#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26992	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-25298664	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298695|imex:IM-27619-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	intact:EBI-2880701(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:225	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.3x10^-9(molar)	2019/12/24	2020/03/16	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:Y498+BqCOJzweS8FKTAlcX93C+k	false	sufficient binding region:1..23-346	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26992	uniprotkb:O75462-PRO_0000011039	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-25298660	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298695|imex:IM-27619-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	intact:EBI-15587902(chain-parent)	-	-	chain-seq-start:38|chain-seq-end:422	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.3x10^-9(molar)	2019/12/24	2020/03/16	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rigid:Y498+BqCOJzweS8FKTAlcX93C+k	false	sufficient binding region:1..23-346	sufficient binding region:?-?|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26992	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-25298664	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298775|imex:IM-27619-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	intact:EBI-2880701(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:225	figure legend:1B-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:66.0x10^-9(molar)	2019/12/24	2020/03/16	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:A0arDWYA3t4nMuq9tcEDMans0n0	false	sufficient binding region:1..23-346	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26992	uniprotkb:O75462	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298793|imex:IM-27619-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N	-	-	-	figure legend:1B-2|caution:"The Expression system for CLF1 is unclear; the text under figure 1 states \"we used a His-tagged CLF-1 construct purified from the medium of stably transfected CHO cells (Fig. 1B)\" whereas the Methods section (cDNA constructs etc..) states CLF1 was expressed in human-293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-9(molar)	2019/12/24	2020/01/02	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606	rigid:X9zIhjpa5X3CAh/KFby6tUbEjhY	false	sufficient binding region:1..23-346	his tag:c-c|sufficient binding region:2-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-25298664	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298836|imex:IM-27619-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	intact:EBI-2880701(chain-parent)	-	-	chain-seq-start:28|chain-seq-end:225	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-9(molar)	2019/12/24	2020/03/16	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:UUzZizOjCpjcf1O5t7kqaYTklYU	false	sufficient binding region:54-2107	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:O75462-PRO_0000011039	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-25298660	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298836|imex:IM-27619-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	intact:EBI-15587902(chain-parent)	-	-	chain-seq-start:38|chain-seq-end:422	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-9(molar)	2019/12/24	2020/03/16	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rigid:UUzZizOjCpjcf1O5t7kqaYTklYU	false	sufficient binding region:54-2107	sufficient binding region:?-?|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673-PRO_0000033164	uniprotkb:Q92673	intact:EBI-25298876	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	psi-mi:q92673-pro_0000033164(display_long)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25298859|imex:IM-27619-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1171329(chain-parent)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	-	chain-seq-start:29|chain-seq-end:81	-	figure legend:1D/F|comment:"Binding of CLC:CLF-1 (or CLF-1 alone) to SORLA was completely abolished in the presence of a surplus of sorLA's own propeptide."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:96i/C8RWZFo9JkrAMQtZB6o9r9I9606	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rigid:iAg7F3X8U4cRwEiwG8BrTGR2Pc8	false	-	sufficient binding region:54-2107	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:O75462	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299035|imex:IM-27619-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N	-	-	-	figure legend:1E, 2B|caution:"The Expression system for CLF1 is unclear; the text under figure 1 states \"we used a His-tagged CLF-1 construct purified from the medium of stably transfected CHO cells (Fig. 1B)\" whereas the Methods section (cDNA constructs etc..) states CLF1 was expressed in human-293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-9(molar)	2019/12/24	2020/01/03	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606	rigid:m9ZT9Msv5F6Tr2GWIkGXQk7Kl7s	false	sufficient binding region:54-2107	sufficient binding region:2-?|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	intact:EBI-25299062	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	-	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:clc_cntfra_fusion protein(display_short)|psi-mi:EBI-25299062(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299051|imex:IM-27619-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	uniprotkb:P26992(multiple parent)|uniprotkb:Q9UBD9(multiple parent)	-	-	-	figure legend:2B|comment:"Binding of the fusion protein to preformed CLF-1:sorLA complex was observed."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/01/23	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:thQtqH7o0Xpb/FNHwJITanHxzfc9606	rigid:EQCOLw4jEtNFZzIzfJde4DmiJ8s	false	sufficient binding region:54-2107	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:O75462	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299051|imex:IM-27619-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N	-	-	-	figure legend:2B|comment:"Binding of the fusion protein to preformed CLF-1:sorLA complex was observed."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/01/23	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606	rigid:EQCOLw4jEtNFZzIzfJde4DmiJ8s	false	sufficient binding region:54-2107	sufficient binding region:2-?|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299268|imex:IM-27619-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6 A/C|comment:"Interaction between the luminal domains of CNTFRa and sorLA;Concentration-dependent binding of sCNTFRa to the immobilized luminal (entire extracellular) part of sorLA."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:14.0x10^-9(molar)	2019/12/24	2020/01/03	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	sufficient binding region:54-731(IPR006581)	sufficient binding region:1..23-346	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:P30533	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-715927|uniprotkb:Q2M310|uniprotkb:Q53HQ3|uniprotkb:Q53HS6|uniprotkb:D3DVR9|ensembl:ENSP00000497444	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:amrp_human(display_long)|uniprotkb:Low density lipoprotein receptor-related protein-associated protein 1(gene name synonym)|uniprotkb:LRPAP1(gene name)|psi-mi:LRPAP1(display_short)|uniprotkb:A2MRAP(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299285|imex:IM-27619-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_002328.1|ensembl:ENSG00000163956(gene)|ensembl:ENST00000650182(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0012505"(endomembrane system)|go:"GO:0031904"(endosome lumen)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035473"(lipase binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900116"(extracellular negative regulation of signal transduction)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|interpro:IPR009066(Alpha-2-macroglobulin receptor-associated protein, domain 1)|interpro:IPR010483(Alpha-2-macroglobulin RAP, C-terminal)|interpro:IPR036744|interpro:IPR037999|interpro:IPR038001|interpro:IPR038003|mint:P30533|rcsb pdb:1LRE|rcsb pdb:1NRE|rcsb pdb:1OP1|rcsb pdb:1OV2|rcsb pdb:2FCW|rcsb pdb:2FTU|rcsb pdb:2FYL|rcsb pdb:2P01|rcsb pdb:2P03|dip:DIP-39355N	-	-	-	figure legend:6B|comment:"It is stated that:- \"Soluble CNTFRa bound to immobilized sorLA and competed with RAP for binding (Fig. 6A and B.)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/01/03	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:TIbL+P1GW4op4Qawa4lpg8iXUaQ9606	rigid:kOIdbNEs1YMPD+FlhWehp8IVSyE	false	sufficient binding region:54-2107	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25405249|imex:IM-27619-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6B-2|comment:"It is stated that:- \"Soluble CNTFRa bound to immobilized sorLA and competed with RAP for binding (Fig. 6A and B.)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/01/23	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:z/Q2u3u03of5gEXp9wEUrhOXT4k	false	sufficient binding region:54-2107	sufficient binding region:1..23-346	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:P30533	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-715927|uniprotkb:Q2M310|uniprotkb:Q53HQ3|uniprotkb:Q53HS6|uniprotkb:D3DVR9|ensembl:ENSP00000497444	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:amrp_human(display_long)|uniprotkb:Low density lipoprotein receptor-related protein-associated protein 1(gene name synonym)|uniprotkb:LRPAP1(gene name)|psi-mi:LRPAP1(display_short)|uniprotkb:A2MRAP(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25405249|imex:IM-27619-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_002328.1|ensembl:ENSG00000163956(gene)|ensembl:ENST00000650182(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0012505"(endomembrane system)|go:"GO:0031904"(endosome lumen)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035473"(lipase binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900116"(extracellular negative regulation of signal transduction)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|interpro:IPR009066(Alpha-2-macroglobulin receptor-associated protein, domain 1)|interpro:IPR010483(Alpha-2-macroglobulin RAP, C-terminal)|interpro:IPR036744|interpro:IPR037999|interpro:IPR038001|interpro:IPR038003|mint:P30533|rcsb pdb:1LRE|rcsb pdb:1NRE|rcsb pdb:1OP1|rcsb pdb:1OV2|rcsb pdb:2FCW|rcsb pdb:2FTU|rcsb pdb:2FYL|rcsb pdb:2P01|rcsb pdb:2P03|dip:DIP-39355N	-	-	-	figure legend:6B-2|comment:"It is stated that:- \"Soluble CNTFRa bound to immobilized sorLA and competed with RAP for binding (Fig. 6A and B.)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/01/23	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:TIbL+P1GW4op4Qawa4lpg8iXUaQ9606	rigid:z/Q2u3u03of5gEXp9wEUrhOXT4k	false	sufficient binding region:54-2107	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:O75462	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25405305|imex:IM-27619-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N	-	-	-	figure legend:1D/F-2|comment:"Binding of CLC:CLF-1 (or CLF-1 alone) to SORLA was completely abolished in the presence of a surplus of sorLA's own propeptide."|comment:"The Expression system for CLF1 is unclear; the text under figure 1 states \"we used a His-tagged CLF-1 construct purified from the medium of stably transfected CHO cells (Fig. 1B)\" whereas the Methods section (cDNA constructs etc..) states CLF1 was expressed in human-293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/02/14	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606	rigid:98Xk8tu36T8myDKkASJ2EKWxVAM	false	sufficient binding region:54-2107	sufficient binding region:2-?|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92673	uniprotkb:Q92673-PRO_0000033164	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-25298876	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:q92673-pro_0000033164(display_long)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25405305|imex:IM-27619-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	intact:EBI-1171329(chain-parent)	-	-	chain-seq-start:29|chain-seq-end:81	figure legend:1D/F-2|comment:"Binding of CLC:CLF-1 (or CLF-1 alone) to SORLA was completely abolished in the presence of a surplus of sorLA's own propeptide."|comment:"The Expression system for CLF1 is unclear; the text under figure 1 states \"we used a His-tagged CLF-1 construct purified from the medium of stably transfected CHO cells (Fig. 1B)\" whereas the Methods section (cDNA constructs etc..) states CLF1 was expressed in human-293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/02/14	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:96i/C8RWZFo9JkrAMQtZB6o9r9I9606	rigid:98Xk8tu36T8myDKkASJ2EKWxVAM	false	sufficient binding region:54-2107	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75462-PRO_0000011039	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-25298660	intact:EBI-25298664	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299106|imex:IM-27619-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	intact:EBI-2880701(chain-parent)	go:"GO:0005622"(intracellular anatomical structure)	chain-seq-start:38|chain-seq-end:422	chain-seq-start:28|chain-seq-end:225	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:UUzZizOjCpjcf1O5t7kqaYTklYU	false	sufficient binding region:?-?|his tag:c-c	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75462-PRO_0000011039	uniprotkb:Q92673	intact:EBI-25298660	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299106|imex:IM-27619-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	go:"GO:0005622"(intracellular anatomical structure)	chain-seq-start:38|chain-seq-end:422	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rigid:UUzZizOjCpjcf1O5t7kqaYTklYU	false	sufficient binding region:?-?|his tag:c-c	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P26992	uniprotkb:O75462-PRO_0000011039	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-25298660	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299125|imex:IM-27619-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	intact:EBI-15587902(chain-parent)	go:"GO:0005622"(intracellular anatomical structure)	-	chain-seq-start:38|chain-seq-end:422	figure legend:3C|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rigid:Y498+BqCOJzweS8FKTAlcX93C+k	false	-	sufficient binding region:?-?|his tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P26992	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	intact:EBI-25298664	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299125|imex:IM-27619-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	intact:EBI-2880701(chain-parent)	go:"GO:0005622"(intracellular anatomical structure)	-	chain-seq-start:28|chain-seq-end:225	figure legend:3C|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:Y498+BqCOJzweS8FKTAlcX93C+k	false	-	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75462-PRO_0000011039	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-25298660	intact:EBI-25298664	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299191|imex:IM-27619-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	intact:EBI-2880701(chain-parent)	go:"GO:0097708"(intracellular vesicle)	chain-seq-start:38|chain-seq-end:422	chain-seq-start:28|chain-seq-end:225	figure legend:4A|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:Gk0Xz4hrs53kxP9LVTMSh0apYuo	false	sufficient binding region:?-?|his tag:c-c	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75462-PRO_0000011039	uniprotkb:O88307	intact:EBI-25298660	intact:EBI-7540114|uniprotkb:Q3UHM3|uniprotkb:O54711|uniprotkb:O70581|intact:MINT-1342356|ensembl:ENSMUSP00000058613	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:sorl_mouse(display_long)|uniprotkb:Sorl1(gene name)|psi-mi:Sorl1(display_short)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:Gp250(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299191|imex:IM-27619-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	refseq:NP_035566.2|ensembl:ENSMUSG00000049313(gene)|ensembl:ENSMUST00000060989(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|interpro:IPR006581(VPS10)|dip:DIP-42439N	go:"GO:0097708"(intracellular vesicle)	chain-seq-start:38|chain-seq-end:422	comment:mint|function:"Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems"	figure legend:4A|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:Q9DlzVMLmbQrNjfd9Pr/1B5FeTw10090	rigid:Gk0Xz4hrs53kxP9LVTMSh0apYuo	false	sufficient binding region:?-?|his tag:c-c	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75462-PRO_0000011039	uniprotkb:Q9UBD9-PRO_0000015616	intact:EBI-25298660	intact:EBI-25298664	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:q9ubd9-pro_0000015616(display_long)|uniprotkb:CLCF1(gene name)|psi-mi:CLCF1(display_short)|uniprotkb:B-cell-stimulating factor 3(gene name synonym)|uniprotkb:BSF3(gene name synonym)|uniprotkb:CLC(gene name synonym)|uniprotkb:NNT1(gene name synonym)|uniprotkb:Novel neurotrophin-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299206|imex:IM-27619-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	intact:EBI-2880701(chain-parent)	go:"GO:0097708"(intracellular vesicle)	chain-seq-start:38|chain-seq-end:422	chain-seq-start:28|chain-seq-end:225	figure legend:4B|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:WthiiXvM9rfVWTwXx92PDsj9upQ9606	rigid:Gk0Xz4hrs53kxP9LVTMSh0apYuo	false	sufficient binding region:?-?|his tag:c-c	his tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75462-PRO_0000011039	uniprotkb:O88307	intact:EBI-25298660	intact:EBI-7540114|uniprotkb:Q3UHM3|uniprotkb:O54711|uniprotkb:O70581|intact:MINT-1342356|ensembl:ENSMUSP00000058613	psi-mi:o75462-pro_0000011039(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name)	psi-mi:sorl_mouse(display_long)|uniprotkb:Sorl1(gene name)|psi-mi:Sorl1(display_short)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:Gp250(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299206|imex:IM-27619-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15587902(chain-parent)	refseq:NP_035566.2|ensembl:ENSMUSG00000049313(gene)|ensembl:ENSMUST00000060989(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|interpro:IPR006581(VPS10)|dip:DIP-42439N	go:"GO:0097708"(intracellular vesicle)	chain-seq-start:38|chain-seq-end:422	comment:mint|function:"Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems"	figure legend:4B|comment:An anti-His antibody was used to detect binding of CLF-1/CLC Complex;so either, or both,  molecules were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/24	2020/03/16	rogid:V6pIjKT9k1fzwnjiKy/2Bq5E5po9606	rogid:Q9DlzVMLmbQrNjfd9Pr/1B5FeTw10090	rigid:Gk0Xz4hrs53kxP9LVTMSh0apYuo	false	sufficient binding region:?-?|his tag:c-c	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299255|imex:IM-27619-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0097708"(intracellular vesicle)	-	-	figure legend:5B|agonist:"Exogenous  CLC (Q9UBD9)"|agonist:"Exogenous CLC:CLF-1 (Q9UBD9 + P26992)"|comment:"Staining was particularly strong in the cells treated with CLC:CLF-1, but minor staining was also seen upon stimulation with CLC and, surprisingly, in cells not subjected to either of the two ligands."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2019/12/24	2020/01/03	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0030"(cross-linking study)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299398|imex:IM-27619-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6D-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/12/24	2020/01/06	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	-	myc tag:22..22-22..22|sufficient binding region:1..1-342..342	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0030"(cross-linking study)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299408|imex:IM-27619-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6D-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/12/24	2020/01/06	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	-	myc tag:22..22-22..22|sufficient binding region:1..1-342..342	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299439|imex:IM-27619-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6D|comment:"A weak band (SorLA) is seen in the absence of cross-linker and the presence of DTT."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/12/24	2020/01/06	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	-	myc tag:22..22-22..22|sufficient binding region:1..1-342..342	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92673	uniprotkb:P26992	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	intact:EBI-743758|uniprotkb:Q5U050|ensembl:ENSP00000242338|ensembl:ENSP00000368265|ensembl:ENSP00000480451	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:cntfr_human(display_long)|uniprotkb:CNTFR(gene name)|psi-mi:CNTFR(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Larsen et al. (2016)	pubmed:26858303|imex:IM-27619	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25299482|imex:IM-27619-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	refseq:NP_001193940.1|refseq:NP_001833.1|refseq:NP_671693.1|ensembl:ENSG00000122756(gene)|ensembl:ENST00000351266(transcript)|ensembl:ENST00000378980(transcript)|ensembl:ENST00000610543(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0003360"(brainstem development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097059"(CNTFR-CLCF1 complex)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1UC6|reactome:R-HSA-6788467|interpro:IPR003961(Fibronectin, type III)|refseq:XP_016869752.1|refseq:XP_016869753.1|refseq:XP_016869754.1|dip:DIP-5777N	-	-	-	figure legend:6D|comment:"A weak band (CNTFRa) is seen in the absence of cross-linker and the presence of DTT."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/12/24	2020/01/06	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rogid:+WoR9qZI3KqV3gNjKgIPjlZY+lw9606	rigid:zR/azjJ/x1+Xn4vi1Hoj440Sx1s	false	-	myc tag:22..22-22..22|sufficient binding region:1..1-342..342	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)