#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WUJ0	uniprotkb:P15927	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q8WXF1	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q86YZ3	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1047017|uniprotkb:Q5U1F4|ensembl:ENSP00000357791|uniprotkb:Q5DT20	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:horn_human(display_long)|uniprotkb:HRNR(gene name)|psi-mi:HRNR(display_short)|uniprotkb:S100A18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001009931.1|ensembl:ENSG00000197915(gene)|ensembl:ENST00000368801(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031424"(keratinization)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0043163"(cell envelope organization)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR033201|interpro:IPR034325|mint:Q86YZ3|reactome:R-HSA-6798695|ensembl:ENSP00000357791	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:j5ATFM7OQGbf5j+CZpJ3bJoadnc9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q6PIJ6	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2513135|ensembl:ENSP00000342023|uniprotkb:Q9HC40|uniprotkb:Q86VN3|uniprotkb:Q7Z2U0|uniprotkb:Q9H837|uniprotkb:Q9BXY6|uniprotkb:Q6PK72	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:fbx38_human(display_long)|uniprotkb:FBXO38(gene name)|psi-mi:FBXO38(display_short)|uniprotkb:SP329(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR042354|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000145868(gene)|ensembl:ENST00000340253(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|refseq:NP_110420.3|refseq:NP_001258652.1|refseq:XP_005268570.1	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:/j2W7mAL7RdWukKthtgCaX3cV3k9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P13051	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1025947|uniprotkb:O00637|uniprotkb:O00719|uniprotkb:Q93028|uniprotkb:A8K5M6|uniprotkb:B2R8Y1|ensembl:ENSP00000242576	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:ung_human(display_long)|uniprotkb:UNG(gene name)|psi-mi:UNG(display_short)|uniprotkb:DGU(gene name synonym)|uniprotkb:UNG15(gene name synonym)|uniprotkb:UNG1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_003353.1|refseq:NP_550433.1|ensembl:ENSG00000076248(gene)|ensembl:ENST00000242576(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045008"(depyrimidination)|go:"GO:0045190"(isotype switching)|go:"GO:0097510"(base-excision repair, AP site formation via deaminated base removal)|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR018085|interpro:IPR036895|rcsb pdb:1AKZ|rcsb pdb:1DPU|rcsb pdb:1EMH|rcsb pdb:1EMJ|rcsb pdb:1Q3F|rcsb pdb:1SSP|rcsb pdb:1UGH|rcsb pdb:1YUO|rcsb pdb:2HXM|rcsb pdb:2OXM|rcsb pdb:2OYT|rcsb pdb:2SSP|rcsb pdb:3FCF|rcsb pdb:3FCI|rcsb pdb:3FCK|rcsb pdb:3FCL|rcsb pdb:3TKB|rcsb pdb:4SKN|rcsb pdb:5AYR|rcsb pdb:5JK7|rcsb pdb:6VBA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|dip:DIP-24194N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:pjzUi17Vpmhp1JddThFwPvNhZCE9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P36551	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-3907775|uniprotkb:B4DSD5|uniprotkb:A8K275|uniprotkb:Q96AF3|uniprotkb:Q14060|uniprotkb:Q53F08|uniprotkb:Q8IZ45|ensembl:ENSP00000497326	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:hem6_human(display_long)|uniprotkb:CPOX(gene name)|psi-mi:CPOX(display_short)|uniprotkb:CPO(gene name synonym)|uniprotkb:CPX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_000088.3|ensembl:ENSG00000080819(gene)|ensembl:ENST00000647941(transcript)|go:"GO:0004109"(coproporphyrinogen oxidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001260(Coproporphyrinogen III oxidase)|interpro:IPR018375|interpro:IPR036406|rcsb pdb:2AEX|reactome:R-HSA-189451	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:6OcfvXHAsnD3PgxF7vrqSF+cVMA9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P12270	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q6KB66	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-3046635|ensembl:ENSP00000378292|uniprotkb:Q7Z3Q0|uniprotkb:Q6P1A5	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:k2c80_human(display_long)|uniprotkb:KRT80(gene name)|psi-mi:KRT80(display_short)|uniprotkb:KB20(gene name synonym)|uniprotkb:Cytokeratin-80(gene name synonym)|uniprotkb:Keratin-80(gene name synonym)|uniprotkb:Type-II keratin Kb20(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	ensembl:ENSG00000167767(gene)|ensembl:ENST00000394815(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|interpro:IPR003054(Type II keratin)|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0005737"(cytoplasm)|refseq:NP_001074961.1|refseq:NP_872313.2	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:bFGJxzEmmWY5N3kaTviqyx5qSkY9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q8WV92	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2691489|uniprotkb:Q69YV0|ensembl:ENSP00000289359	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:mitd1_human(display_long)|uniprotkb:MITD1(gene name)|psi-mi:MITD1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_620153.1|refseq:NP_001307346.1|refseq:NP_001307347.1|refseq:NP_001307348.1|ensembl:ENSG00000158411(gene)|ensembl:ENST00000289359(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007330(MIT)|interpro:IPR032341|interpro:IPR036181|interpro:IPR038113|rcsb pdb:2YMB|rcsb pdb:4A5X|rcsb pdb:4A5Z	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:VY5MeLAmoWXB0gKSJR3d9OhT1Vk9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q5XUX0	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-6162477|uniprotkb:Q5K680|uniprotkb:Q8WYV1|uniprotkb:Q96D73|uniprotkb:Q9UFV4|ensembl:ENSP00000310841	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:fbx31_human(display_long)|uniprotkb:FBXO31(gene name)|psi-mi:FBXO31(display_short)|uniprotkb:FBX14(gene name synonym)|uniprotkb:FBX31(gene name synonym)|uniprotkb:PP2386(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001269612.1|refseq:NP_079011.3|dip:DIP-60449N|ensembl:ENSG00000103264(gene)|ensembl:ENST00000311635(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR026941|interpro:IPR036047|rcsb pdb:5VZT|rcsb pdb:5VZU|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:0nP/jd8zyh8MyYl22ZPicbiNyVU9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P30043	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2837485|uniprotkb:P53005|uniprotkb:P32078|uniprotkb:Q32LZ2|uniprotkb:B2R5C6|uniprotkb:A6NKD8|ensembl:ENSP00000263368	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:blvrb_human(display_long)|uniprotkb:BLVRB(gene name)|psi-mi:BLVRB(display_short)|uniprotkb:FLR(gene name synonym)|uniprotkb:Biliverdin reductase B(gene name synonym)|uniprotkb:Biliverdin-IX beta-reductase(gene name synonym)|uniprotkb:Green heme-binding protein(gene name synonym)|uniprotkb:NADPH-dependent diaphorase(gene name synonym)|uniprotkb:NADPH-flavin reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_000704.1|ensembl:ENSG00000090013(gene)|ensembl:ENST00000263368(transcript)|go:"GO:0004074"("biliverdin reductase (NAD(P)+) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106276"(biliberdin reductase NAD+ activity)|go:"GO:0106277"("biliverdin reductase (NADP+) activity")|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1HDO|rcsb pdb:1HE2|rcsb pdb:1HE3|rcsb pdb:1HE4|rcsb pdb:1HE5|rcsb pdb:5OOG|rcsb pdb:5OOH|rcsb pdb:6OPL|reactome:R-HSA-189483|reactome:R-HSA-9707564	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:dAGhnUTdZxBN2cUpArtdmrVdeKw9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P30086	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-716384|uniprotkb:B2R4S1|ensembl:ENSP00000261313	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:pebp1_human(display_long)|uniprotkb:Prostatic-binding protein(gene name synonym)|uniprotkb:HCNPpp(gene name synonym)|uniprotkb:Neuropolypeptide h3(gene name synonym)|uniprotkb:Raf kinase inhibitor protein(gene name synonym)|uniprotkb:PEBP1(gene name)|psi-mi:PEBP1(display_short)|uniprotkb:PEBP(gene name synonym)|uniprotkb:PBP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_002558.1|ensembl:ENSG00000089220(gene)|ensembl:ENST00000261313(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001858(Phosphatidylethanolamine-binding, conserved site)|interpro:IPR008914(Phosphatidylethanolamine-binding protein PEBP)|interpro:IPR035810|interpro:IPR036610|mint:P30086|rcsb pdb:1BD9|rcsb pdb:1BEH|rcsb pdb:2L7W|rcsb pdb:2QYQ|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|dip:DIP-44269N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:6NY/YmyO5c8tNYfXtujwvP2chIc9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q5JTJ3	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2874677|ensembl:ENSP00000355572|uniprotkb:Q8TA88|uniprotkb:Q5JTJ4|uniprotkb:Q5JTJ2	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:coa6_human(display_long)|uniprotkb:COA6(gene name)|psi-mi:COA6(display_short)|uniprotkb:C1orf31(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	ensembl:ENSG00000168275(gene)|ensembl:ENST00000366613(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005886"(plasma membrane)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0042774"(plasma membrane ATP synthesis coupled electron transport)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|interpro:IPR042289|rcsb pdb:6NL3|rcsb pdb:6PCE|rcsb pdb:6PCF|reactome:R-HSA-1268020|refseq:NP_001013003.1|refseq:NP_001288662.1|refseq:NP_001193570.2	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:RhW1GWfW6148hd0Pa3uXIkRYkRY9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q12904	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1045802|uniprotkb:Q6FG28|uniprotkb:Q96CQ9|uniprotkb:B4E1S7|uniprotkb:B3KTR2|ensembl:ENSP00000350699|ensembl:ENSP00000499850|ensembl:ENSP00000499921|ensembl:ENSP00000500025|ensembl:ENSP00000500159|ensembl:ENSP00000500170|ensembl:ENSP00000500620|ensembl:ENSP00000500668|ensembl:ENSP00000500732|ensembl:ENSP00000500794	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:aimp1_human(display_long)|uniprotkb:AIMP1(gene name)|psi-mi:AIMP1(display_short)|uniprotkb:EMAP2(gene name synonym)|uniprotkb:SCYE1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001135887.1|refseq:NP_001135888.1|refseq:NP_004748.2|ensembl:ENSG00000164022(gene)|ensembl:ENST00000358008(transcript)|ensembl:ENST00000671868(transcript)|ensembl:ENST00000671960(transcript)|ensembl:ENST00000672285(transcript)|ensembl:ENST00000672328(transcript)|ensembl:ENST00000672337(transcript)|ensembl:ENST00000672341(transcript)|ensembl:ENST00000672911(transcript)|ensembl:ENST00000673018(transcript)|ensembl:ENST00000673123(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051020"(GTPase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070094"(positive regulation of glucagon secretion)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q12904|rcsb pdb:1E7Z|rcsb pdb:1EUJ|rcsb pdb:1FL0|rcsb pdb:4R3Z|reactome:R-HSA-2408522|reactome:R-HSA-379716|refseq:XP_016864324.1|refseq:XP_016864325.1	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:UtCeSRjFyuuEHUxVF2HkG9RA55k9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:O75531	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1055977|uniprotkb:O60558|uniprotkb:Q6FGG7|ensembl:ENSP00000310275|ensembl:ENSP00000416128|ensembl:ENSP00000432867|ensembl:ENSP00000433760	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:baf_human(display_long)|uniprotkb:BANF1(gene name)|psi-mi:BANF1(display_short)|uniprotkb:BAF(gene name synonym)|uniprotkb:BCRG1(gene name synonym)|uniprotkb:Breakpoint cluster region protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001137457.1|refseq:NP_003851.1|ensembl:ENST00000445560(transcript)|ensembl:ENST00000527348(transcript)|ensembl:ENST00000533166(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097726"(LEM domain binding)|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617|mint:O75531|rcsb pdb:1CI4|rcsb pdb:1QCK|rcsb pdb:2BZF|rcsb pdb:2EZX|rcsb pdb:2EZY|rcsb pdb:2EZZ|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:6UNT|rcsb pdb:6URE|rcsb pdb:6URJ|rcsb pdb:6URK|rcsb pdb:6URL|rcsb pdb:6URN|rcsb pdb:6URR|rcsb pdb:6URZ|rcsb pdb:6US0|rcsb pdb:6US1|rcsb pdb:6US7|rcsb pdb:6USB|rcsb pdb:6USD|rcsb pdb:6USI|rcsb pdb:7NDY|ensembl:ENSG00000175334(gene)|ensembl:ENST00000312175(transcript)|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2980766|reactome:R-HSA-2995383|refseq:XP_016874003.1|refseq:XP_016874004.1|dip:DIP-50395N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:JSfPqQhIXIFEXNQn1+I8v5zG+Hw9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:P78347	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-359622|uniprotkb:Q75M88|uniprotkb:O14743|uniprotkb:O15359|uniprotkb:O43546|uniprotkb:O43588|uniprotkb:O43589|uniprotkb:Q9BSZ4|uniprotkb:Q86U51|uniprotkb:Q75M85|uniprotkb:Q75M86|uniprotkb:Q75M87|ensembl:ENSP00000460070	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:gtf2i_human(display_long)|uniprotkb:GTF2I(gene name)|psi-mi:GTF2I(display_short)|uniprotkb:BAP135(gene name synonym)|uniprotkb:WBSCR6(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)|uniprotkb:SRF-Phox1-interacting protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 6 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001509.3|refseq:NP_127492.1|refseq:NP_127493.1|refseq:NP_127494.1|ensembl:ENSG00000263001(gene)|ensembl:ENST00000573035(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|mint:P78347|rcsb pdb:2D9B|rcsb pdb:2DN4|rcsb pdb:2ED2|rcsb pdb:2EJE|interpro:IPR036647|refseq:NP_001157108.1|refseq:NP_001267729.1|dip:DIP-24252N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:DqfrIS0Ey+XvZfTXmk9KQzBtQo49606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q969H0	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q9BVC5	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-5458641|uniprotkb:B3KXN3|ensembl:ENSP00000258457|uniprotkb:B4E2G9	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:ashwn_human(display_long)|uniprotkb:C2orf49(gene name)|psi-mi:C2orf49(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_076998.1|ensembl:ENSG00000135974(gene)|ensembl:ENST00000258457(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR024887|reactome:R-HSA-6784531|refseq:NP_001273466.1|refseq:XP_016860381.1	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:G3jad0mGv7VlRQWj5kloN+mO+X49606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q9P2E9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2371806|uniprotkb:A2A2S6|uniprotkb:A6NCN6|uniprotkb:O75300|uniprotkb:O75301|uniprotkb:Q5W165|uniprotkb:Q96SB2|uniprotkb:Q9BWP1|uniprotkb:Q9H476|uniprotkb:A0A0A0MRV0|intact:EBI-28985482|ensembl:ENSP00000246043|ensembl:ENSP00000367044	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:rrbp1_human(display_long)|uniprotkb:RRBP1(gene name)|psi-mi:RRBP1(display_short)|uniprotkb:KIAA1398(gene name synonym)|uniprotkb:Ribosome receptor protein(gene name synonym)|uniprotkb:180 kDa ribosome receptor homolog(gene name synonym)|uniprotkb:ES/130-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001036041.1|refseq:NP_004578.2|ensembl:ENSP00000246043|ensembl:ENST00000360807|ensembl:ENSP00000354045|ensembl:ENST00000377807|ensembl:ENSP00000367038|ensembl:ENSP00000367044|ensembl:ENSG00000125844(gene)|ensembl:ENST00000246043(transcript)|ensembl:ENST00000377813(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR007794(Ribosome receptor lysine or proline rich)|interpro:IPR040248|mint:Q9P2E9	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:uOiVzIAM5bsSl2s1BSIfnUtZ3Ms9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q562R1	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-1773495|uniprotkb:Q562R2|uniprotkb:Q562S9|uniprotkb:Q562X8|uniprotkb:B2RPJ1|ensembl:ENSP00000416706	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:actbl_human(display_long)|uniprotkb:ACTBL2(gene name)|psi-mi:ACTBL2(display_short)|uniprotkb:Kappa-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001017992.1|ensembl:ENSG00000169067(gene)|ensembl:ENST00000423391(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:Q562R1	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:GTzKP5YRJGH8ocAJW0WEsdQFEdc9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q01518	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2808398|ensembl:ENSP00000361878|ensembl:ENSP00000361883|ensembl:ENSP00000361891|uniprotkb:Q6I9U6|uniprotkb:Q5T0S2|uniprotkb:Q53HR7|uniprotkb:Q5T0S1	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:cap1_human(display_long)|uniprotkb:CAP1(gene name)|psi-mi:CAP1(display_short)|uniprotkb:CAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	ensembl:ENSG00000131236(gene)|ensembl:ENST00000372792(transcript)|ensembl:ENST00000372797(transcript)|ensembl:ENST00000372805(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045761"(regulation of adenylate cyclase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|go:"GO:0001667"(ameboidal-type cell migration)|interpro:IPR036222|interpro:IPR036223|mint:Q01518|rcsb pdb:1K8F|reactome:R-HSA-114608|reactome:R-HSA-428890|reactome:R-HSA-6798695|refseq:XP_011538811.1|refseq:XP_011538812.1|refseq:XP_011538813.1|refseq:XP_011538814.1|refseq:XP_011538815.1|refseq:XP_011538816.1|refseq:XP_011538817.1|refseq:NP_001099000.1|refseq:NP_006358.1|refseq:XP_016855556.1|refseq:XP_016855557.1|refseq:XP_016855558.1|refseq:XP_016855559.1|refseq:XP_016855560.1|refseq:XP_016855561.1|refseq:XP_005270425.1|dip:DIP-62063N	-	-	crc64:7789D1FAC0D1AB7B	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:BXrQm0u+e0xVOl2b+A18GrZy5Eg9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8WUJ0	uniprotkb:Q8WUF8	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	intact:EBI-2556079|uniprotkb:Q9H0U8|uniprotkb:B2R7C6|uniprotkb:B4DJ14|uniprotkb:B4DLG5|ensembl:ENSP00000379294	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:f172a_human(display_long)|uniprotkb:C5orf21(gene name synonym)|uniprotkb:FAM172A(gene name)|psi-mi:FAM172A(display_short)|uniprotkb:Protein FAM172A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945299|imex:IM-27219-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	refseq:NP_001156889.1|refseq:NP_001156890.1|refseq:NP_114431.2|refseq:XP_011541974.1|refseq:XP_006714780.1|refseq:XP_016865444.1|refseq:XP_016865445.1|ensembl:ENSG00000113391(gene)|ensembl:ENST00000395965(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0014032"(neural crest cell development)|go:"GO:0031048"(heterochromatin assembly by small RNA)|interpro:IPR029058|interpro:IPR039929	-	-	-	figure legend:Table EV1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/02	2019/08/05	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rogid:6bDzV1sfpO3EGQ74VuWXY9g5p5A9606	rigid:qWFsHbwyrNmPgwKGH/RH+lqdoQ4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945366|imex:IM-27219-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 1B, 5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	-	ha tag:n-n|necessary binding region:76-78	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:P63208	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945686|imex:IM-27219-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	intact:EBI-21945719(see-also)	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rigid:Ddbg9yF9z2UXP5wx/sItw5egKsM	false	ha tag:?-?|mutation with complex effect:465-465	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:P01106	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945686|imex:IM-27219-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	intact:EBI-21945719(see-also)	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	rigid:Ddbg9yF9z2UXP5wx/sItw5egKsM	false	ha tag:?-?|mutation with complex effect:465-465	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945686|imex:IM-27219-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	intact:EBI-21945719(see-also)	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:Ddbg9yF9z2UXP5wx/sItw5egKsM	false	ha tag:?-?|mutation with complex effect:465-465	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01106	uniprotkb:Q969H0	intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7|ensembl:ENSP00000367207|ensembl:ENSP00000499105	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945697|imex:IM-27219-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002458.2|dip:DIP-28143N|ensembl:ENSG00000136997(gene)|ensembl:ENST00000377970(transcript)|ensembl:ENST00000652288(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P01106|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|rcsb pdb:2OR9|rcsb pdb:4Y7R|rcsb pdb:5I4Z|rcsb pdb:5I50|rcsb pdb:6C4U|rcsb pdb:6E16|rcsb pdb:6E24|rcsb pdb:6G6J|rcsb pdb:6G6K|rcsb pdb:6G6L|reactome:R-HSA-1362277|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015671"(oxygen transport)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-4411364|reactome:R-HSA-5687128|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8866911|reactome:R-HSA-8951430|reactome:R-HSA-9018519|reactome:R-HSA-9616222	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	-	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/02	rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rigid:1nWTi6e7kBe3EBz7vpLg4cJpMkU	false	-	ha tag:?-?|sufficient binding region:1-277..277,325..325-707	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:P63208	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945707|imex:IM-27219-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	-	-	-	figure legend:Fig. 4C|comment:myc-tagged CUL1 was also present in this interaction but the origin of this construct could not be traced.|comment:The ability of FBXW7 to interact with SKP1 and CUL1 was disturbed by STYX in a dose‐dependent manner. The ability of CUL1 to interact with SKP1 was unaffected by STYX levels.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945707|imex:IM-27219-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 4C|comment:myc-tagged CUL1 was also present in this interaction but the origin of this construct could not be traced.|comment:The ability of FBXW7 to interact with SKP1 and CUL1 was disturbed by STYX in a dose‐dependent manner. The ability of CUL1 to interact with SKP1 was unaffected by STYX levels.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:P63208	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945719|imex:IM-27219-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	intact:EBI-21945686(see-also)	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	ha tag:?-?|mutation:465-465	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945719|imex:IM-27219-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	intact:EBI-21945686(see-also)	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	ha tag:?-?|mutation:465-465	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63208	uniprotkb:Q969H0	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21950121|imex:IM-27219-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	-	-	-	figure legend:Supp Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rigid:Crzae6LDeN4kW0WK1yEBJbJV4ZI	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945415|imex:IM-27219-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0-1	uniprotkb:Q8WUJ0	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945449|imex:IM-27219-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1D, 4B, 5A Supp. Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	nYFP:?-?|necessary binding region:278..278-324..324	cYFP:?-?|mutation with no effect:120-120	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q969H0-1	uniprotkb:Q8WUJ0	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945544|imex:IM-27219-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q969H0-4	uniprotkb:Q8WUJ0	intact:EBI-6502391|ensembl:ENSP00000296555	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-4(display_long)|uniprotkb:Archipelago gamma(isoform synonym)|uniprotkb:FBW7gamma(isoform synonym)|uniprotkb:Hippocampal(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945563|imex:IM-27219-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-359574(isoform-parent)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000296555(transcript)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:xeyzrm5fZ+9G0V4JKgINiLqqK3I9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:cNdsT3jjJXjbRu7fEX3ePWra6SI	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q969H0-4	uniprotkb:Q8WUJ0	intact:EBI-6502391|ensembl:ENSP00000296555	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-4(display_long)|uniprotkb:Archipelago gamma(isoform synonym)|uniprotkb:FBW7gamma(isoform synonym)|uniprotkb:Hippocampal(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945618|imex:IM-27219-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-359574(isoform-parent)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000296555(transcript)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:xeyzrm5fZ+9G0V4JKgINiLqqK3I9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:cNdsT3jjJXjbRu7fEX3ePWra6SI	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969H0-1	uniprotkb:Q8WUJ0	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945609|imex:IM-27219-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969H0-1	uniprotkb:Q969H0-1	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21950061|imex:IM-27219-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	-	-	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rigid:vxBYJd/EwhvfBxzSllEjvDW20HY	false	yellow fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21945639|imex:IM-27219-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969H0-1	uniprotkb:Q8WUJ0	intact:EBI-6162410|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:q969h0-1(display_long)|uniprotkb:Archipelago alpha(isoform synonym)|uniprotkb:FBW7alpha(isoform synonym)|uniprotkb:110K(isoform synonym)|uniprotkb:common(isoform synonym)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21950081|imex:IM-27219-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|intact:EBI-359574(isoform-parent)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Supp. Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	glutathione s tranferase tag:n-n|sufficient binding region:278..278-324..324(IPR001810)	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969H0	uniprotkb:P63208	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21949825|imex:IM-27219-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	-	-	-	figure legend:Fig. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21949825|imex:IM-27219-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:GUbzpRq6fWOpOkSLPZr1t3Yvp9E	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63208	uniprotkb:Q969H0	intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym)	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21949841|imex:IM-27219-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	-	-	-	figure legend:Fig. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rigid:Crzae6LDeN4kW0WK1yEBJbJV4ZI	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969H0	uniprotkb:Q8WUJ0	intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9	intact:EBI-20979851|ensembl:ENSP00000346599|ensembl:ENSP00000403214|uniprotkb:B9EJG0|uniprotkb:Q99850	psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym)	psi-mi:styx_human(display_long)|uniprotkb:STYX(gene name)|psi-mi:STYX(display_short)|uniprotkb:Inactive tyrosine-protein phosphatase STYX(gene name synonym)|uniprotkb:Phosphoserine/threonine/tyrosine interaction protein(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Reiterer et al. (2017)	pubmed:28007894|imex:IM-27219	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21949922|imex:IM-27219-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0045204"(MAPK export from nucleus)|go:"GO:0062026"(negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1990444"(F-box domain binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR020422|interpro:IPR029021|mint:Q8WUJ0|rcsb pdb:2R0B|ensembl:ENSG00000198252(gene)|ensembl:ENST00000354586(transcript)|ensembl:ENST00000442123(transcript)|go:"GO:0001691"(pseudophosphatase activity)|go:"GO:0005634"(nucleus)|refseq:NP_001124173.1|refseq:NP_660294.1	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/02	2019/08/05	rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606	rogid:6qIvezdp697wx1UlhRoT4RvYji89606	rigid:D/eQvRGrK9iGCvVsguwM2NW0qdQ	false	glutathione s tranferase tag:n-n	binding-associated region:142-144|binding-associated region:76-78	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)