#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43347	uniprotkb:O43347	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281387|imex:IM-27526-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	-	-	-	figure legend:Fig. 2A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/25	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rigid:86Z6Ix4xXHLESGTPuMIH4ukIZAY	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DH6	uniprotkb:Q96DH6	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281436|imex:IM-27526-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	-	-	-	figure legend:Fig. 2A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/25	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rigid:1/13UORWqzLeNVverCRn3fZJqkQ	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43347	uniprotkb:O43347	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:"MI:0872"(atomic force microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281463|imex:IM-27526-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	-	-	-	figure legend:Fig. 2B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/25	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rigid:86Z6Ix4xXHLESGTPuMIH4ukIZAY	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96DH6	uniprotkb:Q96DH6	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:"MI:0872"(atomic force microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281455|imex:IM-27526-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	-	-	-	figure legend:Fig. 2B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/25	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rigid:1/13UORWqzLeNVverCRn3fZJqkQ	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43347	uniprotkb:P10636-8	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281615|imex:IM-27526-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	-	-	-	figure legend:Fig. 2C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/26	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rigid:6sFNzveSe5/dszir4d1FUS72VF8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DH6	uniprotkb:P10636-8	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281640|imex:IM-27526-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	-	-	-	figure legend:Fig. 2C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/26	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rigid:WnMxfXC7oroCYZZP10xuNOAnmbE	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43347	uniprotkb:P10636-8	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281771|imex:IM-27526-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	-	-	-	figure legend:Supp. Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/26	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rigid:6sFNzveSe5/dszir4d1FUS72VF8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DH6	uniprotkb:P10636-8	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-366233|ensembl:ENSP00000303214|ensembl:ENSP00000460965|ensembl:ENSP00000477703|ensembl:ENSP00000484491|ensembl:ENSP00000487819|intact:EBI-7470331|intact:MINT-134477|intact:EBI-7470384|intact:EBI-7638179|intact:EBI-7638125|intact:EBI-7638230|intact:EBI-7638364|intact:EBI-7961077|intact:EBI-7470086|intact:EBI-7637965|intact:EBI-7638329|intact:EBI-7470156|intact:EBI-7470185|intact:EBI-7470243|intact:EBI-7638049|intact:EBI-7470111|intact:EBI-7637861	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:p10636-8(display_long)|uniprotkb:Tau-4(isoform synonym)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MAPTL(gene name synonym)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:2N4R(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281777|imex:IM-27526-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	intact:EBI-366182(tau_human)|ensembl:ENSG00000277956(gene)|ensembl:ENSG00000186868(gene)|ensembl:ENSG00000276155(gene)|ensembl:ENST00000351559(transcript)|ensembl:ENST00000574436(transcript)|ensembl:ENST00000620070(transcript)|ensembl:ENST00000621329(transcript)|ensembl:ENST00000634049(transcript)	-	-	-	figure legend:Supp Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/25	2019/03/26	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:S/u8VrnYmDN6stlDTynwCvSaOeo9606	rigid:WnMxfXC7oroCYZZP10xuNOAnmbE	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DH6	uniprotkb:Q96DH6	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281668|imex:IM-27526-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 3C|comment:Cytoplasmic accumulation of MSI2 oligomers was observed in AD brains but not the controls|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2019/03/25	2019/03/26	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rigid:1/13UORWqzLeNVverCRn3fZJqkQ	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P10636	uniprotkb:Q96DH6	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281759|imex:IM-27526-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 6, 7|comment:Observed in AD brains. Use of anti-beta-sheet oligomer antibody suggested MSI protein colocalised with tau oligomers.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2019/03/25	2019/03/26	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rigid:yfSe8Ew0qwd9a/hrTpBfXuArVkY	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P10636	uniprotkb:O43347	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	intact:EBI-726515|uniprotkb:Q96PU0|uniprotkb:Q96PU1|uniprotkb:Q96PU2|uniprotkb:Q96PU3|intact:EBI-28986772|ensembl:ENSP00000257552	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:msi1h_human(display_long)|uniprotkb:MSI1(gene name)|psi-mi:MSI1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281765|imex:IM-27526-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	refseq:NP_002433.1|ensembl:ENSP00000257552|refseq:XP_011536663.1|ensembl:ENSG00000135097(gene)|ensembl:ENST00000257552(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007399"(nervous system development)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|reactome:R-HSA-9010553	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 6, 7|comment:Observed in AD brains. Use of anti-beta-sheet oligomer antibody suggested MSI protein colocalised with tau oligomers.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2019/03/25	2019/03/26	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rogid:41/VCaTWDXjzXSisiAoG19FFVF09606	rigid:AtZkCUEikJCkB9p4j8Q/0V0MKo0	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q96DH6	uniprotkb:Q96DH6	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	intact:EBI-2462339|uniprotkb:Q7Z6M7|uniprotkb:Q8N9T4|ensembl:ENSP00000284073|ensembl:ENSP00000502137	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:msi2h_human(display_long)|uniprotkb:MSI2(gene name)|psi-mi:MSI2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Sengupta et al. (2018)	pubmed:30367664|imex:IM-27526	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21281742|imex:IM-27526-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	refseq:NP_620412.1|refseq:NP_733839.1|ensembl:ENSG00000153944(gene)|ensembl:ENST00000284073(transcript)|ensembl:ENST00000674964(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048864"(stem cell development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034126|interpro:IPR034130|interpro:IPR035979|mint:Q96DH6|rcsb pdb:6C8U|rcsb pdb:6DBP|rcsb pdb:6NTY|reactome:R-HSA-9013418	go:"GO:0097458"(obsolete neuron part)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figs 4, 5|comment:Cytoplasmic accumulation of MSI2 oligomers was observed in AD brains but not the controls|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2019/03/25	2019/03/26	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rogid:/tSHeNbYwUTw4kGlF3LQw+5OVjs9606	rigid:1/13UORWqzLeNVverCRn3fZJqkQ	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)