#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596800|imex:IM-27967-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 1a|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596864|imex:IM-27967-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 1b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597109|imex:IM-27967-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 6a, Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.24x10^-6 ~0.015(molar)|kon:3.77x10^3 ~4.35(per mole per second)|koff:4.68x10^-3(second -1)	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597153|imex:IM-27967-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 6b, Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:3.98x10^3 ~2.0(per mole per second)|kd:0.15x10^-6 ~0.001(molar)|koff:6.23x10^-4(second -1)	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597181|imex:IM-27967-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 6b, Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:3.1x10^3 ~1.97(per mole per second)|kd:0.48x10^-6 ~0.003(molar)|koff:1.51x10^-3(second -1)	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K0BWD0	uniprotkb:K0BWD0	intact:EBI-25565992	intact:EBI-25565992	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:k0bwd0_mers(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:3C-like proteinase(gene name synonym)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Guanine-N7 methyltransferase(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:Host translation inhibitor nsp1(gene name synonym)|uniprotkb:Leader protein(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p65 homolog(gene name synonym)|uniprotkb:nsp12(gene name synonym)|uniprotkb:nsp14(gene name synonym)|uniprotkb:nsp15(gene name synonym)|uniprotkb:nsp13(gene name synonym)|uniprotkb:nsp16(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Aouadi et al. (2017)	pubmed:28031370|imex:IM-27967	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597198|imex:IM-27967-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|interpro:IPR022733|interpro:IPR044315|interpro:IPR044327|interpro:IPR044330|rcsb pdb:4P16|rcsb pdb:5V69|rcsb pdb:5V6A|rcsb pdb:5WWP|rcsb pdb:5YN5|rcsb pdb:5YN6|rcsb pdb:5YN8|rcsb pdb:5YNB|rcsb pdb:5YNF|rcsb pdb:5YNI|rcsb pdb:5YNJ|rcsb pdb:5YNM|rcsb pdb:5YNN|rcsb pdb:5YNO|rcsb pdb:5YNP|rcsb pdb:5YNQ|rcsb pdb:6BI8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR041679|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR032592|interpro:IPR042570|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR024375|interpro:IPR038400|interpro:IPR038123|interpro:IPR014828(Nsp7 replicase)|interpro:IPR037204|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR038083|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|interpro:IPR021590|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044343|interpro:IPR044350|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044382|interpro:IPR044388|interpro:IPR044401	-	-	-	figure legend:Fig. 6b, Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:3.3x10^3 ~2.2(per mole per second)|kd:0.19x10^-6 ~0.001(molar)|koff:6.51x10^-4(second -1)	2020/05/11	2020/05/11	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rogid:u9TWbKf58gKvK2U0hDw6YNZrBo81235996	rigid:yzrM8ArFXWopslHjzyXuxK+dgzA	false	sufficient binding region:6777..6777-7073..7073(IPR009461)|his tag:n-n	sufficient binding region:4246..4246-4368..4368(IPR018995)|biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)