#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30559	uniprotkb:P30559	intact:EBI-11724233|uniprotkb:Q15071|ensembl:ENSP00000324270	intact:EBI-11724233|uniprotkb:Q15071|ensembl:ENSP00000324270	psi-mi:oxyr_human(display_long)|uniprotkb:OXTR(gene name)|psi-mi:OXTR(display_short)	psi-mi:oxyr_human(display_long)|uniprotkb:OXTR(gene name)|psi-mi:OXTR(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407859|imex:IM-27040-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000907.2|refseq:XP_011532064.1|ensembl:ENSG00000180914(gene)|ensembl:ENST00000316793(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0032570"(response to progesterone)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0034059"(response to anoxia)|go:"GO:0032355"(response to estradiol)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6TPK|reactome:R-HSA-388479|reactome:R-HSA-416476	refseq:NP_000907.2|refseq:XP_011532064.1|ensembl:ENSG00000180914(gene)|ensembl:ENST00000316793(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0032570"(response to progesterone)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0034059"(response to anoxia)|go:"GO:0032355"(response to estradiol)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6TPK|reactome:R-HSA-388479|reactome:R-HSA-416476	-	-	-	figure legend:Supplementary figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2019/05/06	2019/05/27	rogid:e89klfpNQCOwfhTh3Jujc8s1iAU9606	rogid:e89klfpNQCOwfhTh3Jujc8s1iAU9606	rigid:JyjnbV0N7yqFwR3MrEdepvMsUzY	false	red fluorescent protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P30559	uniprotkb:P28223	intact:EBI-11724233|uniprotkb:Q15071|ensembl:ENSP00000324270	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	psi-mi:oxyr_human(display_long)|uniprotkb:OXTR(gene name)|psi-mi:OXTR(display_short)	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407869|imex:IM-27040-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000907.2|refseq:XP_011532064.1|ensembl:ENSG00000180914(gene)|ensembl:ENST00000316793(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0032570"(response to progesterone)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0034059"(response to anoxia)|go:"GO:0032355"(response to estradiol)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6TPK|reactome:R-HSA-388479|reactome:R-HSA-416476	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2019/05/06	2019/05/27	rogid:e89klfpNQCOwfhTh3Jujc8s1iAU9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:uz1+rrTIhadjiK8vZCKZGt2W138	false	red fluorescent protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P28223	uniprotkb:P30559	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	intact:EBI-11724233|uniprotkb:Q15071|ensembl:ENSP00000324270	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:oxyr_human(display_long)|uniprotkb:OXTR(gene name)|psi-mi:OXTR(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407885|imex:IM-27040-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	refseq:NP_000907.2|refseq:XP_011532064.1|ensembl:ENSG00000180914(gene)|ensembl:ENST00000316793(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0032570"(response to progesterone)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0034059"(response to anoxia)|go:"GO:0032355"(response to estradiol)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6TPK|reactome:R-HSA-388479|reactome:R-HSA-416476	go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2019/05/06	2019/05/27	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:e89klfpNQCOwfhTh3Jujc8s1iAU9606	rigid:uz1+rrTIhadjiK8vZCKZGt2W138	false	green fluorescent protein tag:c-c	red fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P14842	uniprotkb:P70536	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-21407912|ensembl:ENSRNOP00000007724|uniprotkb:Q53ZC5	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:oxyr_rat(display_long)|uniprotkb:Oxtr(gene name)|psi-mi:Oxtr(display_short)|uniprotkb:Otr(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407902|imex:IM-27040-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N	rgd:3239|ensembl:ENSRNOG00000005806(gene)|ensembl:ENSRNOT00000007724(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0034059"(response to anoxia)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044058"(regulation of digestive system process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-388479|reactome:R-RNO-416476|refseq:NP_037003.2|refseq:XP_006237070.1|refseq:XP_008761401.1|refseq:XP_008761402.1|refseq:XP_008761403.1|refseq:XP_008761404.1	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	-	figure legend:Figure 3A|comment:"A high density of PLA positive OTR-5HTR 2A heteroreceptor complexes clusters was found in the pyramidal cell layer of the CA2 and CA3 regions.  Positive complexes were also found in PoDG (polymorph layer of the dentate gyrus)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-hippocampus)|taxid:10116(Hippocampus of rat brain)	-	2019/05/06	2019/09/27	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:UBNJCplklQDilm1JKxGtEoCVpb010116	rigid:EDJfJoW/kqFi0tJknZvvgRLHNNA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14842	uniprotkb:P70536	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-21407912|ensembl:ENSRNOP00000007724|uniprotkb:Q53ZC5	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:oxyr_rat(display_long)|uniprotkb:Oxtr(gene name)|psi-mi:Oxtr(display_short)|uniprotkb:Otr(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407988|imex:IM-27040-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N	rgd:3239|ensembl:ENSRNOG00000005806(gene)|ensembl:ENSRNOT00000007724(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0034059"(response to anoxia)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044058"(regulation of digestive system process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-388479|reactome:R-RNO-416476|refseq:NP_037003.2|refseq:XP_006237070.1|refseq:XP_008761401.1|refseq:XP_008761402.1|refseq:XP_008761403.1|refseq:XP_008761404.1	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	-	figure legend:Figure 3B|comment:In the cingulate cortex   PLA positive OTR-5HTR 2A heteroreceptor complexes clusters are found in layers II and III.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2019/05/06	2019/09/27	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:UBNJCplklQDilm1JKxGtEoCVpb010116	rigid:EDJfJoW/kqFi0tJknZvvgRLHNNA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14842	uniprotkb:P70536	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-21407912|ensembl:ENSRNOP00000007724|uniprotkb:Q53ZC5	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:oxyr_rat(display_long)|uniprotkb:Oxtr(gene name)|psi-mi:Oxtr(display_short)|uniprotkb:Otr(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Chruścicka et al. (2019)	pubmed:31038917|imex:IM-27040	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21408005|imex:IM-27040-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N	rgd:3239|ensembl:ENSRNOG00000005806(gene)|ensembl:ENSRNOT00000007724(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004990"(oxytocin receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0030431"(sleep)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0034059"(response to anoxia)|go:"GO:0034097"(response to cytokine)|go:"GO:0035176"(social behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042755"(eating behavior)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044058"(regulation of digestive system process)|go:"GO:0044849"(estrous cycle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR002062(Oxytocin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-388479|reactome:R-RNO-416476|refseq:NP_037003.2|refseq:XP_006237070.1|refseq:XP_008761401.1|refseq:XP_008761402.1|refseq:XP_008761403.1|refseq:XP_008761404.1	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	-	figure legend:Figure 3B|comment:PLA positive clusters was found in the nucleus accumbens shell  and core.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-nucleus accumbens)|taxid:10116(Rat brain nucleus accumbens)	-	2019/05/06	2019/09/27	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:UBNJCplklQDilm1JKxGtEoCVpb010116	rigid:EDJfJoW/kqFi0tJknZvvgRLHNNA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)