#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17794"	uniprotkb:P0AB71	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232693|imex:IM-27509-121	author score:RF = 0.5214	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P0A9B2	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-368904|uniprotkb:P06977|ensemblbacteria:AAC74849|ensemblbacteria:BAA15576	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:g3p1_ecoli(display_long)|uniprotkb:gapA(gene name)|psi-mi:gapA(display_short)|uniprotkb:NAD-dependent glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:JW1768(locus name)|uniprotkb:b1779(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232707|imex:IM-27509-123	author score:RF = 0.1897	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	refseq:NP_416293.1|refseq:WP_000153502.1|ensemblbacteria:AAC74849(transcript)|ensemblbacteria:b1779(gene)|ensemblbacteria:BAA15576(gene)|ensemblbacteria:BAA15576(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1DC4|rcsb pdb:1DC5|rcsb pdb:1DC6|rcsb pdb:1GAD|rcsb pdb:1GAE|rcsb pdb:1S7C|rcsb pdb:2VYN|rcsb pdb:2VYV|rcsb pdb:5ZA0|rcsb pdb:6IO4|rcsb pdb:6IO6|rcsb pdb:6IOJ|rcsb pdb:6UTM|rcsb pdb:6UTN|rcsb pdb:6UTO|rcsb pdb:1DC3|mint:P0A9B2|dip:DIP-31848N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wjDK2dtZ4nPJZ0L7OVRiKfQITtg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P00350	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-907049|uniprotkb:Q59416|uniprotkb:Q79DT3|uniprotkb:P78080|uniprotkb:Q47571|uniprotkb:Q59366|uniprotkb:Q59402|uniprotkb:Q59411|uniprotkb:Q59412|uniprotkb:Q59413|uniprotkb:Q59414|ensemblbacteria:AAC75090|ensemblbacteria:BAA15869	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:6pgd_ecoli(display_long)|uniprotkb:gnd(gene name)|psi-mi:gnd(display_short)|uniprotkb:b2029(locus name)|uniprotkb:JW2011(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232721|imex:IM-27509-125	author score:RF = 0.1913	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	refseq:NP_416533.1|refseq:WP_000043484.1|dip:DIP-9819N|ensemblbacteria:AAC75090(transcript)|ensemblbacteria:b2029(gene)|ensemblbacteria:BAA15869(gene)|ensemblbacteria:BAA15869(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2ZYA|rcsb pdb:2ZYD|rcsb pdb:3FWN	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:/i9Nawn7MRXxPQlihWGV8uUvLuQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P26616	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232735|imex:IM-27509-127	author score:RF = 0.1817	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P22259	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232749|imex:IM-27509-161	author score:RF = 0.4426	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P0A799	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232763|imex:IM-27509-81	author score:RF = 0.3662	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17794"	uniprotkb:P0A9G6	intact:EBI-22230925|chebi:"CHEBI:12987"|chebi:"CHEBI:11879"|chebi:"CHEBI:1657"|chebi:"CHEBI:11880"|chebi:"CHEBI:21029"	intact:EBI-907399|uniprotkb:P05313|uniprotkb:Q2M6T9|ensemblbacteria:AAC76985|ensemblbacteria:BAE78017	psi-mi:3phosphodglyceric acid(display_short)|psi-mi:"CHEBI:17794"(display_long)|intact:"(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid"(iupac name)|intact:3-phospho-D-glycerate(synonym)|intact:3-Phospho-D-glycerate(synonym)|intact:3-Phosphoglycerate(synonym)|intact:D-glycerate 3-phosphate(synonym)|intact:D-Glycerate 3-phosphate(synonym)|intact:"3-Phospho-(R)-glycerate"(synonym)	psi-mi:acea_ecoli(display_long)|uniprotkb:aceA(gene name)|psi-mi:aceA(display_short)|uniprotkb:icl(gene name synonym)|uniprotkb:b4015(locus name)|uniprotkb:JW3975(locus name)|uniprotkb:Isocitrase(gene name synonym)|uniprotkb:Isocitratase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232679|imex:IM-27509-41	author score:RF = 0.1959	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439183(identity)	refseq:NP_418439.1|refseq:WP_000857856.1|dip:DIP-35893N|ensemblbacteria:AAC76985(transcript)|ensemblbacteria:b4015(gene)|ensemblbacteria:BAE78017(gene)|ensemblbacteria:BAE78017(transcript)|go:"GO:0004451"(isocitrate lyase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0043169"(cation binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR006254(Isocitrate lyase)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018523|interpro:IPR039556|interpro:IPR040442|rcsb pdb:1IGW	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:+0Nz3An+6VGpaPiJkdPlRZU28ac83333	-	false	-	green fluorescent protein tag:c-c|his tag:n-n	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P0AB71	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232791|imex:IM-27509-83	author score:RF = 0.2656	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P00350	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-907049|uniprotkb:Q59416|uniprotkb:Q79DT3|uniprotkb:P78080|uniprotkb:Q47571|uniprotkb:Q59366|uniprotkb:Q59402|uniprotkb:Q59411|uniprotkb:Q59412|uniprotkb:Q59413|uniprotkb:Q59414|ensemblbacteria:AAC75090|ensemblbacteria:BAA15869	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:6pgd_ecoli(display_long)|uniprotkb:gnd(gene name)|psi-mi:gnd(display_short)|uniprotkb:b2029(locus name)|uniprotkb:JW2011(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232805|imex:IM-27509-21	author score:RF = 0.3524	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:NP_416533.1|refseq:WP_000043484.1|dip:DIP-9819N|ensemblbacteria:AAC75090(transcript)|ensemblbacteria:b2029(gene)|ensemblbacteria:BAA15869(gene)|ensemblbacteria:BAA15869(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2ZYA|rcsb pdb:2ZYD|rcsb pdb:3FWN	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:/i9Nawn7MRXxPQlihWGV8uUvLuQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P26616	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232819|imex:IM-27509-1	author score:RF = 0.2719	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P76558	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232833|imex:IM-27509-3	author score:RF = 0.1875	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P0A6T1	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-909327|uniprotkb:P11537|ensemblbacteria:AAC76995|ensemblbacteria:BAE78027|uniprotkb:Q2M6S9	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:g6pi_ecoli(display_long)|uniprotkb:JW3985(locus name)|uniprotkb:pgi(gene name)|psi-mi:pgi(display_short)|uniprotkb:b4025(locus name)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232847|imex:IM-27509-43	author score:RF = 0.5173	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	ensemblbacteria:AAC76995(transcript)|ensemblbacteria:b4025(gene)|ensemblbacteria:BAE78027(gene)|ensemblbacteria:BAE78027(transcript)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:3NBU|refseq:NP_418449.1|refseq:WP_000789986.1|dip:DIP-35887N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:bdyHyVvqc51JroAVGucRt+FDfyo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P0A955	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-558114|uniprotkb:P10177|ensemblbacteria:AAC74920|ensemblbacteria:BAA15658	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:alkh_ecoli(display_long)|uniprotkb:hga(gene name synonym)|uniprotkb:kdgA(gene name synonym)|uniprotkb:b1850(locus name)|uniprotkb:eda(gene name)|psi-mi:eda(display_short)|uniprotkb:JW1839(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232777|imex:IM-27509-141	author score:RF = 0.4836	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:NP_416364.1|refseq:WP_000800512.1|dip:DIP-36196N|ensemblbacteria:AAC74920(transcript)|ensemblbacteria:b1850(gene)|ensemblbacteria:BAA15658(gene)|ensemblbacteria:BAA15658(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008152"(metabolic process)|go:"GO:0008675"(2-dehydro-3-deoxy-phosphogluconate aldolase activity)|go:"GO:0008700"(4-hydroxy-2-oxoglutarate aldolase activity)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016020"(membrane)|go:"GO:0016833"(oxo-acid-lyase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0106009"("(4S)-4-hydroxy-2-oxoglutarate aldolase activity")|interpro:IPR000887(KDPG and KHG aldolase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR031337|interpro:IPR031338|rcsb pdb:1EUA|rcsb pdb:1EUN|rcsb pdb:1FQ0|rcsb pdb:1FWR|rcsb pdb:1WAU|rcsb pdb:1WBH|rcsb pdb:2C0A	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:Agz2bUIVoEJVknE7nyuAjbOYppc83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15422"	uniprotkb:P22259	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233085|imex:IM-27509-61	author score:RF = 0.3768	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5957(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15422"	uniprotkb:P0AB71	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233071|imex:IM-27509-165	author score:RF = 0.3265	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5957(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15422"	uniprotkb:P27550	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233057|imex:IM-27509-101	author score:RF = 0.2435	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5957(identity)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17196"	uniprotkb:P76558	intact:EBI-22231279|chebi:"CHEBI:40902"|chebi:"CHEBI:6191"|chebi:"CHEBI:13083"|chebi:"CHEBI:21242"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:l-asparagine(display_short)|psi-mi:"CHEBI:17196"(display_long)|intact:"(2S)-2,4-diamino-4-oxobutanoic acid"(synonym)|intact:"(2S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-Asparagine"(synonym)|intact:2-Aminosuccinamic acid(synonym)|intact:alpha-aminosuccinamic acid(synonym)|intact:Asn(synonym)|intact:ASPARAGINE(synonym)|intact:Aspartamic acid(synonym)|intact:L-2-aminosuccinamic acid(synonym)|intact:L-Asparagin(synonym)|intact:L-Asparagine(synonym)|intact:L-aspartic acid beta-amide(synonym)|intact:N(synonym)|intact:L-asparagine(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233043|imex:IM-27509-91	author score:RF = 0.1888	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6267(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17196"	uniprotkb:P62707	intact:EBI-22231279|chebi:"CHEBI:40902"|chebi:"CHEBI:6191"|chebi:"CHEBI:13083"|chebi:"CHEBI:21242"	intact:EBI-552773|uniprotkb:P31217|ensemblbacteria:AAC73842|ensemblbacteria:BAA35417	psi-mi:l-asparagine(display_short)|psi-mi:"CHEBI:17196"(display_long)|intact:"(2S)-2,4-diamino-4-oxobutanoic acid"(synonym)|intact:"(2S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-Asparagine"(synonym)|intact:2-Aminosuccinamic acid(synonym)|intact:alpha-aminosuccinamic acid(synonym)|intact:Asn(synonym)|intact:ASPARAGINE(synonym)|intact:Aspartamic acid(synonym)|intact:L-2-aminosuccinamic acid(synonym)|intact:L-Asparagin(synonym)|intact:L-Asparagine(synonym)|intact:L-aspartic acid beta-amide(synonym)|intact:N(synonym)|intact:L-asparagine(iupac name)	psi-mi:gpma_ecoli(display_long)|uniprotkb:gpmA(gene name)|psi-mi:gpmA(display_short)|uniprotkb:gpm(gene name synonym)|uniprotkb:pgm(gene name synonym)|uniprotkb:pgmA(gene name synonym)|uniprotkb:b0755(locus name)|uniprotkb:JW0738(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233029|imex:IM-27509-89	author score:RF = 0.1982	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6267(identity)	refseq:NP_415276.1|refseq:WP_001295305.1|dip:DIP-35899N|ensemblbacteria:AAC73842(transcript)|ensemblbacteria:b0755(gene)|ensemblbacteria:BAA35417(gene)|ensemblbacteria:BAA35417(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0046538"(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity)|go:"GO:0061621"(canonical glycolysis)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:1E58|rcsb pdb:1E59	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:VZTBGgO6fb6Nu2eTmgdl+KEBrdo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17196"	uniprotkb:P0ADF6	intact:EBI-22231279|chebi:"CHEBI:40902"|chebi:"CHEBI:6191"|chebi:"CHEBI:13083"|chebi:"CHEBI:21242"	intact:EBI-561851|ensemblbacteria:AAC74921|ensemblbacteria:BAA15659|uniprotkb:P25530	psi-mi:l-asparagine(display_short)|psi-mi:"CHEBI:17196"(display_long)|intact:"(2S)-2,4-diamino-4-oxobutanoic acid"(synonym)|intact:"(2S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-2-amino-3-carbamoylpropanoic acid"(synonym)|intact:"(S)-Asparagine"(synonym)|intact:2-Aminosuccinamic acid(synonym)|intact:alpha-aminosuccinamic acid(synonym)|intact:Asn(synonym)|intact:ASPARAGINE(synonym)|intact:Aspartamic acid(synonym)|intact:L-2-aminosuccinamic acid(synonym)|intact:L-Asparagin(synonym)|intact:L-Asparagine(synonym)|intact:L-aspartic acid beta-amide(synonym)|intact:N(synonym)|intact:L-asparagine(iupac name)	psi-mi:edd_ecoli(display_long)|uniprotkb:6-phosphogluconate dehydratase(gene name synonym)|uniprotkb:edd(gene name)|psi-mi:edd(display_short)|uniprotkb:Entner-Doudoroff dehydrase(gene name synonym)|uniprotkb:JW1840(locus name)|uniprotkb:b1851(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233015|imex:IM-27509-7	author score:RF = 0.2815	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6267(identity)	interpro:IPR042096|ensemblbacteria:AAC74921(transcript)|ensemblbacteria:b1851(gene)|ensemblbacteria:BAA15659(gene)|ensemblbacteria:BAA15659(transcript)|go:"GO:0004456"(phosphogluconate dehydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009255"(Entner-Doudoroff pathway through 6-phosphogluconate)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000581(Dihydroxy-acid and 6-phosphogluconate dehydratase)|interpro:IPR004786(6-phosphogluconate dehydratase)|interpro:IPR020558|interpro:IPR037237|refseq:NP_416365.1|refseq:WP_001069467.1|dip:DIP-47906N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:HVhiaAiNiB52qoBhleI5kH9QnBw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0A7Z0	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-909486|ensemblbacteria:AAC75951|ensemblbacteria:BAE76978|uniprotkb:P27252|uniprotkb:Q2M9S8	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:rpia_ecoli(display_long)|uniprotkb:rpiA(gene name)|psi-mi:rpiA(display_short)|uniprotkb:b2914(locus name)|uniprotkb:JW5475(locus name)|uniprotkb:ygfC(gene name synonym)|uniprotkb:Phosphoriboisomerase A(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233001|imex:IM-27509-87	author score:RF = 0.3729	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	ensemblbacteria:AAC75951(transcript)|ensemblbacteria:b2914(gene)|ensemblbacteria:BAE76978(gene)|ensemblbacteria:BAE76978(transcript)|go:"GO:0004751"(ribose-5-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006014"(D-ribose metabolic process)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0042802"(identical protein binding)|interpro:IPR004788(Ribose 5-phosphate isomerase)|interpro:IPR020672|interpro:IPR037171|rcsb pdb:1KS2|rcsb pdb:1LKZ|rcsb pdb:1O8B|refseq:NP_417389.1|refseq:WP_000189743.1|dip:DIP-10739N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wF4A1Xq1PauoLTM+1S75hKJKPJg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0AG07	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-546020|uniprotkb:P32661|uniprotkb:Q2M751|ensemblbacteria:BAE77905|ensemblbacteria:AAC76411	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:rpe_ecoli(display_long)|uniprotkb:rpe(gene name)|psi-mi:rpe(display_short)|uniprotkb:dod(gene name synonym)|uniprotkb:b3386(locus name)|uniprotkb:yhfD(gene name synonym)|uniprotkb:Pentose-5-phosphate 3-epimerase(gene name synonym)|uniprotkb:R5P3E(gene name synonym)|uniprotkb:JW3349(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232987|imex:IM-27509-163	author score:RF = 0.3783	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_417845.1|ensemblbacteria:BAE77905(transcript)|go:"GO:0004750"(D-ribulose-phosphate 3-epimerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019323"(pentose catabolic process)|go:"GO:0044262"(cellular carbohydrate metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000056(Ribulose-phosphate 3-epimerase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR026019|ensemblbacteria:BAE77905(gene)|ensemblbacteria:AAC76411(transcript)|ensemblbacteria:b3386(gene)|refseq:WP_000816280.1|dip:DIP-47869N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:tejKtdI7JB2CFwzaNTuPBkSZ3pw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0A799	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232973|imex:IM-27509-129	author score:RF = 0.3166	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0A796	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232959|imex:IM-27509-23	author score:RF = 0.2317	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P22259	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232945|imex:IM-27509-85	author score:RF = 0.2752	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P76558	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232931|imex:IM-27509-147	author score:RF = 0.2559	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0A9B2	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-368904|uniprotkb:P06977|ensemblbacteria:AAC74849|ensemblbacteria:BAA15576	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:g3p1_ecoli(display_long)|uniprotkb:gapA(gene name)|psi-mi:gapA(display_short)|uniprotkb:NAD-dependent glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:JW1768(locus name)|uniprotkb:b1779(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232917|imex:IM-27509-145	author score:RF = 0.7528	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_416293.1|refseq:WP_000153502.1|ensemblbacteria:AAC74849(transcript)|ensemblbacteria:b1779(gene)|ensemblbacteria:BAA15576(gene)|ensemblbacteria:BAA15576(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1DC4|rcsb pdb:1DC5|rcsb pdb:1DC6|rcsb pdb:1GAD|rcsb pdb:1GAE|rcsb pdb:1S7C|rcsb pdb:2VYN|rcsb pdb:2VYV|rcsb pdb:5ZA0|rcsb pdb:6IO4|rcsb pdb:6IO6|rcsb pdb:6IOJ|rcsb pdb:6UTM|rcsb pdb:6UTN|rcsb pdb:6UTO|rcsb pdb:1DC3|mint:P0A9B2|dip:DIP-31848N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wjDK2dtZ4nPJZ0L7OVRiKfQITtg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P0AB71	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232903|imex:IM-27509-47	author score:RF = 0.3258	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16027"	uniprotkb:P27550	intact:EBI-6868581|chebi:"CHEBI:13740"|chebi:"CHEBI:40510"|chebi:"CHEBI:22242"|chebi:"CHEBI:40726"|chebi:"CHEBI:40786"|chebi:"CHEBI:40826"|chebi:"CHEBI:47222"|chebi:"CHEBI:12056"|chebi:"CHEBI:2356"|chebi:"CHEBI:13736"|chebi:"CHEBI:13234"|chebi:"CHEBI:13235"|chebi:"CHEBI:22245"	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	psi-mi:amp(display_short)|psi-mi:"CHEBI:16027"(display_long)|intact:5'-Adenosine monophosphate(synonym)|intact:5'-Adenylic acid(synonym)|intact:5'-AMP(synonym)|intact:5'-O-phosphonoadenosine(synonym)|intact:"adenosine 5'-(dihydrogen phosphate)"(synonym)|intact:Adenosine 5'-monophosphate(synonym)|intact:Adenosine 5'-phosphate(synonym)|intact:ADENOSINE MONOPHOSPHATE(synonym)|intact:adenosine phosphate(synonym)|intact:Adenosine-5'-monophosphoric acid(synonym)|intact:adenosine-5'P(synonym)|intact:adenosini phosphas(synonym)|intact:Adenylate(synonym)|intact:Adenylic acid(synonym)|intact:Ado5'P(synonym)|intact:AMP(synonym)|intact:fosfato de adenosina(synonym)|intact:pA(synonym)|intact:PAdo(synonym)|intact:phosphate d'adenosine(synonym)|intact:5'-adenylic acid(iupac name)	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232889|imex:IM-27509-45	author score:RF = 0.2367	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:15938965(identity)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P0AC53	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-555656|uniprotkb:P22992|uniprotkb:P78069|uniprotkb:Q60134|uniprotkb:Q60139|ensemblbacteria:AAC74922|ensemblbacteria:BAA15660	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:g6pd_ecoli(display_long)|uniprotkb:zwf(gene name)|psi-mi:zwf(display_short)|uniprotkb:b1852(locus name)|uniprotkb:JW1841(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232875|imex:IM-27509-143	author score:RF = 0.1857	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:NP_416366.1|refseq:WP_000301727.1|dip:DIP-35780N|mint:P0AC53|ensemblbacteria:AAC74922(transcript)|ensemblbacteria:b1852(gene)|ensemblbacteria:BAA15660(gene)|ensemblbacteria:BAA15660(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009372"(quorum sensing)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:ntoYKRWiGdynkH9k+qgl63mGoAM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:48928"	uniprotkb:P0A799	intact:EBI-10825124|chebi:"CHEBI:40282"|chebi:"CHEBI:2231"|chebi:"CHEBI:33851"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:6-phospho-d-gluconic acid(display_short)|psi-mi:"CHEBI:48928"(display_long)|intact:6-Phospho-D-gluconate(synonym)|intact:6-O-phosphono-D-gluconic acid(iupac name)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22232861|imex:IM-27509-5	author score:RF = 0.2482	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:91493(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15422"	uniprotkb:P0A799	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233099|imex:IM-27509-25	author score:RF = 0.2997	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5957(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15422"	uniprotkb:P0AC53	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-555656|uniprotkb:P22992|uniprotkb:P78069|uniprotkb:Q60134|uniprotkb:Q60139|ensemblbacteria:AAC74922|ensemblbacteria:BAA15660	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:g6pd_ecoli(display_long)|uniprotkb:zwf(gene name)|psi-mi:zwf(display_short)|uniprotkb:b1852(locus name)|uniprotkb:JW1841(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233113|imex:IM-27509-27	author score:RF = 0.2212	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5957(identity)	refseq:NP_416366.1|refseq:WP_000301727.1|dip:DIP-35780N|mint:P0AC53|ensemblbacteria:AAC74922(transcript)|ensemblbacteria:b1852(gene)|ensemblbacteria:BAA15660(gene)|ensemblbacteria:BAA15660(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009372"(quorum sensing)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:ntoYKRWiGdynkH9k+qgl63mGoAM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30769"	uniprotkb:P0AB71	intact:EBI-22231416|chebi:"CHEBI:41523"|chebi:"CHEBI:3727"|chebi:"CHEBI:23322"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:citric acid(display_short)|psi-mi:"CHEBI:30769"(display_long)|intact:2-Hydroxy-1,2,3-propanetricarboxylic acid(synonym)|intact:2-Hydroxytricarballylic acid(synonym)|intact:3-Carboxy-3-hydroxypentane-1,5-dioic acid(synonym)|intact:Citric acid(synonym)|intact:CITRIC ACID(synonym)|intact:Citronensaeure(synonym)|intact:E330(synonym)|intact:H3cit(synonym)|intact:2-hydroxypropane-1,2,3-tricarboxylic acid(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233127|imex:IM-27509-29	author score:RF = 0.3812	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:311(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30769"	uniprotkb:P08200	intact:EBI-22231416|chebi:"CHEBI:41523"|chebi:"CHEBI:3727"|chebi:"CHEBI:23322"	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	psi-mi:citric acid(display_short)|psi-mi:"CHEBI:30769"(display_long)|intact:2-Hydroxy-1,2,3-propanetricarboxylic acid(synonym)|intact:2-Hydroxytricarballylic acid(synonym)|intact:3-Carboxy-3-hydroxypentane-1,5-dioic acid(synonym)|intact:Citric acid(synonym)|intact:CITRIC ACID(synonym)|intact:Citronensaeure(synonym)|intact:E330(synonym)|intact:H3cit(synonym)|intact:2-hydroxypropane-1,2,3-tricarboxylic acid(iupac name)	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233141|imex:IM-27509-63	author score:RF = 0.2224	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:311(identity)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30769"	uniprotkb:P76558	intact:EBI-22231416|chebi:"CHEBI:41523"|chebi:"CHEBI:3727"|chebi:"CHEBI:23322"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:citric acid(display_short)|psi-mi:"CHEBI:30769"(display_long)|intact:2-Hydroxy-1,2,3-propanetricarboxylic acid(synonym)|intact:2-Hydroxytricarballylic acid(synonym)|intact:3-Carboxy-3-hydroxypentane-1,5-dioic acid(synonym)|intact:Citric acid(synonym)|intact:CITRIC ACID(synonym)|intact:Citronensaeure(synonym)|intact:E330(synonym)|intact:H3cit(synonym)|intact:2-hydroxypropane-1,2,3-tricarboxylic acid(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233155|imex:IM-27509-103	author score:RF = 0.2479	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:311(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30769"	uniprotkb:P22259	intact:EBI-22231416|chebi:"CHEBI:41523"|chebi:"CHEBI:3727"|chebi:"CHEBI:23322"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:citric acid(display_short)|psi-mi:"CHEBI:30769"(display_long)|intact:2-Hydroxy-1,2,3-propanetricarboxylic acid(synonym)|intact:2-Hydroxytricarballylic acid(synonym)|intact:3-Carboxy-3-hydroxypentane-1,5-dioic acid(synonym)|intact:Citric acid(synonym)|intact:CITRIC ACID(synonym)|intact:Citronensaeure(synonym)|intact:E330(synonym)|intact:H3cit(synonym)|intact:2-hydroxypropane-1,2,3-tricarboxylic acid(iupac name)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233169|imex:IM-27509-167	author score:RF = 0.1833	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:311(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17677"	uniprotkb:P0ADF6	intact:EBI-9685188|chebi:"CHEBI:3285"|chebi:"CHEBI:41675"|chebi:"CHEBI:23522"|chebi:"CHEBI:13286"	intact:EBI-561851|ensemblbacteria:AAC74921|ensemblbacteria:BAA15659|uniprotkb:P25530	psi-mi:ctp(display_short)|psi-mi:"CHEBI:17677"(display_long)|intact:5'-CTP(synonym)|intact:CTP(synonym)|intact:Cytidine 5'-triphosphate(synonym)|intact:Cytidine triphosphate(synonym)|intact:CYTIDINE-5'-TRIPHOSPHATE(synonym)|intact:H4ctp(synonym)|intact:"cytidine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:edd_ecoli(display_long)|uniprotkb:6-phosphogluconate dehydratase(gene name synonym)|uniprotkb:edd(gene name)|psi-mi:edd(display_short)|uniprotkb:Entner-Doudoroff dehydrase(gene name synonym)|uniprotkb:JW1840(locus name)|uniprotkb:b1851(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233183|imex:IM-27509-169	author score:RF = 0.194	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6176(identity)	interpro:IPR042096|ensemblbacteria:AAC74921(transcript)|ensemblbacteria:b1851(gene)|ensemblbacteria:BAA15659(gene)|ensemblbacteria:BAA15659(transcript)|go:"GO:0004456"(phosphogluconate dehydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009255"(Entner-Doudoroff pathway through 6-phosphogluconate)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000581(Dihydroxy-acid and 6-phosphogluconate dehydratase)|interpro:IPR004786(6-phosphogluconate dehydratase)|interpro:IPR020558|interpro:IPR037237|refseq:NP_416365.1|refseq:WP_001069467.1|dip:DIP-47906N	-	inchi key:PCDQPRRSZKQHHS-XVFCMESISA-N	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:HVhiaAiNiB52qoBhleI5kH9QnBw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17677"	uniprotkb:P0A796	intact:EBI-9685188|chebi:"CHEBI:3285"|chebi:"CHEBI:41675"|chebi:"CHEBI:23522"|chebi:"CHEBI:13286"	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:ctp(display_short)|psi-mi:"CHEBI:17677"(display_long)|intact:5'-CTP(synonym)|intact:CTP(synonym)|intact:Cytidine 5'-triphosphate(synonym)|intact:Cytidine triphosphate(synonym)|intact:CYTIDINE-5'-TRIPHOSPHATE(synonym)|intact:H4ctp(synonym)|intact:"cytidine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233197|imex:IM-27509-105	author score:RF = 0.3814	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6176(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	inchi key:PCDQPRRSZKQHHS-XVFCMESISA-N	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17482"	uniprotkb:P0ADF6	intact:EBI-22231517|chebi:"CHEBI:21259"|chebi:"CHEBI:6205"|chebi:"CHEBI:13093"	intact:EBI-561851|ensemblbacteria:AAC74921|ensemblbacteria:BAA15659|uniprotkb:P25530	psi-mi:lcystathionine(display_short)|psi-mi:"CHEBI:17482"(display_long)|intact:"(R)-S-(2-amino-2-carboxyethyl)-L-Homocysteine"(synonym)|intact:"L-(+)-Cystathionine"(synonym)|intact:L-Cystathionine(synonym)|intact:"S-(beta-amino-beta-carboxyethyl)homocysteine"(synonym)|intact:"(2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid"(iupac name)|intact:L-cystathionine(iupac name)	psi-mi:edd_ecoli(display_long)|uniprotkb:6-phosphogluconate dehydratase(gene name synonym)|uniprotkb:edd(gene name)|psi-mi:edd(display_short)|uniprotkb:Entner-Doudoroff dehydrase(gene name synonym)|uniprotkb:JW1840(locus name)|uniprotkb:b1851(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233211|imex:IM-27509-181	author score:RF = 0.222	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439258(identity)	interpro:IPR042096|ensemblbacteria:AAC74921(transcript)|ensemblbacteria:b1851(gene)|ensemblbacteria:BAA15659(gene)|ensemblbacteria:BAA15659(transcript)|go:"GO:0004456"(phosphogluconate dehydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009255"(Entner-Doudoroff pathway through 6-phosphogluconate)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000581(Dihydroxy-acid and 6-phosphogluconate dehydratase)|interpro:IPR004786(6-phosphogluconate dehydratase)|interpro:IPR020558|interpro:IPR037237|refseq:NP_416365.1|refseq:WP_001069467.1|dip:DIP-47906N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:HVhiaAiNiB52qoBhleI5kH9QnBw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P27550	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233225|imex:IM-27509-107	author score:RF = 0.2928	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	-	comment:Flavin adenine dinucleotide	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P0A9B2	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-368904|uniprotkb:P06977|ensemblbacteria:AAC74849|ensemblbacteria:BAA15576	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:g3p1_ecoli(display_long)|uniprotkb:gapA(gene name)|psi-mi:gapA(display_short)|uniprotkb:NAD-dependent glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:JW1768(locus name)|uniprotkb:b1779(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233239|imex:IM-27509-93	author score:RF = 0.4969	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	refseq:NP_416293.1|refseq:WP_000153502.1|ensemblbacteria:AAC74849(transcript)|ensemblbacteria:b1779(gene)|ensemblbacteria:BAA15576(gene)|ensemblbacteria:BAA15576(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1DC4|rcsb pdb:1DC5|rcsb pdb:1DC6|rcsb pdb:1GAD|rcsb pdb:1GAE|rcsb pdb:1S7C|rcsb pdb:2VYN|rcsb pdb:2VYV|rcsb pdb:5ZA0|rcsb pdb:6IO4|rcsb pdb:6IO6|rcsb pdb:6IOJ|rcsb pdb:6UTM|rcsb pdb:6UTN|rcsb pdb:6UTO|rcsb pdb:1DC3|mint:P0A9B2|dip:DIP-31848N	-	comment:Flavin adenine dinucleotide	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wjDK2dtZ4nPJZ0L7OVRiKfQITtg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P26616	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233253|imex:IM-27509-31	author score:RF = 0.3875	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	comment:Flavin adenine dinucleotide	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P0A796	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233281|imex:IM-27509-9	author score:RF = 0.3287	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	comment:Flavin adenine dinucleotide	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P61889	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-558740|uniprotkb:O30401|uniprotkb:O30402|uniprotkb:O30403|uniprotkb:P06994|uniprotkb:Q2M8X7|uniprotkb:Q59343|uniprotkb:Q59344|uniprotkb:Q59345|uniprotkb:Q59346|uniprotkb:Q59347|uniprotkb:Q59348|uniprotkb:Q60133|uniprotkb:Q60150|uniprotkb:Q933J3|uniprotkb:Q93R02|uniprotkb:Q9FDQ3|uniprotkb:Q9FDQ4|uniprotkb:Q9FDQ5|ensemblbacteria:AAC76268|ensemblbacteria:BAE77279	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:mdh_ecoli(display_long)|uniprotkb:mdh(gene name)|psi-mi:mdh(display_short)|uniprotkb:b3236(locus name)|uniprotkb:JW3205(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233267|imex:IM-27509-183	author score:RF = 0.2228	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	refseq:NP_417703.1|refseq:WP_001295272.1|dip:DIP-35924N|ensemblbacteria:AAC76268(transcript)|ensemblbacteria:b3236(gene)|ensemblbacteria:BAE77279(gene)|ensemblbacteria:BAE77279(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006113"(fermentation)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR023958|interpro:IPR036291|rcsb pdb:1CME|rcsb pdb:1EMD|rcsb pdb:1IB6|rcsb pdb:1IE3|rcsb pdb:2CMD|rcsb pdb:2PWZ|rcsb pdb:3HHP|rcsb pdb:5KKA|rcsb pdb:5Z3W|rcsb pdb:6KA0|rcsb pdb:6KA1|rcsb pdb:7CGC|rcsb pdb:7CGD	-	comment:Flavin adenine dinucleotide	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:nnTexl7xgSz5zJEjD9mdRqxluTI83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0ADF6	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-561851|ensemblbacteria:AAC74921|ensemblbacteria:BAA15659|uniprotkb:P25530	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:edd_ecoli(display_long)|uniprotkb:6-phosphogluconate dehydratase(gene name synonym)|uniprotkb:edd(gene name)|psi-mi:edd(display_short)|uniprotkb:Entner-Doudoroff dehydrase(gene name synonym)|uniprotkb:JW1840(locus name)|uniprotkb:b1851(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233365|imex:IM-27509-65	author score:RF = 0.269	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	interpro:IPR042096|ensemblbacteria:AAC74921(transcript)|ensemblbacteria:b1851(gene)|ensemblbacteria:BAA15659(gene)|ensemblbacteria:BAA15659(transcript)|go:"GO:0004456"(phosphogluconate dehydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009255"(Entner-Doudoroff pathway through 6-phosphogluconate)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000581(Dihydroxy-acid and 6-phosphogluconate dehydratase)|interpro:IPR004786(6-phosphogluconate dehydratase)|interpro:IPR020558|interpro:IPR037237|refseq:NP_416365.1|refseq:WP_001069467.1|dip:DIP-47906N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:HVhiaAiNiB52qoBhleI5kH9QnBw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P27550	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233351|imex:IM-27509-185	author score:RF = 0.235	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:14314"	uniprotkb:P0AG07	intact:EBI-22231646	intact:EBI-546020|uniprotkb:P32661|uniprotkb:Q2M751|ensemblbacteria:BAE77905|ensemblbacteria:AAC76411	psi-mi:dglucose 6phosphate(display_short)|psi-mi:"CHEBI:14314"(display_long)|intact:6-O-phosphono-D-glucose(synonym)|intact:"D-glucose 6-(dihydrogen phosphate)"(synonym)	psi-mi:rpe_ecoli(display_long)|uniprotkb:rpe(gene name)|psi-mi:rpe(display_short)|uniprotkb:dod(gene name synonym)|uniprotkb:b3386(locus name)|uniprotkb:yhfD(gene name synonym)|uniprotkb:Pentose-5-phosphate 3-epimerase(gene name synonym)|uniprotkb:R5P3E(gene name synonym)|uniprotkb:JW3349(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233337|imex:IM-27509-37	author score:RF = 0.3682	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439958(identity)	refseq:NP_417845.1|ensemblbacteria:BAE77905(transcript)|go:"GO:0004750"(D-ribulose-phosphate 3-epimerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019323"(pentose catabolic process)|go:"GO:0044262"(cellular carbohydrate metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000056(Ribulose-phosphate 3-epimerase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR026019|ensemblbacteria:BAE77905(gene)|ensemblbacteria:AAC76411(transcript)|ensemblbacteria:b3386(gene)|refseq:WP_000816280.1|dip:DIP-47869N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:tejKtdI7JB2CFwzaNTuPBkSZ3pw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:14314"	uniprotkb:P0A6T1	intact:EBI-22231646	intact:EBI-909327|uniprotkb:P11537|ensemblbacteria:AAC76995|ensemblbacteria:BAE78027|uniprotkb:Q2M6S9	psi-mi:dglucose 6phosphate(display_short)|psi-mi:"CHEBI:14314"(display_long)|intact:6-O-phosphono-D-glucose(synonym)|intact:"D-glucose 6-(dihydrogen phosphate)"(synonym)	psi-mi:g6pi_ecoli(display_long)|uniprotkb:JW3985(locus name)|uniprotkb:pgi(gene name)|psi-mi:pgi(display_short)|uniprotkb:b4025(locus name)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233323|imex:IM-27509-35	author score:RF = 0.4522	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439958(identity)	ensemblbacteria:AAC76995(transcript)|ensemblbacteria:b4025(gene)|ensemblbacteria:BAE78027(gene)|ensemblbacteria:BAE78027(transcript)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:3NBU|refseq:NP_418449.1|refseq:WP_000789986.1|dip:DIP-35887N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:bdyHyVvqc51JroAVGucRt+FDfyo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:78682"	uniprotkb:P0A796	intact:EBI-22231629	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:dfructose 1,6bisphosphate(display_short)|psi-mi:"CHEBI:78682"(display_long)|intact:Diphosphofructose(synonym)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233309|imex:IM-27509-33	author score:RF = 0.1945	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:445557(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16238"	uniprotkb:P0A9M8	intact:EBI-1225105|chebi:"CHEBI:42388"|chebi:"CHEBI:4956"|chebi:"CHEBI:13315"|chebi:"CHEBI:21125"	intact:EBI-555015|uniprotkb:P39184|uniprotkb:P78091|uniprotkb:P78189|uniprotkb:P78190|uniprotkb:Q9EUP2|ensemblbacteria:AAC75357|ensemblbacteria:BAA16136	psi-mi:fad(display_short)|psi-mi:"CHEBI:16238"(display_long)|intact:"Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine"(synonym)|intact:"adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]"(synonym)|intact:FAD(synonym)|intact:Flavin adenine dinucleotide(synonym)|intact:FLAVIN-ADENINE DINUCLEOTIDE(synonym)|intact:"Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine"(synonym)|intact:Riboflavin 5'-adenosine diphosphate(synonym)|intact:"adenosine 5'-(3-{D-ribo-5-[7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl} dihydrogen diphosphate)"(iupac name)	psi-mi:pta_ecoli(display_long)|uniprotkb:Phosphotransacetylase(gene name synonym)|uniprotkb:pta(gene name)|psi-mi:pta(display_short)|uniprotkb:b2297(locus name)|uniprotkb:JW2294(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233295|imex:IM-27509-149	author score:RF = 0.2773	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:643975(identity)	refseq:NP_416800.1|refseq:WP_000086722.1|dip:DIP-35815N|ensemblbacteria:AAC75357(transcript)|ensemblbacteria:b2297(gene)|ensemblbacteria:BAA16136(gene)|ensemblbacteria:BAA16136(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006083"(acetate metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008959"(phosphate acetyltransferase activity)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0070689"(L-threonine catabolic process to propionate)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR004614(Phosphate acetyltransferase)|interpro:IPR010766(DRTGG)|interpro:IPR016475(Phosphate acetyltransferase, bacteria)|interpro:IPR027417|interpro:IPR028979|interpro:IPR042112|interpro:IPR042113	-	comment:Flavin adenine dinucleotide	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:fX/+B9FY1uClR9GtT9XfqA4V+H083333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0A799	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233465|imex:IM-27509-95	author score:RF = 0.3442	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0AB71	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233381|imex:IM-27509-151	author score:RF = 0.288	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0AD61	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-909449|ensemblbacteria:AAC74746|ensemblbacteria:BAA15445|uniprotkb:P14178|uniprotkb:P76921|uniprotkb:P78165|uniprotkb:P78231	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:kpyk1_ecoli(display_long)|uniprotkb:pykF(gene name)|psi-mi:pykF(display_short)|uniprotkb:b1676(locus name)|uniprotkb:JW1666(locus name)|uniprotkb:PK-1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233493|imex:IM-27509-109	author score:RF = 0.2596	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|rcsb pdb:1E0T|ensemblbacteria:AAC74746(transcript)|ensemblbacteria:b1676(gene)|ensemblbacteria:BAA15445(gene)|ensemblbacteria:BAA15445(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1902912"(pyruvate kinase complex)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|rcsb pdb:1E0U|rcsb pdb:1PKY|rcsb pdb:4YNG|refseq:NP_416191.1|refseq:WP_001295403.1|dip:DIP-36221N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:EI7T9Ijr8cYfRi7pGlGxV5Vidu883333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0A858	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-368978|uniprotkb:P04790|uniprotkb:Q2M8L5|ensemblbacteria:AAC76901|ensemblbacteria:BAE77391	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:tpis_ecoli(display_long)|uniprotkb:tpiA(gene name)|psi-mi:tpiA(display_short)|uniprotkb:tpi(gene name synonym)|uniprotkb:b3919(locus name)|uniprotkb:JW3890(locus name)|uniprotkb:Triose-phosphate isomerase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233507|imex:IM-27509-111	author score:RF = 0.2483	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:WP_001216325.1|refseq:NP_418354.1|ensemblbacteria:AAC76901(transcript)|ensemblbacteria:b3919(gene)|ensemblbacteria:BAE77391(gene)|ensemblbacteria:BAE77391(transcript)|go:"GO:0004807"(triose-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|interpro:IPR000652(Triosephosphate isomerase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR020861|interpro:IPR022896|interpro:IPR035990|rcsb pdb:1TMH|rcsb pdb:1TRE|dip:DIP-31849N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	crc64:E398251020012D94	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:ROHSCnYvM5DH+Tm9MnhUXkXWKbQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0AC53	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-555656|uniprotkb:P22992|uniprotkb:P78069|uniprotkb:Q60134|uniprotkb:Q60139|ensemblbacteria:AAC74922|ensemblbacteria:BAA15660	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:g6pd_ecoli(display_long)|uniprotkb:zwf(gene name)|psi-mi:zwf(display_short)|uniprotkb:b1852(locus name)|uniprotkb:JW1841(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233521|imex:IM-27509-155	author score:RF = 0.2289	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_416366.1|refseq:WP_000301727.1|dip:DIP-35780N|mint:P0AC53|ensemblbacteria:AAC74922(transcript)|ensemblbacteria:b1852(gene)|ensemblbacteria:BAA15660(gene)|ensemblbacteria:BAA15660(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009372"(quorum sensing)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:ntoYKRWiGdynkH9k+qgl63mGoAM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15971"	uniprotkb:P26616	intact:EBI-22231930|chebi:"CHEBI:43239"|chebi:"CHEBI:43114"|chebi:"CHEBI:43190"|chebi:"CHEBI:43048"|chebi:"CHEBI:6240"|chebi:"CHEBI:13117"|chebi:"CHEBI:21324"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:lhistidine(display_short)|psi-mi:"CHEBI:15971"(display_long)|intact:"(S)-4-(2-Amino-2-carboxyethyl)imidazole"(synonym)|intact:"(S)-alpha-amino-1H-Imidazole-4-propanoic acid"(synonym)|intact:"(S)-alpha-Amino-1H-imidazole-4-propionic acid"(synonym)|intact:H(synonym)|intact:His(synonym)|intact:HISTIDINE(synonym)|intact:"L-(-)-histidine"(synonym)|intact:L-Histidin(synonym)|intact:L-Histidine(synonym)|intact:"(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid"(iupac name)|intact:L-histidine(iupac name)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233535|imex:IM-27509-39	author score:RF = 0.1822	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6274(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15971"	uniprotkb:P76558	intact:EBI-22231930|chebi:"CHEBI:43239"|chebi:"CHEBI:43114"|chebi:"CHEBI:43190"|chebi:"CHEBI:43048"|chebi:"CHEBI:6240"|chebi:"CHEBI:13117"|chebi:"CHEBI:21324"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:lhistidine(display_short)|psi-mi:"CHEBI:15971"(display_long)|intact:"(S)-4-(2-Amino-2-carboxyethyl)imidazole"(synonym)|intact:"(S)-alpha-amino-1H-Imidazole-4-propanoic acid"(synonym)|intact:"(S)-alpha-Amino-1H-imidazole-4-propionic acid"(synonym)|intact:H(synonym)|intact:His(synonym)|intact:HISTIDINE(synonym)|intact:"L-(-)-histidine"(synonym)|intact:L-Histidin(synonym)|intact:L-Histidine(synonym)|intact:"(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid"(iupac name)|intact:L-histidine(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233549|imex:IM-27509-113	author score:RF = 0.2356	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6274(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15971"	uniprotkb:P0A799	intact:EBI-22231930|chebi:"CHEBI:43239"|chebi:"CHEBI:43114"|chebi:"CHEBI:43190"|chebi:"CHEBI:43048"|chebi:"CHEBI:6240"|chebi:"CHEBI:13117"|chebi:"CHEBI:21324"	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:lhistidine(display_short)|psi-mi:"CHEBI:15971"(display_long)|intact:"(S)-4-(2-Amino-2-carboxyethyl)imidazole"(synonym)|intact:"(S)-alpha-amino-1H-Imidazole-4-propanoic acid"(synonym)|intact:"(S)-alpha-Amino-1H-imidazole-4-propionic acid"(synonym)|intact:H(synonym)|intact:His(synonym)|intact:HISTIDINE(synonym)|intact:"L-(-)-histidine"(synonym)|intact:L-Histidin(synonym)|intact:L-Histidine(synonym)|intact:"(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid"(iupac name)|intact:L-histidine(iupac name)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233563|imex:IM-27509-49	author score:RF = 0.2714	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6274(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17202"	uniprotkb:P0AC53	intact:EBI-9007843|chebi:"CHEBI:5849"|chebi:"CHEBI:12057"|chebi:"CHEBI:12063"|chebi:"CHEBI:13372"|chebi:"CHEBI:13373"|chebi:"CHEBI:14457"|chebi:"CHEBI:19271"|chebi:"CHEBI:43418"|chebi:"CHEBI:43475"|chebi:"CHEBI:43524"|chebi:"CHEBI:43528"|chebi:"CHEBI:43563"|chebi:"CHEBI:43611"|chebi:"CHEBI:781325"|chebi:"CHEBI:47501"	intact:EBI-555656|uniprotkb:P22992|uniprotkb:P78069|uniprotkb:Q60134|uniprotkb:Q60139|ensemblbacteria:AAC74922|ensemblbacteria:BAA15660	psi-mi:imp(display_short)|psi-mi:"CHEBI:17202"(display_long)|intact:2'-inosine-5'-monophosphate(synonym)|intact:5'-IMP(synonym)|intact:5'-Inosinate(synonym)|intact:5'-Inosine monophosphate(synonym)|intact:5'-Inosinic acid(synonym)|intact:hypoxanthosine 5'-monophosphate(synonym)|intact:IMP(synonym)|intact:Inosine 5'-monophosphate(synonym)|intact:Inosine 5'-phosphate(synonym)|intact:Inosine monophosphate(synonym)|intact:inosinic acid(synonym)|intact:Inosinic acid(synonym)|intact:ribosylhypoxanthine monophosphate(synonym)|intact:5'-inosinic acid(iupac name)	psi-mi:g6pd_ecoli(display_long)|uniprotkb:zwf(gene name)|psi-mi:zwf(display_short)|uniprotkb:b1852(locus name)|uniprotkb:JW1841(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233577|imex:IM-27509-71	author score:RF = 0.2748	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398640(identity)	refseq:NP_416366.1|refseq:WP_000301727.1|dip:DIP-35780N|mint:P0AC53|ensemblbacteria:AAC74922(transcript)|ensemblbacteria:b1852(gene)|ensemblbacteria:BAA15660(gene)|ensemblbacteria:BAA15660(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009372"(quorum sensing)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291	-	inchi key:GRSZFWQUAKGDAV-KQYNXXCUSA-N	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:ntoYKRWiGdynkH9k+qgl63mGoAM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30838"	uniprotkb:P0A955	intact:EBI-22232009|chebi:"CHEBI:6074"|chebi:"CHEBI:24933"	intact:EBI-558114|uniprotkb:P10177|ensemblbacteria:AAC74920|ensemblbacteria:BAA15658	psi-mi:itaconic acid(display_short)|psi-mi:"CHEBI:30838"(display_long)|intact:2-methylenesuccinic acid(synonym)|intact:2-propene-1,2-dicarboxylic acid(synonym)|intact:Itaconic acid(synonym)|intact:methylenebutanedioic acid(synonym)|intact:Methylenesuccinic acid(synonym)|intact:propylenedicarboxylic acid(synonym)|intact:2-methylidenebutanedioic acid(iupac name)	psi-mi:alkh_ecoli(display_long)|uniprotkb:hga(gene name synonym)|uniprotkb:kdgA(gene name synonym)|uniprotkb:b1850(locus name)|uniprotkb:eda(gene name)|psi-mi:eda(display_short)|uniprotkb:JW1839(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233591|imex:IM-27509-131	author score:RF = 0.2559	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:811(identity)	refseq:NP_416364.1|refseq:WP_000800512.1|dip:DIP-36196N|ensemblbacteria:AAC74920(transcript)|ensemblbacteria:b1850(gene)|ensemblbacteria:BAA15658(gene)|ensemblbacteria:BAA15658(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008152"(metabolic process)|go:"GO:0008675"(2-dehydro-3-deoxy-phosphogluconate aldolase activity)|go:"GO:0008700"(4-hydroxy-2-oxoglutarate aldolase activity)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016020"(membrane)|go:"GO:0016833"(oxo-acid-lyase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0106009"("(4S)-4-hydroxy-2-oxoglutarate aldolase activity")|interpro:IPR000887(KDPG and KHG aldolase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR031337|interpro:IPR031338|rcsb pdb:1EUA|rcsb pdb:1EUN|rcsb pdb:1FQ0|rcsb pdb:1FWR|rcsb pdb:1WAU|rcsb pdb:1WBH|rcsb pdb:2C0A	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:Agz2bUIVoEJVknE7nyuAjbOYppc83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0A6T1	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-909327|uniprotkb:P11537|ensemblbacteria:AAC76995|ensemblbacteria:BAE78027|uniprotkb:Q2M6S9	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:g6pi_ecoli(display_long)|uniprotkb:JW3985(locus name)|uniprotkb:pgi(gene name)|psi-mi:pgi(display_short)|uniprotkb:b4025(locus name)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233451|imex:IM-27509-69	author score:RF = 0.3184	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	ensemblbacteria:AAC76995(transcript)|ensemblbacteria:b4025(gene)|ensemblbacteria:BAE78027(gene)|ensemblbacteria:BAE78027(transcript)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:3NBU|refseq:NP_418449.1|refseq:WP_000789986.1|dip:DIP-35887N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:bdyHyVvqc51JroAVGucRt+FDfyo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0A796	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233437|imex:IM-27509-187	author score:RF = 0.3499	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P00350	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-907049|uniprotkb:Q59416|uniprotkb:Q79DT3|uniprotkb:P78080|uniprotkb:Q47571|uniprotkb:Q59366|uniprotkb:Q59402|uniprotkb:Q59411|uniprotkb:Q59412|uniprotkb:Q59413|uniprotkb:Q59414|ensemblbacteria:AAC75090|ensemblbacteria:BAA15869	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:6pgd_ecoli(display_long)|uniprotkb:gnd(gene name)|psi-mi:gnd(display_short)|uniprotkb:b2029(locus name)|uniprotkb:JW2011(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233395|imex:IM-27509-171	author score:RF = 0.2674	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_416533.1|refseq:WP_000043484.1|dip:DIP-9819N|ensemblbacteria:AAC75090(transcript)|ensemblbacteria:b2029(gene)|ensemblbacteria:BAA15869(gene)|ensemblbacteria:BAA15869(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2ZYA|rcsb pdb:2ZYD|rcsb pdb:3FWN	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:/i9Nawn7MRXxPQlihWGV8uUvLuQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P76558	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233423|imex:IM-27509-67	author score:RF = 0.292	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P62707	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-552773|uniprotkb:P31217|ensemblbacteria:AAC73842|ensemblbacteria:BAA35417	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:gpma_ecoli(display_long)|uniprotkb:gpmA(gene name)|psi-mi:gpmA(display_short)|uniprotkb:gpm(gene name synonym)|uniprotkb:pgm(gene name synonym)|uniprotkb:pgmA(gene name synonym)|uniprotkb:b0755(locus name)|uniprotkb:JW0738(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233409|imex:IM-27509-153	author score:RF = 0.2117	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_415276.1|refseq:WP_001295305.1|dip:DIP-35899N|ensemblbacteria:AAC73842(transcript)|ensemblbacteria:b0755(gene)|ensemblbacteria:BAA35417(gene)|ensemblbacteria:BAA35417(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0046538"(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity)|go:"GO:0061621"(canonical glycolysis)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:1E58|rcsb pdb:1E59	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:VZTBGgO6fb6Nu2eTmgdl+KEBrdo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15996"	uniprotkb:P0A9M8	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-555015|uniprotkb:P39184|uniprotkb:P78091|uniprotkb:P78189|uniprotkb:P78190|uniprotkb:Q9EUP2|ensemblbacteria:AAC75357|ensemblbacteria:BAA16136	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pta_ecoli(display_long)|uniprotkb:Phosphotransacetylase(gene name synonym)|uniprotkb:pta(gene name)|psi-mi:pta(display_short)|uniprotkb:b2297(locus name)|uniprotkb:JW2294(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233479|imex:IM-27509-97	author score:RF = 0.2482	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:135398633(identity)	refseq:NP_416800.1|refseq:WP_000086722.1|dip:DIP-35815N|ensemblbacteria:AAC75357(transcript)|ensemblbacteria:b2297(gene)|ensemblbacteria:BAA16136(gene)|ensemblbacteria:BAA16136(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006083"(acetate metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008959"(phosphate acetyltransferase activity)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0070689"(L-threonine catabolic process to propionate)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR004614(Phosphate acetyltransferase)|interpro:IPR010766(DRTGG)|interpro:IPR016475(Phosphate acetyltransferase, bacteria)|interpro:IPR027417|interpro:IPR028979|interpro:IPR042112|interpro:IPR042113	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:fX/+B9FY1uClR9GtT9XfqA4V+H083333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:25523"	uniprotkb:P0AB71	intact:EBI-8874319	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:nadp(display_short)|psi-mi:"CHEBI:25523"(display_long)|intact:nicotinamide-adenine dinucleotide phosphate(synonym)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233745|imex:IM-27509-191	author score:RF = 0.2288	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5886(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:13389"	uniprotkb:P0A796	intact:EBI-22232180	intact:EBI-554405|uniprotkb:P06998|uniprotkb:Q2M8L2|ensemblbacteria:BAE77394|ensemblbacteria:AAC76898	psi-mi:nad(display_short)|psi-mi:"CHEBI:13389"(display_long)|intact:nicotinamide-adenine dinucleotide(synonym)	psi-mi:pfka_ecoli(display_long)|uniprotkb:6-phosphofructokinase isozyme I(gene name synonym)|uniprotkb:Phosphohexokinase 1(gene name synonym)|uniprotkb:pfkA(gene name)|psi-mi:pfkA(display_short)|uniprotkb:b3916(locus name)|uniprotkb:JW3887(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233731|imex:IM-27509-53	author score:RF = 0.3465	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5893(identity)	refseq:NP_418351.1|refseq:WP_000591795.1|dip:DIP-35841N|ensemblbacteria:BAE77394(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032553"(ribonucleotide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044275"(cellular carbohydrate catabolic process)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR012003(ATP-dependent phosphofructokinase, prokaryotic)|interpro:IPR012828(6-phosphofructokinase)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|rcsb pdb:1PFK|rcsb pdb:2PFK|ensemblbacteria:AAC76898(transcript)|ensemblbacteria:b3916(gene)|ensemblbacteria:BAE77394(gene)	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D03D79F6A5536A41	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0EViZVHHTAqeY2iYS5AizEVYVwM83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:13389"	uniprotkb:P0A9B2	intact:EBI-22232180	intact:EBI-368904|uniprotkb:P06977|ensemblbacteria:AAC74849|ensemblbacteria:BAA15576	psi-mi:nad(display_short)|psi-mi:"CHEBI:13389"(display_long)|intact:nicotinamide-adenine dinucleotide(synonym)	psi-mi:g3p1_ecoli(display_long)|uniprotkb:gapA(gene name)|psi-mi:gapA(display_short)|uniprotkb:NAD-dependent glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:JW1768(locus name)|uniprotkb:b1779(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233703|imex:IM-27509-75	author score:RF = 0.5493	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5893(identity)	refseq:NP_416293.1|refseq:WP_000153502.1|ensemblbacteria:AAC74849(transcript)|ensemblbacteria:b1779(gene)|ensemblbacteria:BAA15576(gene)|ensemblbacteria:BAA15576(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1DC4|rcsb pdb:1DC5|rcsb pdb:1DC6|rcsb pdb:1GAD|rcsb pdb:1GAE|rcsb pdb:1S7C|rcsb pdb:2VYN|rcsb pdb:2VYV|rcsb pdb:5ZA0|rcsb pdb:6IO4|rcsb pdb:6IO6|rcsb pdb:6IOJ|rcsb pdb:6UTM|rcsb pdb:6UTN|rcsb pdb:6UTO|rcsb pdb:1DC3|mint:P0A9B2|dip:DIP-31848N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wjDK2dtZ4nPJZ0L7OVRiKfQITtg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30794"	uniprotkb:P76558	intact:EBI-22232110|chebi:"CHEBI:44060"|chebi:"CHEBI:6660"|chebi:"CHEBI:25132"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:malonic acid(display_short)|psi-mi:"CHEBI:30794"(display_long)|intact:H2malo(synonym)|intact:HOOC-CH2-COOH(synonym)|intact:Malonic acid(synonym)|intact:MALONIC ACID(synonym)|intact:Propanedioic acid(synonym)|intact:propanedioic acid(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233689|imex:IM-27509-11	author score:RF = 0.3192	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:867(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30794"	uniprotkb:P26616	intact:EBI-22232110|chebi:"CHEBI:44060"|chebi:"CHEBI:6660"|chebi:"CHEBI:25132"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:malonic acid(display_short)|psi-mi:"CHEBI:30794"(display_long)|intact:H2malo(synonym)|intact:HOOC-CH2-COOH(synonym)|intact:Malonic acid(synonym)|intact:MALONIC ACID(synonym)|intact:Propanedioic acid(synonym)|intact:propanedioic acid(iupac name)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233675|imex:IM-27509-117	author score:RF = 0.2632	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:867(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30794"	uniprotkb:P0AB71	intact:EBI-22232110|chebi:"CHEBI:44060"|chebi:"CHEBI:6660"|chebi:"CHEBI:25132"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:malonic acid(display_short)|psi-mi:"CHEBI:30794"(display_long)|intact:H2malo(synonym)|intact:HOOC-CH2-COOH(synonym)|intact:Malonic acid(synonym)|intact:MALONIC ACID(synonym)|intact:Propanedioic acid(synonym)|intact:propanedioic acid(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233661|imex:IM-27509-51	author score:RF = 0.5633	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:867(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:30794"	uniprotkb:P0A9G6	intact:EBI-22232110|chebi:"CHEBI:44060"|chebi:"CHEBI:6660"|chebi:"CHEBI:25132"	intact:EBI-907399|uniprotkb:P05313|uniprotkb:Q2M6T9|ensemblbacteria:AAC76985|ensemblbacteria:BAE78017	psi-mi:malonic acid(display_short)|psi-mi:"CHEBI:30794"(display_long)|intact:H2malo(synonym)|intact:HOOC-CH2-COOH(synonym)|intact:Malonic acid(synonym)|intact:MALONIC ACID(synonym)|intact:Propanedioic acid(synonym)|intact:propanedioic acid(iupac name)	psi-mi:acea_ecoli(display_long)|uniprotkb:aceA(gene name)|psi-mi:aceA(display_short)|uniprotkb:icl(gene name synonym)|uniprotkb:b4015(locus name)|uniprotkb:JW3975(locus name)|uniprotkb:Isocitrase(gene name synonym)|uniprotkb:Isocitratase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233647|imex:IM-27509-157	author score:RF = 0.2864	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:867(identity)	refseq:NP_418439.1|refseq:WP_000857856.1|dip:DIP-35893N|ensemblbacteria:AAC76985(transcript)|ensemblbacteria:b4015(gene)|ensemblbacteria:BAE78017(gene)|ensemblbacteria:BAE78017(transcript)|go:"GO:0004451"(isocitrate lyase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0043169"(cation binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR006254(Isocitrate lyase)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018523|interpro:IPR039556|interpro:IPR040442|rcsb pdb:1IGW	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:+0Nz3An+6VGpaPiJkdPlRZU28ac83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:25115"	uniprotkb:P0A799	intact:EBI-22232077	intact:EBI-551506|uniprotkb:P11665|uniprotkb:Q2M9R6|ensemblbacteria:AAC75963|ensemblbacteria:BAE76990	psi-mi:malate(display_short)|psi-mi:"CHEBI:25115"(display_long)|intact:malate anion(synonym)|intact:malates(synonym)|intact:malic acid anion(synonym)	psi-mi:pgk_ecoli(display_long)|uniprotkb:pgk(gene name)|psi-mi:pgk(display_short)|uniprotkb:b2926(locus name)|uniprotkb:JW2893(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233633|imex:IM-27509-115	author score:RF = 0.2965	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:222656(identity)	refseq:NP_417401.1|refseq:WP_000111269.1|dip:DIP-36163N|ensemblbacteria:AAC75963(transcript)|ensemblbacteria:b2926(gene)|ensemblbacteria:BAE76990(gene)|ensemblbacteria:BAE76990(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|rcsb pdb:1ZMR	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:mK6/4kaBHShzk+vtw+ha6/5YnZk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:25115"	uniprotkb:P76558	intact:EBI-22232077	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:malate(display_short)|psi-mi:"CHEBI:25115"(display_long)|intact:malate anion(synonym)|intact:malates(synonym)|intact:malic acid anion(synonym)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233619|imex:IM-27509-189	author score:RF = 0.2377	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:222656(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15603"	uniprotkb:P0AG07	intact:EBI-22232037|chebi:"CHEBI:43695"|chebi:"CHEBI:43814"|chebi:"CHEBI:43733"|chebi:"CHEBI:43646"|chebi:"CHEBI:10866"|chebi:"CHEBI:6260"|chebi:"CHEBI:13131"|chebi:"CHEBI:21348"	intact:EBI-546020|uniprotkb:P32661|uniprotkb:Q2M751|ensemblbacteria:BAE77905|ensemblbacteria:AAC76411	psi-mi:lleucine(display_short)|psi-mi:"CHEBI:15603"(display_long)|intact:"(2S)-2-amino-4-methylpentanoic acid"(synonym)|intact:"(2S)-alpha-2-Amino-4-methylvaleric acid"(synonym)|intact:"(2S)-alpha-Leucine"(synonym)|intact:"(S)-(+)-leucine"(synonym)|intact:"(S)-leucine"(synonym)|intact:2-Amino-4-methylvaleric acid(synonym)|intact:L(synonym)|intact:L-Leucin(synonym)|intact:L-Leucine(synonym)|intact:L-Leuzin(synonym)|intact:Leu(synonym)|intact:LEUCINE(synonym)|intact:L-leucine(iupac name)	psi-mi:rpe_ecoli(display_long)|uniprotkb:rpe(gene name)|psi-mi:rpe(display_short)|uniprotkb:dod(gene name synonym)|uniprotkb:b3386(locus name)|uniprotkb:yhfD(gene name synonym)|uniprotkb:Pentose-5-phosphate 3-epimerase(gene name synonym)|uniprotkb:R5P3E(gene name synonym)|uniprotkb:JW3349(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233605|imex:IM-27509-73	author score:RF = 0.1824	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6106(identity)	refseq:NP_417845.1|ensemblbacteria:BAE77905(transcript)|go:"GO:0004750"(D-ribulose-phosphate 3-epimerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019323"(pentose catabolic process)|go:"GO:0044262"(cellular carbohydrate metabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000056(Ribulose-phosphate 3-epimerase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR026019|ensemblbacteria:BAE77905(gene)|ensemblbacteria:AAC76411(transcript)|ensemblbacteria:b3386(gene)|refseq:WP_000816280.1|dip:DIP-47869N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:tejKtdI7JB2CFwzaNTuPBkSZ3pw83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:25523"	uniprotkb:P00350	intact:EBI-8874319	intact:EBI-907049|uniprotkb:Q59416|uniprotkb:Q79DT3|uniprotkb:P78080|uniprotkb:Q47571|uniprotkb:Q59366|uniprotkb:Q59402|uniprotkb:Q59411|uniprotkb:Q59412|uniprotkb:Q59413|uniprotkb:Q59414|ensemblbacteria:AAC75090|ensemblbacteria:BAA15869	psi-mi:nadp(display_short)|psi-mi:"CHEBI:25523"(display_long)|intact:nicotinamide-adenine dinucleotide phosphate(synonym)	psi-mi:6pgd_ecoli(display_long)|uniprotkb:gnd(gene name)|psi-mi:gnd(display_short)|uniprotkb:b2029(locus name)|uniprotkb:JW2011(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233759|imex:IM-27509-77	author score:RF = 0.3577	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5886(identity)	refseq:NP_416533.1|refseq:WP_000043484.1|dip:DIP-9819N|ensemblbacteria:AAC75090(transcript)|ensemblbacteria:b2029(gene)|ensemblbacteria:BAA15869(gene)|ensemblbacteria:BAA15869(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR036291|rcsb pdb:2ZYA|rcsb pdb:2ZYD|rcsb pdb:3FWN	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:/i9Nawn7MRXxPQlihWGV8uUvLuQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:25523"	uniprotkb:P08200	intact:EBI-8874319	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	psi-mi:nadp(display_short)|psi-mi:"CHEBI:25523"(display_long)|intact:nicotinamide-adenine dinucleotide phosphate(synonym)	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233773|imex:IM-27509-119	author score:RF = 0.3145	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5886(identity)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P0A955	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-558114|uniprotkb:P10177|ensemblbacteria:AAC74920|ensemblbacteria:BAA15658	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:alkh_ecoli(display_long)|uniprotkb:hga(gene name synonym)|uniprotkb:kdgA(gene name synonym)|uniprotkb:b1850(locus name)|uniprotkb:eda(gene name)|psi-mi:eda(display_short)|uniprotkb:JW1839(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233787|imex:IM-27509-79	author score:RF = 0.1923	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	refseq:NP_416364.1|refseq:WP_000800512.1|dip:DIP-36196N|ensemblbacteria:AAC74920(transcript)|ensemblbacteria:b1850(gene)|ensemblbacteria:BAA15658(gene)|ensemblbacteria:BAA15658(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008152"(metabolic process)|go:"GO:0008675"(2-dehydro-3-deoxy-phosphogluconate aldolase activity)|go:"GO:0008700"(4-hydroxy-2-oxoglutarate aldolase activity)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016020"(membrane)|go:"GO:0016833"(oxo-acid-lyase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0106009"("(4S)-4-hydroxy-2-oxoglutarate aldolase activity")|interpro:IPR000887(KDPG and KHG aldolase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR031337|interpro:IPR031338|rcsb pdb:1EUA|rcsb pdb:1EUN|rcsb pdb:1FQ0|rcsb pdb:1FWR|rcsb pdb:1WAU|rcsb pdb:1WBH|rcsb pdb:2C0A	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:Agz2bUIVoEJVknE7nyuAjbOYppc83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P0A6P9	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-368855|uniprotkb:P08324|uniprotkb:Q2MA53|ensemblbacteria:AAC75821|ensemblbacteria:BAE76853	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:eno_ecoli(display_long)|uniprotkb:eno(gene name)|psi-mi:eno(display_short)|uniprotkb:b2779(locus name)|uniprotkb:JW2750(locus name)|uniprotkb:2-phosphoglycerate dehydratase(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233801|imex:IM-27509-159	author score:RF = 0.2497	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	refseq:NP_417259.1|refseq:WP_000036723.1|ensemblbacteria:AAC75821(transcript)|ensemblbacteria:b2779(gene)|ensemblbacteria:BAE76853(gene)|ensemblbacteria:BAE76853(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|rcsb pdb:1E9I|rcsb pdb:2FYM|rcsb pdb:3H8A|rcsb pdb:5OHG|rcsb pdb:6BFY|rcsb pdb:6BFZ|rcsb pdb:6D3Q|rcsb pdb:6NPF|dip:DIP-31847N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:QL3m2hiqjaMw26gQ6jViBr2mxjY83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P0AB71	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233815|imex:IM-27509-173	author score:RF = 0.1974	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P62707	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-552773|uniprotkb:P31217|ensemblbacteria:AAC73842|ensemblbacteria:BAA35417	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:gpma_ecoli(display_long)|uniprotkb:gpmA(gene name)|psi-mi:gpmA(display_short)|uniprotkb:gpm(gene name synonym)|uniprotkb:pgm(gene name synonym)|uniprotkb:pgmA(gene name synonym)|uniprotkb:b0755(locus name)|uniprotkb:JW0738(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233829|imex:IM-27509-193	author score:RF = 0.6324	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	refseq:NP_415276.1|refseq:WP_001295305.1|dip:DIP-35899N|ensemblbacteria:AAC73842(transcript)|ensemblbacteria:b0755(gene)|ensemblbacteria:BAA35417(gene)|ensemblbacteria:BAA35417(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0046538"(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity)|go:"GO:0061621"(canonical glycolysis)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:1E58|rcsb pdb:1E59	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:VZTBGgO6fb6Nu2eTmgdl+KEBrdo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P08200	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-369069|ensemblbacteria:AAC74220|ensemblbacteria:BAA35958	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:idh_ecoli(display_long)|uniprotkb:icd(gene name)|psi-mi:icd(display_short)|uniprotkb:icdA(gene name synonym)|uniprotkb:icdE(gene name synonym)|uniprotkb:b1136(locus name)|uniprotkb:JW1122(locus name)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233843|imex:IM-27509-135	author score:RF = 0.1942	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	refseq:NP_415654.1|refseq:WP_000444484.1|ensemblbacteria:AAC74220(transcript)|ensemblbacteria:b1136(gene)|ensemblbacteria:BAA35958(gene)|ensemblbacteria:BAA35958(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0022900"(electron transport chain)|go:"GO:0051287"(NAD binding)|interpro:IPR004439(Isocitrate dehydrogenase NADP-dependent, prokaryotic)|interpro:IPR019818|interpro:IPR024084|rcsb pdb:1AI2|rcsb pdb:1AI3|rcsb pdb:1BL5|rcsb pdb:1CW1|rcsb pdb:1CW4|rcsb pdb:1CW7|rcsb pdb:1GRO|rcsb pdb:1GRP|rcsb pdb:1HJ6|rcsb pdb:1IDC|rcsb pdb:1IDD|rcsb pdb:1IDE|rcsb pdb:1IDF|rcsb pdb:1IKA|rcsb pdb:1ISO|rcsb pdb:1P8F|rcsb pdb:1PB1|rcsb pdb:1PB3|rcsb pdb:1SJS|rcsb pdb:3ICD|rcsb pdb:3LCB|rcsb pdb:4AJ3|rcsb pdb:4AJA|rcsb pdb:4AJB|rcsb pdb:4AJC|rcsb pdb:4AJR|rcsb pdb:4AJS|rcsb pdb:4BNP|rcsb pdb:4ICD|rcsb pdb:4P69|rcsb pdb:5ICD|rcsb pdb:6ICD|rcsb pdb:7ICD|rcsb pdb:8ICD|rcsb pdb:9ICD|dip:DIP-10006N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:SNDyns4HsBiJFC6fsc7PtQ3DAN483333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18021"	uniprotkb:P22259	intact:EBI-22232267|chebi:"CHEBI:8147"|chebi:"CHEBI:14812"|chebi:"CHEBI:26054"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:phosphoenolpyruvate(display_short)|psi-mi:"CHEBI:18021"(display_long)|intact:"2-(phosphonooxy)-2-propenoate"(synonym)|intact:"2-(phosphonooxy)acrylate"(synonym)|intact:"2-hydroxy-2-propenoate (dihydrogen phosphate) (ester)"(synonym)|intact:"2-hydroxy-2-propenoate phosphate (ester)"(synonym)|intact:O-phosphono-enol-pyruvate(synonym)|intact:PEP(synonym)|intact:Phosphoenolpyruvate(synonym)|intact:PHOSPHOENOLPYRUVATE(synonym)|intact:"phosphoenolpyruvate(1-)"(synonym)|intact:"2-(phosphonooxy)prop-2-enoate"(iupac name)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233857|imex:IM-27509-13	author score:RF = 0.4234	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1005(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17111"	uniprotkb:P0AB71	intact:EBI-22232369|chebi:"CHEBI:12160"|chebi:"CHEBI:12159"|chebi:"CHEBI:2121"|chebi:"CHEBI:45139"|chebi:"CHEBI:20625"	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:5ophosphonoalphadribofuranosyl diphosphate(display_short)|psi-mi:"CHEBI:17111"(display_long)|intact:5-Phospho-alpha-D-ribose 1-diphosphate(synonym)|intact:5-Phosphoribosyl 1-pyrophosphate(synonym)|intact:5-Phosphoribosyl diphosphate(synonym)|intact:"alpha-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)"(synonym)|intact:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID(synonym)|intact:phosphoribosyl pyrophosphate(synonym)|intact:phosphoribosylpyrophosphate(synonym)|intact:PRib-PP(synonym)|intact:PRPP(synonym)|intact:"5-O-phosphono-alpha-D-ribofuranose 1-(trihydrogen diphosphate)"(iupac name)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233871|imex:IM-27509-195	author score:RF = 0.2275	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1041(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:26008"	uniprotkb:P0AB71	intact:EBI-22232403	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:phenylpyruvate(display_short)|psi-mi:"CHEBI:26008"(display_long)|intact:phenylpyruvates(synonym)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233885|imex:IM-27509-15	author score:RF = 0.1828	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:997(identity)	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:26008"	uniprotkb:P76558	intact:EBI-22232403	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:phenylpyruvate(display_short)|psi-mi:"CHEBI:26008"(display_long)|intact:phenylpyruvates(synonym)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233899|imex:IM-27509-55	author score:RF = 0.2987	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:997(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:26008"	uniprotkb:P0A9M8	intact:EBI-22232403	intact:EBI-555015|uniprotkb:P39184|uniprotkb:P78091|uniprotkb:P78189|uniprotkb:P78190|uniprotkb:Q9EUP2|ensemblbacteria:AAC75357|ensemblbacteria:BAA16136	psi-mi:phenylpyruvate(display_short)|psi-mi:"CHEBI:26008"(display_long)|intact:phenylpyruvates(synonym)	psi-mi:pta_ecoli(display_long)|uniprotkb:Phosphotransacetylase(gene name synonym)|uniprotkb:pta(gene name)|psi-mi:pta(display_short)|uniprotkb:b2297(locus name)|uniprotkb:JW2294(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233913|imex:IM-27509-175	author score:RF = 0.2416	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:997(identity)	refseq:NP_416800.1|refseq:WP_000086722.1|dip:DIP-35815N|ensemblbacteria:AAC75357(transcript)|ensemblbacteria:b2297(gene)|ensemblbacteria:BAA16136(gene)|ensemblbacteria:BAA16136(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006083"(acetate metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008959"(phosphate acetyltransferase activity)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0070689"(L-threonine catabolic process to propionate)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR004614(Phosphate acetyltransferase)|interpro:IPR010766(DRTGG)|interpro:IPR016475(Phosphate acetyltransferase, bacteria)|interpro:IPR027417|interpro:IPR028979|interpro:IPR042112|interpro:IPR042113	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:fX/+B9FY1uClR9GtT9XfqA4V+H083333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17363"	uniprotkb:P0A6T1	intact:EBI-22232448|chebi:"CHEBI:40192"|chebi:"CHEBI:4243"|chebi:"CHEBI:21088"|chebi:"CHEBI:13018"	intact:EBI-909327|uniprotkb:P11537|ensemblbacteria:AAC76995|ensemblbacteria:BAE78027|uniprotkb:Q2M6S9	psi-mi:dribulose 5phosphate(display_short)|psi-mi:"CHEBI:17363"(display_long)|intact:"D-erythro-pent-2-ulose 5-(dihydrogen phosphate)"(synonym)|intact:D-Ribulose 5-phosphate(synonym)|intact:5-O-phosphono-D-ribulose(iupac name)	psi-mi:g6pi_ecoli(display_long)|uniprotkb:JW3985(locus name)|uniprotkb:pgi(gene name)|psi-mi:pgi(display_short)|uniprotkb:b4025(locus name)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233927|imex:IM-27509-177	author score:RF = 0.2564	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:439184(identity)	ensemblbacteria:AAC76995(transcript)|ensemblbacteria:b4025(gene)|ensemblbacteria:BAE78027(gene)|ensemblbacteria:BAE78027(transcript)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:3NBU|refseq:NP_418449.1|refseq:WP_000789986.1|dip:DIP-35887N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:bdyHyVvqc51JroAVGucRt+FDfyo83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16610"	uniprotkb:P0AC33	intact:EBI-8850170|chebi:"CHEBI:9218"|chebi:"CHEBI:123634"|chebi:"CHEBI:15095"|chebi:"CHEBI:15097"|chebi:"CHEBI:26732"|chebi:"CHEBI:26733"|chebi:"CHEBI:45647"	intact:EBI-549075|uniprotkb:P00923|uniprotkb:P76889|ensemblbacteria:AAC74684|ensemblbacteria:BAA15360	psi-mi:spermidine(display_short)|psi-mi:"CHEBI:16610"(display_long)|intact:1,5,10-triazadecane(synonym)|intact:4-azaoctamethylenediamine(synonym)|intact:4-azaoctane-1,8-diamine(synonym)|intact:"N-(3-Aminopropyl)-1,4-butane-diamine"(synonym)|intact:Spermidin(synonym)|intact:SPERMIDINE(synonym)|intact:Spermidine(synonym)|intact:"N-(3-aminopropyl)butane-1,4-diamine"(iupac name)	psi-mi:fuma_ecoli(display_long)|uniprotkb:fumA(gene name)|psi-mi:fumA(display_short)|uniprotkb:Fumarase A(gene name synonym)|uniprotkb:Oxaloacetate keto--enol-isomerase(gene name synonym)|uniprotkb:Oxaloacetate tautomerase(gene name synonym)|uniprotkb:JW1604(locus name)|uniprotkb:b1612(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233941|imex:IM-27509-17	author score:RF = 0.2789	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:1102(identity)	refseq:NP_416129.1|refseq:WP_000066639.1|dip:DIP-36200N|ensemblbacteria:AAC74684(transcript)|ensemblbacteria:b1612(gene)|ensemblbacteria:BAA15360(gene)|ensemblbacteria:BAA15360(transcript)|go:"GO:0004333"(fumarate hydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050163"(oxaloacetate tautomerase activity)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR004646(Fe-S type hydro-lyases tartrate/fumarate alpha region)|interpro:IPR004647(Fe-S type hydro-lyases tartrate/fumarate beta region)|interpro:IPR011167(Iron-dependent fumarate hydratase)|interpro:IPR020557|interpro:IPR036660	-	inchi key:ATHGHQPFGPMSJY-UHFFFAOYSA-N	crc64:6082744088C64603	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0i8LsxVKd96UND96XCKj98sX8O883333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16828"	uniprotkb:P76558	intact:EBI-22232488|chebi:"CHEBI:21407"|chebi:"CHEBI:45988"|chebi:"CHEBI:46125"|chebi:"CHEBI:46086"|chebi:"CHEBI:46225"|chebi:"CHEBI:184633"|chebi:"CHEBI:6310"|chebi:"CHEBI:13178"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:ltryptophan(display_short)|psi-mi:"CHEBI:16828"(display_long)|intact:"(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid"(synonym)|intact:"(S)-alpha-amino-1H-indole-3-propanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-(3-indolyl)-propionic acid"(synonym)|intact:"(S)-tryptophan"(synonym)|intact:"L-(-)-tryptophan"(synonym)|intact:L-beta-3-indolylalanine(synonym)|intact:L-Tryptophan(synonym)|intact:L-tryptophan(synonym)|intact:Trp(synonym)|intact:Tryptophan(synonym)|intact:TRYPTOPHAN(synonym)|intact:tryptophan(synonym)|intact:W(synonym)|intact:L-tryptophan(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233955|imex:IM-27509-197	author score:RF = 0.2985	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6305(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:16828"	uniprotkb:P0A9M8	intact:EBI-22232488|chebi:"CHEBI:21407"|chebi:"CHEBI:45988"|chebi:"CHEBI:46125"|chebi:"CHEBI:46086"|chebi:"CHEBI:46225"|chebi:"CHEBI:184633"|chebi:"CHEBI:6310"|chebi:"CHEBI:13178"	intact:EBI-555015|uniprotkb:P39184|uniprotkb:P78091|uniprotkb:P78189|uniprotkb:P78190|uniprotkb:Q9EUP2|ensemblbacteria:AAC75357|ensemblbacteria:BAA16136	psi-mi:ltryptophan(display_short)|psi-mi:"CHEBI:16828"(display_long)|intact:"(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid"(synonym)|intact:"(S)-alpha-amino-1H-indole-3-propanoic acid"(synonym)|intact:"(S)-alpha-Amino-beta-(3-indolyl)-propionic acid"(synonym)|intact:"(S)-tryptophan"(synonym)|intact:"L-(-)-tryptophan"(synonym)|intact:L-beta-3-indolylalanine(synonym)|intact:L-Tryptophan(synonym)|intact:L-tryptophan(synonym)|intact:Trp(synonym)|intact:Tryptophan(synonym)|intact:TRYPTOPHAN(synonym)|intact:tryptophan(synonym)|intact:W(synonym)|intact:L-tryptophan(iupac name)	psi-mi:pta_ecoli(display_long)|uniprotkb:Phosphotransacetylase(gene name synonym)|uniprotkb:pta(gene name)|psi-mi:pta(display_short)|uniprotkb:b2297(locus name)|uniprotkb:JW2294(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233969|imex:IM-27509-137	author score:RF = 0.2164	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6305(identity)	refseq:NP_416800.1|refseq:WP_000086722.1|dip:DIP-35815N|ensemblbacteria:AAC75357(transcript)|ensemblbacteria:b2297(gene)|ensemblbacteria:BAA16136(gene)|ensemblbacteria:BAA16136(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006083"(acetate metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008959"(phosphate acetyltransferase activity)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0070689"(L-threonine catabolic process to propionate)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR004614(Phosphate acetyltransferase)|interpro:IPR010766(DRTGG)|interpro:IPR016475(Phosphate acetyltransferase, bacteria)|interpro:IPR027417|interpro:IPR028979|interpro:IPR042112|interpro:IPR042113	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:fX/+B9FY1uClR9GtT9XfqA4V+H083333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:13389"	uniprotkb:P26616	intact:EBI-22232180	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:nad(display_short)|psi-mi:"CHEBI:13389"(display_long)|intact:nicotinamide-adenine dinucleotide(synonym)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233717|imex:IM-27509-133	author score:RF = 0.4975	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:5893(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17489"	uniprotkb:P27550	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233997|imex:IM-27509-199	author score:RF = 0.3737	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6076(identity)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17489"	uniprotkb:P0A9B2	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-368904|uniprotkb:P06977|ensemblbacteria:AAC74849|ensemblbacteria:BAA15576	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:g3p1_ecoli(display_long)|uniprotkb:gapA(gene name)|psi-mi:gapA(display_short)|uniprotkb:NAD-dependent glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:JW1768(locus name)|uniprotkb:b1779(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22234011|imex:IM-27509-57	author score:RF = 0.4736	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6076(identity)	refseq:NP_416293.1|refseq:WP_000153502.1|ensemblbacteria:AAC74849(transcript)|ensemblbacteria:b1779(gene)|ensemblbacteria:BAA15576(gene)|ensemblbacteria:BAA15576(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|rcsb pdb:1DC4|rcsb pdb:1DC5|rcsb pdb:1DC6|rcsb pdb:1GAD|rcsb pdb:1GAE|rcsb pdb:1S7C|rcsb pdb:2VYN|rcsb pdb:2VYV|rcsb pdb:5ZA0|rcsb pdb:6IO4|rcsb pdb:6IO6|rcsb pdb:6IOJ|rcsb pdb:6UTM|rcsb pdb:6UTN|rcsb pdb:6UTO|rcsb pdb:1DC3|mint:P0A9B2|dip:DIP-31848N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:wjDK2dtZ4nPJZ0L7OVRiKfQITtg83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17489"	uniprotkb:P26616	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-9146434|uniprotkb:P78224|ensemblbacteria:AAC74552|ensemblbacteria:BAA15127	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:mao1_ecoli(display_long)|uniprotkb:sfcA(gene name synonym)|uniprotkb:JW5238(locus name)|uniprotkb:b1479(locus name)|uniprotkb:maeA(gene name)|psi-mi:maeA(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22234025|imex:IM-27509-201	author score:RF = 0.2858	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6076(identity)	interpro:IPR001891(Malic oxidoreductase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR023667|refseq:NP_415996.2|refseq:WP_000433476.1|interpro:IPR036291|interpro:IPR037062|rcsb pdb:6AGS|ensemblbacteria:AAC74552(transcript)|ensemblbacteria:b1479(gene)|ensemblbacteria:BAA15127(gene)|ensemblbacteria:BAA15127(transcript)|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:NIRBduUzrz+wtzbUMhqaCqAapOk83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:17489"	uniprotkb:P76558	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-545413|uniprotkb:P78200|uniprotkb:P78201|ensemblbacteria:AAC75516|ensemblbacteria:BAA16337	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:mao2_ecoli(display_long)|uniprotkb:maeB(gene name)|psi-mi:maeB(display_short)|uniprotkb:b2463(locus name)|uniprotkb:ypfF(gene name synonym)|uniprotkb:JW2447(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22234039|imex:IM-27509-59	author score:RF = 0.2883	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:6076(identity)	refseq:NP_416958.1|refseq:WP_000342644.1|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR012188(Malic enzyme, phosphate acetyl/butaryl transferase)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR036291|interpro:IPR037062|interpro:IPR042112|interpro:IPR042113|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC75516(transcript)|ensemblbacteria:b2463(gene)|ensemblbacteria:BAA16337(gene)|ensemblbacteria:BAA16337(transcript)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|dip:DIP-10141N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:v0w6uG/0hasSdOZcudKKN5H2a6I83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:18077"	uniprotkb:P22259	intact:EBI-22232543|chebi:"CHEBI:46175"|chebi:"CHEBI:14093"|chebi:"CHEBI:10530"|chebi:"CHEBI:27000"	intact:EBI-1132692|uniprotkb:Q2M768|ensemblbacteria:AAC76428|ensemblbacteria:BAE77888	psi-mi:dttp(display_short)|psi-mi:"CHEBI:18077"(display_long)|intact:2'-deoxythymidine triphosphate(synonym)|intact:5'-TTP(synonym)|intact:deoxy-TTP(synonym)|intact:Deoxythymidine 5'-triphosphate(synonym)|intact:Deoxythymidine triphosphate(synonym)|intact:dThd5'PPP(synonym)|intact:dTTP(synonym)|intact:pppdT(synonym)|intact:thymidine 5'-triphosphate(synonym)|intact:THYMIDINE-5'-TRIPHOSPHATE(synonym)|intact:TTP(synonym)|intact:"thymidine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:pcka_ecoli(display_long)|uniprotkb:pckA(gene name)|psi-mi:pckA(display_short)|uniprotkb:pck(gene name synonym)|uniprotkb:b3403(locus name)|uniprotkb:JW3366(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22233983|imex:IM-27509-99	author score:RF = 0.2596	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	pubchem:64968(identity)	rcsb pdb:6COM|refseq:WP_001265681.1|refseq:NP_417862.1|interpro:IPR001272(Phosphoenolpyruvate carboxykinase, ATP-utilising)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR015994("Phosphoenolpyruvate carboxykinase (ATP), conserved site")|rcsb pdb:1AQ2|rcsb pdb:1AYL|rcsb pdb:1K3C|rcsb pdb:1K3D|rcsb pdb:1OEN|rcsb pdb:1OS1|rcsb pdb:2OLQ|rcsb pdb:2OLR|rcsb pdb:2PXZ|rcsb pdb:2PY7|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|ensemblbacteria:AAC76428(transcript)|ensemblbacteria:b3403(gene)|ensemblbacteria:BAE77888(gene)|ensemblbacteria:BAE77888(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004612"("phosphoenolpyruvate carboxykinase (ATP) activity")|go:"GO:0005509"(calcium ion binding)|rcsb pdb:6ASI|rcsb pdb:6ASM|rcsb pdb:6ASN|rcsb pdb:6AT2|rcsb pdb:6AT3|rcsb pdb:6AT4|rcsb pdb:6CRT|rcsb pdb:6V2M|rcsb pdb:6V2L|rcsb pdb:6V2N	-	-	-	figure legend:Dataset EV2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/06	-	rogid:z3A0I9z8mkutYnICdpKb9w7o6bQ83333	-	false	-	his tag:n-n|green fluorescent protein tag:c-c	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:4170"	uniprotkb:P0AC53	intact:EBI-22232653	intact:EBI-555656|uniprotkb:P22992|uniprotkb:P78069|uniprotkb:Q60134|uniprotkb:Q60139|ensemblbacteria:AAC74922|ensemblbacteria:BAA15660	psi-mi:d-glucopyranose 6-phosphate(display_short)|psi-mi:"CHEBI:4170"(display_long)|intact:6-O-phosphono-D-glucopyranose(synonym)|intact:D-Glucose 6-phosphate(synonym)|intact:Glc6P(synonym)|intact:Robison ester(synonym)|intact:"D-glucopyranose 6-(dihydrogen phosphate)"(iupac name)	psi-mi:g6pd_ecoli(display_long)|uniprotkb:zwf(gene name)|psi-mi:zwf(display_short)|uniprotkb:b1852(locus name)|uniprotkb:JW1841(locus name)	psi-mi:"MI:0415"(enzymatic study)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22249081|imex:IM-27509-179	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_416366.1|refseq:WP_000301727.1|dip:DIP-35780N|mint:P0AC53|ensemblbacteria:AAC74922(transcript)|ensemblbacteria:b1852(gene)|ensemblbacteria:BAA15660(gene)|ensemblbacteria:BAA15660(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009372"(quorum sensing)|go:"GO:0042802"(identical protein binding)|go:"GO:0050661"(NADP binding)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291	go:"GO:0004344"(glucose dehydrogenase activity)	-	-	figure legend:Figure 5A, Dataset EV3|antagonist:"ATP (CHEBI:15422)"|antagonist:"GTP (CHEBI:15996)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/03	-	rogid:ntoYKRWiGdynkH9k+qgl63mGoAM83333	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:4170"	chebi:"CHEBI:18009"	intact:EBI-22232653	intact:EBI-6554966	psi-mi:d-glucopyranose 6-phosphate(display_short)|psi-mi:"CHEBI:4170"(display_long)|intact:6-O-phosphono-D-glucopyranose(synonym)|intact:D-Glucose 6-phosphate(synonym)|intact:Glc6P(synonym)|intact:Robison ester(synonym)|intact:"D-glucopyranose 6-(dihydrogen phosphate)"(iupac name)	psi-mi:nadp+(display_short)|psi-mi:"CHEBI:18009"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22249081|imex:IM-27509-179	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004344"(glucose dehydrogenase activity)	-	-	figure legend:Figure 5A, Dataset EV3|antagonist:"ATP (CHEBI:15422)"|antagonist:"GTP (CHEBI:15996)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/03	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15350"	chebi:"CHEBI:15346"	intact:EBI-22266287|chebi:"CHEBI:46262"|chebi:"CHEBI:2407"	intact:EBI-20642390|chebi:"CHEBI:741566"|chebi:"CHEBI:41631"|chebi:"CHEBI:41597"|chebi:"CHEBI:3771"|chebi:"CHEBI:13294"|chebi:"CHEBI:13295"|chebi:"CHEBI:13298"|chebi:"CHEBI:23355"	psi-mi:acetyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:15350"(display_long)|intact:acetic acid, monoanhydride with phosphoric acid(synonym)|intact:acetyl dihydrogen phosphate(synonym)|intact:Acetyl phosphate(synonym)|intact:ACETYLPHOSPHATE(synonym)|intact:acetylphosphoric acid(synonym)|intact:monoacetyl phosphate(synonym)|intact:"(acetyloxy)phosphonic acid"(iupac name)|intact:acetic phosphoric monoanhydride(iupac name)	psi-mi:coenzyme a(display_short)|psi-mi:"CHEBI:15346"(display_long)|intact:"[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate"(synonym)|intact:"3'-phosphoadenosine-(5')diphospho(4')pantatheine"(synonym)|intact:CoA(synonym)|intact:CoA-SH(synonym)|intact:CoASH(synonym)|intact:Coenzym A(synonym)|intact:Coenzyme A(synonym)|intact:COENZYME A(synonym)|intact:HSCoA(synonym)|intact:Koenzym A(synonym)|intact:"3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}"(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22266246|imex:IM-27509-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0008959"(phosphate acetyltransferase activity)	-	-	figure legend:Figure 5B, Dataset EV3|comment:"The assay showed a small, but insignificant concentration‐dependent inhibitory effect of phenylpyruvate (CHEBI:26008) and no inhibitory effect of l‐tryptophan (CHEBI:16828) on phosphate acetyltransferase activity."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/03	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15350"	uniprotkb:P0A9M8	intact:EBI-22266287|chebi:"CHEBI:46262"|chebi:"CHEBI:2407"	intact:EBI-555015|uniprotkb:P39184|uniprotkb:P78091|uniprotkb:P78189|uniprotkb:P78190|uniprotkb:Q9EUP2|ensemblbacteria:AAC75357|ensemblbacteria:BAA16136	psi-mi:acetyl dihydrogen phosphate(display_short)|psi-mi:"CHEBI:15350"(display_long)|intact:acetic acid, monoanhydride with phosphoric acid(synonym)|intact:acetyl dihydrogen phosphate(synonym)|intact:Acetyl phosphate(synonym)|intact:ACETYLPHOSPHATE(synonym)|intact:acetylphosphoric acid(synonym)|intact:monoacetyl phosphate(synonym)|intact:"(acetyloxy)phosphonic acid"(iupac name)|intact:acetic phosphoric monoanhydride(iupac name)	psi-mi:pta_ecoli(display_long)|uniprotkb:Phosphotransacetylase(gene name synonym)|uniprotkb:pta(gene name)|psi-mi:pta(display_short)|uniprotkb:b2297(locus name)|uniprotkb:JW2294(locus name)	psi-mi:"MI:0415"(enzymatic study)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22266246|imex:IM-27509-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_416800.1|refseq:WP_000086722.1|dip:DIP-35815N|ensemblbacteria:AAC75357(transcript)|ensemblbacteria:b2297(gene)|ensemblbacteria:BAA16136(gene)|ensemblbacteria:BAA16136(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006083"(acetate metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008959"(phosphate acetyltransferase activity)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0070689"(L-threonine catabolic process to propionate)|interpro:IPR002505(Phosphate acetyl/butaryl transferase)|interpro:IPR004614(Phosphate acetyltransferase)|interpro:IPR010766(DRTGG)|interpro:IPR016475(Phosphate acetyltransferase, bacteria)|interpro:IPR027417|interpro:IPR028979|interpro:IPR042112|interpro:IPR042113	go:"GO:0008959"(phosphate acetyltransferase activity)	-	-	figure legend:Figure 5B, Dataset EV3|comment:"The assay showed a small, but insignificant concentration‐dependent inhibitory effect of phenylpyruvate (CHEBI:26008) and no inhibitory effect of l‐tryptophan (CHEBI:16828) on phosphate acetyltransferase activity."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/03	-	rogid:fX/+B9FY1uClR9GtT9XfqA4V+H083333	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78682"	uniprotkb:P0AB71	intact:EBI-22231629	intact:EBI-370916|uniprotkb:P11604|uniprotkb:Q2M9R7|ensemblbacteria:AAC75962|ensemblbacteria:BAE76989	psi-mi:dfructose 1,6bisphosphate(display_short)|psi-mi:"CHEBI:78682"(display_long)|intact:Diphosphofructose(synonym)	psi-mi:alf_ecoli(display_long)|uniprotkb:fbaA(gene name)|psi-mi:fbaA(display_short)|uniprotkb:fba(gene name synonym)|uniprotkb:fda(gene name synonym)|uniprotkb:Fructose-1,6-bisphosphate aldolase(gene name synonym)|uniprotkb:Fructose-bisphosphate aldolase class II(gene name synonym)|uniprotkb:b2925(locus name)|uniprotkb:JW2892(locus name)	psi-mi:"MI:0415"(enzymatic study)	Diether et al. (2019)	doi:10.15252/msb.20199008|pubmed:31464375|imex:IM-27509	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22266381|imex:IM-27509-139	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_000034372.1|refseq:NP_417400.1|rcsb pdb:5GK6|rcsb pdb:5GK7|rcsb pdb:5GK8|rcsb pdb:5VJD|rcsb pdb:5VJE|rcsb pdb:5GK5|ensemblbacteria:AAC75962(transcript)|ensemblbacteria:b2925(gene)|ensemblbacteria:BAE76989(gene)|ensemblbacteria:BAE76989(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000771(Ketose-bisphosphate aldolase, class-II)|interpro:IPR006411(Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:1B57|rcsb pdb:1DOS|rcsb pdb:1GYN|rcsb pdb:1ZEN|rcsb pdb:5GK3|rcsb pdb:5GK4|dip:DIP-31872N	go:"GO:0097023"(fructose 6-phosphate aldolase activity)	-	-	figure legend:Figure 5C, Dataset EV3|agonist:"3PG (CHEBI:17794)"|agonist:"ATP (CHEBI:15422)"|agonist:"PEP (CHEBI:18021)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/21	2019/12/03	-	rogid:uOxFq16Vcd8IYHALwE3bQut48Ww83333	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)