#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:26355"	uniprotkb:P11712	intact:EBI-1225103	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446252|imex:IM-27053-1|pdbe:5XXI	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2.3Å|3d-r-factors:"R-work: 0.204  R-free: 0.269"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:28-489	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6541"	uniprotkb:P11712	intact:EBI-21446242	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:losartan(display_short)|psi-mi:"CHEBI:6541"(display_long)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol"(synonym)|intact:"2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole"(synonym)|intact:Losartan(synonym)|intact:losartan(synonym)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol"(iupac name)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446252|imex:IM-27053-1|pdbe:5XXI	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2.3Å|3d-r-factors:"R-work: 0.204  R-free: 0.269"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:28-489	3	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:26355"	uniprotkb:P11712	intact:EBI-1225103	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446259|imex:IM-27053-3|pdbe:5X24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2.48Å|3d-r-factors:"R-work: 0.229  R-free: 0.27"|comment:"CYP2C9*3 (I359L) variant"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:19-490|mutation:359-359	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6541"	uniprotkb:P11712	intact:EBI-21446242	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:losartan(display_short)|psi-mi:"CHEBI:6541"(display_long)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol"(synonym)|intact:"2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole"(synonym)|intact:Losartan(synonym)|intact:losartan(synonym)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol"(iupac name)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446259|imex:IM-27053-3|pdbe:5X24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2.48Å|3d-r-factors:"R-work: 0.229  R-free: 0.27"|comment:"CYP2C9*3 (I359L) variant"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:19-490|mutation:359-359	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:26355"	uniprotkb:P11712	intact:EBI-1225103	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446273|imex:IM-27053-5|pdbe:5X23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2Å|3d-r-factors:"R-work: 0.217  R-free: 0.253"|comment:"CYP2C9 *30 (A477T) variant"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:19-490|mutation:477-477	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6541"	uniprotkb:P11712	intact:EBI-21446242	intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682	psi-mi:losartan(display_short)|psi-mi:"CHEBI:6541"(display_long)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol"(synonym)|intact:"2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole"(synonym)|intact:Losartan(synonym)|intact:losartan(synonym)|intact:"(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol"(iupac name)	psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maekawa et al. (2017)	pubmed:28972767|imex:IM-27053	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21446273|imex:IM-27053-5|pdbe:5X23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity)	-	-	-	figure legend:Table S2|3d-resolution:2Å|3d-r-factors:"R-work: 0.217  R-free: 0.253"|comment:"CYP2C9 *30 (A477T) variant"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/31	2019/06/03	-	rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606	-	false	-	his tag:c-c|sufficient binding region:19-490|mutation:477-477	3	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)