#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459169|imex:IM-27135-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	go:"GO:0005886"(plasma membrane)|go:"GO:0005622"(intracellular anatomical structure)	-	-	figure legend:Figure 1A,3A|agonist:cocaine|agonist:PRE-084 -a Sigma 1R agonist|comment:Both Cocaine and PRE-084 increased colocalization of sigma- 1 R and GHS-R1a at the cell surface.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/27	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459192|imex:IM-27135-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 1C, 3B|comment:"Addition of Cocaine or  PRE-084 (Sigma-1R agonist) did not show any significant effect of treatments versus control."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	green fluorescent protein tag:?-?	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459229|imex:IM-27135-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A-Control|comment:In the presence of interference peptides,   fluorescence decreased by twofold only with TM5 and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/27	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:UAoWDNfVt15rAy/p/fK9AqsX+ig	false	cYFP:?-?	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-2	uniprotkb:Q92847-1	intact:EBI-21459245|ensembl:ENSP00000395344	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459237|imex:IM-27135-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2B/C-Control|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/27	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	cYFP:?-?	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q99720	uniprotkb:Q92847-1	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459518|imex:IM-27135-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2E-control|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/28	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	cYFP:?-?	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q99720	uniprotkb:Q92847-2	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459527|imex:IM-27135-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2F/G control|comment:In the presence of interference peptides,   fluorescence decreased only with TM1 and TM2  peptides.  A similar result was obtained in the presence of unfused GHS-R1b.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/28	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:+PKoHP015KC1zaQJL4enzelqDA4	false	cYFP:?-?	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461562|imex:IM-27135-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A-2|comment:In the presence of interference peptides,   fluorescence decreased by twofold only with TM5 and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:sYkmpsYsxtWrkN41QrcjNTLoy7Q	false	sufficient binding region:264-286|transactivating tag:n-n	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461562|imex:IM-27135-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A-2|comment:In the presence of interference peptides,   fluorescence decreased by twofold only with TM5 and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:sYkmpsYsxtWrkN41QrcjNTLoy7Q	false	sufficient binding region:264-286|transactivating tag:n-n	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461577|imex:IM-27135-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A-1|comment:In the presence of interference peptides,   fluorescence decreased by twofold only with TM5 and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:sYkmpsYsxtWrkN41QrcjNTLoy7Q	false	cYFP:?-?	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461577|imex:IM-27135-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A-1|comment:In the presence of interference peptides,   fluorescence decreased by twofold only with TM5 and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:sYkmpsYsxtWrkN41QrcjNTLoy7Q	false	cYFP:?-?	sufficient binding region:209-236|transactivating tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461616|imex:IM-27135-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2B/C-1|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:209-236|transactivating tag:c-c	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-2	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461616|imex:IM-27135-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2B/C-1|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:209-236|transactivating tag:c-c	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461631|imex:IM-27135-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2B/C-2|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:264-286|transactivating tag:n-n	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-2	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461631|imex:IM-27135-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2B/C-2|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:264-286|transactivating tag:n-n	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461669|imex:IM-27135-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2E-1|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:209-236|transactivating tag:c-c	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461669|imex:IM-27135-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 2E-1|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:209-236|transactivating tag:c-c	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461686|imex:IM-27135-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2E-2|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:40-68|transactivating tag:c-c	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461686|imex:IM-27135-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 2E-2|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:40-68|transactivating tag:c-c	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461713|imex:IM-27135-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2E-3|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:80-101|transactivating tag:n-n	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461713|imex:IM-27135-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 2E-3|comment:In the presence of interference peptides,   fluorescence decreased with  TM1, TM2, and TM5 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:77djNz+ZPjl2ES/8Y+/oK1+usi0	false	sufficient binding region:80-101|transactivating tag:n-n	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-2	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461729|imex:IM-27135-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2F/G-1|comment:In the presence of interference peptides,   fluorescence decreased only with TM1 and TM2  peptides.  A similar result was obtained in the presence of unfused GHS-R1b.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:0NTL2Jwunv/SuWkvxK21g6HN7Ns	false	sufficient binding region:40-68|transactivating tag:c-c	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461729|imex:IM-27135-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 2F/G-1|comment:In the presence of interference peptides,   fluorescence decreased only with TM1 and TM2  peptides.  A similar result was obtained in the presence of unfused GHS-R1b.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:0NTL2Jwunv/SuWkvxK21g6HN7Ns	false	sufficient binding region:40-68|transactivating tag:c-c	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-2	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461744|imex:IM-27135-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2F/G-2|comment:In the presence of interference peptides,   fluorescence decreased only with TM1 and TM2  peptides.  A similar result was obtained in the presence of unfused GHS-R1b.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:0NTL2Jwunv/SuWkvxK21g6HN7Ns	false	sufficient binding region:80-101|transactivating tag:n-n	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q99720	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-3248663|ensembl:ENSP00000277010|uniprotkb:O00673|uniprotkb:Q2TSD1|uniprotkb:Q7Z653|uniprotkb:Q153Z1|uniprotkb:Q53GN2|uniprotkb:Q9NYX0|uniprotkb:O00725|uniprotkb:Q8N7H3|uniprotkb:Q0Z9W6|uniprotkb:D3DRM7	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:sgmr1_human(display_long)|uniprotkb:SIGMAR1(gene name)|psi-mi:SIGMAR1(display_short)|uniprotkb:OPRS1(gene name synonym)|uniprotkb:SRBP(gene name synonym)|uniprotkb:Aging-associated gene 8 protein(gene name synonym)|uniprotkb:SR31747-binding protein(gene name synonym)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:AAG8(orf name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461744|imex:IM-27135-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	ensembl:ENSG00000147955(gene)|ensembl:ENST00000277010(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)|mint:Q99720|rcsb pdb:5HK1|rcsb pdb:5HK2|rcsb pdb:6DJZ|rcsb pdb:6DK0|rcsb pdb:6DK1|reactome:R-HSA-9679191|refseq:NP_005857.1|refseq:NP_671513.1|refseq:NP_001269134.1|refseq:NP_001269135.1|refseq:NP_001269136.1|refseq:NP_001269137.1|refseq:NP_001269138.1|dip:DIP-61974N	-	-	-	figure legend:Figure 2F/G-2|comment:In the presence of interference peptides,   fluorescence decreased only with TM1 and TM2  peptides.  A similar result was obtained in the presence of unfused GHS-R1b.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:iEc1O6PXikkaE/0zk0A5Z7fMIZ49606	rigid:0NTL2Jwunv/SuWkvxK21g6HN7Ns	false	sufficient binding region:80-101|transactivating tag:n-n	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-1	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055664|imex:IM-27135-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2B/C-3|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/10/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:160-181|transactivating tag:n-n	nYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92847-1	uniprotkb:Q92847-2	intact:EBI-21459171|ensembl:ENSP00000241256	intact:EBI-21459245|ensembl:ENSP00000395344	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055664|imex:IM-27135-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript)	-	-	-	figure legend:Figure 2B/C-3|comment:In the presence of interference peptides,  fluorescence decreased by twofold only with TM5 and TM6 peptides.  However in the presence of non-fused GHS-R1a, fluorescence was reduced in the presence of TM4, TM5, and TM6 peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/10/02	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606	rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8	false	sufficient binding region:160-181|transactivating tag:n-n	cYFP:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9QYH7	uniprotkb:O08725	intact:EBI-21461916|ensembl:ENSRNOP00000014103|uniprotkb:Q9ET69	intact:EBI-21459556|ensembl:ENSRNOP00000038418	psi-mi:ghrl_rat(display_long)|uniprotkb:Growth hormone secretagogue(gene name synonym)|uniprotkb:Growth hormone-releasing peptide(gene name synonym)|uniprotkb:Motilin-related peptide(gene name synonym)|uniprotkb:Ghrl(gene name)|psi-mi:Ghrl(display_short)	psi-mi:ghsr_rat(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:Ghsr(gene name)|psi-mi:Ghsr(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459552|imex:IM-27135-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010349(gene)|ensembl:ENSRNOT00000014103(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0016358"(dendrite development)|go:"GO:0016608"(growth hormone-releasing hormone activity)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031768"(ghrelin receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032097"(positive regulation of response to food)|go:"GO:0032100"(positive regulation of appetite)|refseq:NP_067701.1|rgd:632283|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035483"(gastric emptying)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042322"(negative regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046697"(decidualization)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051464"(positive regulation of cortisol secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120058"(positive regulation of small intestinal transit)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903012"(positive regulation of bone development)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904306"(positive regulation of gastro-intestinal system smooth muscle contraction)|go:"GO:1904346"(positive regulation of gastric mucosal blood circulation)|go:"GO:1904349"(positive regulation of small intestine smooth muscle contraction)|go:"GO:1905333"(regulation of gastric motility)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR005441(Preproghrelin peptide)|interpro:IPR006737(Motilin/ghrelin-associated peptide)|interpro:IPR006738(Motilin/ghrelin)|reactome:R-RNO-416476|reactome:R-RNO-422085	refseq:NP_114464.1|refseq:XP_017446630.1|refseq:XP_017446631.1|rgd:621397|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036321"(ghrelin secretion)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042562"(hormone binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043134"(regulation of hindgut contraction)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046697"(decidualization)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0060123"(regulation of growth hormone secretion)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSRNOG00000024119(gene)|ensembl:ENSRNOT00000034960(transcript)|go:"GO:0001616"(growth hormone secretagogue receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007611"(learning or memory)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016520"(growth hormone-releasing hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0032094"(response to food)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0120058"(positive regulation of small intestinal transit)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904008"(response to monosodium glutamate)|go:"GO:1904349"(positive regulation of small intestine smooth muscle contraction)|go:"GO:1905333"(regulation of gastric motility)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003905(Growth hormone secretagogue receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR039129|reactome:R-RNO-416476	-	-	-	figure legend:Figure 5C/D, 6|comment:"It is stated that \"GHS-R1a-Sigma 1 R heteroreceptor complexes were identified in striatal primary cultures\".  The  Methods section states use of \"anti-GHS-R1a antibody (1/100, AbCam,Cambridge, UK)\";however the image legend text  states that  \"a polyclonal anti-ghrelin primary antibody (1/100, AbCam,\" was used...).  The only Uniprot entry for Rat GHSR has been used here as that would appear to be the most probable protein detected."|agonist:Cocaine|comment:"Interaction was seen in thick striatal sections and also striatal primary cultures (neurons)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-striatal neurons)|taxid:10116(Rattus norvegicus)	-	2019/05/27	2019/07/02	rogid:Enr13zHHFN58ZWz4jq16vBbJdG010116	rogid:8hmG0S4y77LmOEyoAR1kwg3wB0810116	rigid:6vjauvnNrdcL4RiGJAFXetxh/DE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QYH7	uniprotkb:Q9R0C9	intact:EBI-21461916|ensembl:ENSRNOP00000014103|uniprotkb:Q9ET69	intact:EBI-1557826|uniprotkb:Q9R1J7|uniprotkb:Q9Z2W2|ensembl:ENSRNOP00000019795	psi-mi:ghrl_rat(display_long)|uniprotkb:Growth hormone secretagogue(gene name synonym)|uniprotkb:Growth hormone-releasing peptide(gene name synonym)|uniprotkb:Motilin-related peptide(gene name synonym)|uniprotkb:Ghrl(gene name)|psi-mi:Ghrl(display_short)	psi-mi:sgmr1_rat(display_long)|uniprotkb:Sigma 1-type opioid receptor(gene name synonym)|uniprotkb:Sigmar1(gene name)|psi-mi:Sigmar1(display_short)|uniprotkb:Oprs1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Aguinaga et al. (2019)	pubmed:29876881|imex:IM-27135	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21459552|imex:IM-27135-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010349(gene)|ensembl:ENSRNOT00000014103(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0016358"(dendrite development)|go:"GO:0016608"(growth hormone-releasing hormone activity)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031768"(ghrelin receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032097"(positive regulation of response to food)|go:"GO:0032100"(positive regulation of appetite)|refseq:NP_067701.1|rgd:632283|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035483"(gastric emptying)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042322"(negative regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046697"(decidualization)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0051464"(positive regulation of cortisol secretion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120058"(positive regulation of small intestinal transit)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903012"(positive regulation of bone development)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904306"(positive regulation of gastro-intestinal system smooth muscle contraction)|go:"GO:1904346"(positive regulation of gastric mucosal blood circulation)|go:"GO:1904349"(positive regulation of small intestine smooth muscle contraction)|go:"GO:1905333"(regulation of gastric motility)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000253"(positive regulation of feeding behavior)|interpro:IPR005441(Preproghrelin peptide)|interpro:IPR006737(Motilin/ghrelin-associated peptide)|interpro:IPR006738(Motilin/ghrelin)|reactome:R-RNO-416476|reactome:R-RNO-422085	rgd:68364|refseq:NP_112258.1|ensembl:ENSRNOG00000014604(gene)|ensembl:ENSRNOT00000019795(transcript)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006869"(lipid transport)|go:"GO:0007399"(nervous system development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036474"(cell death in response to hydrogen peroxide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	-	-	figure legend:Figure 5C/D, 6|comment:"It is stated that \"GHS-R1a-Sigma 1 R heteroreceptor complexes were identified in striatal primary cultures\".  The  Methods section states use of \"anti-GHS-R1a antibody (1/100, AbCam,Cambridge, UK)\";however the image legend text  states that  \"a polyclonal anti-ghrelin primary antibody (1/100, AbCam,\" was used...).  The only Uniprot entry for Rat GHSR has been used here as that would appear to be the most probable protein detected."|agonist:Cocaine|comment:"Interaction was seen in thick striatal sections and also striatal primary cultures (neurons)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-striatal neurons)|taxid:10116(Rattus norvegicus)	-	2019/05/27	2019/07/02	rogid:Enr13zHHFN58ZWz4jq16vBbJdG010116	rogid:vmBRHHmEmLai9FHo38yHlnwvEyY10116	rigid:6vjauvnNrdcL4RiGJAFXetxh/DE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)