#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P83110	uniprotkb:P83110	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017643|pdbe:4ri0|imex:IM-27346-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	-	-	-	figure legend:Table 3|3d-resolution:3.27 A|3d-r-factors:"Free: 0.233   Working: 0.199"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:3y27DzEz3/YME5lQ6ErWIKXm1r8	false	sufficient binding region:130-453|his tag:c-c|mutation:305-305	sufficient binding region:130-453|his tag:c-c|mutation:305-305	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02666	uniprotkb:P83110	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017660|imex:IM-27346-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	-	-	-	figure legend:Figure 7, Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/11/04	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:9N/ict3REurhr/o2Qyinh9oGd88	false	-	sufficient binding region:130-453|his tag:c-c|mutation:305-305	3	3	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P83110	uniprotkb:P83110	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017895|imex:IM-27346-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	-	-	-	figure legend:Figure 7, 10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/11/04	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:3y27DzEz3/YME5lQ6ErWIKXm1r8	false	sufficient binding region:130-453|his tag:c-c|mutation:305-305|necessary binding region:358-453(IPR036034)	sufficient binding region:130-453|his tag:c-c|mutation:305-305|necessary binding region:358-453(IPR036034)	3	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
intact:EBI-22017690	uniprotkb:P83110	-	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:"ala(mca)irrvsysf–anb–nh2"(display_short)|psi-mi:EBI-22017690(display_long)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017679|imex:IM-27346-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 8, 9, Table 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:0.958x10^-6(molar)|kcat:0.029(second -1)	2019/08/28	2019/09/16	rogid:lGM+IjSH1TosXaoNI9eY4iaMPGM-2	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:+PbXCU6kaRakWvduIXq905byRuY	false	fluorophore:n-n	sufficient binding region:130-453|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-22017690	uniprotkb:P83110	-	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:"ala(mca)irrvsysf–anb–nh2"(display_short)|psi-mi:EBI-22017690(display_long)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017694|imex:IM-27346-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 8, 9, Table 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.029(second -1)|km:0.878x10^-6(molar)	2019/08/28	2019/09/16	rogid:lGM+IjSH1TosXaoNI9eY4iaMPGM-2	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:+PbXCU6kaRakWvduIXq905byRuY	false	fluorophore:n-n	his tag:n-n|sufficient binding region:122-349	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-22017690	uniprotkb:P83110-2	-	intact:EBI-22017714|ensembl:ENSP00000371952	psi-mi:"ala(mca)irrvsysf–anb–nh2"(display_short)|psi-mi:EBI-22017690(display_long)	psi-mi:p83110-2(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:pS(isoform synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017704|imex:IM-27346-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000170801(gene)|ensembl:ENST00000382512(transcript)|intact:EBI-2867394(isoform-parent)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 8, Table 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.03(second -1)|km:0.74x10^-6(molar)	2019/08/28	2019/09/16	rogid:lGM+IjSH1TosXaoNI9eY4iaMPGM-2	rogid:wieknztK6gJa6wpCub2XXsGT+mQ9606	rigid:q7BD9Y58x1wQek4wocfDaTH6DoI	false	fluorophore:n-n	sufficient binding region:130-349|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02666	uniprotkb:P83110	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017824|imex:IM-27346-21	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 8D,9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:9N/ict3REurhr/o2Qyinh9oGd88	false	-	sufficient binding region:130-453|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02666	uniprotkb:P83110	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017855|imex:IM-27346-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:9N/ict3REurhr/o2Qyinh9oGd88	false	-	his tag:n-n|sufficient binding region:122-349	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02666	uniprotkb:P83110-2	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	intact:EBI-22017714|ensembl:ENSP00000371952	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:p83110-2(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:pS(isoform synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017874|imex:IM-27346-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	ensembl:ENSG00000170801(gene)|ensembl:ENST00000382512(transcript)|intact:EBI-2867394(isoform-parent)	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rogid:wieknztK6gJa6wpCub2XXsGT+mQ9606	rigid:KvMgVZ+wJ+YoOZMfbT24EwJPxNY	false	-	sufficient binding region:130-349|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P83110	uniprotkb:P02666	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	intact:EBI-5260183|uniprotkb:A1YQZ8|uniprotkb:A6N8V0|uniprotkb:Q2TA13|uniprotkb:Q5EEQ6|uniprotkb:Q5EEQ7|uniprotkb:Q6UN63|uniprotkb:Q9BDG5|uniprotkb:Q9TSD5	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:casb_bovin(display_long)|uniprotkb:CSN2(gene name)|psi-mi:CSN2(display_short)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017922|imex:IM-27346-27	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	dip:DIP-46257N|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009408"(response to heat)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1903488"(negative regulation of lactation)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR001588(Casein, alpha/beta)|interpro:IPR016345(Casein, beta)|interpro:IPR031305	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 11,12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rogid:wtuOGN4l9NtBjB0YyHhilo7usl49913	rigid:9N/ict3REurhr/o2Qyinh9oGd88	false	sufficient binding region:130-453|his tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q29558	uniprotkb:P83110	intact:EBI-22017993	intact:EBI-2867394|uniprotkb:Q7Z7A2|ensembl:ENSP00000303766	psi-mi:maox_pig(display_long)|uniprotkb:Malic enzyme 1(gene name synonym)|uniprotkb:ME1(gene name)|psi-mi:ME1(display_short)	psi-mi:htra3_human(display_long)|uniprotkb:HTRA3(gene name)|psi-mi:HTRA3(display_short)|uniprotkb:PRSP(gene name synonym)|uniprotkb:High-temperature requirement factor A3(gene name synonym)|uniprotkb:Pregnancy-related serine protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Glaza et al. (2014)	imex:IM-27346|pubmed:26110759	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22017985|imex:IM-27346-31	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015884(Malic enzyme, conserved site)|interpro:IPR012301(Malic enzyme, N-terminal)|interpro:IPR037062|interpro:IPR012302(Malic enzyme, NAD-binding)|interpro:IPR001891(Malic oxidoreductase)|interpro:IPR036291|go:"GO:0004470"(malic enzyme activity)|go:"GO:0004471"("malate dehydrogenase (decarboxylating) (NAD+) activity")|go:"GO:0004473"("malate dehydrogenase (decarboxylating) (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0009725"(response to hormone)|go:"GO:0030145"(manganese ion binding)|go:"GO:0051287"(NAD binding)	refseq:NP_001284488.1|refseq:NP_444272.1|ensembl:ENSG00000170801(gene)|ensembl:ENST00000307358(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2P3W|rcsb pdb:4RI0	go:"GO:0004252"(serine-type endopeptidase activity)	-	-	figure legend:Figure 11,12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/28	2019/09/16	rogid:uUF17/P9m7k1jH2a/kny4jbvMkw9823	rogid:oJfuPj+xPZ+WkCu+VlJeqJAr/3k9606	rigid:ZMWqXGZZyvAen3muCjRohzgt5zs	false	-	sufficient binding region:130-453|his tag:c-c	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)