#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48357	uniprotkb:Q92847-1	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914351|imex:IM-27212-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/12	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:7tSkvXS3tXy5c6/VMRncFBLZRa4	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O43613	uniprotkb:Q92847-1	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914403|imex:IM-27212-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:Sbmhq8pyYLfFbQy9VH39WEcp5rg	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P48357	uniprotkb:O43613	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914466|imex:IM-27212-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	-	-	-	figure legend:Figure 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rigid:Iq22wyvXEPEOAu0x7KOBPwVk/t0	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P48357	uniprotkb:Q92847-1	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914366|imex:IM-27212-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/12	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:7tSkvXS3tXy5c6/VMRncFBLZRa4	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43613	uniprotkb:Q92847-1	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914453|imex:IM-27212-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:Sbmhq8pyYLfFbQy9VH39WEcp5rg	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48357	uniprotkb:O43613	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914481|imex:IM-27212-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	-	-	-	figure legend:Figure 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rigid:Iq22wyvXEPEOAu0x7KOBPwVk/t0	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48357	uniprotkb:Q92847-1	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914383|imex:IM-27212-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/12	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:7tSkvXS3tXy5c6/VMRncFBLZRa4	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:O43613	uniprotkb:Q92847-1	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914445|imex:IM-27212-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:Sbmhq8pyYLfFbQy9VH39WEcp5rg	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P48357	uniprotkb:O43613	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914495|imex:IM-27212-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	-	-	-	figure legend:Figure 4B|comment:GHS-R1a-cYFP and OX 1 -nYFP interact to give  YFP fluorescence; Leptin receptor was detected by anti-Luc antibody .|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rigid:Qxw+Xm5T82pTFuENuCNXMlbIK+M	false	renilla luciferase protein tag:c-c	nYFP:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P48357	uniprotkb:Q92847-1	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914495|imex:IM-27212-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 4B|comment:GHS-R1a-cYFP and OX 1 -nYFP interact to give  YFP fluorescence; Leptin receptor was detected by anti-Luc antibody .|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/08/01	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:Qxw+Xm5T82pTFuENuCNXMlbIK+M	false	renilla luciferase protein tag:c-c	cYFP:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P48357	uniprotkb:O43613	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21914411|uniprotkb:A8K3A6|uniprotkb:Q9HBV6|ensembl:ENSP00000362810|ensembl:ENSP00000384387	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:ox1r_human(display_long)|uniprotkb:Hypocretin receptor type 1(gene name synonym)|uniprotkb:HCRTR1(gene name)|psi-mi:HCRTR1(display_short)|uniprotkb:Orexin receptor type 1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914534|imex:IM-27212-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	refseq:NP_001516.2|refseq:XP_016856594.1|refseq:XP_016856595.1|ensembl:ENSG00000121764(gene)|ensembl:ENST00000373706(transcript)|ensembl:ENST00000403528(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007631"(feeding behavior)|go:"GO:0016499"(orexin receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000204(Orexin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004059(Orexin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4ZJ8|rcsb pdb:4ZJC|rcsb pdb:6TO7|rcsb pdb:6TOD|rcsb pdb:6TOS|rcsb pdb:6TOT|rcsb pdb:6TP3|rcsb pdb:6TP4|rcsb pdb:6TP6|rcsb pdb:6TQ4|rcsb pdb:6TQ6|rcsb pdb:6TQ7|rcsb pdb:6TQ9|rcsb pdb:6V9S|reactome:R-HSA-389397|reactome:R-HSA-416476	-	-	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/12	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:Seq20+4pOemA9p7viI9Krm/n/Kc9606	rigid:Qxw+Xm5T82pTFuENuCNXMlbIK+M	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P48357	uniprotkb:Q92847-1	intact:EBI-518596|intact:EBI-1964991|intact:EBI-1965023|intact:EBI-1965042|intact:EBI-1759938|intact:EBI-1759955|intact:EBI-1759923|uniprotkb:Q13592|uniprotkb:Q13593|uniprotkb:Q13594|uniprotkb:Q92919|uniprotkb:Q92920|uniprotkb:Q92921|ensembl:ENSP00000330393	intact:EBI-21459171|ensembl:ENSP00000241256	psi-mi:lepr_human(display_long)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:HuB219(gene name synonym)|uniprotkb:LEPR(gene name)|psi-mi:LEPR(display_short)|uniprotkb:DB(gene name synonym)|uniprotkb:OBR(gene name synonym)	psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Medrano et al. (2018)	pubmed:28717967|imex:IM-27212	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21914534|imex:IM-27212-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2341"(luminescence transmitter)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003679.1|refseq:NP_001003680.1|refseq:NP_001185616.1|refseq:NP_001185617.1|refseq:NP_001185618.1|refseq:NP_002294.2|dip:DIP-6117N|ensembl:ENSG00000116678(gene)|ensembl:ENST00000349533(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|rcsb pdb:3V6O|rcsb pdb:6E2P|reactome:R-HSA-2586552	intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript)	-	-	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/07/12	rogid:vNif9Lpk4eP33Q1wzUAg5MvL2jk9606	rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606	rigid:Qxw+Xm5T82pTFuENuCNXMlbIK+M	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0866"(tag visualisation)