#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QXT0	uniprotkb:P11021	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21300840|imex:IM-27146-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:2SHzwuvl/HuRbs46vPoAGXvB2AA	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QXT0	uniprotkb:P11021	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21300867|imex:IM-27146-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:2SHzwuvl/HuRbs46vPoAGXvB2AA	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21303437|imex:IM-27146-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21303454|imex:IM-27146-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21303469|imex:IM-27146-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/04/15	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	his tag:n-n	t7 tag:n-n|his tag:n-n|sufficient binding region:29-510	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21397886|imex:IM-27146-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	mutation increasing interaction:28-28,31-31,86-86	t7 tag:n-n|his tag:n-n|binding-associated region:29-510	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z2B5	uniprotkb:Q9QXT0	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21397902|imex:IM-27146-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	-	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/05/02	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rigid:cauXh0eMnRRRzPyAopt0Gjb2wAo	false	t7 tag:n-n|his tag:n-n|binding-associated region:29-510	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2B5	uniprotkb:P11021	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21397902|imex:IM-27146-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/05/02	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:cauXh0eMnRRRzPyAopt0Gjb2wAo	false	t7 tag:n-n|his tag:n-n|binding-associated region:29-510	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:P11021	uniprotkb:Q9Z2B5	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21459409|imex:IM-27146-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/06/27	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:/r7VQFyyUPjbLx5chCyQsBQqnfk	false	-	t7 tag:n-n|his tag:n-n|binding-associated region:29-510	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21335520|imex:IM-27146-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 3d, Supplementary Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	his tag:n-n|mutation disrupting interaction:137-137,164-164,28-28,31-31,86-86,171-171	his tag:n-n|t7 tag:n-n|sufficient binding region:29-510	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QXT0	uniprotkb:Q9Z2B5	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21459422|imex:IM-27146-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Figure 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/06/27	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:+deZjQLU+XhaZ4aJF0wmIlDkV3Y	false	his tag:n-n|mutation:28-28,31-31,86-86	his tag:n-n|t7 tag:n-n|sufficient binding region:29-510	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZWX6	uniprotkb:Q9Z2B5	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	intact:EBI-1226344|uniprotkb:Q9CTK8|uniprotkb:Q9CWT5	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:e2ak3_mouse(display_long)|uniprotkb:Eif2ak3(gene name)|psi-mi:Eif2ak3(display_short)|uniprotkb:Pek(gene name synonym)|uniprotkb:Perk(gene name synonym)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21397873|imex:IM-27146-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)	refseq:NP_001300847.1|mint:Q9Z2B5|dip:DIP-39494N|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3QD2|rcsb pdb:4YZY|reactome:R-MMU-381042|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007595"(lactation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0001501"(skeletal system development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)	-	-	-	figure legend:Figure 3f, 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/27	2019/06/21	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	rogid:JA/YbWOU0ieAQ90kq+sS7Ul6iVI10090	rigid:Kc/mtqZUXf7sD0CW9mv4njs5eJ4	false	O-phospho-L-serine:52-52|glutathione s tranferase tag:n-n|mutation disrupting interaction rate:52-52	myc tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9QXT0	uniprotkb:P20029	intact:EBI-8321111|uniprotkb:Q3UBH8|intact:MINT-1864121|ensembl:ENSMUSP00000026446|ensembl:ENSMUSP00000151918	intact:EBI-772325|uniprotkb:Q3UFF2|uniprotkb:O35642|uniprotkb:Q61630|intact:EBI-4280750|ensembl:ENSMUSP00000028222|ensembl:ENSMUSP00000097747	psi-mi:cnpy2_mouse(display_long)|uniprotkb:Msap(gene name synonym)|uniprotkb:Zsig9(gene name synonym)|uniprotkb:Cnpy2(gene name)|psi-mi:Cnpy2(display_short)|uniprotkb:Tmem4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein ZSIG9(gene name synonym)	psi-mi:bip_mouse(display_long)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hong et al. (2017)	pubmed:28869608|imex:IM-27146	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21397924|imex:IM-27146-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064337.1|refseq:XP_006513965.1|ensembl:ENSMUSG00000025381(gene)|ensembl:ENSMUST00000026446(transcript)|ensembl:ENSMUST00000219037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9QXT0	refseq:NP_001156906.1|refseq:NP_071705.3|dip:DIP-32341N|ensembl:ENSMUSG00000026864(gene)|ensembl:ENSMUST00000028222(transcript)|ensembl:ENSMUST00000100171(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P20029|reactome:R-MMU-3371453|reactome:R-MMU-983170	-	comment:mint|function:"Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation"	-	figure legend:Supplementary Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2019/02/27	2019/05/02	rogid:XUcxQStzyg2+ed7SFuFNT3uaePs10090	rogid:AyJwwnH8IAQqF/cbTn336A79MOY10090	rigid:Z6lDerJojzAxe9vICaqGxJ2Bymg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)