#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15927	uniprotkb:Q6PCD5	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Knies et al. (2017)	pubmed:28691929|imex:IM-27281	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21989474|imex:IM-27281-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	-	-	-	figure legend:Figure 4d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/08/22	2019/08/22	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rigid:N8dAf7OdeH7QAzrOVtnBCnUz67g	false	-	flag tag:?-?|mutation decreasing interaction strength:639-639	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PCD5	uniprotkb:Q6PCD5	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:"MI:0096"(pull down)	Knies et al. (2017)	pubmed:28691929|imex:IM-27281	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21989493|imex:IM-27281-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	-	-	-	figure legend:Figure 4e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/22	2019/08/22	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rigid:cNZsSYMW1KDzCQkdioaGHZhx0zw	false	his tag:?-?|mutation with no effect:315-315	green fluorescent protein tag:?-?|mutation with no effect:315-315,639-639	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15927	uniprotkb:Q6PCD5	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Knies et al. (2017)	pubmed:28691929|imex:IM-27281	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22180740|imex:IM-27281-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	-	-	-	figure legend:Figure 4b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/08/22	2019/11/01	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rigid:N8dAf7OdeH7QAzrOVtnBCnUz67g	false	-	flag tag:?-?|mutation disrupting interaction strength:639-639	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)