#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:26355"	uniprotkb:P08684	intact:EBI-1225103	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923627|imex:IM-27170-1|pdbe:5TE8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Table S1|3d-resolution:2.7Å|3d-r-factors:"Rwork: 0.224  Rfree: 0.292"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/18	2019/07/18	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	sufficient binding region:21-503	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6931"	uniprotkb:P08684	intact:EBI-21923616	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:midazolam(display_short)|psi-mi:"CHEBI:6931"(display_long)|intact:Buccolam(synonym)|intact:Dormicum(synonym)|intact:mezolam(synonym)|intact:midazolam(synonym)|intact:midazolamum(synonym)|intact:"8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine"(iupac name)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923627|imex:IM-27170-1|pdbe:5TE8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Table S1|3d-resolution:2.7Å|3d-r-factors:"Rwork: 0.224  Rfree: 0.292"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/18	2019/07/18	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	sufficient binding region:21-503	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:26355"	uniprotkb:P08684	intact:EBI-1225103	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0966"(ultraviolet-visible spectroscopy)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923651|imex:IM-27170-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.8x10^-6 ~0.4(molar)	2019/07/18	2019/07/18	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	mutation decreasing interaction strength:119-119	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6931"	uniprotkb:P08684	intact:EBI-21923616	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:midazolam(display_short)|psi-mi:"CHEBI:6931"(display_long)|intact:Buccolam(synonym)|intact:Dormicum(synonym)|intact:mezolam(synonym)|intact:midazolam(synonym)|intact:midazolamum(synonym)|intact:"8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine"(iupac name)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0966"(ultraviolet-visible spectroscopy)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923651|imex:IM-27170-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.8x10^-6 ~0.4(molar)	2019/07/18	2019/07/18	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	mutation decreasing interaction strength:119-119	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:26355"	uniprotkb:P08684	intact:EBI-1225103	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0966"(ultraviolet-visible spectroscopy)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21949892|imex:IM-27170-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-6 ~0.2(molar)	2019/07/18	2019/08/05	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	mutation decreasing interaction strength:119-119	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:6931"	uniprotkb:P08684	intact:EBI-21923616	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:midazolam(display_short)|psi-mi:"CHEBI:6931"(display_long)|intact:Buccolam(synonym)|intact:Dormicum(synonym)|intact:mezolam(synonym)|intact:midazolam(synonym)|intact:midazolamum(synonym)|intact:"8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine"(iupac name)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0966"(ultraviolet-visible spectroscopy)	Sevrioukova et al. (2017)	pubmed:28031486|imex:IM-27170	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21949892|imex:IM-27170-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-6 ~0.2(molar)	2019/07/18	2019/08/05	-	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	-	false	-	mutation decreasing interaction strength:119-119	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)