#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067	uniprotkb:O60602	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21272870|imex:IM-27502-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:Fig. 2N|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2019/03/14	2019/11/29	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:lvocJ35dgcZ/5Stn/rRLQAv7+Fw	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:O60602	intact:EBI-821758	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273633|imex:IM-27502-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig.4I, Supp Fig 5I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:mStT7ART8YJoC020VO78eiWj49A	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-14348029	uniprotkb:O60602	-	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273637|imex:IM-27502-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig.4I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	-	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	-	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273641|imex:IM-27502-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Fig.4I, Supp. Fig. 5H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:mStT7ART8YJoC020VO78eiWj49A	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000092	uniprotkb:O60602	intact:EBI-821758	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273641|imex:IM-27502-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig.4I, Supp. Fig. 5H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:mStT7ART8YJoC020VO78eiWj49A	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000093	uniprotkb:P05067-PRO_0000000093	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-2431589|intact:EBI-20772365	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273647|imex:IM-27502-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:711	chain-seq-start:672|chain-seq-end:711	figure legend:Fig.4I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rigid:ZOjePjxp4q8v6UeJDL9ag8ptHj8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O60602	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273647|imex:IM-27502-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:711	-	figure legend:Fig.4I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:ZOjePjxp4q8v6UeJDL9ag8ptHj8	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O60602	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273665|imex:IM-27502-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:711	-	figure legend:Fig.4I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:ZOjePjxp4q8v6UeJDL9ag8ptHj8	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000092	uniprotkb:O60602	intact:EBI-821758	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273679|imex:IM-27502-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig.4J, 4L, Supp. Fig. 5J|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.5x10^-9(molar)	2019/03/14	2019/03/16	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:mStT7ART8YJoC020VO78eiWj49A	false	sufficient binding region:11-42|necessary binding region:39-42	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-14348029	uniprotkb:O60602	-	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273691|imex:IM-27502-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig.4K, 4L|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.4x10^-10(molar)	2019/03/14	2019/03/16	-	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	-	false	-	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O60602	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21273698|imex:IM-27502-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	chain-seq-start:672|chain-seq-end:711	-	figure legend:Fig.4I|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-6(molar)	2019/03/14	2019/03/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:ZOjePjxp4q8v6UeJDL9ag8ptHj8	false	necessary binding region:29-40	fc-igg tag:c-c|v5 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Chakrabarty et al. (2018)	pubmed:30158114|imex:IM-27502	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21274302|imex:IM-27502-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. Fig. 5C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/14	2019/03/18	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)