#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q22397	uniprotkb:G5EDM4-1	intact:EBI-21449230|ensemblmetazoa:T11F9.4a.1|uniprotkb:B2D6M4	intact:EBI-25423624|ensemblmetazoa:C01F6.6a.1	psi-mi:aat6_caeel(display_long)|uniprotkb:aat-6(gene name)|psi-mi:aat-6(display_short)|uniprotkb:T11F9.4(orf name)	psi-mi:g5edm4-1(display_long)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:nrfl-1(gene name)|psi-mi:nrfl-1(display_short)|uniprotkb:mpz-2(gene name synonym)|uniprotkb:tag-60(gene name synonym)|uniprotkb:C01F6.6(orf name)	psi-mi:"MI:0018"(two hybrid)	Hagiwara et al. (2011)	pubmed:22916205|imex:IM-27668	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21450260|imex:IM-27668-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505905.2|wormbase:T11F9.4a|interpro:IPR002293(Amino acid/polyamine transporter I)|ensemblmetazoa:T11F9.4a.1(transcript)|ensemblmetazoa:WBGene00000007(gene)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|wormbase:T11F9.4b|refseq:NP_001123014.1	ensemblmetazoa:C01F6.6a.1(transcript)|ensemblmetazoa:WBGene00006438(gene)|intact:EBI-313674(isoform-parent)	-	-	-	figure legend:Table 1, Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/06/07	2020/02/10	rogid:2uyibSqkrYbZkqCKhIDeyc0Vexo6239	rogid:WbTvGjSnMxnKlKVHTRnxI4g0Dnc6239	rigid:QIKdw0jy8ZPZHTXnm0vSVAWOmho	false	sufficient binding region:487-523|necessary binding region:521-523	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q22397	uniprotkb:G5EDM4-2	intact:EBI-21449230|ensemblmetazoa:T11F9.4a.1|uniprotkb:B2D6M4	intact:EBI-25423633|ensemblmetazoa:C01F6.6b.1	psi-mi:aat6_caeel(display_long)|uniprotkb:aat-6(gene name)|psi-mi:aat-6(display_short)|uniprotkb:T11F9.4(orf name)	psi-mi:g5edm4-2(display_long)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:nrfl-1(gene name)|psi-mi:nrfl-1(display_short)|uniprotkb:mpz-2(gene name synonym)|uniprotkb:tag-60(gene name synonym)|uniprotkb:C01F6.6(orf name)	psi-mi:"MI:0018"(two hybrid)	Hagiwara et al. (2011)	pubmed:22916205|imex:IM-27668	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21450341|imex:IM-27668-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505905.2|wormbase:T11F9.4a|interpro:IPR002293(Amino acid/polyamine transporter I)|ensemblmetazoa:T11F9.4a.1(transcript)|ensemblmetazoa:WBGene00000007(gene)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|wormbase:T11F9.4b|refseq:NP_001123014.1	ensemblmetazoa:C01F6.6b.1(transcript)|ensemblmetazoa:WBGene00006438(gene)|intact:EBI-313674(isoform-parent)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/06/07	2020/02/10	rogid:2uyibSqkrYbZkqCKhIDeyc0Vexo6239	rogid:gmSqwJYDjQwmAq4FtlRLXkzyG/o6239	rigid:oZhFrG8iXQieOYmHJsHnC11YhPw	false	sufficient binding region:487-523	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q22397	uniprotkb:G5EDM4-1	intact:EBI-21449230|ensemblmetazoa:T11F9.4a.1|uniprotkb:B2D6M4	intact:EBI-25423624|ensemblmetazoa:C01F6.6a.1	psi-mi:aat6_caeel(display_long)|uniprotkb:aat-6(gene name)|psi-mi:aat-6(display_short)|uniprotkb:T11F9.4(orf name)	psi-mi:g5edm4-1(display_long)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:nrfl-1(gene name)|psi-mi:nrfl-1(display_short)|uniprotkb:mpz-2(gene name synonym)|uniprotkb:tag-60(gene name synonym)|uniprotkb:C01F6.6(orf name)	psi-mi:"MI:0096"(pull down)	Hagiwara et al. (2011)	pubmed:22916205|imex:IM-27668	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21450276|imex:IM-27668-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505905.2|wormbase:T11F9.4a|interpro:IPR002293(Amino acid/polyamine transporter I)|ensemblmetazoa:T11F9.4a.1(transcript)|ensemblmetazoa:WBGene00000007(gene)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|wormbase:T11F9.4b|refseq:NP_001123014.1	ensemblmetazoa:C01F6.6a.1(transcript)|ensemblmetazoa:WBGene00006438(gene)|intact:EBI-313674(isoform-parent)	-	-	-	figure legend:Fig. 2B, 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/07	2020/02/10	rogid:2uyibSqkrYbZkqCKhIDeyc0Vexo6239	rogid:WbTvGjSnMxnKlKVHTRnxI4g0Dnc6239	rigid:QIKdw0jy8ZPZHTXnm0vSVAWOmho	false	sufficient binding region:487-523|necessary binding region:521-523|glutathione s tranferase tag:n-n	flag tag:?-?|mutation with no effect:26-27|mutation disrupting interaction strength:26-27,154-155|mutation decreasing interaction strength:154-155	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:G5EDM4	uniprotkb:Q22397	intact:EBI-313674|intact:EBI-21450249|intact:EBI-2913474|ensemblmetazoa:C01F6.6a.1|uniprotkb:G5EC64|uniprotkb:G5EE55|uniprotkb:G5EFP7|uniprotkb:I2HAG6|uniprotkb:I2HAI6|uniprotkb:Q27GP2|uniprotkb:X5LQ26|uniprotkb:X5LVA5|uniprotkb:X5MBG4	intact:EBI-21449230|ensemblmetazoa:T11F9.4a.1|uniprotkb:B2D6M4	psi-mi:nhrf1_caeel(display_long)|uniprotkb:nrfl-1(gene name)|psi-mi:nrfl-1(display_short)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:mpz-2(gene name synonym)|uniprotkb:tag-60(gene name synonym)|uniprotkb:C01F6.6(orf name)	psi-mi:aat6_caeel(display_long)|uniprotkb:aat-6(gene name)|psi-mi:aat-6(display_short)|uniprotkb:T11F9.4(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Hagiwara et al. (2011)	pubmed:22916205|imex:IM-27668	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21450364|imex:IM-27668-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q8MM77(uniprot-removed-ac)|wormbase:C01F6.6g|refseq:NP_741478.1|wormbase:C01F6.6a|wormbase:C01F6.6c|wormbase:C01F6.6d|wormbase:C01F6.6e|wormbase:C01F6.6f|interpro:IPR001478(PDZ/DHR/GLGF)|wormbase:C01F6.6b|ensemblmetazoa:C01F6.6a.1(transcript)|ensemblmetazoa:WBGene00006438(gene)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0043495"(protein-membrane adaptor activity)|wormbase:C01F6.6h|wormbase:C01F6.6i|wormbase:C01F6.6j|interpro:IPR036034|interpro:IPR041489|refseq:NP_001040908.1|refseq:NP_001040909.1|refseq:NP_001040910.1|refseq:NP_001263761.1|refseq:NP_001263762.1|refseq:NP_001294067.1|refseq:NP_001294068.1|refseq:NP_001294128.1|refseq:NP_741479.1	refseq:NP_505905.2|wormbase:T11F9.4a|interpro:IPR002293(Amino acid/polyamine transporter I)|ensemblmetazoa:T11F9.4a.1(transcript)|ensemblmetazoa:WBGene00000007(gene)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|wormbase:T11F9.4b|refseq:NP_001123014.1	go:"GO:0044425"(obsolete membrane part)	-	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2019/06/07	2020/02/07	rogid:WbTvGjSnMxnKlKVHTRnxI4g0Dnc6239	rogid:2uyibSqkrYbZkqCKhIDeyc0Vexo6239	rigid:QIKdw0jy8ZPZHTXnm0vSVAWOmho	false	-	green fluorescent protein tag:517-518	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:G5EDM4	uniprotkb:Q22397	intact:EBI-313674|intact:EBI-21450249|intact:EBI-2913474|ensemblmetazoa:C01F6.6a.1|uniprotkb:G5EC64|uniprotkb:G5EE55|uniprotkb:G5EFP7|uniprotkb:I2HAG6|uniprotkb:I2HAI6|uniprotkb:Q27GP2|uniprotkb:X5LQ26|uniprotkb:X5LVA5|uniprotkb:X5MBG4	intact:EBI-21449230|ensemblmetazoa:T11F9.4a.1|uniprotkb:B2D6M4	psi-mi:nhrf1_caeel(display_long)|uniprotkb:nrfl-1(gene name)|psi-mi:nrfl-1(display_short)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:mpz-2(gene name synonym)|uniprotkb:tag-60(gene name synonym)|uniprotkb:C01F6.6(orf name)	psi-mi:aat6_caeel(display_long)|uniprotkb:aat-6(gene name)|psi-mi:aat-6(display_short)|uniprotkb:T11F9.4(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hagiwara et al. (2011)	pubmed:22916205|imex:IM-27668	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21450381|imex:IM-27668-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q8MM77(uniprot-removed-ac)|wormbase:C01F6.6g|refseq:NP_741478.1|wormbase:C01F6.6a|wormbase:C01F6.6c|wormbase:C01F6.6d|wormbase:C01F6.6e|wormbase:C01F6.6f|interpro:IPR001478(PDZ/DHR/GLGF)|wormbase:C01F6.6b|ensemblmetazoa:C01F6.6a.1(transcript)|ensemblmetazoa:WBGene00006438(gene)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0043495"(protein-membrane adaptor activity)|wormbase:C01F6.6h|wormbase:C01F6.6i|wormbase:C01F6.6j|interpro:IPR036034|interpro:IPR041489|refseq:NP_001040908.1|refseq:NP_001040909.1|refseq:NP_001040910.1|refseq:NP_001263761.1|refseq:NP_001263762.1|refseq:NP_001294067.1|refseq:NP_001294068.1|refseq:NP_001294128.1|refseq:NP_741479.1	refseq:NP_505905.2|wormbase:T11F9.4a|interpro:IPR002293(Amino acid/polyamine transporter I)|ensemblmetazoa:T11F9.4a.1(transcript)|ensemblmetazoa:WBGene00000007(gene)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030165"(PDZ domain binding)|wormbase:T11F9.4b|refseq:NP_001123014.1	-	-	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	-	2019/06/07	2019/10/18	rogid:WbTvGjSnMxnKlKVHTRnxI4g0Dnc6239	rogid:2uyibSqkrYbZkqCKhIDeyc0Vexo6239	rigid:QIKdw0jy8ZPZHTXnm0vSVAWOmho	false	-	green fluorescent protein tag:517-518	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0867"(tag visualisation by fluorescence)