#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NRF8	uniprotkb:Q9NRF8	intact:EBI-740874|ensembl:ENSP00000352222|ensembl:ENSP00000369590|ensembl:ENSP00000401264|uniprotkb:Q9BRI0|uniprotkb:Q9H809|uniprotkb:Q9H8K9|uniprotkb:B3KWM2	intact:EBI-740874|ensembl:ENSP00000352222|ensembl:ENSP00000369590|ensembl:ENSP00000401264|uniprotkb:Q9BRI0|uniprotkb:Q9H809|uniprotkb:Q9H8K9|uniprotkb:B3KWM2	psi-mi:pyrg2_human(display_long)|uniprotkb:UTP--ammonia ligase 2(gene name synonym)|uniprotkb:CTP synthetase 2(gene name synonym)|uniprotkb:CTPS2(gene name)|psi-mi:CTPS2(display_short)	psi-mi:pyrg2_human(display_long)|uniprotkb:UTP--ammonia ligase 2(gene name synonym)|uniprotkb:CTP synthetase 2(gene name synonym)|uniprotkb:CTPS2(gene name)|psi-mi:CTPS2(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Lynch et al. (2019)	imex:IM-27633|pubmed:31873303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397607|imex:IM-27633-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000047230(gene)|refseq:NP_001137474.1|refseq:NP_062831.3|refseq:NP_787055.1|ensembl:ENST00000359276(transcript)|ensembl:ENST00000380241(transcript)|ensembl:ENST00000443824(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|rcsb pdb:2V4U|rcsb pdb:2VKT|rcsb pdb:3IHL|rcsb pdb:6PK4|rcsb pdb:6PK7|reactome:R-HSA-499943|refseq:XP_006724566.1|refseq:XP_005274619.1	ensembl:ENSG00000047230(gene)|refseq:NP_001137474.1|refseq:NP_062831.3|refseq:NP_787055.1|ensembl:ENST00000359276(transcript)|ensembl:ENST00000380241(transcript)|ensembl:ENST00000443824(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|rcsb pdb:2V4U|rcsb pdb:2VKT|rcsb pdb:3IHL|rcsb pdb:6PK4|rcsb pdb:6PK7|reactome:R-HSA-499943|refseq:XP_006724566.1|refseq:XP_005274619.1	-	-	-	figure legend:Fig 1, Fig 4, Extended Data Fig 1,2,3a-d, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/08	2020/01/14	rogid:BU/tvZTUS1d42+j0qSGAg7ND25Y9606	rogid:BU/tvZTUS1d42+j0qSGAg7ND25Y9606	rigid:SdSBrqxuWbH9NrV3pCk0M0hL4No	false	mutation with no effect:355-355|mutation with no effect:352-352	mutation with no effect:355-355|mutation with no effect:352-352	4	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9NRF8	uniprotkb:Q9NRF8	intact:EBI-740874|ensembl:ENSP00000352222|ensembl:ENSP00000369590|ensembl:ENSP00000401264|uniprotkb:Q9BRI0|uniprotkb:Q9H809|uniprotkb:Q9H8K9|uniprotkb:B3KWM2	intact:EBI-740874|ensembl:ENSP00000352222|ensembl:ENSP00000369590|ensembl:ENSP00000401264|uniprotkb:Q9BRI0|uniprotkb:Q9H809|uniprotkb:Q9H8K9|uniprotkb:B3KWM2	psi-mi:pyrg2_human(display_long)|uniprotkb:UTP--ammonia ligase 2(gene name synonym)|uniprotkb:CTP synthetase 2(gene name synonym)|uniprotkb:CTPS2(gene name)|psi-mi:CTPS2(display_short)	psi-mi:pyrg2_human(display_long)|uniprotkb:UTP--ammonia ligase 2(gene name synonym)|uniprotkb:CTP synthetase 2(gene name synonym)|uniprotkb:CTPS2(gene name)|psi-mi:CTPS2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Lynch et al. (2019)	imex:IM-27633|pubmed:31873303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25397622|imex:IM-27633-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000047230(gene)|refseq:NP_001137474.1|refseq:NP_062831.3|refseq:NP_787055.1|ensembl:ENST00000359276(transcript)|ensembl:ENST00000380241(transcript)|ensembl:ENST00000443824(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|rcsb pdb:2V4U|rcsb pdb:2VKT|rcsb pdb:3IHL|rcsb pdb:6PK4|rcsb pdb:6PK7|reactome:R-HSA-499943|refseq:XP_006724566.1|refseq:XP_005274619.1	ensembl:ENSG00000047230(gene)|refseq:NP_001137474.1|refseq:NP_062831.3|refseq:NP_787055.1|ensembl:ENST00000359276(transcript)|ensembl:ENST00000380241(transcript)|ensembl:ENST00000443824(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|rcsb pdb:2V4U|rcsb pdb:2VKT|rcsb pdb:3IHL|rcsb pdb:6PK4|rcsb pdb:6PK7|reactome:R-HSA-499943|refseq:XP_006724566.1|refseq:XP_005274619.1	-	-	-	figure legend:Extended Data Fig 8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2020/01/08	2020/01/15	rogid:BU/tvZTUS1d42+j0qSGAg7ND25Y9606	rogid:BU/tvZTUS1d42+j0qSGAg7ND25Y9606	rigid:5WPVRciJcFylNdhH+6GkMNCcg6w	false	mutation causing an interaction:352-352	mutation causing an interaction:352-352	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0396"(predetermined participant)