#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283395|imex:IM-27536-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2A, 2H, 2I, 4B, Supp Fig. 1B, 2E, 3A|comment:SNCA nucleation seeds, generated by ultrasonication of mature SNCA fibers, promotes the amyloid conversion of SNCA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P37840	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283401|imex:IM-27536-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2A, 2H, 3A, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	-	necessary binding region:111-140|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P37840	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283401|imex:IM-27536-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2A, 2H, 3A, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	-	necessary binding region:111-140|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42858	uniprotkb:P42858	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283447|imex:IM-27536-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rigid:5PniyGAqIwvVQFb1o3V2RavDyyw	false	mutation:18-18	mutation:18-18	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42858	uniprotkb:P42858	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283465|imex:IM-27536-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rigid:op3i6fjrnumdDI1suYnx0OgDytg	false	mutation:18-18	mutation:18-18	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42858	uniprotkb:O75920-2	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283465|imex:IM-27536-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	-	-	-	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rigid:op3i6fjrnumdDI1suYnx0OgDytg	false	mutation:18-18	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283514|imex:IM-27536-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P05067-PRO_0000000092	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-821758	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283518|imex:IM-27536-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:z0Me8q16nrujjqcyQyql6ySryHE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P05067-PRO_0000000092	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-821758	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283518|imex:IM-27536-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:z0Me8q16nrujjqcyQyql6ySryHE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04925	uniprotkb:P04925	intact:EBI-768613|ensembl:ENSMUSP00000088833	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283523|imex:IM-27536-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523	-	-	-	figure legend:Fig. 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rigid:nB8UAu94uMDt+4jGujfj8HPTfco	false	his tag:n-n|sufficient binding region:23-230	his tag:n-n|sufficient binding region:23-230	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P04925	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283535|imex:IM-27536-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523	-	-	-	figure legend:Fig. 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rigid:6xd6H4RVK9dju4qg+2TR+vBpvtU	false	-	his tag:n-n|sufficient binding region:23-230	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P04925	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283535|imex:IM-27536-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523	-	-	-	figure legend:Fig. 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rigid:6xd6H4RVK9dju4qg+2TR+vBpvtU	false	-	his tag:n-n|sufficient binding region:23-230	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283414|imex:IM-27536-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/12/05	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75920-2	uniprotkb:P37840	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22267726|imex:IM-27536-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/12/05	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	-	his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75920-2	uniprotkb:P37840	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22267726|imex:IM-27536-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/12/05	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	-	his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283556|imex:IM-27536-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 3B, 4C, 4D, Supp. Fig. 2C, 3F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283567|imex:IM-27536-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 3C, Supp. Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283609|imex:IM-27536-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 4A, Supp. Fig. 2A, 3A|stimulant:O75920-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283621|imex:IM-27536-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Supp. Fig. 2D, 3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283642|imex:IM-27536-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283662|imex:IM-27536-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Supp. Fig. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37840	uniprotkb:O75920-2	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283674|imex:IM-27536-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	-	-	-	figure legend:Fig. 5A, 5B, Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-6 ~3.0(molar)	2019/03/28	2019/03/28	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	his tag:n-n|15n label:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75920-2	uniprotkb:P37840	intact:EBI-21283682|ensembl:ENSP00000321791|ensembl:ENSP00000370127|ensembl:ENSP00000481118|ensembl:ENSP00000482392|ensembl:ENSP00000487374	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:o75920-2(display_long)|uniprotkb:SERF1A(gene name)|psi-mi:SERF1A(display_short)|uniprotkb:FAM2A(gene name synonym)|uniprotkb:SERF1B(gene name)|psi-mi:SERF1B(display_short)|uniprotkb:FAM2B(gene name synonym)|uniprotkb:SERF1(gene name synonym)|uniprotkb:SMAM1(gene name synonym)|uniprotkb:Protein 4F5(gene name synonym)|uniprotkb:SMA modifier 1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283699|imex:IM-27536-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2115181(isoform-parent)|ensembl:ENSG00000172058(gene)|ensembl:ENSG00000205572(gene)|ensembl:ENSG00000275581(gene)|ensembl:ENSG00000277429(gene)|ensembl:ENSG00000278839(gene)|ensembl:ENST00000317633(transcript)|ensembl:ENST00000380751(transcript)|ensembl:ENST00000611616(transcript)|ensembl:ENST00000621283(transcript)|ensembl:ENST00000627372(transcript)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.0x10^-6(molar)	2019/03/28	2019/12/04	rogid:Xg+7giETDBLkQB4y8j6vsMlMtpE9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rigid:Qup9wzULkeuN1SoJ5RQzwKCPAh8	false	atto 550:?-?|his tag:c-c|v5 tag:c-c	sufficient binding region:1-110|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P00889	uniprotkb:P00889	intact:EBI-21283572|ensembl:ENSSSCP00000056310|ensembl:ENSSSCP00005023708|ensembl:ENSSSCP00005023775|ensembl:ENSSSCP00015041581|ensembl:ENSSSCP00070050810	intact:EBI-21283572|ensembl:ENSSSCP00000056310|ensembl:ENSSSCP00005023708|ensembl:ENSSSCP00005023775|ensembl:ENSSSCP00015041581|ensembl:ENSSSCP00070050810	psi-mi:cisy_pig(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym)	psi-mi:cisy_pig(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283593|imex:IM-27536-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00000035686(gene)|ensembl:ENSSSCG00005024394(gene)|ensembl:ENSSSCG00015074449(gene)|ensembl:ENSSSCG00070029675(gene)|ensembl:ENSSSCT00000045632(transcript)|ensembl:ENSSSCT00005038623(transcript)|ensembl:ENSSSCT00005038710(transcript)|ensembl:ENSSSCT00015100520(transcript)|ensembl:ENSSSCT00070059648(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0036440"(citrate synthase activity)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:1CTS|rcsb pdb:2CTS|rcsb pdb:3ENJ|rcsb pdb:4CTS|rcsb pdb:5UQS|reactome:R-SSC-71403|go:"GO:0004108"("citrate (Si)-synthase activity")|refseq:NP_999441.1	ensembl:ENSSSCG00000035686(gene)|ensembl:ENSSSCG00005024394(gene)|ensembl:ENSSSCG00015074449(gene)|ensembl:ENSSSCG00070029675(gene)|ensembl:ENSSSCT00000045632(transcript)|ensembl:ENSSSCT00005038623(transcript)|ensembl:ENSSSCT00005038710(transcript)|ensembl:ENSSSCT00015100520(transcript)|ensembl:ENSSSCT00070059648(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0036440"(citrate synthase activity)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:1CTS|rcsb pdb:2CTS|rcsb pdb:3ENJ|rcsb pdb:4CTS|rcsb pdb:5UQS|reactome:R-SSC-71403|go:"GO:0004108"("citrate (Si)-synthase activity")|refseq:NP_999441.1	-	-	-	figure legend:Fig. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:yLKlOdPew/8iFmH5YFM08lEynoI9823	rogid:yLKlOdPew/8iFmH5YFM08lEynoI9823	rigid:FZVGUTkE0ofDrEj0SwYC0aZ41Dk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01308	uniprotkb:P01308	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:1232"(aggregation assay)	Falsone et al. (2012)	pubmed:22854022|imex:IM-27536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21283598|imex:IM-27536-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	-	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	figure legend:Fig. 3F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/28	2019/03/28	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rigid:G7zQotcx6N1ROS55MQ1QCp3vXiU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)