#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48995	uniprotkb:Q9EPK8	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301034|imex:IM-26946-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Figure 1b, Supplemental Fig. S2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48995	uniprotkb:Q13563	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301034|imex:IM-26946-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Figure 1b, Supplemental Fig. S2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301039|imex:IM-26946-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Figure 1b, Supplemental Fig. S2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301039|imex:IM-26946-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Figure 1b, Supplemental Fig. S2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301076|imex:IM-26946-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Supplemental Fig. S2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301076|imex:IM-26946-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:Q9EPK8	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301081|imex:IM-26946-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Supplemental Fig. S2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301081|imex:IM-26946-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:Q9EPK8	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21305443|imex:IM-26946-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Supplemental Fig. S3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:WH5Xe7XWgYARodOFISKByy3tseM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21305472|imex:IM-26946-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:H0NbdUjzQJlxKwCBC1145oz+x/g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21305476|imex:IM-26946-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Supplemental Fig. S3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:WH5Xe7XWgYARodOFISKByy3tseM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21305480|imex:IM-26946-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:7F2wkAREzJhJq1VfAbY2ZqX2Jmo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21305993|imex:IM-26946-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:7F2wkAREzJhJq1VfAbY2ZqX2Jmo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306038|imex:IM-26946-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S3f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:H0NbdUjzQJlxKwCBC1145oz+x/g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48995	uniprotkb:Q9EPK8	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301057|imex:IM-26946-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Figure 1b, Supplemental Fig. S2b|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48995	uniprotkb:Q13563	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301057|imex:IM-26946-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Figure 1b, Supplemental Fig. S2b|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301062|imex:IM-26946-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Figure 1b, Supplemental Fig. S2b|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301062|imex:IM-26946-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Figure 1b, Supplemental Fig. S2b|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:Q9EPK8	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301086|imex:IM-26946-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Supplemental Fig. S2d|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301086|imex:IM-26946-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S2d|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301098|imex:IM-26946-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Supplemental Fig. S2d|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301098|imex:IM-26946-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S2d|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/12	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:Q9EPK8	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306059|imex:IM-26946-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Supplemental Fig. S4a|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:WH5Xe7XWgYARodOFISKByy3tseM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306063|imex:IM-26946-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S4b|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:H0NbdUjzQJlxKwCBC1145oz+x/g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:Q13563	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306069|imex:IM-26946-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	figure legend:Supplemental Fig. S4c|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rigid:WH5Xe7XWgYARodOFISKByy3tseM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306077|imex:IM-26946-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S4d|comment:"Faint band was observed possibly due to weak interaction. | The host is mesenteric artery endothelial cells from rat"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:7F2wkAREzJhJq1VfAbY2ZqX2Jmo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306082|imex:IM-26946-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S4e|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:7F2wkAREzJhJq1VfAbY2ZqX2Jmo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EPK8	uniprotkb:P48995	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21306087|imex:IM-26946-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	-	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	-	figure legend:Supplemental Fig. S4f|comment:The host is mesenteric artery endothelial cells from rat|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat_aortic_endothelial_cell)|taxid:10116(rat aortic endothelial cell line)	-	2019/04/05	2019/04/15	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:H0NbdUjzQJlxKwCBC1145oz+x/g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13563	uniprotkb:P48995	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-929665|uniprotkb:Q14CE4|ensembl:ENSP00000419313	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpc1_human(display_long)|uniprotkb:TRPC1(gene name)|psi-mi:TRPC1(display_short)|uniprotkb:TRP1(gene name synonym)|uniprotkb:Transient receptor protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301123|imex:IM-26946-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:NP_003295.1|refseq:NP_001238774.1|dip:DIP-35698N|ensembl:ENSG00000144935(gene)|ensembl:ENST00000476941(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005457(Transient receptor potential channel 1)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|reactome:R-HSA-5578775|reactome:R-HSA-983695	go:"GO:0005886"(plasma membrane)	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	-	figure legend:Supplemental Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:H+7DrzEcXydnh0OjQAw0KsLLxMs9606	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	mcherry fluorescent protein tag:?-?	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q13563	uniprotkb:Q9EPK8	intact:EBI-7813714|ensembl:ENSP00000237596|intact:MINT-6618167|uniprotkb:O60441|uniprotkb:Q15764|uniprotkb:Q2M1Q5|uniprotkb:Q2M1Q3	intact:EBI-7091763|ensembl:ENSMUSP00000071859|ensembl:ENSMUSP00000107844|uniprotkb:Q91XR5|intact:MINT-4050076|uniprotkb:Q9EQZ4|uniprotkb:A0JNY0|uniprotkb:Q9ERZ7|uniprotkb:Q9ES76	psi-mi:pkd2_human(display_long)|uniprotkb:PKD2(gene name)|psi-mi:PKD2(display_short)|uniprotkb:Polycystic kidney disease 2 protein(gene name synonym)|uniprotkb:Autosomal dominant polycystic kidney disease type II protein(gene name synonym)|uniprotkb:Polycystwin(gene name synonym)|uniprotkb:R48321(gene name synonym)|uniprotkb:TRPP2(gene name synonym)|uniprotkb:Transient receptor potential cation channel subfamily P member 2(gene name synonym)	psi-mi:trpv4_mouse(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Trp12(gene name synonym)|uniprotkb:Vrl2(gene name synonym)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Du et al. (2014)	pubmed:25114176|imex:IM-26946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21301123|imex:IM-26946-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118762(gene)|ensembl:ENST00000237596(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002133"(polycystin complex)|go:"GO:0003127"(detection of nodal flow)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|rcsb pdb:2KQ6|rcsb pdb:2Y4Q|rcsb pdb:3HRN|rcsb pdb:3HRO|rcsb pdb:5K47|rcsb pdb:5MKE|rcsb pdb:5MKF|rcsb pdb:5T4D|rcsb pdb:6A70|rcsb pdb:6D1W|rcsb pdb:6T9N|rcsb pdb:6T9O|rcsb pdb:6WB8|reactome:R-HSA-5620916|rcsb pdb:2KLE|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034703"(cation channel complex)|go:"GO:0035502"(metanephric part of ureteric bud development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044782"(cilium organization)|go:"GO:0045180"(basal cortex)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072208"(metanephric smooth muscle tissue development)|go:"GO:0072214"(metanephric cortex development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072219"(metanephric cortical collecting duct development)|go:"GO:0072235"(metanephric distal tubule development)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003915(Polycystic kidney disease type 2 protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR027359|mint:Q13563|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:2KLD|refseq:NP_000288.1|dip:DIP-47455N	refseq:XP_006530495.2|ensembl:ENSMUSG00000014158(gene)|ensembl:ENSMUST00000071968(transcript)|ensembl:ENSMUST00000112225(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|mint:Q9EPK8|reactome:R-MMU-3295583|refseq:NP_071300.2|dip:DIP-44011N	go:"GO:0005886"(plasma membrane)	function:Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis|function:"Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:173900]. ADPKD2 represents approximately 15% of the cases of ADPKD, a common genetic disease affecting about 1:400 to 1:1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy"|comment:mint	comment:mint|function:"Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism"	figure legend:Supplemental Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/05	2019/04/12	rogid:pDoR2jCJL0PTiy/tfJyUe/IVPT49606	rogid:3XLb2ly4P+/uFUm/PntfFRLywkw10090	rigid:isgUsksohCRMlQPTok7NodUfZFM	false	mcherry fluorescent protein tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)