#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WWI1-3 uniprotkb:Q6UXM1-1 intact:EBI-4400717|ensembl:ENSP00000342112 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0018"(two hybrid) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412629|imex:IM-27677-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) - isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345. - figure legend:1A-1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/13 2020/01/27 rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:RGMhyUB5wUYMDGl5GeNY6egrH/U false sufficient binding region:1153-1349 sufficient binding region:831-881 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UPQ0-1 uniprotkb:Q6UXM1-1 intact:EBI-25412679|ensembl:ENSP00000316891 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q9upq0-1(display_long)|uniprotkb:LIMCH1(gene name)|psi-mi:LIMCH1(display_short)|uniprotkb:KIAA1102(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0018"(two hybrid) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412648|imex:IM-27677-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000064042(gene)|ensembl:ENST00000313860(transcript)|intact:EBI-2687222(isoform-parent) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) - - - figure legend:1A-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/13 2020/01/27 rogid:neDT1Rx97o6shpmtkOqJy31ueTA9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:EVG1X2MQinVZVvOhU2nMlOg+fuw false sufficient binding region:931-1083 sufficient binding region:831-881 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8WWI1-3 uniprotkb:Q96JA1 intact:EBI-4400717|ensembl:ENSP00000342112 intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261 psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412689|imex:IM-27677-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript) refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004 - isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345. - figure legend:1C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606 rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606 rigid:nWdTArGO975jT8jQLRurpkBOaXc false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UPQ0-1 uniprotkb:Q96JA1 intact:EBI-25412679|ensembl:ENSP00000316891 intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261 psi-mi:q9upq0-1(display_long)|uniprotkb:LIMCH1(gene name)|psi-mi:LIMCH1(display_short)|uniprotkb:KIAA1102(gene name synonym) psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412717|imex:IM-27677-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000064042(gene)|ensembl:ENST00000313860(transcript)|intact:EBI-2687222(isoform-parent) refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004 - - - figure legend:1C-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:neDT1Rx97o6shpmtkOqJy31ueTA9606 rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606 rigid:py43RPRgVezW0OJ6ir58peKyZfk false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8WWI1-3 uniprotkb:Q6UXM1-1 intact:EBI-4400717|ensembl:ENSP00000342112 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412723|imex:IM-27677-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) - isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345. - figure legend:1D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:RGMhyUB5wUYMDGl5GeNY6egrH/U false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UPQ0-1 uniprotkb:Q6UXM1-1 intact:EBI-25412679|ensembl:ENSP00000316891 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q9upq0-1(display_long)|uniprotkb:LIMCH1(gene name)|psi-mi:LIMCH1(display_short)|uniprotkb:KIAA1102(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25412729|imex:IM-27677-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000064042(gene)|ensembl:ENST00000313860(transcript)|intact:EBI-2687222(isoform-parent) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) - - - figure legend:1D-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:neDT1Rx97o6shpmtkOqJy31ueTA9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:EVG1X2MQinVZVvOhU2nMlOg+fuw false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UPQ0-1 uniprotkb:Q6UXM1-1 intact:EBI-25412679|ensembl:ENSP00000316891 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q9upq0-1(display_long)|uniprotkb:LIMCH1(gene name)|psi-mi:LIMCH1(display_short)|uniprotkb:KIAA1102(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0663"(confocal microscopy) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25412790|imex:IM-27677-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000064042(gene)|ensembl:ENST00000313860(transcript)|intact:EBI-2687222(isoform-parent) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) go:"GO:0048471"(perinuclear region of cytoplasm) - - figure legend:2A-1|comment:LRIG3 and LIMCH1 co-localized in the perinuclear region and at the edges of the cell.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:neDT1Rx97o6shpmtkOqJy31ueTA9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:EVG1X2MQinVZVvOhU2nMlOg+fuw false flag tag:?-? myc tag:?-? - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q8WWI1-3 uniprotkb:Q96JA1 intact:EBI-4400717|ensembl:ENSP00000342112 intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261 psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25412796|imex:IM-27677-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript) refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004 go:"GO:0048471"(perinuclear region of cytoplasm) isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345. - figure legend:2A-2|comment:LRIG1 and LMO7 co-localized in the cytoplasmic periphery and at cytoskeletal like structures within the cytoplasm. There was also some co-localization in the perinuclear region.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606 rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606 rigid:nWdTArGO975jT8jQLRurpkBOaXc false flag tag:?-? myc tag:?-? - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q9UPQ0-1 uniprotkb:Q96JA1 intact:EBI-25412679|ensembl:ENSP00000316891 intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261 psi-mi:q9upq0-1(display_long)|uniprotkb:LIMCH1(gene name)|psi-mi:LIMCH1(display_short)|uniprotkb:KIAA1102(gene name synonym) psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25412802|imex:IM-27677-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000064042(gene)|ensembl:ENST00000313860(transcript)|intact:EBI-2687222(isoform-parent) refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004 - - - figure legend:2A-3|comment:LRIG1 and LIMCH1 co-localized at large cytoplasmic punctae and in the cytoplasmic periphery.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:neDT1Rx97o6shpmtkOqJy31ueTA9606 rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606 rigid:py43RPRgVezW0OJ6ir58peKyZfk false flag tag:?-? myc tag:?-? - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q8WWI1-3 uniprotkb:Q6UXM1-1 intact:EBI-4400717|ensembl:ENSP00000342112 intact:EBI-25412632|ensembl:ENSP00000326759 psi-mi:q8wwi1-3(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:q6uxm1-1(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0663"(confocal microscopy) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25412808|imex:IM-27677-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-350367(isoform-parent)|ensembl:ENSG00000136153(gene)|ensembl:ENST00000341547(transcript) ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|intact:EBI-9207843(isoform-parent) go:"GO:0048471"(perinuclear region of cytoplasm) isoform-comment:Contains a phosphoserine at position 342. Contains a phosphoserine at position 345. - figure legend:2A-4|comment:LRIG3 and LMO7 co-localized in the perinuclear region, at punctae and at the edges of the cell.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/01/13 2020/01/27 rogid:dM3TAvyjRRXsMct2+383oZOsvrI9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:RGMhyUB5wUYMDGl5GeNY6egrH/U false flag tag:?-? myc tag:?-? - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q8WWI1 uniprotkb:Q6UXM1 intact:EBI-350367|uniprotkb:O15462|uniprotkb:O95346|uniprotkb:Q9UKC1|uniprotkb:Q9UQM5|uniprotkb:Q9Y6A7|uniprotkb:Q5TBK6|uniprotkb:E9PLH4 intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759 psi-mi:lmo7_human(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name) psi-mi:"MI:0813"(proximity ligation assay) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-25412836|imex:IM-27677-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005349.3|refseq:NP_056667.2|refseq:NP_001293009.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023051"(regulation of signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR003096(SM22/calponin)|interpro:IPR029978|interpro:IPR031865|interpro:IPR036034|interpro:IPR036872|rcsb pdb:2EAQ|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENST00000341547|ensembl:ENSP00000342112|ensembl:ENSG00000136153|refseq:NP_001317512.1|mint:Q8WWI1|dip:DIP-33107N refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179 - - - figure legend:2B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h460)|taxid:9606(Homo sapiens non-small-cell lung cancer cell line H460) - 2020/01/13 2020/01/27 rogid:d8c3oZaqaloIUBqxgvpNI3PP2fU9606 rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606 rigid:6NUWAACg/uygt9B5r9FXZeiSukw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q8WWI1 uniprotkb:Q96JA1 intact:EBI-350367|uniprotkb:O15462|uniprotkb:O95346|uniprotkb:Q9UKC1|uniprotkb:Q9UQM5|uniprotkb:Q9Y6A7|uniprotkb:Q5TBK6|uniprotkb:E9PLH4 intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261 psi-mi:lmo7_human(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Karlsson et al. (2018) imex:IM-27677|pubmed:30429017 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-25412840|imex:IM-27677-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005349.3|refseq:NP_056667.2|refseq:NP_001293009.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023051"(regulation of signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR003096(SM22/calponin)|interpro:IPR029978|interpro:IPR031865|interpro:IPR036034|interpro:IPR036872|rcsb pdb:2EAQ|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENST00000341547|ensembl:ENSP00000342112|ensembl:ENSG00000136153|refseq:NP_001317512.1|mint:Q8WWI1|dip:DIP-33107N refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004 - - - figure legend:2B-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h460)|taxid:9606(Homo sapiens non-small-cell lung cancer cell line H460) - 2020/01/13 2020/01/27 rogid:d8c3oZaqaloIUBqxgvpNI3PP2fU9606 rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606 rigid:0TTKb4JymLD36m7iqzse5sEKowQ false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)