#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DP58	uniprotkb:P43681	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-7132379|ensembl:ENSP00000359285|uniprotkb:Q4JGR7|intact:MINT-3015931|uniprotkb:Q4VAQ6|intact:MINT-4869480|uniprotkb:Q4VAQ5	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha4_human(display_long)|uniprotkb:CHRNA4(gene name)|psi-mi:CHRNA4(display_short)|uniprotkb:NACRA4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:XP_011526826.1|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2GVT|rcsb pdb:2LLY|rcsb pdb:5KXI|rcsb pdb:6CNJ|rcsb pdb:6CNK|rcsb pdb:6UR8|rcsb pdb:6USF|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597|ensembl:ENSG00000101204(gene)|ensembl:ENST00000370263(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|refseq:NP_001243502.1|refseq:NP_000735.1	-	-	comment:mint|comment:homomint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane|function:"Defects in CHRNA4 are the cause of autosomal dominant nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is a disease characterized by clusters of motor seizures during sleep"	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:1mIuzGVLlNQeGoCu/fI+lbDZir49606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P36544	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-79333|uniprotkb:A8K7Q4|ensembl:ENSP00000303727|uniprotkb:Q15826|uniprotkb:Q96RH2|uniprotkb:Q99555|uniprotkb:Q9BXH0|uniprotkb:B4DFS0|uniprotkb:Q8IUZ4	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha7_human(display_long)|uniprotkb:CHRNA7(gene name)|psi-mi:CHRNA7(display_short)|uniprotkb:NACHRA7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	ensembl:ENSG00000175344(gene)|ensembl:ENST00000306901(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140059"(dendrite arborization)|refseq:NP_683709.1|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2MAW|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFM|rcsb pdb:5AFN|rcsb pdb:7EKI|rcsb pdb:7EKP|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|refseq:NP_000737.1|rcsb pdb:7EKT|go:"GO:1902004"(positive regulation of amyloid-beta formation)|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|reactome:R-HSA-629594|go:"GO:1905144"(response to acetylcholine)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1901214"(regulation of neuron death)|refseq:XP_016877373.1|refseq:NP_001177384.1|refseq:XP_005254807.1	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:9wcnxJ2Eh9S6aVCvKwKSwLMJnMI9606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P30532	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-6657490|ensembl:ENSP00000299565|uniprotkb:Q15824|uniprotkb:Q99554	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha5_human(display_long)|uniprotkb:CHRNA5(gene name)|psi-mi:CHRNA5(display_short)|uniprotkb:NACHRA5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	ensembl:ENST00000299565(transcript)|ensembl:ENSG00000169684(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-629594|reactome:R-HSA-629597|refseq:NP_000736.2	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:SF5Eefx2OvGB+G2A83M28/M67kU9606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P30926	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9009018|uniprotkb:Q16607|uniprotkb:Q8WXC8|uniprotkb:A4FTX5|uniprotkb:Q4VBA5|uniprotkb:Q9BQR4|uniprotkb:E9PHE8|ensembl:ENSP00000261751	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_human(display_long)|uniprotkb:CHRNB4(gene name)|psi-mi:CHRNB4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_000741.1|refseq:NP_001243496.1|ensembl:ENSG00000117971(gene)|ensembl:ENST00000261751(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050877"(nervous system process)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2ASG|rcsb pdb:6PV7|rcsb pdb:6PV8|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597|reactome:R-HSA-6798695	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:31HwoG50GcMIBsOUpF49pqIFThs9606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P17787	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008612|uniprotkb:Q9UEH9|ensembl:ENSP00000357461	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_human(display_long)|uniprotkb:CHRNB2(gene name)|psi-mi:CHRNB2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_000739.1|ensembl:ENSG00000160716(gene)|ensembl:ENST00000368476(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1905144"(response to acetylcholine)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2GVT|go:"GO:0009897"(external side of plasma membrane)|rcsb pdb:2K58|rcsb pdb:2K59|rcsb pdb:2KSR|rcsb pdb:2LM2|rcsb pdb:5KXI|rcsb pdb:6CNJ|rcsb pdb:6CNK|rcsb pdb:6UR8|rcsb pdb:6USF|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Ru/U+9R/PxJ2AZ3QQJ7fsoFhX9c9606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q15825	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008629|uniprotkb:B4DQH1|uniprotkb:B2R8V4|ensembl:ENSP00000276410	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha6_human(display_long)|uniprotkb:CHRNA6(gene name)|psi-mi:CHRNA6(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_001186208.1|refseq:NP_004189.1|ensembl:ENSG00000147434(gene)|ensembl:ENST00000276410(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-629594|reactome:R-HSA-629597	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:WU9+ZUV2UjIu2I7GBD+NG7i/DH89606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P32297	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9009052|uniprotkb:Q4KMN8|uniprotkb:Q9BRR4|uniprotkb:Q96RH3|uniprotkb:Q86U77|uniprotkb:Q9BQ93|uniprotkb:Q15823|uniprotkb:Q99553|ensembl:ENSP00000315602|ensembl:ENSP00000452896	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha3_human(display_long)|uniprotkb:CHRNA3(gene name)|psi-mi:CHRNA3(display_short)|uniprotkb:NACHRA3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21292857|imex:IM-27549-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_000734.2|refseq:NP_001160166.1|ensembl:ENSG00000080644(gene)|ensembl:ENST00000326828(transcript)|ensembl:ENST00000559658(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:1905144"(response to acetylcholine)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:4ZK4|rcsb pdb:5SYO|rcsb pdb:5TVC|rcsb pdb:6PV7|rcsb pdb:6PV8|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597	-	-	-	figure legend:Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:ilCINkXU6nZ21qjEWkZfdrb9lfQ9606	rigid:qwU7bBJIMli8vdQmcGIel7Nl0L0	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P05067-PRO_0000000092	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-821758	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298317|imex:IM-27549-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 4A|comment:Preincubation of rat frontal cortical extracts with oligomeric Abeta1-42 significantly reduced the amount of alpha3, alpha4, alpha5, and alpha7 nAChR subunits which bound to Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:CVDuPvoQLzgSDbZ5KXSvugawhpU	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P43143	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10955878	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298317|imex:IM-27549-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 4A|comment:Preincubation of rat frontal cortical extracts with oligomeric Abeta1-42 significantly reduced the amount of alpha3, alpha4, alpha5, and alpha7 nAChR subunits which bound to Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:CVDuPvoQLzgSDbZ5KXSvugawhpU	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12392	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298317|imex:IM-27549-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	-	-	figure legend:Fig. 4A|comment:Preincubation of rat frontal cortical extracts with oligomeric Abeta1-42 significantly reduced the amount of alpha3, alpha4, alpha5, and alpha7 nAChR subunits which bound to Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:CVDuPvoQLzgSDbZ5KXSvugawhpU	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12390	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298317|imex:IM-27549-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 4A|comment:Preincubation of rat frontal cortical extracts with oligomeric Abeta1-42 significantly reduced the amount of alpha3, alpha4, alpha5, and alpha7 nAChR subunits which bound to Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:CVDuPvoQLzgSDbZ5KXSvugawhpU	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P09483	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q05941	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-79422|uniprotkb:Q53YK2	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha7_rat(display_long)|uniprotkb:Chrna7(gene name)|psi-mi:Chrna7(display_short)|uniprotkb:Acra7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0060112"(generation of ovulation cycle rhythm)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1905144"(response to acetylcholine)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001988"(positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)|go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030673"(axolemma)|go:"GO:0032094"(response to food)|go:"GO:0030424"(axon)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|rgd:2348|reactome:R-RNO-629594|refseq:NP_036964.3|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:JMMrLrOpwsSACaDfzOCXTed3Y7M10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P43143	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10955878	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P20420	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10828372	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12392	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12390	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P04757	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008804	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha3_rat(display_long)|uniprotkb:Chrna3(gene name)|psi-mi:Chrna3(display_short)|uniprotkb:Acra3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298349|imex:IM-27549-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|rcsb pdb:1OLF|rcsb pdb:1OLJ|rgd:2345|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Nbu0OL3WY94E0WXv3lUFC/hL9K010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P09483	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q05941	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-79422|uniprotkb:Q53YK2	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha7_rat(display_long)|uniprotkb:Chrna7(gene name)|psi-mi:Chrna7(display_short)|uniprotkb:Acra7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0060112"(generation of ovulation cycle rhythm)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1905144"(response to acetylcholine)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001988"(positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)|go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030673"(axolemma)|go:"GO:0032094"(response to food)|go:"GO:0030424"(axon)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|rgd:2348|reactome:R-RNO-629594|refseq:NP_036964.3|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:JMMrLrOpwsSACaDfzOCXTed3Y7M10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P43143	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10955878	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P20420	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10828372	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12392	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12390	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P04757	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008804	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha3_rat(display_long)|uniprotkb:Chrna3(gene name)|psi-mi:Chrna3(display_short)|uniprotkb:Acra3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298372|imex:IM-27549-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|rcsb pdb:1OLF|rcsb pdb:1OLJ|rgd:2345|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Nbu0OL3WY94E0WXv3lUFC/hL9K010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P09483	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q05941	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-79422|uniprotkb:Q53YK2	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha7_rat(display_long)|uniprotkb:Chrna7(gene name)|psi-mi:Chrna7(display_short)|uniprotkb:Acra7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0060112"(generation of ovulation cycle rhythm)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1905144"(response to acetylcholine)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001988"(positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)|go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030673"(axolemma)|go:"GO:0032094"(response to food)|go:"GO:0030424"(axon)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|rgd:2348|reactome:R-RNO-629594|refseq:NP_036964.3|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:JMMrLrOpwsSACaDfzOCXTed3Y7M10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P43143	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10955878	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P20420	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10828372	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12392	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P12390	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P04757	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-9008804	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha3_rat(display_long)|uniprotkb:Chrna3(gene name)|psi-mi:Chrna3(display_short)|uniprotkb:Acra3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298415|imex:IM-27549-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|rcsb pdb:1OLF|rcsb pdb:1OLJ|rgd:2345|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:Fig. 1B, 4A, 4C|comment:Preincubation with the reverse peptide, Abeta42–1, did not affect the amount of any of the measured nAChR subunits purified with Lynx1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Nbu0OL3WY94E0WXv3lUFC/hL9K010116	rigid:w8JUbJdp3I5eaFbCxhXJbYE9RQo	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P43143	intact:EBI-821758	intact:EBI-10955878	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298430|imex:IM-27549-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4D|comment:Pre-incubation with Lynx1 significantly reduced the amount of alpha4, alpha7, and beta2  nAChR subunits that were isolated by affinity purification with oligomeric Ab1-42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:n9u0nUAs8cH5VMOTN73+tx1pyXQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P20420	intact:EBI-821758	intact:EBI-10828372	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298430|imex:IM-27549-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4D|comment:Pre-incubation with Lynx1 significantly reduced the amount of alpha4, alpha7, and beta2  nAChR subunits that were isolated by affinity purification with oligomeric Ab1-42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:n9u0nUAs8cH5VMOTN73+tx1pyXQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P0DP58	intact:EBI-821758	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298430|imex:IM-27549-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4D|comment:Pre-incubation with Lynx1 significantly reduced the amount of alpha4, alpha7, and beta2  nAChR subunits that were isolated by affinity purification with oligomeric Ab1-42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rigid:n9u0nUAs8cH5VMOTN73+tx1pyXQ	false	-	sufficient binding region:21-93	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P12392	intact:EBI-821758	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298430|imex:IM-27549-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4D|comment:Pre-incubation with Lynx1 significantly reduced the amount of alpha4, alpha7, and beta2  nAChR subunits that were isolated by affinity purification with oligomeric Ab1-42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:n9u0nUAs8cH5VMOTN73+tx1pyXQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P04757	intact:EBI-821758	intact:EBI-9008804	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha3_rat(display_long)|uniprotkb:Chrna3(gene name)|psi-mi:Chrna3(display_short)|uniprotkb:Acra3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298430|imex:IM-27549-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|rcsb pdb:1OLF|rcsb pdb:1OLJ|rgd:2345|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4D|comment:Pre-incubation with Lynx1 significantly reduced the amount of alpha4, alpha7, and beta2  nAChR subunits that were isolated by affinity purification with oligomeric Ab1-42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/12/19	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:Nbu0OL3WY94E0WXv3lUFC/hL9K010116	rigid:n9u0nUAs8cH5VMOTN73+tx1pyXQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P09483	intact:EBI-821758	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	chain-seq-start:672|chain-seq-end:713	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:Q05941	intact:EBI-821758	intact:EBI-79422|uniprotkb:Q53YK2	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha7_rat(display_long)|uniprotkb:Chrna7(gene name)|psi-mi:Chrna7(display_short)|uniprotkb:Acra7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0060112"(generation of ovulation cycle rhythm)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1905144"(response to acetylcholine)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001988"(positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)|go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007613"(memory)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030673"(axolemma)|go:"GO:0032094"(response to food)|go:"GO:0030424"(axon)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|rgd:2348|reactome:R-RNO-629594|refseq:NP_036964.3|interpro:IPR036719|interpro:IPR036734	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:JMMrLrOpwsSACaDfzOCXTed3Y7M10116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P43143	intact:EBI-821758	intact:EBI-10955878	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha6_rat(display_long)|uniprotkb:Chrna6(gene name)|psi-mi:Chrna6(display_short)|uniprotkb:Acra6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:69281|refseq:NP_476532.1|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR036719|interpro:IPR036734	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:RkB5H36TOLBFFg0cnwYx0vVuSm010116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P20420	intact:EBI-821758	intact:EBI-10828372	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P12392	intact:EBI-821758	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P12390	intact:EBI-821758	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P04757	intact:EBI-821758	intact:EBI-9008804	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:acha3_rat(display_long)|uniprotkb:Chrna3(gene name)|psi-mi:Chrna3(display_short)|uniprotkb:Acra3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298452|imex:IM-27549-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014056"(regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|rcsb pdb:1OLF|rcsb pdb:1OLJ|rgd:2345|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Fig. 4C, 4D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:Nbu0OL3WY94E0WXv3lUFC/hL9K010116	rigid:vA3wuPMsXmFcnVoXLE6uie8ulas	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q8R493	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10949297|uniprotkb:Q8VI06|ensembl:ENSMUSP00000034854	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb4_mouse(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298462|imex:IM-27549-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_683746.1|ensembl:ENSMUSG00000035200(gene)|ensembl:ENSMUST00000034854(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-MMU-629587|reactome:R-MMU-629594|reactome:R-MMU-629597|reactome:R-MMU-6798695	-	-	-	figure legend:Supp. Fig. 1|comment:Subunits were not detected following knockout of the gene, binding of other subunits was not affected.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Oxc9Wv9H4zGazKU2a4/3X8/3pxw10090	rigid:/UdM7//hKi0vtSMPrz9RxTabsqk	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:Q9ERK7	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10769401|uniprotkb:Q8BGP7|ensembl:ENSMUSP00000029562	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:achb2_mouse(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298462|imex:IM-27549-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_033732.2|reactome:R-MMU-629587|reactome:R-MMU-629594|reactome:R-MMU-629597|ensembl:ENSMUSG00000027950(gene)|ensembl:ENSMUST00000029562(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|dip:DIP-48730N	-	-	-	figure legend:Supp. Fig. 1|comment:Subunits were not detected following knockout of the gene, binding of other subunits was not affected.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:oeSo9N32iwfTXZjeikOyJsQgo0U10090	rigid:/UdM7//hKi0vtSMPrz9RxTabsqk	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP58	uniprotkb:P49582	intact:EBI-21292823|ensembl:ENSP00000477648|ensembl:ENSP00000478390|ensembl:ENSP00000478402|ensembl:ENSP00000498325|uniprotkb:A0A140VJN6|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-10769323|ensembl:ENSMUSP00000032738	psi-mi:lynx1_human(display_long)|uniprotkb:LYNX1(gene name)|psi-mi:LYNX1(display_short)|uniprotkb:Endogenous prototoxin LYNX1(gene name synonym)|uniprotkb:Testicular tissue protein Li 112(gene name synonym)	psi-mi:acha7_mouse(display_long)|uniprotkb:Chrna7(gene name)|psi-mi:Chrna7(display_short)|uniprotkb:Acra7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Thomsen et al. (2016)	pubmed:27460145|imex:IM-27549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21298462|imex:IM-27549-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180155(gene)|ensembl:ENST00000614491(transcript)|ensembl:ENST00000620006(transcript)|ensembl:ENST00000621401(transcript)|ensembl:ENST00000652477(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR035076|rcsb pdb:1VYE|rcsb pdb:2L03|refseq:NP_076435.1|refseq:NP_803252.1|refseq:NP_803429.1|refseq:NP_803430.1	refseq:NP_031416.3|ensembl:ENSMUSG00000030525(gene)|ensembl:ENSMUST00000032738(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001988"(positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)|go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030673"(axolemma)|go:"GO:0032094"(response to food)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0060112"(generation of ovulation cycle rhythm)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1905144"(response to acetylcholine)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:1905923"(positive regulation of acetylcholine biosynthetic process)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-MMU-629594|dip:DIP-48732N	-	-	-	figure legend:Supp. Fig. 1|comment:Subunits were not detected following knockout of the gene, binding of other subunits was not affected.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/01	2019/04/05	rogid:lc13pLUWQP0az2ZlR5rj5IumS4c9606	rogid:Pvp4ttz6IakmMosoURJI2gFoOcg10090	rigid:/UdM7//hKi0vtSMPrz9RxTabsqk	false	sufficient binding region:21-93	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)