#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTC4	uniprotkb:P0DTC4	intact:EBI-25475850	intact:EBI-25475850	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:"MI:1104"(solid state nmr)	Mandala et al. (2020)	imex:IM-28517|pubmed:33177698	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453180|imex:IM-28517-1|wwpdb:7k3g|bmrb:30795	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:2D, Table 1, supp. Tables 1+2.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/17	2020/11/23	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	rigid:Bz2PUGNqeZFB9XZdE010jKbxANI	false	sufficient binding region:8-38|his tag:n-n|13c label:?-?|15n label:?-?	sufficient binding region:8-38|his tag:n-n|13c label:?-?|15n label:?-?	5	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTC4	uniprotkb:P0DTC4	intact:EBI-25475850	intact:EBI-25475850	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:"MI:1104"(solid state nmr)	Mandala et al. (2020)	imex:IM-28517|pubmed:33177698	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453205|imex:IM-28517-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:2, Extended Data 5, supp. Table 3|comment:"An equimolar mixture of 13C-labeled protein and 4-19F-Phe-labeled protein  was used to measure intermolecular 13C-19F distances using the rotational-echo double-resonance (REDOR) technique."|comment:A single pentamer model, characterized by having Asn15 and Val25 at similar pore-facing orientations and all three Phe residues facing lipids, was found to best describe the experimental data.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/17	2020/11/23	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	rigid:0nMHlhkxTVbw2Y1f2euX7kfSho8	false	sufficient binding region:8-38|his tag:n-n|isotope label:20-20,23-23,26-26	sufficient binding region:8-38|his tag:n-n|13c label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:76400"	uniprotkb:P0DTC4	intact:EBI-9028401	intact:EBI-25475850	psi-mi:"5-(n,n-hexamethylene)amiloride"(display_short)|psi-mi:"CHEBI:76400"(display_long)|intact:HMA(synonym)	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:"MI:1104"(solid state nmr)	Mandala et al. (2020)	imex:IM-28517|pubmed:33177698	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453231|imex:IM-28517-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	-	-	figure legend:4|comment:"The CSPs (Chemical Shift Perturbations) of HMA are larger than those of AMT."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/17	2020/11/23	-	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	-	false	-	sufficient binding region:8-38|his tag:n-n|13c label:?-?|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:2618"	uniprotkb:P0DTC4	intact:EBI-8852144|chebi:"CHEBI:127647"	intact:EBI-25475850	psi-mi:amantadine(display_short)|psi-mi:"CHEBI:2618"(display_long)|intact:1-adamantanamine(synonym)|intact:1-adamantylamine(synonym)|intact:1-aminoadamantane(synonym)|intact:amantadina(synonym)|intact:amantadine(synonym)|intact:Amantadine(synonym)|intact:amantadinum(synonym)|intact:Amantidine(synonym)|intact:Aminoadamantane(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decan-1-amine"(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decan-1-ylamine"(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decane-1-amine"(synonym)|intact:Viregyt(synonym)|intact:Virosol(synonym)|intact:adamantan-1-ylamine(iupac name)	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:"MI:1104"(solid state nmr)	Mandala et al. (2020)	imex:IM-28517|pubmed:33177698	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453243|imex:IM-28517-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	inchi key:DKNWSYNQZKUICI-UHFFFAOYSA-N	-	figure legend:4C,  Extended Data Fig. 10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/17	2020/11/23	-	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	-	false	-	sufficient binding region:8-38|his tag:n-n|13c label:?-?|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:2618"	uniprotkb:P0DTC4	intact:EBI-8852144|chebi:"CHEBI:127647"	intact:EBI-25475850	psi-mi:amantadine(display_short)|psi-mi:"CHEBI:2618"(display_long)|intact:1-adamantanamine(synonym)|intact:1-adamantylamine(synonym)|intact:1-aminoadamantane(synonym)|intact:amantadina(synonym)|intact:amantadine(synonym)|intact:Amantadine(synonym)|intact:amantadinum(synonym)|intact:Amantidine(synonym)|intact:Aminoadamantane(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decan-1-amine"(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decan-1-ylamine"(synonym)|intact:"tricyclo[3.3.1.1(3,7)]decane-1-amine"(synonym)|intact:Viregyt(synonym)|intact:Virosol(synonym)|intact:adamantan-1-ylamine(iupac name)	psi-mi:vemp_sars2(display_long)|uniprotkb:E(gene name)|psi-mi:E(display_short)|uniprotkb:4(orf name)	psi-mi:"MI:1104"(solid state nmr)	Mandala et al. (2020)	imex:IM-28517|pubmed:33177698	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26453258|imex:IM-28517-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:7M4R|rcsb pdb:7NTK|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044662"(disruption by virus of host cell membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|refseq:YP_009724392.1|interpro:IPR043506|interpro:IPR044377|interpro:IPR003873(Nonstructural protein NS3/small envelope protein E)|rcsb pdb:7K3G|reactome:R-HSA-9694322|reactome:R-HSA-9694493|reactome:R-HSA-9694614|reactome:R-HSA-9694635	-	inchi key:DKNWSYNQZKUICI-UHFFFAOYSA-N	-	figure legend:Extended Data Fig. 10|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/17	2020/11/23	-	rogid:UWky5j9vE+Fp5EQSeWzUPWq6Ghc2697049	-	false	isotope label:?-?	sufficient binding region:8-38|his tag:n-n|13c label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)