkb:Q96SJ5|uniprotkb:Q8NCD6|ensembl:ENSP00000365107 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gwl_human(display_long)|uniprotkb:GW(gene name synonym)|uniprotkb:GWL(gene name synonym)|uniprotkb:THC2(gene name synonym)|uniprotkb:MASTL(gene name)|psi-mi:MASTL(display_short)|uniprotkb:Microtubule-associated serine/threonine-protein kinase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001165774.1|refseq:NP_001165775.1|refseq:NP_116233.2|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000120539(gene)|ensembl:ENST00000375940(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR037638|rcsb pdb:5LOH|reactome:R-HSA-2465910|interpro:IPR000961(Protein kinase, C-terminal) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+KiVOlyI1QBhdDo8TjgbqpYr/cE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75616 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P19387 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-394729|uniprotkb:O15161|ensembl:ENSP00000219252 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpb3_human(display_long)|uniprotkb:POLR2C(gene name)|psi-mi:POLR2C(display_short)|uniprotkb:A-152E5.7(orf name)|uniprotkb:DNA-directed RNA polymerase II subunit C(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 33 kDa polypeptide(gene name synonym)|uniprotkb:RPB31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_116558.1|ensembl:ENSG00000102978(gene)|ensembl:ENST00000219252(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR036603|interpro:IPR036643|mint:P19387|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32911N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UXFC+i+QqB2WRgL9OiYSQ66L36c9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q13416 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NFH4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2563158|ensembl:ENSP00000251074|ensembl:ENSP00000448054|uniprotkb:Q9H644 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nup37_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit Nup37(gene name synonym)|uniprotkb:NUP37(gene name)|psi-mi:NUP37(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_076962.2|ensembl:ENSG00000075188(gene)|ensembl:ENST00000251074(transcript)|ensembl:ENST00000552283(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037626|mint:Q8NFH4|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:mOkDLvRNOkSg/v6jnvOox6ZNTzo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P82673 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2513649|ensembl:ENSP00000081029|uniprotkb:Q6P4C6|uniprotkb:Q7L1M6|uniprotkb:Q9HC14|uniprotkb:Q96AI0|uniprotkb:Q32LZ1|uniprotkb:Q9H044|uniprotkb:Q9P1R5|uniprotkb:Q8NBP4 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt35_human(display_long)|uniprotkb:MRPS35(gene name)|psi-mi:MRPS35(display_short)|uniprotkb:MRPS28(gene name synonym)|uniprotkb:28S ribosomal protein S28, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS35(gene name synonym)|uniprotkb:HDCMD11P(orf name)|uniprotkb:MDS023(orf name)|uniprotkb:PSEC0213(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000061794(gene)|ensembl:ENST00000081029(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR019349|interpro:IPR039848|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_001177793.1|refseq:NP_068593.2 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:L7fhBRRkth1ePVbRtuVTvC5zcR09606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q2TAL8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2798044|uniprotkb:Q8TEA5|uniprotkb:Q4G0F7|uniprotkb:Q7L621|ensembl:ENSP00000350094|ensembl:ENSP00000378830|ensembl:ENSP00000412890 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:qric1_human(display_long)|uniprotkb:QRICH1(gene name)|psi-mi:QRICH1(display_short)|uniprotkb:Glutamine-rich protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001307509.1|refseq:NP_001307510.1|refseq:NP_001307511.1|refseq:NP_001307512.1|refseq:NP_001307513.1|refseq:NP_001307514.1|refseq:XP_011532165.1|refseq:NP_060200.2|refseq:NP_942581.1|ensembl:ENSG00000198218(gene)|ensembl:ENST00000357496(transcript)|ensembl:ENST00000395443(transcript)|ensembl:ENST00000424300(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0140467"(integrated stress response signaling)|interpro:IPR021893 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lZutsiEMc3Fpej5M2vhosiQZnoA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5VZL5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2514659|intact:EBI-28984130|ensembl:ENSP00000322915|uniprotkb:A0JP19|uniprotkb:O43308|uniprotkb:A0JP20|uniprotkb:Q5T5E2|uniprotkb:Q7L3Q4|uniprotkb:Q5T5E1|intact:EBI-2556245 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:zmym4_human(display_long)|uniprotkb:ZMYM4(gene name)|psi-mi:ZMYM4(display_short)|uniprotkb:KIAA0425(gene name synonym)|uniprotkb:ZNF262(gene name synonym)|uniprotkb:Zinc finger protein 262(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000146463(gene)|ensembl:ENST00000314607(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|refseq:XP_016858292.1|refseq:XP_016858293.1|refseq:XP_011540725.1|refseq:XP_011540727.1|refseq:NP_005086.2|ensembl:ENSP00000322915|refseq:XP_005271388.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:jc8YwR+37J3uD08cXiUnOA2hHEI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8NC60 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-717871|uniprotkb:Q8N7L6|uniprotkb:Q9BSQ9|ensembl:ENSP00000264230 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:noa1_human(display_long)|uniprotkb:NOA1(gene name)|psi-mi:NOA1(display_short)|uniprotkb:C4orf14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_115689.1|ensembl:ENSG00000084092(gene)|ensembl:ENST00000264230(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043457"(regulation of cellular respiration)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:lynfPNtWZ/q7Df9/hpwiyIjUD2Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96N67 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P31327 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-536811|uniprotkb:O43774|uniprotkb:Q7Z5I5|uniprotkb:B7Z818|uniprotkb:Q53TL5|uniprotkb:J3KQL0|uniprotkb:Q59HF8|ensembl:ENSP00000233072|ensembl:ENSP00000500537|ensembl:ENSP00000501022|ensembl:ENSP00000501073 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:cpsm_human(display_long)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)|uniprotkb:CPS1(gene name)|psi-mi:CPS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001116105.1|refseq:NP_001116106.1|refseq:NP_001866.2|refseq:XP_011508943.1|refseq:XP_011508944.1|refseq:XP_011508945.1|refseq:XP_011508946.1|ensembl:ENSG00000021826(gene)|ensembl:ENST00000233072(transcript)|ensembl:ENST00000673510(transcript)|ensembl:ENST00000673630(transcript)|ensembl:ENST00000673711(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:P31327|rcsb pdb:2YVQ|rcsb pdb:4UTR|rcsb pdb:4UTV|rcsb pdb:4UTX|rcsb pdb:4UTZ|rcsb pdb:4UU7|rcsb pdb:4UU8|rcsb pdb:4UUA|rcsb pdb:4UUB|rcsb pdb:5DOT|rcsb pdb:5DOU|rcsb pdb:5OJO|rcsb pdb:6UEL|rcsb pdb:6W2J|reactome:R-HSA-70635 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:497s02igPCWuQcU4lVrMpl5SRig9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9UHW5 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-395491|uniprotkb:Q53FS3|uniprotkb:Q6UVZ6|uniprotkb:Q7Z3D3|uniprotkb:Q8NEI2|uniprotkb:Q96HK9|uniprotkb:B2RC54|uniprotkb:D4YWV1|ensembl:ENSP00000228827|uniprotkb:F5H759 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:gpn3_human(display_long)|uniprotkb:ATPBD1C(gene name synonym)|uniprotkb:ATP-binding domain 1 family member C(gene name synonym)|uniprotkb:GPN3(gene name)|psi-mi:GPN3(display_short)|uniprotkb:AD-009(orf name)|uniprotkb:UNQ1876/PRO4319(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001157844.1|refseq:NP_001157845.1|refseq:NP_057385.3|ensembl:ENSG00000111231(gene)|ensembl:ENST00000228827(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030228|mint:Q9UHW5 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:fKBsnLcvitaM76zQUW+MQXDPxTA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O14602 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-286439|uniprotkb:Q9BS77|ensembl:ENSP00000354722 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:if1ay_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 4C(gene name synonym)|uniprotkb:EIF1AY(gene name)|psi-mi:EIF1AY(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004672.2|refseq:NP_001265541.1|ensembl:ENSG00000198692(gene)|ensembl:ENST00000361365(transcript)|go:"GO:0003743"(translation initiation factor activity)|interpro:IPR001253("Eukaryotic initiation factor 1A (eIF-1A)")|interpro:IPR006196(S1, IF1 type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018104 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8nbys9cgdyGlFgYev/Ws9Q0cu6s9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P30048 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-748336|intact:EBI-10975142|uniprotkb:P35690|uniprotkb:Q0D2H1|uniprotkb:Q13776|uniprotkb:Q5T5V2|uniprotkb:Q96HK4|uniprotkb:B2R7Z0|uniprotkb:D3DRC9|uniprotkb:E9PH29|ensembl:ENSP00000298510 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:prdx3_human(display_long)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:Peroxiredoxin III(gene name synonym)|uniprotkb:Antioxidant protein 1(gene name synonym)|uniprotkb:Protein MER5 homolog(gene name synonym)|uniprotkb:HBC189(gene name synonym)|uniprotkb:PRDX3(gene name)|psi-mi:PRDX3(display_short)|uniprotkb:AOP1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001289201.1|refseq:NP_006784.1|ensembl:ENSG00000165672(gene)|ensembl:ENST00000298510(transcript)|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008785"(alkyl hydroperoxide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:P30048|rcsb pdb:5JCG|rcsb pdb:5UCX|reactome:R-HSA-3299685|go:"GO:0005769"(early endosome)|dip:DIP-33600N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+J/zV8u0jGCSzTGXafxgecTv/149606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q15843 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BYN8 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721378|uniprotkb:Q96Q58|ensembl:ENSP00000369682 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rt26_human(display_long)|uniprotkb:28S ribosomal protein S13, mitochondrial(gene name synonym)|uniprotkb:MRPS26(gene name)|psi-mi:MRPS26(display_short)|uniprotkb:RPMS13(gene name synonym)|uniprotkb:C20orf193(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_110438.1|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125901(gene)|ensembl:ENST00000380325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR026140|mint:Q9BYN8 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:ZygMazfhjHbx+aFhRkeG87c4L6E9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q99567 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-726178|uniprotkb:Q9BWE5|uniprotkb:D3DTM2|intact:EBI-28967918|ensembl:ENSP00000458954 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nup88_human(display_long)|uniprotkb:Nucleoporin Nup88(gene name synonym)|uniprotkb:88 kDa nucleoporin(gene name synonym)|uniprotkb:NUP88(gene name)|psi-mi:NUP88(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSP00000458954|refseq:NP_002523.2|refseq:NP_001307582.1|ensembl:ENSG00000108559(gene)|ensembl:ENST00000573584(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005215"(transporter activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|interpro:IPR019321|interpro:IPR037700|mint:Q99567|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:4e7YTurNWkXUn9zj0JiD2muc94A9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H269 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2655929|uniprotkb:Q5JUB1|uniprotkb:Q8WU31|uniprotkb:Q96EE7|uniprotkb:Q96N92|uniprotkb:Q9H1Q4|uniprotkb:Q9H1Q5|ensembl:ENSP00000369810 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vps16_human(display_long)|uniprotkb:VPS16(gene name)|psi-mi:VPS16(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_072097.2|refseq:NP_536338.1|ensembl:ENSG00000215305(gene)|ensembl:ENST00000380445(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR006925(Vps16, C-terminal)|interpro:IPR006926(Vps16, N-terminal)|interpro:IPR016534(Vacuolar protein sorting-associated protein 16)|interpro:IPR038132|mint:Q9H269|rcsb pdb:4BX9 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:bm088LmFRv3w0wfvlPMFeottZkw9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H089 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-4402486|uniprotkb:A0JLT4|uniprotkb:A0PJK3|uniprotkb:A6NI18|uniprotkb:Q7L9H8|uniprotkb:Q9NUK8|ensembl:ENSP00000265245 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:lsg1_human(display_long)|uniprotkb:LSG1(gene name)|psi-mi:LSG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060855.2|ensembl:ENSG00000041802(gene)|ensembl:ENST00000265245(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051168"(nuclear export)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378|interpro:IPR043358|mint:Q9H089|rcsb pdb:6LSR - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:66YYrxhw+MOGH9+lyrsQ4JPDA3w9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9P253 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BZE1 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-5325218|ensembl:ENSP00000354086|uniprotkb:Q96Q67|uniprotkb:Q9BWR1|uniprotkb:Q9P0P3 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm37_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL37(gene name synonym)|uniprotkb:MRPL37(gene name)|psi-mi:MRPL37(display_short)|uniprotkb:MRPL2(gene name synonym)|uniprotkb:RPML2(gene name synonym)|uniprotkb:39S ribosomal protein L2, mitochondrial(gene name synonym)|uniprotkb:HSPC235(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000116221(gene)|ensembl:ENST00000360840(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR010793(Ribosomal protein S30, mitochondrial)|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:3J7Y|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:3J9M|rcsb pdb:7ODR|rcsb pdb:5OOL|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:5OOM|rcsb pdb:7OF0|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OG4|refseq:NP_057575.2|dip:DIP-59718N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:rYwNelB9BJA4STHaD5AlJjUxCpM9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q86V97 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2514778|ensembl:ENSP00000368799|uniprotkb:Q96MP6|uniprotkb:Q8NDM5|uniprotkb:Q5T6Y8|uniprotkb:Q8N8L0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:kbtb6_human(display_long)|uniprotkb:KBTBD6(gene name)|psi-mi:KBTBD6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000165572(gene)|ensembl:ENST00000379485(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4XC2|refseq:NP_690867.3 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:iMugkQiayHqkx3aiExLs32a5Bv49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9HD33 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2560181|uniprotkb:Q8N5D1|uniprotkb:Q6XRG1|ensembl:ENSP00000417602 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm47_human(display_long)|uniprotkb:MRPL47(gene name)|psi-mi:MRPL47(display_short)|uniprotkb:NCM1(gene name synonym)|uniprotkb:Nasopharyngeal carcinoma metastasis-related protein 1(gene name synonym)|uniprotkb:CGI-204(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein uL29m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_065142.2|refseq:NP_817125.1|ensembl:ENSG00000136522(gene)|ensembl:ENST00000476781(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR010729(Ribosomal protein L47, mitochondrial)|interpro:IPR038340|mint:Q9HD33|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU3|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Zwk2kFYyc2Efry0CU19e8o7GEW89606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96S55 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2513471|ensembl:ENSP00000370150|ensembl:ENSP00000477551|uniprotkb:Q9NRJ6|uniprotkb:Q5W0E2|uniprotkb:Q53EP6|uniprotkb:Q8WV26|uniprotkb:Q5W0E4|uniprotkb:Q59ET8|uniprotkb:Q9H681|uniprotkb:B2RDB0 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:wrip1_human(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000124535(gene)|ensembl:ENST00000380773(transcript)|ensembl:ENST00000618555(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q96S55|rcsb pdb:3VHS|rcsb pdb:3VHT|go:"GO:0017116"(single-stranded DNA helicase activity)|refseq:NP_064520.2|refseq:NP_569079.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Q8qVSqItgTO7sbWGAQ3XAoFFUr89606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P11474 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8IXM3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-912501|uniprotkb:Q96Q49|ensembl:ENSP00000360498 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm41_human(display_long)|uniprotkb:MRPL27(gene name synonym)|uniprotkb:39S ribosomal protein L27 homolog(gene name synonym)|uniprotkb:MRP-L27 homolog(gene name synonym)|uniprotkb:Bcl-2-interacting mitochondrial ribosomal protein L41(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 3 protein(gene name synonym)|uniprotkb:MRPL41(gene name)|psi-mi:MRPL41(display_short)|uniprotkb:BMRP(gene name synonym)|uniprotkb:RPML27(gene name synonym)|uniprotkb:PIG3(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_115866.1|ensembl:ENSG00000182154(gene)|ensembl:ENST00000371443(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019189|mint:Q8IXM3|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1qftd9Vr6Rsymp6hgM29FeOvChA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q92882 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P84085 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-4289908|uniprotkb:P26437|ensembl:ENSP00000000233 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:arf5_human(display_long)|uniprotkb:ARF5(gene name)|psi-mi:ARF5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSG00000004059(gene)|ensembl:ENST00000000233(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84085|rcsb pdb:2B6H|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001653.1|dip:DIP-61289N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P51114 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P09110 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-3926709|ensembl:ENSP00000333664|uniprotkb:G5E935|uniprotkb:Q96CA6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:thik_human(display_long)|uniprotkb:ACAA1(gene name)|psi-mi:ACAA1(display_short)|uniprotkb:ACAA(gene name synonym)|uniprotkb:PTHIO(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:Acetyl-CoA C-myristoyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001123882.1|refseq:NP_001598.1|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008775"(acetate CoA-transferase activity)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2IIK|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-6798695|reactome:R-HSA-9033241|reactome:R-HSA-9033500|ensembl:ENSG00000060971(gene)|ensembl:ENST00000333167(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005576"(extracellular region) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:yWp9R9bAzdied8kfDD+qVrY8Slk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5JPH6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-13943410|ensembl:ENSP00000395196|ensembl:ENSP00000501251|uniprotkb:B3KTT2|uniprotkb:D3DWF1|uniprotkb:Q86YH3|uniprotkb:Q8TF31 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syem_human(display_long)|uniprotkb:EARS2(gene name)|psi-mi:EARS2(display_short)|uniprotkb:Glutamyl-tRNA synthetase(gene name synonym)|uniprotkb:KIAA1970(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 interpro:IPR008925(Aminoacyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020058|interpro:IPR020751|interpro:IPR033910|reactome:R-HSA-379726|ensembl:ENSG00000103356(gene)|ensembl:ENST00000449606(transcript)|ensembl:ENST00000674054(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0050561"("glutamate-tRNA(Gln) ligase activity")|go:"GO:0070127"(tRNA aminoacylation for mitochondrial protein translation)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004527(Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial)|refseq:NP_001077083.1|refseq:NP_001295140.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Jo4TXXabhrL7bgEVz1Ffm/766PA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q96SZ6 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-372956|uniprotkb:Q5QP47|uniprotkb:Q9BVG6|uniprotkb:Q9BWZ5|uniprotkb:Q9H859|uniprotkb:Q9NZZ9|uniprotkb:Q9Y3F0|uniprotkb:A8K7R0|uniprotkb:Q5QP46|uniprotkb:Q5QP48|uniprotkb:Q675N4|uniprotkb:Q675N5|ensembl:ENSP00000350558 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ck5p1_human(display_long)|uniprotkb:CDK5RAP1(gene name)|psi-mi:CDK5RAP1(display_short)|uniprotkb:CDK5 activator-binding protein C42(gene name synonym)|uniprotkb:C20orf34(gene name synonym)|uniprotkb:CDK5 regulatory subunit-associated protein 1(gene name synonym)|uniprotkb:mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase(gene name synonym)|uniprotkb:"mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase"(gene name synonym)|uniprotkb:CGI-05(orf name)|uniprotkb:HSPC167(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057492.2|refseq:NP_001265097.1|refseq:NP_001265098.1|refseq:NP_057166.4|ensembl:ENSG00000101391(gene)|ensembl:ENST00000357886(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035597"(N6-isopentenyladenosine methylthiotransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0070900"(mitochondrial tRNA modification)|interpro:IPR002792(Deoxyribonuclease/rho motif-related TRAM)|interpro:IPR005839(Protein of unknown function UPF0004)|interpro:IPR006463("tRNA-i(6)A37 modification enzyme MiaB")|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013848(Protein of unknown function UPF0004, N-terminal)|interpro:IPR020612|interpro:IPR023404|interpro:IPR038135 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:33pH+WYmB7Ub9Gi3y3JDiDV0rHo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H6S0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1057466|uniprotkb:B2RP66|ensembl:ENSP00000161863 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ytdc2_human(display_long)|uniprotkb:YTHDC2(gene name)|psi-mi:YTHDC2(display_short)|uniprotkb:YTH domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_073739.3|ensembl:ENSG00000047188(gene)|ensembl:ENST00000161863(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:Q9H6S0|rcsb pdb:2YU6|rcsb pdb:6K6U|refseq:XP_016865219.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8J8b1Q3F6rfXUwtp7EOeU2y89Lc9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P37198 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P50336 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-716607|uniprotkb:Q5VTW8|uniprotkb:D3DVG0|ensembl:ENSP00000343943|ensembl:ENSP00000356978 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ppox_human(display_long)|uniprotkb:PPOX(gene name)|psi-mi:PPOX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_000300.1|refseq:NP_001116236.1|ensembl:ENSG00000143224(gene)|ensembl:ENST00000352210(transcript)|ensembl:ENST00000367999(transcript)|go:"GO:0004729"(oxygen-dependent protoporphyrinogen oxidase activity)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR004572(Protoporphyrinogen oxidase)|interpro:IPR036188|mint:P50336|rcsb pdb:3NKS|rcsb pdb:4IVM|rcsb pdb:4IVO|reactome:R-HSA-189451 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:Y+DmgW/MogsQTWJlcL2S08lRNIk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9H6T3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O43149 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-715672|uniprotkb:Q6NXG0|uniprotkb:Q6ZRA1|uniprotkb:Q6ZSF4|uniprotkb:Q9NVB9|uniprotkb:A7MBM5|ensembl:ENSP00000371051 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:zzef1_human(display_long)|uniprotkb:ZZEF1(gene name)|psi-mi:ZZEF1(display_short)|uniprotkb:KIAA0399(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_055928.3|go:"GO:0005509"(calcium ion binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011992(EF-Hand type)|interpro:IPR040099|interpro:IPR041986|interpro:IPR043145|mint:O43149|ensembl:ENST00000381638(transcript)|ensembl:ENSG00000074755(gene) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:LpYXMInET7VBZ/ZLV23wuQksKTA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P35658 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9Y4W2 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q8N122 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P42677 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-356336|ensembl:ENSP00000499044|uniprotkb:Q5T4L6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rs27_human(display_long)|uniprotkb:RPS27(gene name)|psi-mi:RPS27(display_short)|uniprotkb:MPS1(gene name synonym)|uniprotkb:Metallopan-stimulin 1(gene name synonym)|uniprotkb:Small ribosomal subunit protein eS27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001021.1|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|ensembl:ENSG00000177954(gene)|ensembl:ENST00000651669(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:P42677|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-141444|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2500257|rcsb pdb:6OM7|reactome:R-HSA-5663220|reactome:R-HSA-6791226|reactome:R-HSA-68877|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-9648025|reactome:R-HSA-975956|reactome:R-HSA-975957|dip:DIP-44182N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5ST30 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2116622|uniprotkb:A2ABL7|uniprotkb:Q2M2A0|uniprotkb:Q59FI1|uniprotkb:Q5SQ96|uniprotkb:Q5SS98|uniprotkb:Q6DKJ5|uniprotkb:Q6ZV24|uniprotkb:Q96GN2|uniprotkb:Q96H77|uniprotkb:Q96Q02|uniprotkb:Q9H6R2|uniprotkb:Q9UFH7|uniprotkb:B4E3P5|uniprotkb:F5GXJ0|uniprotkb:B4DET4|uniprotkb:F5H323|ensembl:ENSP00000316092|ensembl:ENSP00000400867|ensembl:ENSP00000441000|ensembl:ENSP00000502585 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syvm_human(display_long)|uniprotkb:VARS2(gene name)|psi-mi:VARS2(display_short)|uniprotkb:KIAA1885(gene name synonym)|uniprotkb:VARS2L(gene name synonym)|uniprotkb:VARSL(gene name synonym)|uniprotkb:Valyl-tRNA synthetase-like(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001161205.1|refseq:NP_001161206.1|refseq:NP_065175.4|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|reactome:R-HSA-379726|ensembl:ENSG00000137411(gene)|ensembl:ENSG00000223494(gene)|ensembl:ENST00000321897(transcript)|ensembl:ENST00000415079(transcript)|ensembl:ENST00000541562(transcript)|ensembl:ENST00000676266(transcript) - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:eVvhK0wl8GhhjZ5SF+jSwmYnY9Y9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BYD3 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-721368|uniprotkb:A6NNV7|uniprotkb:Q9BW07|uniprotkb:Q9H4N2|uniprotkb:Q9Y317|ensembl:ENSP00000253099|ensembl:ENSP00000306902 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rm04_human(display_long)|uniprotkb:MRPL4(gene name)|psi-mi:MRPL4(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL4m(gene name synonym)|uniprotkb:CDABP0091(orf name)|uniprotkb:CGI-28(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_057040.2|refseq:NP_666499.1|refseq:NP_666500.1|ensembl:ENSG00000105364(gene)|ensembl:ENST00000253099(transcript)|ensembl:ENST00000307422(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013005(Ribosomal protein L4/L1e, bacterial-type)|interpro:IPR023574|mint:Q9BYD3|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:v1MODeAQQcG4MKCE/hvEg2NBwmk9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O14981 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1043840|uniprotkb:O43578|ensembl:ENSP00000265990|uniprotkb:B4E0W6 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:btaf1_human(display_long)|uniprotkb:BTAF1(gene name)|psi-mi:BTAF1(display_short)|uniprotkb:TAF172(gene name synonym)|uniprotkb:ATP-dependent helicase BTAF1(gene name synonym)|uniprotkb:TBP-associated factor 172(gene name synonym)|uniprotkb:"TAF(II)170"(gene name synonym)|uniprotkb:B-TFIID transcription factor-associated 170 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_003963.1|ensembl:ENSG00000095564(gene)|ensembl:ENST00000265990(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022707|interpro:IPR027417|interpro:IPR038718|interpro:IPR044078|mint:O14981 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:TUDUowqheA9/EO9RjuCwgwa6HY49606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O60678 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2809009|uniprotkb:B4DUC7|uniprotkb:A0A0A0MSN7|ensembl:ENSP00000331879 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:anm3_human(display_long)|uniprotkb:PRMT3(gene name)|psi-mi:PRMT3(display_short)|uniprotkb:HRMT1L3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_005779.1|ensembl:ENSG00000185238(gene)|ensembl:ENST00000331079(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1900053"(negative regulation of retinoic acid biosynthetic process)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR036236|mint:O60678|rcsb pdb:2FYT|rcsb pdb:3SMQ|rcsb pdb:4HSG|rcsb pdb:4QQN|rcsb pdb:4RYL|reactome:R-HSA-3214858|reactome:R-HSA-8876725 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:XtFHON3qMCvjDhtN8RpXJo9KODU9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P52788 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-724744|uniprotkb:A6NHA7|uniprotkb:A6NI34|uniprotkb:O00544|uniprotkb:Q9UQS1|uniprotkb:B2R9M0|ensembl:ENSP00000385746 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:spsy_human(display_long)|uniprotkb:Spermidine aminopropyltransferase(gene name synonym)|uniprotkb:SMS(gene name)|psi-mi:SMS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_004586.2|ensembl:ENSG00000102172(gene)|ensembl:ENST00000404933(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0016768"(spermine synthase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR015576(Spermine synthase-related)|interpro:IPR029063|interpro:IPR030373|interpro:IPR030374|interpro:IPR035246|interpro:IPR040900|mint:P52788|rcsb pdb:3C6K|rcsb pdb:3C6M|reactome:R-HSA-351202|interpro:IPR037163|refseq:NP_001245352.1 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:RxMB1ienUWc30YDh7Zz7V49PjdQ9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9BTT0 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-2685059|uniprotkb:Q5TB18|uniprotkb:Q8N1S4|uniprotkb:Q8WWW9|uniprotkb:B4E0I6|uniprotkb:E9PEA6|uniprotkb:Q5TB20|ensembl:ENSP00000463154 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:an32e_human(display_long)|uniprotkb:LANP-like protein(gene name synonym)|uniprotkb:ANP32E(gene name)|psi-mi:ANP32E(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001129950.1|refseq:NP_001129951.1|refseq:NP_112182.1|refseq:NP_001267488.1|refseq:NP_001267489.1|ensembl:ENSG00000143401(gene)|ensembl:ENST00000583931(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043486"(histone exchange)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q9BTT0|rcsb pdb:4CAY|rcsb pdb:4NFT - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:byeFwwxqINXwewx0Gx/QXSyes8g9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q14157 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q9NSE4 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q5T4S7 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:8Iown8oj965YAir+95+3om5+1YM9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:Q07021 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837 - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P10809 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:P38646 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96T52 uniprotkb:O75792 intact:EBI-20843876|ensembl:ENSP00000329553|ensembl:ENSP00000384966|ensembl:ENSP00000399353|uniprotkb:Q75MF1|uniprotkb:Q75MN9|uniprotkb:Q75MP0|uniprotkb:Q75MS5|uniprotkb:Q75MS8|uniprotkb:Q96HJ2 intact:EBI-9027352|uniprotkb:Q96F11|uniprotkb:B2RCY1|ensembl:ENSP00000221486 psi-mi:imp2l_human(display_long)|uniprotkb:IMP2-like protein(gene name synonym)|uniprotkb:IMMP2L(gene name)|psi-mi:IMMP2L(display_short) psi-mi:rnh2a_human(display_long)|uniprotkb:RNASEH2A(gene name)|psi-mi:RNASEH2A(display_short)|uniprotkb:Aicardi-Goutieres syndrome 4 protein(gene name synonym)|uniprotkb:RNASEHI(gene name synonym)|uniprotkb:RNHIA(gene name synonym)|uniprotkb:"RNase H(35)"(gene name synonym)|uniprotkb:Ribonuclease HI large subunit(gene name synonym)|uniprotkb:Ribonuclease HI subunit A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-27050444|imex:IM-29123-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001541"(ovarian follicle development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008015"(blood circulation)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030728"(ovulation)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0042720"(mitochondrial inner membrane peptidase complex)|go:"GO:0061300"(cerebellum vasculature development)|interpro:IPR000223(Peptidase S26A, signal peptidase I)|interpro:IPR019533|interpro:IPR019758|interpro:IPR036286|interpro:IPR037730|ensembl:ENST00000452895(transcript)|ensembl:ENSG00000184903(gene)|ensembl:ENST00000331762(transcript)|ensembl:ENST00000405709(transcript)|refseq:NP_001231535.1|refseq:NP_115938.1|refseq:XP_005250687.1|refseq:XP_016868194.1 refseq:NP_006388.2|ensembl:ENSG00000104889(gene)|ensembl:ENST00000221486(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006298"(mismatch repair)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0032299"(ribonuclease H2 complex)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0046872"(metal ion binding)|interpro:IPR001352(Ribonuclease HII/HIII)|interpro:IPR004649(Ribonuclease HII)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR023160|interpro:IPR024567|interpro:IPR036397|rcsb pdb:3P56|rcsb pdb:3PUF - - - figure legend:ST5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-Flp-In T-REx 293)|taxid:9606(human-Flp-In T-REx 293) - 2021/07/02 2021/07/28 rogid:qxvuxLbGYmT+qn2S5kkZRyLicto9606 rogid:UCK5FUsIvOKaNqxTiD2uRHyJ/ws9606 rigid:RtG736E0SSTFESWy87XZqFaHYoc false tandem tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43464-PRO_0000026946 uniprotkb:Q16891 intact:EBI-5271862 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:o43464-pro_0000026946(display_long)|uniprotkb:OMI(gene name synonym)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:0435"(protease assay) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-27053807|imex:IM-29123-20 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-517086(chain-parent) refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N - chain-seq-start:134|chain-seq-end:458 - figure legend:f4a|inhibition:UCF-101|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/02 2021/08/03 rogid:z6a6Ek9Avx6mic1XjrMd72abFRE9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 rigid:bUuFsiIe6UiaJnHZwQcm8yAMP9M false his tag:c-c his tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O43464-PRO_0000026946 uniprotkb:P02666 intact:EBI-5271862 intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5 psi-mi:o43464-pro_0000026946(display_long)|uniprotkb:OMI(gene name synonym)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym) psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short) psi-mi:"MI:0435"(protease assay) Botham et al. (2019) pubmed:31617661|imex:IM-29123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0471"(MINT) intact:EBI-27053822|imex:IM-29123-22 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-517086(chain-parent) dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305 - chain-seq-start:134|chain-seq-end:458 - figure legend:f4a|inhibition:UCF-101|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/07/02 2021/08/03 rogid:z6a6Ek9Avx6mic1XjrMd72abFRE9606 rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913 rigid:D2Gxhnb1FGAO8pG2s2vi68OZ8Og false his tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)