#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NZC2	uniprotkb:P05067-PRO_0000000092	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-821758	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020072|imex:IM-27107-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 1A, 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/24	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:TIrDN+dUjRsKCopIMacJClUdsy8	false	v5 tag:?-?|sufficient binding region:19..19-174..174|fc-igg tag:?-?|mutation with no effect:47-47|mutation with no effect:62-62	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZC2	uniprotkb:P05067-PRO_0000000092	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-821758	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020084|imex:IM-27107-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/24	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:TIrDN+dUjRsKCopIMacJClUdsy8	false	flag tag:?-?|ha tag:?-?|mutation increasing interaction strength:47-47|mutation increasing interaction strength:62-62	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86YW5	uniprotkb:P05067-PRO_0000000092	intact:EBI-17245072|uniprotkb:Q8IWY2|uniprotkb:Q496B3|uniprotkb:Q8IWY1|ensembl:ENSP00000402855	intact:EBI-821758	psi-mi:trml1_human(display_long)|uniprotkb:TREML1(gene name)|psi-mi:TREML1(display_short)|uniprotkb:TLT1(gene name synonym)|uniprotkb:Triggering receptor expressed on myeloid cells-like protein 1(gene name synonym)|uniprotkb:UNQ1825/PRO3438(orf name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020368|imex:IM-27107-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258736.1|refseq:NP_001258737.1|refseq:NP_835468.1|refseq:XP_016866312.1|refseq:XP_016866313.1|ensembl:ENSG00000161911(gene)|ensembl:ENST00000426005(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0045087"(innate immune response)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FRG|reactome:R-HSA-198933	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 1D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/24	rogid:twIFL8mwwbC1tG7ehJDBRa8QwTI9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:BzPviZKuetoZgX7Ug6i7sr5X98M	false	v5 tag:?-?|sufficient binding region:16..16-162..162|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99NH8	uniprotkb:P05067-PRO_0000000092	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	intact:EBI-821758	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21457429|imex:IM-27107-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 1A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/24	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:nXdfSO09fLZghPHJBWHhxjAgHhE	false	v5 tag:?-?|sufficient binding region:19..19-171..171|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZC2	uniprotkb:P02649	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020105|imex:IM-27107-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 1C, 1E|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/01/17	2019/06/24	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	rigid:nmQHOUH8XYc5iaEA1aps0Kg+W7I	false	v5 tag:?-?|sufficient binding region:19..19-174..174|fc-igg tag:?-?|mutation with no effect:47-47|mutation with no effect:62-62	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02649	uniprotkb:Q9NP99	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	intact:EBI-13943454|ensembl:ENSP00000244709|uniprotkb:B4DWG2|uniprotkb:K7EJW1|uniprotkb:Q53FL8|uniprotkb:Q5T2C9|uniprotkb:Q86YU1	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:trem1_human(display_long)|uniprotkb:TREM1(gene name)|psi-mi:TREM1(display_short)|uniprotkb:Triggering receptor expressed on monocytes 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020385|imex:IM-27107-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR039141|rcsb pdb:1Q8M|rcsb pdb:1SMO|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2172127|ensembl:ENSG00000124731(gene)|ensembl:ENST00000244709(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006959"(humoral immune response)|refseq:NP_001229518.1|refseq:NP_001229519.1|refseq:NP_061113.1|refseq:XP_016866445.1|refseq:XP_016866446.1	-	-	-	figure legend:Fig. 1E|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/01/17	2019/01/22	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	rogid:CcD61qYSjl6xkKd7Gh+ZFVDoURY9606	rigid:3WHjCt2wqZ0RTgO5T0K51S4uN/k	false	-	v5 tag:?-?|sufficient binding region:21..21-205..205|fc-igg tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZC2	uniprotkb:P02649	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020409|imex:IM-27107-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 2C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.9x10^-9(molar)	2019/01/17	2019/01/23	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	rigid:nmQHOUH8XYc5iaEA1aps0Kg+W7I	false	sufficient binding region:19..19-174..174|fc-igg tag:?-?|mutation with no effect:47-47|v5 tag:?-?|mutation with no effect:62-62	lipoconjugated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZC2	uniprotkb:P02649	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21020678|imex:IM-27107-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 2C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-8(molar)	2019/01/17	2019/01/23	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	rigid:nmQHOUH8XYc5iaEA1aps0Kg+W7I	false	sufficient binding region:19..19-174..174|mutation increasing interaction strength:47-47|fc-igg tag:?-?|v5 tag:?-?|mutation increasing interaction strength:62-62	lipoconjugated residue:?-?|variant:130-130	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q9NZC2	-	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022275|imex:IM-27107-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 2C, 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-12(molar)	2019/01/17	2019/01/23	-	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	-	false	-	sufficient binding region:19..19-174..174|mutation with no effect:47-47|fc-igg tag:?-?|v5 tag:?-?|mutation with no effect:62-62	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q9NZC2	intact:EBI-821758	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022296|imex:IM-27107-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 2C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-7(molar)	2019/01/17	2019/01/23	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:TIrDN+dUjRsKCopIMacJClUdsy8	false	-	sufficient binding region:19..19-174..174|mutation with no effect:47-47|fc-igg tag:?-?|v5 tag:?-?|mutation with no effect:62-62	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000093	uniprotkb:Q9NZC2	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022313|imex:IM-27107-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	chain-seq-start:672|chain-seq-end:711	-	figure legend:Fig. 2C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.4x10^-7(molar)	2019/01/17	2019/01/23	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:nygu1LDLCIxW5nTyQK5Z1PpBTWA	false	-	sufficient binding region:19..19-174..174|mutation with no effect:47-47|fc-igg tag:?-?|v5 tag:?-?|mutation with no effect:62-62	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q9NP99	-	intact:EBI-13943454|ensembl:ENSP00000244709|uniprotkb:B4DWG2|uniprotkb:K7EJW1|uniprotkb:Q53FL8|uniprotkb:Q5T2C9|uniprotkb:Q86YU1	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trem1_human(display_long)|uniprotkb:TREM1(gene name)|psi-mi:TREM1(display_short)|uniprotkb:Triggering receptor expressed on monocytes 1(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022330|imex:IM-27107-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR039141|rcsb pdb:1Q8M|rcsb pdb:1SMO|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2172127|ensembl:ENSG00000124731(gene)|ensembl:ENST00000244709(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006959"(humoral immune response)|refseq:NP_001229518.1|refseq:NP_001229519.1|refseq:NP_061113.1|refseq:XP_016866445.1|refseq:XP_016866446.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-7(molar)	2019/01/17	2019/01/23	-	rogid:CcD61qYSjl6xkKd7Gh+ZFVDoURY9606	-	false	-	sufficient binding region:21..21-205..205|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q86YW5	-	intact:EBI-17245072|uniprotkb:Q8IWY2|uniprotkb:Q496B3|uniprotkb:Q8IWY1|ensembl:ENSP00000402855	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trml1_human(display_long)|uniprotkb:TREML1(gene name)|psi-mi:TREML1(display_short)|uniprotkb:TLT1(gene name synonym)|uniprotkb:Triggering receptor expressed on myeloid cells-like protein 1(gene name synonym)|uniprotkb:UNQ1825/PRO3438(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022347|imex:IM-27107-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	refseq:NP_001258736.1|refseq:NP_001258737.1|refseq:NP_835468.1|refseq:XP_016866312.1|refseq:XP_016866313.1|ensembl:ENSG00000161911(gene)|ensembl:ENST00000426005(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0045087"(innate immune response)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FRG|reactome:R-HSA-198933	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-12(molar)	2019/01/17	2019/01/23	-	rogid:twIFL8mwwbC1tG7ehJDBRa8QwTI9606	-	false	-	sufficient binding region:16..16-162..162|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q9JKE2	-	intact:EBI-21022358|ensembl:ENSMUSP00000038636|uniprotkb:Q3TAL7	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trem1_mouse(display_long)|uniprotkb:Trem1(gene name)|psi-mi:Trem1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022391|imex:IM-27107-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	ensembl:ENSMUSG00000042265(gene)|ensembl:ENSMUST00000048782(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR039141|rcsb pdb:1U9K|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-2172127|refseq:NP_067381.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-12(molar)	2019/01/17	2019/01/23	-	rogid:vFEVJFN5uB1+7JecThWYmh6Om3c10090	-	false	-	sufficient binding region:21..21-205..205|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q99NH8	-	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022402|imex:IM-27107-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-12(molar)	2019/01/17	2019/01/23	-	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	-	false	-	sufficient binding region:19..19-174..174|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K558	intact:EBI-14348029	intact:EBI-7180658|ensembl:ENSMUSP00000024792|intact:MINT-8013457|uniprotkb:Q9D3N6|uniprotkb:B2RRH0	-	psi-mi:trml1_mouse(display_long)|uniprotkb:Treml1(gene name)|psi-mi:Treml1(display_short)|uniprotkb:Tlt1(gene name synonym)|uniprotkb:Triggering receptor expressed on myeloid cells-like protein 1(gene name synonym)	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022419|imex:IM-27107-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSMUSG00000023993(gene)|ensembl:ENSMUST00000024792(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|refseq:NP_082039.1|refseq:NP_001276380.1|refseq:NP_001276386.1	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	-	comment:mint	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig. 2D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-12(molar)	2019/01/17	2019/01/23	rogid:x5Q6zNFX0QIaj8Yfg0dzRzMl+Oo10090	-	-	false	fc-igg tag:?-?|v5 tag:?-?|sufficient binding region:16..16-162..162	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZC2	intact:EBI-14348029	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	-	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022430|imex:IM-27107-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	-	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig. 3|comment:Binding of alpha-beta42 oligomers blocked APOE3 binding. In contrast, addition of alpha-beta42 oligomers to TREM2 previously bound to APOE3 did not block subsequent interaction with alpha-beta42 oligomers.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/01/23	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	-	-	false	sufficient binding region:19..19-174..174|fc-igg tag:?-?|v5 tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZC2	uniprotkb:P02649	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022430|imex:IM-27107-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 3|comment:Binding of alpha-beta42 oligomers blocked APOE3 binding. In contrast, addition of alpha-beta42 oligomers to TREM2 previously bound to APOE3 did not block subsequent interaction with alpha-beta42 oligomers.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/01/23	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	-	false	sufficient binding region:19..19-174..174|fc-igg tag:?-?|v5 tag:?-?	lipoconjugated residue:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:Q9NZC2	-	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022459|imex:IM-27107-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 4B, EV3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/01/23	-	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	-	false	-	mutation with no effect:47-47|mutation with no effect:62-62|sufficient binding region:19..19-174..174|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q99NH8	intact:EBI-821758	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022476|imex:IM-27107-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/25	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rigid:nXdfSO09fLZghPHJBWHhxjAgHhE	false	-	sufficient binding region:19..19-171..171|fc-igg tag:?-?|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-14348029	uniprotkb:Q86YW5	-	intact:EBI-17245072|uniprotkb:Q8IWY2|uniprotkb:Q496B3|uniprotkb:Q8IWY1|ensembl:ENSP00000402855	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:trml1_human(display_long)|uniprotkb:TREML1(gene name)|psi-mi:TREML1(display_short)|uniprotkb:TLT1(gene name synonym)|uniprotkb:Triggering receptor expressed on myeloid cells-like protein 1(gene name synonym)|uniprotkb:UNQ1825/PRO3438(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022493|imex:IM-27107-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	refseq:NP_001258736.1|refseq:NP_001258737.1|refseq:NP_835468.1|refseq:XP_016866312.1|refseq:XP_016866313.1|ensembl:ENSG00000161911(gene)|ensembl:ENST00000426005(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0045087"(innate immune response)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FRG|reactome:R-HSA-198933	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig. 4B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/25	-	rogid:twIFL8mwwbC1tG7ehJDBRa8QwTI9606	-	false	-	fc-igg tag:?-?|v5 tag:?-?|sufficient binding region:16..16-162..162	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q9NZC2	intact:EBI-821758	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lessard et al. (2018)	pubmed:30341064|imex:IM-27107	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21458249|imex:IM-27107-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/17	2019/06/25	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:TIrDN+dUjRsKCopIMacJClUdsy8	false	-	mutation with no effect:62-62|sufficient binding region:19..19-171..171|fc-igg tag:?-?|v5 tag:?-?|mutation with no effect:47-47	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)