#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-21017293 intact:EBI-21017498 rnacentral:URS00002075FA_9606 ensembl:ENST00000295113 psi-mi:hsa-mir-17-5p(display_short)|psi-mi:EBI-21017293(display_long) psi-mi:mrna_frzt(display_short)|psi-mi:EBI-21017498(display_long) psi-mi:"MI:2285"(miRNA interference luciferase reporter assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21017504|imex:IM-26909-1 - - psi-mi:"MI:2274"(regulator) psi-mi:"MI:2275"(regulator target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2204"(micro rna) psi-mi:"MI:0324"(messenger rna) - ensembl:ENSG00000162998(see-also)|refseq:NM_001463.4(see-also) go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing) - - figure legend:Fig 4 F, Tab S1|causality statement:down-regulates quantity by destabilization|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/01/11 2019/01/14 - - - false - luciferase tag:?-?|mutation decreasing interaction:2156-2159 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:1220"(tag visualisation by luciferase assay) intact:EBI-20558516 intact:EBI-21017498 rnacentral:URS000006FDD4_9606 ensembl:ENST00000295113 psi-mi:hsa-mir-19a-3p(display_short)|psi-mi:EBI-20558516(display_long) psi-mi:mrna_frzt(display_short)|psi-mi:EBI-21017498(display_long) psi-mi:"MI:2285"(miRNA interference luciferase reporter assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21018460|imex:IM-26909-3 - - psi-mi:"MI:2274"(regulator) psi-mi:"MI:2275"(regulator target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2204"(micro rna) psi-mi:"MI:0324"(messenger rna) - ensembl:ENSG00000162998(see-also)|refseq:NM_001463.4(see-also) go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing) - - figure legend:Fig 4 F, Tab S1|causality statement:down-regulates quantity by destabilization|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/01/11 2019/01/14 - - - false - luciferase tag:?-?|mutation decreasing interaction:1140-1145 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:P10242 ensembl:ENSG00000284536 intact:EBI-298355|uniprotkb:P78391|uniprotkb:P78392|uniprotkb:P78525|uniprotkb:P78526|uniprotkb:Q14023|uniprotkb:Q14024|uniprotkb:Q9UE83|uniprotkb:Q708E4|uniprotkb:Q708E7|ensembl:ENSP00000356788|uniprotkb:E9PNL6|uniprotkb:E9PI07|uniprotkb:E9PLZ5|uniprotkb:E9PNA4|uniprotkb:E9PRS2 intact:EBI-21280231 psi-mi:myb_human(display_long)|uniprotkb:MYB(gene name)|psi-mi:MYB(display_short)|uniprotkb:Proto-oncogene c-Myb(gene name synonym) psi-mi:hsa-mir-17 gene(display_short)|psi-mi:ENSG00000284536(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21280228|imex:IM-26909-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001155129.1|refseq:NP_001155130.1|refseq:NP_001155131.1|refseq:NP_001155132.1|refseq:NP_001123644.1|refseq:NP_001123645.1|refseq:NP_005366.2|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000845"(positive regulation of testosterone secretion)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR012642(Mitotic Wos2)|interpro:IPR015395(C-myb, C-terminal)|interpro:IPR017930|mint:P10242|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000118513(gene)|ensembl:ENST00000367814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|refseq:NP_001155128.1|dip:DIP-1057N - - - - figure legend:Fig 2 A, B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bv173r)|taxid:9606(BV173R- Human imatinib –resistant variant of BV173 expressing T315I mutation Bcr/Abl) - 2019/01/11 2019/03/22 rogid:do/bvngcNTqnh1KZE4vDAtPP0749606 - - false - sufficient binding region:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:P10242 ensembl:ENSG00000196839 intact:EBI-298355|uniprotkb:P78391|uniprotkb:P78392|uniprotkb:P78525|uniprotkb:P78526|uniprotkb:Q14023|uniprotkb:Q14024|uniprotkb:Q9UE83|uniprotkb:Q708E4|uniprotkb:Q708E7|ensembl:ENSP00000356788|uniprotkb:E9PNL6|uniprotkb:E9PI07|uniprotkb:E9PLZ5|uniprotkb:E9PNA4|uniprotkb:E9PRS2 intact:EBI-21281238 psi-mi:myb_human(display_long)|uniprotkb:MYB(gene name)|psi-mi:MYB(display_short)|uniprotkb:Proto-oncogene c-Myb(gene name synonym) psi-mi:ada_gene(display_short)|psi-mi:ENSG00000196839(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21280278|imex:IM-26909-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001155129.1|refseq:NP_001155130.1|refseq:NP_001155131.1|refseq:NP_001155132.1|refseq:NP_001123644.1|refseq:NP_001123645.1|refseq:NP_005366.2|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000845"(positive regulation of testosterone secretion)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR012642(Mitotic Wos2)|interpro:IPR015395(C-myb, C-terminal)|interpro:IPR017930|mint:P10242|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000118513(gene)|ensembl:ENST00000367814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|refseq:NP_001155128.1|dip:DIP-1057N - - - - figure legend:Fig 2 A, B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-bv173r)|taxid:9606(BV173R- Human imatinib –resistant variant of BV173 expressing T315I mutation Bcr/Abl) - 2019/01/11 2019/03/25 rogid:do/bvngcNTqnh1KZE4vDAtPP0749606 - - false - sufficient binding region:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:P10242 ensembl:ENSG00000284536 intact:EBI-298355|uniprotkb:P78391|uniprotkb:P78392|uniprotkb:P78525|uniprotkb:P78526|uniprotkb:Q14023|uniprotkb:Q14024|uniprotkb:Q9UE83|uniprotkb:Q708E4|uniprotkb:Q708E7|ensembl:ENSP00000356788|uniprotkb:E9PNL6|uniprotkb:E9PI07|uniprotkb:E9PLZ5|uniprotkb:E9PNA4|uniprotkb:E9PRS2 intact:EBI-21280231 psi-mi:myb_human(display_long)|uniprotkb:MYB(gene name)|psi-mi:MYB(display_short)|uniprotkb:Proto-oncogene c-Myb(gene name synonym) psi-mi:hsa-mir-17 gene(display_short)|psi-mi:ENSG00000284536(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21280533|imex:IM-26909-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001155129.1|refseq:NP_001155130.1|refseq:NP_001155131.1|refseq:NP_001155132.1|refseq:NP_001123644.1|refseq:NP_001123645.1|refseq:NP_005366.2|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000845"(positive regulation of testosterone secretion)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR012642(Mitotic Wos2)|interpro:IPR015395(C-myb, C-terminal)|interpro:IPR017930|mint:P10242|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000118513(gene)|ensembl:ENST00000367814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|refseq:NP_001155128.1|dip:DIP-1057N - - - - figure legend:Fig 2 A, B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2019/01/11 2019/03/22 rogid:do/bvngcNTqnh1KZE4vDAtPP0749606 - - false - sufficient binding region:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSG00000196839 uniprotkb:P10242 intact:EBI-21281238 intact:EBI-298355|uniprotkb:P78391|uniprotkb:P78392|uniprotkb:P78525|uniprotkb:P78526|uniprotkb:Q14023|uniprotkb:Q14024|uniprotkb:Q9UE83|uniprotkb:Q708E4|uniprotkb:Q708E7|ensembl:ENSP00000356788|uniprotkb:E9PNL6|uniprotkb:E9PI07|uniprotkb:E9PLZ5|uniprotkb:E9PNA4|uniprotkb:E9PRS2 psi-mi:ada_gene(display_short)|psi-mi:ENSG00000196839(display_long) psi-mi:myb_human(display_long)|uniprotkb:MYB(gene name)|psi-mi:MYB(display_short)|uniprotkb:Proto-oncogene c-Myb(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Spagnuolo et al. (2019) pubmed:30076175|imex:IM-26909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21280538|imex:IM-26909-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_001155129.1|refseq:NP_001155130.1|refseq:NP_001155131.1|refseq:NP_001155132.1|refseq:NP_001123644.1|refseq:NP_001123645.1|refseq:NP_005366.2|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|go:"GO:1904899"(positive regulation of hepatic stellate cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000845"(positive regulation of testosterone secretion)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR012642(Mitotic Wos2)|interpro:IPR015395(C-myb, C-terminal)|interpro:IPR017930|mint:P10242|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000118513(gene)|ensembl:ENST00000367814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045624"(positive regulation of T-helper cell differentiation)|refseq:NP_001155128.1|dip:DIP-1057N - - - figure legend:Fig 2 A, B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2019/01/11 2019/03/25 - rogid:do/bvngcNTqnh1KZE4vDAtPP0749606 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:0421"(identification by antibody)