#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278005|imex:IM-27145-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0071"(molecular sieving) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278005|imex:IM-27145-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0819"(molecular weight estimation by bromide staining) uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278029|imex:IM-27145-3|wwpdb:5XBL - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:Figure 2, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/05/23 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false - - 1 1 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0114"(x-ray crystallography) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278029|imex:IM-27145-3|wwpdb:5XBL - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:Figure 2, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/05/23 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false - - 1 1 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:A0A459NDX2 uniprotkb:Q99ZW2 intact:EBI-21280632 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a459ndx2_lismn(display_long)|uniprotkb:acrIIA2(gene name)|psi-mi:acrIIA2(display_short)|uniprotkb:D4271_13320(orf name)|uniprotkb:D4D89_13255(orf name)|uniprotkb:B1N40_08540(orf name)|uniprotkb:B4X79_13415(orf name)|uniprotkb:E0I39_13150(orf name)|uniprotkb:FJU19_12475(orf name)|uniprotkb:G3R95_002503(orf name)|uniprotkb:AF006_07510(orf name)|uniprotkb:APD94_09090(orf name)|uniprotkb:D4C60_14490(orf name)|uniprotkb:D4D22_14105(orf name)|uniprotkb:D5M63_13385(orf name)|uniprotkb:E1V33_15495(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:1247"(microscale thermophoresis) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278032|imex:IM-27145-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003722517.1|uniprotkb:A0A394VX67(uniprot-removed-ac) ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:Figure 4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:uQJb71M81l9GjRXKHIvcnWR3OyA1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A459NDX2 intact:EBI-21406340 intact:EBI-21280632 rnacentral:URS000080E253 psi-mi:a0a459ndx2_lismn(display_long)|uniprotkb:acrIIA2(gene name)|psi-mi:acrIIA2(display_short)|uniprotkb:D4271_13320(orf name)|uniprotkb:D4D89_13255(orf name)|uniprotkb:B1N40_08540(orf name)|uniprotkb:B4X79_13415(orf name)|uniprotkb:E0I39_13150(orf name)|uniprotkb:FJU19_12475(orf name)|uniprotkb:G3R95_002503(orf name)|uniprotkb:AF006_07510(orf name)|uniprotkb:APD94_09090(orf name)|uniprotkb:D4C60_14490(orf name)|uniprotkb:D4D22_14105(orf name)|uniprotkb:D5M63_13385(orf name)|uniprotkb:E1V33_15495(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:1247"(microscale thermophoresis) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278032|imex:IM-27145-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003722517.1|uniprotkb:A0A394VX67(uniprot-removed-ac) - - - - figure legend:Figure 4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:uQJb71M81l9GjRXKHIvcnWR3OyA1639 - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:1247"(microscale thermophoresis) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21459446|imex:IM-27145-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:Figure 4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:1247"(microscale thermophoresis) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21459446|imex:IM-27145-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:Figure 4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/27 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99ZW2 intact:EBI-21406340 intact:EBI-16146275|ensemblbacteria:AAK33936 rnacentral:URS000080E253 psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278057|imex:IM-27145-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - - figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - - false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99ZW2 uniprotkb:A0A247D711 intact:EBI-16146275|ensemblbacteria:AAK33936 intact:EBI-21280061 psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278057|imex:IM-27145-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q99ZW2 uniprotkb:A0A247D711 intact:EBI-16146275|ensemblbacteria:AAK33936 intact:EBI-21280061 psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278064|imex:IM-27145-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q99ZW2 intact:EBI-21406340 intact:EBI-16146275|ensemblbacteria:AAK33936 rnacentral:URS000080E253 psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21278064|imex:IM-27145-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - - figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - - false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280033|imex:IM-27145-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:"Extended Data Figure 3b (AcrIIA4 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/28 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false mutation with no effect:12-12|mutation with no effect:38-38|glutathione s tranferase tag:n-n|mutation with no effect:23-23 - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280033|imex:IM-27145-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:"Extended Data Figure 3b (AcrIIA4 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/06/28 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false mutation with no effect:12-12|mutation with no effect:38-38|glutathione s tranferase tag:n-n|mutation with no effect:23-23 - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280069|imex:IM-27145-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:"Extended Data Figure 3b (AcrIIA4 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false mutation decreasing interaction:36-36|glutathione s tranferase tag:n-n|mutation decreasing interaction:39-39|mutation decreasing interaction:70-70|mutation decreasing interaction:69-69|mutation decreasing interaction:40-40,14-14|mutation decreasing interaction:36-36,69-69 - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280069|imex:IM-27145-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:"Extended Data Figure 3b (AcrIIA4 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false mutation decreasing interaction:36-36|glutathione s tranferase tag:n-n|mutation decreasing interaction:39-39|mutation decreasing interaction:70-70|mutation decreasing interaction:69-69|mutation decreasing interaction:40-40,14-14|mutation decreasing interaction:36-36,69-69 - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A247D711 uniprotkb:Q99ZW2 intact:EBI-21280061 intact:EBI-16146275|ensemblbacteria:AAK33936 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280075|imex:IM-27145-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1 - - - figure legend:"Extended Data Figure 3b (SpyCas9 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447 - false glutathione s tranferase tag:n-n mutation decreasing interaction:976-976,1200-1200|mutation decreasing interaction:1200-1200,1216-1216|mutation decreasing interaction:1138-1138|mutation decreasing interaction:1332-1332|mutation decreasing interaction:1335-1335|mutation decreasing interaction:1216-1216 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A0A247D711 intact:EBI-21406340 intact:EBI-21280061 rnacentral:URS000080E253 psi-mi:a0a247d711_lismn(display_long)|uniprotkb:acrIIA4(gene name)|psi-mi:acrIIA4(display_short)|uniprotkb:G3O21_003035(orf name)|uniprotkb:APD94_15065(orf name)|uniprotkb:GON91_02470(orf name)|uniprotkb:UI29_15095(orf name) psi-mi:urs000080e253_strpy_grna(display_short)|psi-mi:EBI-21406340(display_long) psi-mi:"MI:0096"(pull down) Dong et al. (2017) pubmed:28448066|imex:IM-27145 taxid:1639(lismn)|taxid:1639(Listeria monocytogenes) taxid:1314(strpy)|taxid:1314(Streptococcus pyogenes) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21280075|imex:IM-27145-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0322"(guide rna) refseq:WP_003723290.1|rcsb pdb:5XBL|rcsb pdb:5XN4 - - - - figure legend:"Extended Data Figure 3b (SpyCas9 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/19 2019/07/02 rogid:6dq/0+DU7ZJg0KTpk+VCZFiJQsI1639 - - false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0396"(predetermined participant)