#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04896	uniprotkb:E1BM79	intact:EBI-1027885|uniprotkb:Q0II85|uniprotkb:Q3SZE7|ensembl:ENSBTAP00000072381	intact:EBI-21453778|ensembl:ENSBTAP00000022120|ensembl:ENSBTAP00000059237	psi-mi:gnas2_bovin(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)	psi-mi:e1bm79_bovin(display_long)|uniprotkb:ADCY9(gene name)|psi-mi:ADCY9(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Qi et al. (2019)	pubmed:31023924|imex:IM-27906	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453775|wwpdb:6R3Q|wwpdb:6R4O|wwpdb:6R4P|emdb:EMD-4719|emdb:EMD-4721|emdb:EMD-4722|emdb:EMD-4723|emdb:EMD-4724|emdb:EMD-4725|emdb:EMD-4726|imex:IM-27906-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052413(gene)|ensembl:ENSBTAT00000070189(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0050890"(cognition)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1AZS|rcsb pdb:1AZT|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|rcsb pdb:3SN6|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6R3Q|rcsb pdb:6R4O|rcsb pdb:6R4P|rcsb pdb:7D68|rcsb pdb:7JJO|refseq:NP_851364.1|refseq:NP_001258700.1|dip:DIP-588N	refseq:NP_001192846.1|refseq:XP_005224539.1|ensembl:ENSBTAG00000016629(gene)|ensembl:ENSBTAT00000022120(transcript)|ensembl:ENSBTAT00000073752(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR018297|interpro:IPR029787|rcsb pdb:6R3Q|rcsb pdb:6R4O|rcsb pdb:6R4P|reactome:R-BTA-163615|reactome:R-BTA-170660|reactome:R-BTA-170670|reactome:R-BTA-418597	-	-	-	figure legend:Fig 1, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/17	2019/06/17	rogid:rTD7fCRhOQ21mLZdPipFi9k9dEM9913	rogid:Zwdx3zCfMjC4/SbRKdLJFyF0njQ9913	rigid:AyXOqRJimyG2M3rOzAOZloe+MVA	false	his tag:c-c	strep tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P04896-1	uniprotkb:E1BM79	intact:EBI-25557057|ensembl:ENSBTAP00000072381	intact:EBI-21453778|ensembl:ENSBTAP00000022120|ensembl:ENSBTAP00000059237	psi-mi:p04896-1(display_long)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Alpha-S2(isoform synonym)	psi-mi:e1bm79_bovin(display_long)|uniprotkb:ADCY9(gene name)|psi-mi:ADCY9(display_short)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2019)	pubmed:31023924|imex:IM-27906	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453818|imex:IM-27906-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000052413(gene)|ensembl:ENSBTAT00000070189(transcript)|intact:EBI-1027885(isoform-parent)	refseq:NP_001192846.1|refseq:XP_005224539.1|ensembl:ENSBTAG00000016629(gene)|ensembl:ENSBTAT00000022120(transcript)|ensembl:ENSBTAT00000073752(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR018297|interpro:IPR029787|rcsb pdb:6R3Q|rcsb pdb:6R4O|rcsb pdb:6R4P|reactome:R-BTA-163615|reactome:R-BTA-170660|reactome:R-BTA-170670|reactome:R-BTA-418597	-	-	-	figure legend:Fig S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/17	2020/04/14	rogid:rTD7fCRhOQ21mLZdPipFi9k9dEM9913	rogid:Zwdx3zCfMjC4/SbRKdLJFyF0njQ9913	rigid:AyXOqRJimyG2M3rOzAOZloe+MVA	false	his tag:c-c	yellow fluorescent protein tag:c-c|strep tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)