#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q14330 uniprotkb:P34972 intact:EBI-21281800|ensembl:ENSP00000401611|ensembl:ENSP00000380613|ensembl:ENSP00000343428|ensembl:ENSP00000380610|uniprotkb:Q6GTM3|uniprotkb:Q96HI6|uniprotkb:Q9H2L2 intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596 psi-mi:gpr18_human(display_long)|uniprotkb:G-protein coupled receptor 18(gene name synonym)|uniprotkb:GPR18(gene name)|psi-mi:GPR18(display_short)|uniprotkb:GPCRW(gene name synonym) psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Reyes-Resina et al. (2018) pubmed:29870711|imex:IM-27440 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0486"(UniProt) intact:EBI-21281835|imex:IM-27440-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR028335|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|ensembl:ENST00000340807(transcript)|ensembl:ENST00000397470(transcript)|ensembl:ENST00000397473(transcript)|ensembl:ENST00000416594(transcript)|go:"GO:0002300"(CD8-positive, alpha-beta intraepithelial T cell differentiation)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|ensembl:ENSG00000125245(gene)|refseq:NP_001091670.1|refseq:NP_005283.1|refseq:XP_006720009.1 refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1 - - - figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/03/26 2019/03/26 rogid:gng0yDZNYF5JAP/AJndp0BZWj3g9606 rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606 rigid:/bpLa5rUCCMWYDqfWVxM4LJgBh4 false enhanced yellow fluorescent protein tag:c-c renilla luciferase protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P34972 uniprotkb:P21554 intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596 intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512 psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym) psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Reyes-Resina et al. (2018) pubmed:29870711|imex:IM-27440 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0486"(UniProt) intact:EBI-21281847|imex:IM-27440-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1 go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N - - - figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/03/26 2019/03/26 rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606 rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606 rigid:lD81JJ5t60PgWWNl/VaKD0cvaps false renilla luciferase protein tag:c-c enhanced yellow fluorescent protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q14330 uniprotkb:P34972 intact:EBI-21281800|ensembl:ENSP00000401611|ensembl:ENSP00000380613|ensembl:ENSP00000343428|ensembl:ENSP00000380610|uniprotkb:Q6GTM3|uniprotkb:Q96HI6|uniprotkb:Q9H2L2 intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596 psi-mi:gpr18_human(display_long)|uniprotkb:G-protein coupled receptor 18(gene name synonym)|uniprotkb:GPR18(gene name)|psi-mi:GPR18(display_short)|uniprotkb:GPCRW(gene name synonym) psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Reyes-Resina et al. (2018) pubmed:29870711|imex:IM-27440 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-21281872|imex:IM-27440-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR028335|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|ensembl:ENST00000340807(transcript)|ensembl:ENST00000397470(transcript)|ensembl:ENST00000397473(transcript)|ensembl:ENST00000416594(transcript)|go:"GO:0002300"(CD8-positive, alpha-beta intraepithelial T cell differentiation)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|ensembl:ENSG00000125245(gene)|refseq:NP_001091670.1|refseq:NP_005283.1|refseq:XP_006720009.1 refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1 - - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/03/26 2019/03/26 rogid:gng0yDZNYF5JAP/AJndp0BZWj3g9606 rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606 rigid:/bpLa5rUCCMWYDqfWVxM4LJgBh4 false enhanced yellow fluorescent protein tag:c-c renilla luciferase protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q8K1Z6 uniprotkb:P47936 intact:EBI-21281942|ensembl:ENSMUSP00000061410|uniprotkb:Q3T9N3 intact:EBI-21281906|ensembl:ENSMUSP00000069957|ensembl:ENSMUSP00000095454|uniprotkb:Q544H5 psi-mi:gpr18_mouse(display_long)|uniprotkb:Gpr18(gene name)|psi-mi:Gpr18(display_short)|uniprotkb:G-protein coupled receptor 18(gene name synonym) psi-mi:cnr2_mouse(display_long)|uniprotkb:Cnr2(gene name)|psi-mi:Cnr2(display_short) psi-mi:"MI:0813"(proximity ligation assay) Reyes-Resina et al. (2018) pubmed:29870711|imex:IM-27440 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0486"(UniProt) intact:EBI-21281897|imex:IM-27440-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000050350(gene)|ensembl:ENSMUST00000055475(transcript)|go:"GO:0002300"(CD8-positive, alpha-beta intraepithelial T cell differentiation)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR028335|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_877958.1 ensembl:ENSMUSG00000062585(gene)|ensembl:ENSMUST00000068830(transcript)|ensembl:ENSMUST00000097843(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|refseq:NP_001292207.1|refseq:NP_034054.3 - - - figure legend:Fig. 4A, 4B, 5A, 5B|agonist:"LPS (CHEBI:89983) + IFNG (P01579)"|comment:"Significant differences were found between wild-type and APPSw,Ind mice both in the percentage of cells displaying redclusters (61% in control vs73% in APPSw,Indmice) and in the number of dots/cell in cells displaying dots (3.5 in control vs 5.0in APPSw,Indmice)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-microglia)|taxid:10090(Mouse micoglia) - 2019/03/26 2019/10/29 rogid:AjOCQ61nyhVLKUUlEOB+iqbypmU10090 rogid:15Ctb0Q2RrPVNp/ACt+csuge9LI10090 rigid:mBh7Srm+wnP8Fko81db9/CXm9mE false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)