#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P47746	uniprotkb:Q60613	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	intact:EBI-2909772|uniprotkb:Q2NLC1|ensembl:ENSMUSP00000101060	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:aa2ar_mouse(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917256|imex:IM-27166-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	ensembl:ENSMUSG00000020178(gene)|ensembl:ENSMUST00000105420(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-417973|reactome:R-MMU-418555|reactome:R-MMU-5683826|refseq:NP_001318024.1|refseq:NP_001318025.1|refseq:NP_033760.2|refseq:XP_006513156.1	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Figure 1, Supplementary Figure 2|comment:When using tissue from mutant mice bearing a genetic deletion of CB1R in forebrain GABAergic neurons, a reduction  in the number of dots was observed, but no reduction was seen when using mice with a genetic deletion of CB1R glutamatergic neurons.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2019/06/05	2019/07/16	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rogid:dRZKNECmwT+CT80r2Nd0BClhXX410090	rigid:UGeMlmRxKpTPBvd+nCAfV+oKMWc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917270|imex:IM-27166-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/06/05	2019/07/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	cYFP:c-c	nYFP:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917278|imex:IM-27166-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/06/05	2019/07/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	cYFP:c-c	sufficient binding region:273-299|transactivating tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917278|imex:IM-27166-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/06/05	2019/07/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	cYFP:c-c	nYFP:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917291|imex:IM-27166-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/06/05	2019/07/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	cYFP:c-c	sufficient binding region:343-368|transactivating tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917291|imex:IM-27166-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/06/05	2019/07/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	cYFP:c-c	nYFP:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P47746	uniprotkb:Q60613	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	intact:EBI-2909772|uniprotkb:Q2NLC1|ensembl:ENSMUSP00000101060	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:aa2ar_mouse(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917577|imex:IM-27166-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	ensembl:ENSMUSG00000020178(gene)|ensembl:ENSMUST00000105420(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-417973|reactome:R-MMU-418555|reactome:R-MMU-5683826|refseq:NP_001318024.1|refseq:NP_001318025.1|refseq:NP_033760.2|refseq:XP_006513156.1	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Figure 3a|comment:Expression of mutant huntingtin does not prevent heteromerization of both receptors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-STHdhq111/q111)|taxid:10090(immortalised embryonic striatal cells with humanised HTT Exon 1 and 111 CAG repeats)	-	2019/06/05	2019/07/16	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rogid:dRZKNECmwT+CT80r2Nd0BClhXX410090	rigid:UGeMlmRxKpTPBvd+nCAfV+oKMWc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P47746	uniprotkb:Q60613	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	intact:EBI-2909772|uniprotkb:Q2NLC1|ensembl:ENSMUSP00000101060	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:aa2ar_mouse(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917696|imex:IM-27166-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	ensembl:ENSMUSG00000020178(gene)|ensembl:ENSMUST00000105420(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-417973|reactome:R-MMU-418555|reactome:R-MMU-5683826|refseq:NP_001318024.1|refseq:NP_001318025.1|refseq:NP_033760.2|refseq:XP_006513156.1	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Figure 4A, Supplementary Figure S7a/b|comment:By the age of 4 months in heterozygous mutant HdhQ7/Q111 mice  expression of A2AR-CB1R heteromers was at similar levels as  wild-type, but by the age of 6-8 months was almost completely lost.  A similar result was obtained using R6/1 or R6/2 mice.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2019/06/05	2019/07/16	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rogid:dRZKNECmwT+CT80r2Nd0BClhXX410090	rigid:UGeMlmRxKpTPBvd+nCAfV+oKMWc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P61168	uniprotkb:P47746	intact:EBI-8019871|uniprotkb:P13953|intact:MINT-5313868|uniprotkb:Q0VGH9|ensembl:ENSMUSP00000075170	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	psi-mi:drd2_mouse(display_long)|uniprotkb:Dopamine D2 receptor(gene name synonym)|uniprotkb:Drd2(gene name)|psi-mi:Drd2(display_short)	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923027|imex:IM-27166-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034207.2|refseq:XP_006510059.1|ensembl:ENSMUSG00000032259(gene)|ensembl:ENSMUST00000075764(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006914"(autophagy)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030534"(adult behavior)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031223"(auditory behavior)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390651	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	go:"GO:0048471"(perinuclear region of cytoplasm)	comment:mint|function:"This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase"	-	figure legend:Supplementary Figure 6C, 7C|comment:CB1R-D2R heteromer expression was not reduced in 6-month-old mutant HdhQ7/Q111 mice compared with their wild-type controls.  A similar result was obtained using R6/1 or R6/2 mice.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-striatum)|taxid:10090(Mouse striatum)	-	2019/06/05	2019/07/17	rogid:b5aAA6i4aqki/+7Ardtrfizn/OY10090	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rigid:1OIBhNjzonWapOGywZ4P/p5q+Fs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P47746	uniprotkb:Q60613	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	intact:EBI-2909772|uniprotkb:Q2NLC1|ensembl:ENSMUSP00000101060	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:aa2ar_mouse(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21917709|imex:IM-27166-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	ensembl:ENSMUSG00000020178(gene)|ensembl:ENSMUST00000105420(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-417973|reactome:R-MMU-418555|reactome:R-MMU-5683826|refseq:NP_001318024.1|refseq:NP_001318025.1|refseq:NP_033760.2|refseq:XP_006513156.1	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Figure 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:11090(mouse-STHdhQ7/Q7)|taxid:11090(mouse STHdhQ7/Q7)	-	2019/06/05	2019/07/16	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rogid:dRZKNECmwT+CT80r2Nd0BClhXX410090	rigid:UGeMlmRxKpTPBvd+nCAfV+oKMWc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Moreno et al. (2018)	pubmed:28102227|imex:IM-27166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923020|imex:IM-27166-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Figure 5, Supplementary figure 8|comment:"A2AR-CB1R heteromers were readily evident in the caudate-putamen of control individuals, and were also detected at those normal levels in asymptomatic huntingtin gene-mutation carriers (HD grade 0) and early symptomatic HD patients (HD grades 1–2).  However  number of cells with A2AR-CB1R heteromers was strongly reduced in caudate-putamen samples from high-grade, advanced HD patients (HD grades 3–4)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-striatum)|taxid:9606(HUMAN BRAIN STRIATUM)	-	2019/06/05	2019/07/17	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)