#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HAU4	uniprotkb:P53804	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-2681313|uniprotkb:P78477|uniprotkb:A8K7H7|uniprotkb:Q9UEK4|uniprotkb:Q569I2|uniprotkb:Q6P578|uniprotkb:B2RPA7|uniprotkb:O60767|uniprotkb:P78476|uniprotkb:D3DSG9|uniprotkb:D3DSH2|uniprotkb:D3DSH3|intact:EBI-28966952|ensembl:ENSP00000346791|ensembl:ENSP00000347889|ensembl:ENSP00000381981	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ttc3_human(display_long)|uniprotkb:DCRR1(gene name synonym)|uniprotkb:RNF105(gene name synonym)|uniprotkb:TPRD(gene name synonym)|uniprotkb:Protein DCRR1(gene name synonym)|uniprotkb:RING finger protein 105(gene name synonym)|uniprotkb:TPR repeat protein D(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 3(gene name synonym)|uniprotkb:TTC3(gene name)|psi-mi:TTC3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase TTC3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2019)	pubmed:30696809|imex:IM-27406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21228397|imex:IM-27406-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	ensembl:ENSP00000346791|ensembl:ENSP00000347889|ensembl:ENSP00000381981|refseq:NP_001307633.1|refseq:XP_011528042.1|refseq:NP_001001894.1|refseq:NP_003307.3|refseq:NP_001317610.1|refseq:NP_001317611.1|refseq:NP_001317612.1|ensembl:ENSG00000182670(gene)|ensembl:ENST00000354749(transcript)|ensembl:ENST00000355666(transcript)|ensembl:ENST00000399017(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR043866	-	-	-	agonist:"TGFB1 (P01137)"|figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-beas_2b)|taxid:9606(Human bronchial epithelial cell line BEAS-2B)	-	2019/03/04	2019/03/04	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:AUMk8fif75q+OlZMhyo2I95YkXQ9606	rigid:tYGIswFeFGqLFRXo7kYS0VHNyHk	false	myc tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HAU4	uniprotkb:P53804	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-2681313|uniprotkb:P78477|uniprotkb:A8K7H7|uniprotkb:Q9UEK4|uniprotkb:Q569I2|uniprotkb:Q6P578|uniprotkb:B2RPA7|uniprotkb:O60767|uniprotkb:P78476|uniprotkb:D3DSG9|uniprotkb:D3DSH2|uniprotkb:D3DSH3|intact:EBI-28966952|ensembl:ENSP00000346791|ensembl:ENSP00000347889|ensembl:ENSP00000381981	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ttc3_human(display_long)|uniprotkb:DCRR1(gene name synonym)|uniprotkb:RNF105(gene name synonym)|uniprotkb:TPRD(gene name synonym)|uniprotkb:Protein DCRR1(gene name synonym)|uniprotkb:RING finger protein 105(gene name synonym)|uniprotkb:TPR repeat protein D(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 3(gene name synonym)|uniprotkb:TTC3(gene name)|psi-mi:TTC3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase TTC3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2019)	pubmed:30696809|imex:IM-27406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21228406|imex:IM-27406-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	ensembl:ENSP00000346791|ensembl:ENSP00000347889|ensembl:ENSP00000381981|refseq:NP_001307633.1|refseq:XP_011528042.1|refseq:NP_001001894.1|refseq:NP_003307.3|refseq:NP_001317610.1|refseq:NP_001317611.1|refseq:NP_001317612.1|ensembl:ENSG00000182670(gene)|ensembl:ENST00000354749(transcript)|ensembl:ENST00000355666(transcript)|ensembl:ENST00000399017(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR043866	-	-	-	agonist:"TGFB1 (P01137)"|figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-beas_2b)|taxid:9606(Human bronchial epithelial cell line BEAS-2B)	-	2019/03/04	2019/03/04	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:AUMk8fif75q+OlZMhyo2I95YkXQ9606	rigid:tYGIswFeFGqLFRXo7kYS0VHNyHk	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)