#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-25420098	intact:EBI-20560157	ensembl:ENST00000627532	rnacentral:URS0000170CF4_9606	psi-mi:mrna_zeb2(display_short)|psi-mi:EBI-25420098(display_long)	psi-mi:hsa-mir-221-3p(display_short)|psi-mi:EBI-20560157(display_long)	psi-mi:"MI:2285"(miRNA interference luciferase reporter assay)	Chen et al. (2010)	pubmed:20516212|imex:IM-27893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25421345|imex:IM-27893-1	-	-	psi-mi:"MI:2275"(regulator target)	psi-mi:"MI:2274"(regulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0324"(messenger rna)	psi-mi:"MI:2204"(micro rna)	ensembl:ENSG00000169554(see-also)|refseq:NM_014795.4(see-also)	-	go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)	-	comment:"\"the sequence of the mir221 was deduced from the 2-O-methyl-modified oligo-RNA  antisense oligonucleotide and from the seed seq\""	figure legend:Fig 4 A, B|causality statement:down-regulates quantity by destabilization|comment:The interaction is dependent on the presence of 10% FBS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2020/01/31	2020/02/01	-	-	-	false	luciferase tag:0-0|binding-associated region:5316-5323	-	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:0396"(predetermined participant)
ensembl:ENSG00000106511	uniprotkb:O60315	intact:EBI-25422576	intact:EBI-717614|uniprotkb:A0JP09|uniprotkb:Q9UED1|uniprotkb:B7Z2P2|uniprotkb:F5H814|ensembl:ENSP00000386854|ensembl:ENSP00000454157|ensembl:ENSP00000487174	uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym)|ensembl:meox2_human_gene(shortlabel)|psi-mi:ENSG00000106511(display_long)	psi-mi:zeb2_human(display_long)|uniprotkb:Zinc finger homeobox protein 1b(gene name synonym)|uniprotkb:Smad-interacting protein 1(gene name synonym)|uniprotkb:ZEB2(gene name)|psi-mi:ZEB2(display_short)|uniprotkb:KIAA0569(gene name synonym)|uniprotkb:SIP1(gene name synonym)|uniprotkb:ZFX1B(gene name synonym)|uniprotkb:HRIHFB2411(orf name)|uniprotkb:ZFHX1B(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Chen et al. (2010)	pubmed:20516212|imex:IM-27893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25422582|imex:IM-27893-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_005915.2	refseq:NP_001165124.1|refseq:NP_055610.1|ensembl:ENST00000409487(transcript)|ensembl:ENST00000558170(transcript)|ensembl:ENST00000627532(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|ensembl:ENSG00000169554(gene)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097324"(melanocyte migration)|go:"GO:1903056"(regulation of melanosome organization)|interpro:IPR001356(Homeobox)|interpro:IPR008598(Drought induced 19)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:O60315|rcsb pdb:2DA7|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:XP_006712944.1|refseq:XP_006712945.1	-	-	-	figure legend:Fig 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2020/01/31	2020/02/04	-	rogid:KIKq943mmyO6wbsDamXsyo0OnEo9606	-	false	sufficient binding region:?-?|sufficient binding region:?-?	flag tag:n-n	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0421"(identification by antibody)