#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814527|imex:IM-28395-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	-	-	-	figure legend:Fig. 1A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/10/07	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation:324-324	sufficient binding region:21-151	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814535|imex:IM-28395-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	-	-	-	figure legend:Fig. 1B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/08/17	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation:324-324	sufficient binding region:21-53	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814551|wwpdb:6E7K|imex:IM-28395-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/10/07	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation:324-324	sufficient binding region:21-151	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814803|imex:IM-28395-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	-	-	-	figure legend:Fig. 3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/08/18	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation:324-324	sufficient binding region:21-151	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814819|imex:IM-28395-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 8A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/10/06	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation disrupting interaction strength:445-445|mutation disrupting interaction strength:404-404|v5 tag:?-?	s tag:?-?|mutation disrupting interaction strength:109-109	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P06858	uniprotkb:Q8IV16	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	intact:EBI-9080234|uniprotkb:Q6P3T2|uniprotkb:Q86W15|intact:EBI-28970171|ensembl:ENSP00000480053	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:hdbp1_human(display_long)|uniprotkb:GPIHBP1(gene name)|psi-mi:GPIHBP1(display_short)|uniprotkb:HBP1(gene name synonym)|uniprotkb:High density lipoprotein-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814865|imex:IM-28395-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	ensembl:ENSP00000480053|refseq:NP_001288701.1|refseq:NP_835466.2|ensembl:ENSG00000277494(gene)|ensembl:ENST00000622500(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017038"(protein import)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035473"(lipase binding)|go:"GO:0035478"(chylomicron binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045056"(transcytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071503"(response to heparin)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090321"(positive regulation of chylomicron remnant clearance)|go:"GO:0140318"(protein transporter activity)|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|reactome:R-HSA-163125|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 8B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/08/18	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	rogid:xEkQbSvjU2SMRcjD/a0DbC5MwKg9606	rigid:ahkslBJFhIyTQRdeFaGAQoQFP98	false	mutation disrupting interaction strength:445-445|mutation disrupting interaction strength:404-404|flag tag:?-?	-	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:53753"	uniprotkb:P06858	intact:EBI-25814906	intact:EBI-715909|uniprotkb:Q16282|uniprotkb:Q16283|uniprotkb:Q96FC4|uniprotkb:B2R5T9|ensembl:ENSP00000497642	psi-mi:triolein(display_short)|psi-mi:"CHEBI:53753"(display_long)|intact:"propane-1,2,3-triyl (9Z,9'Z,9''Z)tris-octadec-9-enoate"(synonym)|intact:"TG(18:1(9Z)/18:1(9Z)/18:1(9Z))[iso]"(synonym)|intact:Trioleoylglyceride(synonym)|intact:Trioleoylglycerol(synonym)|intact:"propane-1,2,3-triyl tris[(9Z)-octadec-9-enoate]"(iupac name)|intact:Oleyl triglyceride(synonym)|intact:"(Z)-9-Octadecenoic acid, 1,2,3-propanetriyl ester"(synonym)|intact:"1,2,3-tri-(9Z-octadecenoyl)-glycerol"(synonym)|intact:Glycerin trioleate(synonym)|intact:Glycerol trioleate(synonym)|intact:Glycerol triolein(synonym)|intact:"Glycerol, tri(cis-9-octadecenoate)"(synonym)|intact:Glyceryl trioleate(synonym)|intact:Glyceryl-1,2,3-trioleate(synonym)|intact:Oleic acid triglyceride(synonym)|intact:Oleic triglyceride(synonym)|intact:Olein(synonym)	psi-mi:lipl_human(display_long)|uniprotkb:LPL(gene name)|psi-mi:LPL(display_short)|uniprotkb:LIPD(gene name synonym)|uniprotkb:Phospholipase A1(gene name synonym)	psi-mi:"MI:1354"(lipase assay)	Birrane et al. (2019)	pubmed:30559189|imex:IM-28395	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:1355"(lipid cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25814928|imex:IM-28395-13	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000228.1|ensembl:ENSG00000175445(gene)|ensembl:ENST00000650287(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008970"(phospholipase A1 activity)|go:"GO:0009409"(response to cold)|go:"GO:0009749"(response to glucose)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0017129"(triglyceride binding)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0052739"(phosphatidylserine 1-acylhydrolase activity)|go:"GO:0052740"(1-acyl-2-lysophosphatidylserine acylhydrolase activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000734(Lipase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR002330(Lipoprotein lipase)|interpro:IPR013818(Lipase, N-terminal)|interpro:IPR016272(Lipoprotein lipase, LIPH)|interpro:IPR029058|interpro:IPR033906|interpro:IPR036392|mint:P06858|rcsb pdb:6E7K|rcsb pdb:6OAU|rcsb pdb:6OAZ|rcsb pdb:6OB0|rcsb pdb:6WN4|reactome:R-HSA-381340|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634	go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0019433"(triglyceride catabolic process)	-	-	figure legend:Fig. 8B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/17	2020/10/07	-	rogid:PM82k8/f6nyAUhaTSvIUvjVkbYU9606	-	false	3h radiolabel:?-?	flag tag:?-?|mutation with no effect:445-445|mutation with no effect:404-404	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)