#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75509	uniprotkb:P08138	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2012)	pubmed:23559013|imex:IM-27537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21397943|imex:IM-27537-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/03	2019/05/03	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rigid:H+e5pJAQa8TiGpL/tfP61C2CdRI	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75509	uniprotkb:P08138	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2012)	pubmed:23559013|imex:IM-27537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21397954|imex:IM-27537-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	-	-	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-foetal_spinal_cord)|taxid:9606(human foetal spinal cord)	-	2019/05/03	2019/05/03	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rigid:H+e5pJAQa8TiGpL/tfP61C2CdRI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75509	uniprotkb:P08138	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Hu et al. (2012)	pubmed:23559013|imex:IM-27537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21397975|imex:IM-27537-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	-	-	-	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/03	2019/05/03	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rigid:H+e5pJAQa8TiGpL/tfP61C2CdRI	false	sufficient binding region:1-349	fc-igg tag:?-?|tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:O75509	uniprotkb:O75509	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:"MI:0892"(solid phase assay)	Hu et al. (2012)	pubmed:23559013|imex:IM-27537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21398019|imex:IM-27537-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	-	-	-	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.0x10^-8(molar)	2019/05/03	2019/05/03	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rigid:H+e5pJAQa8TiGpL/tfP61C2CdRI	false	sufficient binding region:1-349	sufficient binding region:132-213	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:O75509	uniprotkb:P08138	intact:EBI-2313231|uniprotkb:B2RDI9|uniprotkb:Q0D2P5|uniprotkb:Q96D86|ensembl:ENSP00000296861	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	psi-mi:tnr21_human(display_long)|uniprotkb:TNFRSF21(gene name)|psi-mi:TNFRSF21(display_short)|uniprotkb:DR6(gene name synonym)|uniprotkb:Death receptor 6(gene name synonym)|uniprotkb:UNQ437/PRO868(orf name)	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Hu et al. (2012)	pubmed:23559013|imex:IM-27537	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21398019|imex:IM-27537-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055267.1|dip:DIP-53299N|ensembl:ENSG00000146072(gene)|ensembl:ENST00000296861(transcript)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0030424"(axon)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042552"(myelination)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097252"(oligodendrocyte apoptotic process)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022330|interpro:IPR034034|interpro:IPR034037|rcsb pdb:2DBH|rcsb pdb:3QO4|rcsb pdb:3U3P|rcsb pdb:3U3Q|rcsb pdb:3U3S|rcsb pdb:3U3T|rcsb pdb:3U3V|reactome:R-HSA-1989781|go:"GO:0051402"(neuron apoptotic process)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	-	-	-	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.0x10^-8(molar)	2019/05/03	2019/05/03	rogid:U26UBHuKo6Efzen1takNKjzhtcg9606	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rigid:H+e5pJAQa8TiGpL/tfP61C2CdRI	false	sufficient binding region:1-349	fc-igg tag:?-?|tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)