#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6UWF3	uniprotkb:Q6ZN84	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229877|imex:IM-27251-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3A, 3B|comment:MHC-II was also present in the complex but cannot be mapped to a single protein. Complex only isolated when membranes were solubilized with Brij 98 or CHAPS, but not with the tetraspanin-disrupting detergent NP-40.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:Vvi65kH5PcIEnO4D84BzSPqxlrg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11049	uniprotkb:Q6UWF3	intact:EBI-6139068|uniprotkb:Q3KPF9|uniprotkb:B4DVC1|ensembl:ENSP00000325708	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	psi-mi:cd37_human(display_long)|uniprotkb:CD37(gene name)|psi-mi:CD37(display_short)|uniprotkb:TSPAN26(gene name synonym)|uniprotkb:Tetraspanin-26(gene name synonym)	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229882|imex:IM-27251-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525846.1|refseq:NP_001765.1|refseq:NP_001035120.1|refseq:XP_016883002.1|ensembl:ENSG00000104894(gene)|ensembl:ENST00000323906(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P11049	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	-	-	-	figure legend:Fig. 3B|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:UHhxsku7pXLu+xO/q0Bbg9q9LM89606	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rigid:7aKt73j+swzzjA755aU9/N6n1V4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11049	uniprotkb:Q6ZN84	intact:EBI-6139068|uniprotkb:Q3KPF9|uniprotkb:B4DVC1|ensembl:ENSP00000325708	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:cd37_human(display_long)|uniprotkb:CD37(gene name)|psi-mi:CD37(display_short)|uniprotkb:TSPAN26(gene name synonym)|uniprotkb:Tetraspanin-26(gene name synonym)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229882|imex:IM-27251-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011525846.1|refseq:NP_001765.1|refseq:NP_001035120.1|refseq:XP_016883002.1|ensembl:ENSG00000104894(gene)|ensembl:ENST00000323906(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P11049	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3B|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:UHhxsku7pXLu+xO/q0Bbg9q9LM89606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:7aKt73j+swzzjA755aU9/N6n1V4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19397	uniprotkb:Q6UWF3	intact:EBI-6657396|ensembl:ENSP00000271324|ensembl:ENSP00000497382|uniprotkb:Q5U0D6|uniprotkb:B2R905	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	psi-mi:cd53_human(display_long)|uniprotkb:CD53(gene name)|psi-mi:CD53(display_short)|uniprotkb:Cell surface glycoprotein CD53(gene name synonym)|uniprotkb:MOX44(gene name synonym)|uniprotkb:TSPAN25(gene name synonym)|uniprotkb:Tetraspanin-25(gene name synonym)	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229927|imex:IM-27251-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143119(gene)|ensembl:ENST00000271324(transcript)|ensembl:ENST00000648608(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|rcsb pdb:6WVG|reactome:R-HSA-6798695|refseq:NP_000551.1|refseq:NP_001035122.1	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	-	-	-	figure legend:Fig. 3B|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:mO645m0ZAINvowFvsqD9ddnFZd49606	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19397	uniprotkb:Q6ZN84	intact:EBI-6657396|ensembl:ENSP00000271324|ensembl:ENSP00000497382|uniprotkb:Q5U0D6|uniprotkb:B2R905	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:cd53_human(display_long)|uniprotkb:CD53(gene name)|psi-mi:CD53(display_short)|uniprotkb:Cell surface glycoprotein CD53(gene name synonym)|uniprotkb:MOX44(gene name synonym)|uniprotkb:TSPAN25(gene name synonym)|uniprotkb:Tetraspanin-25(gene name synonym)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229927|imex:IM-27251-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143119(gene)|ensembl:ENST00000271324(transcript)|ensembl:ENST00000648608(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|rcsb pdb:6WVG|reactome:R-HSA-6798695|refseq:NP_000551.1|refseq:NP_001035122.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3B|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:mO645m0ZAINvowFvsqD9ddnFZd49606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P11049	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-6139068|uniprotkb:Q3KPF9|uniprotkb:B4DVC1|ensembl:ENSP00000325708	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:cd37_human(display_long)|uniprotkb:CD37(gene name)|psi-mi:CD37(display_short)|uniprotkb:TSPAN26(gene name synonym)|uniprotkb:Tetraspanin-26(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229965|imex:IM-27251-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:XP_011525846.1|refseq:NP_001765.1|refseq:NP_001035120.1|refseq:XP_016883002.1|ensembl:ENSG00000104894(gene)|ensembl:ENST00000323906(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P11049	-	-	-	figure legend:Fig. 3C|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:UHhxsku7pXLu+xO/q0Bbg9q9LM89606	rigid:7aKt73j+swzzjA755aU9/N6n1V4	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q6ZN84	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229965|imex:IM-27251-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3C|comment:Membranes were solubilized with CHAPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:7aKt73j+swzzjA755aU9/N6n1V4	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q6ZN84	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229981|imex:IM-27251-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3D, 5F|comment:Membranes were solubilized with Brij98. A weak interaction with MHCII was also observed when full length SCIMP was present.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:Vvi65kH5PcIEnO4D84BzSPqxlrg	false	sufficient binding region:1-80,104-145|myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P41240	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230018|imex:IM-27251-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:Fig. 5D, 5E|comment:"Cell were treated with pervanadate (PV), (a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:1z5qCbCAnoUQ/pVRRQPI3Zw31Ig	false	myc tag:c-c|mutation with no effect:124-124|sufficient binding region:1-80,104-145|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P62993	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230018|imex:IM-27251-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:Fig. 5D, 5E|comment:"Cell were treated with pervanadate (PV), (a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:1z5qCbCAnoUQ/pVRRQPI3Zw31Ig	false	myc tag:c-c|mutation with no effect:124-124|sufficient binding region:1-80,104-145|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q8WV28	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230018|imex:IM-27251-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1	-	-	-	figure legend:Fig. 5D, 5E|comment:"Cell were treated with pervanadate (PV), (a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:befGiho6PlVSSMPyb84d31TT/So9606	rigid:1z5qCbCAnoUQ/pVRRQPI3Zw31Ig	false	myc tag:c-c|mutation with no effect:124-124|sufficient binding region:1-80,104-145|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41240	uniprotkb:Q6UWF3	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230027|imex:IM-27251-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	-	-	-	figure legend:Fig. 5E|comment:"Cell were treated with pervanadate (PV), (a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rigid:lWvqLAgGPCWvB6uUmSuKSEjaEas	false	-	mutation:131-131|myc tag:c-c|mutation:69-69|phosphorylated residue:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P62993	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230040|imex:IM-27251-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:Fig. 5E|comment:"Cell were treated with pervanadate (PV), ( a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:tuebwV7LIGf4INEZnrMQ+0fmaBo	false	myc tag:c-c|mutation:107-107|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q8WV28	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230040|imex:IM-27251-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1	-	-	-	figure legend:Fig. 5E|comment:"Cell were treated with pervanadate (PV), ( a protein tyrosine phosphatase inhibitor), and lysed with a relatively stringent detergent, laurylmaltoside."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:befGiho6PlVSSMPyb84d31TT/So9606	rigid:tuebwV7LIGf4INEZnrMQ+0fmaBo	false	myc tag:c-c|mutation:107-107|phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P07948	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230084|imex:IM-27251-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Fig. 5F|comment:Membranes were solubilized with Brij98|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:U+IML1enplq/++5a/8k5JMovOFs	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q6ZN84	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230084|imex:IM-27251-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 5F|comment:Membranes were solubilized with Brij98|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:U+IML1enplq/++5a/8k5JMovOFs	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P07948	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230092|imex:IM-27251-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Fig. 5F|comment:Membranes were solubilized with Brij98.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:B/8dJHZZhhb/sHQ5JwMMbwX4L48	false	necessary binding region:81-103|myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19397	uniprotkb:Q6UWF3	intact:EBI-6657396|ensembl:ENSP00000271324|ensembl:ENSP00000497382|uniprotkb:Q5U0D6|uniprotkb:B2R905	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	psi-mi:cd53_human(display_long)|uniprotkb:CD53(gene name)|psi-mi:CD53(display_short)|uniprotkb:Cell surface glycoprotein CD53(gene name synonym)|uniprotkb:MOX44(gene name synonym)|uniprotkb:TSPAN25(gene name synonym)|uniprotkb:Tetraspanin-25(gene name synonym)	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229996|imex:IM-27251-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143119(gene)|ensembl:ENST00000271324(transcript)|ensembl:ENST00000648608(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|rcsb pdb:6WVG|reactome:R-HSA-6798695|refseq:NP_000551.1|refseq:NP_001035122.1	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	-	-	-	figure legend:Fig. 3E|comment:Membranes were solubilized with CHAPS. MHCII was also observed but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2019/03/06	2019/03/06	rogid:mO645m0ZAINvowFvsqD9ddnFZd49606	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19397	uniprotkb:Q6ZN84	intact:EBI-6657396|ensembl:ENSP00000271324|ensembl:ENSP00000497382|uniprotkb:Q5U0D6|uniprotkb:B2R905	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	psi-mi:cd53_human(display_long)|uniprotkb:CD53(gene name)|psi-mi:CD53(display_short)|uniprotkb:Cell surface glycoprotein CD53(gene name synonym)|uniprotkb:MOX44(gene name synonym)|uniprotkb:TSPAN25(gene name synonym)|uniprotkb:Tetraspanin-25(gene name synonym)	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21229996|imex:IM-27251-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143119(gene)|ensembl:ENST00000271324(transcript)|ensembl:ENST00000648608(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|rcsb pdb:6WVG|reactome:R-HSA-6798695|refseq:NP_000551.1|refseq:NP_001035122.1	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	-	-	-	figure legend:Fig. 3E|comment:Membranes were solubilized with CHAPS. MHCII was also observed but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2019/03/06	2019/03/06	rogid:mO645m0ZAINvowFvsqD9ddnFZd49606	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZN84	uniprotkb:P19397	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	intact:EBI-6657396|ensembl:ENSP00000271324|ensembl:ENSP00000497382|uniprotkb:Q5U0D6|uniprotkb:B2R905	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:cd53_human(display_long)|uniprotkb:CD53(gene name)|psi-mi:CD53(display_short)|uniprotkb:Cell surface glycoprotein CD53(gene name synonym)|uniprotkb:MOX44(gene name synonym)|uniprotkb:TSPAN25(gene name synonym)|uniprotkb:Tetraspanin-25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230002|imex:IM-27251-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	ensembl:ENSG00000143119(gene)|ensembl:ENST00000271324(transcript)|ensembl:ENST00000648608(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|rcsb pdb:6WVG|reactome:R-HSA-6798695|refseq:NP_000551.1|refseq:NP_001035122.1	-	-	-	figure legend:Fig. 3E|comment:Membranes were solubilized with CHAPS. MHCII was also observed but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2019/03/06	2019/03/06	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rogid:mO645m0ZAINvowFvsqD9ddnFZd49606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZN84	uniprotkb:Q6UWF3	intact:EBI-14404745|ensembl:ENSP00000415528|uniprotkb:A0AVL7|uniprotkb:Q53FW3|uniprotkb:Q9H5E5	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	psi-mi:ccd81_human(display_long)|uniprotkb:CCDC81(gene name)|psi-mi:CCDC81(display_short)	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230002|imex:IM-27251-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000445632(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR026295|interpro:IPR028034|interpro:IPR040673|ensembl:ENSG00000149201(gene)|refseq:NP_001149946.1|refseq:NP_068599.3	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	-	-	-	figure legend:Fig. 3E|comment:Membranes were solubilized with CHAPS. MHCII was also observed but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2019/03/06	2019/03/06	rogid:JoFC8dj1sUb3PCxIb9iryJmiQRU9606	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rigid:kEhyxzQAzoEkvfdxLbx5VnI5gUI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UU41	uniprotkb:Q9QUN3	intact:EBI-21230112|uniprotkb:B2RVG2|uniprotkb:Q5SX69|ensembl:ENSMUSP00000104174	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:scimp_mouse(display_long)|uniprotkb:Scimp(gene name)|psi-mi:Scimp(display_short)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230130|imex:IM-27251-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001038991.1|ensembl:ENSMUSG00000057135(gene)|ensembl:ENSMUST00000108534(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	-	-	-	figure legend:Fig. 5G|comment:Cells were activated with anti-MHC-II antibody, lysed in laurylmaltoside|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-k46)|taxid:10090(Mouse B-cell K46)	-	2019/03/06	2019/03/06	rogid:g5OcKOZ++VnByDGD/kAhrnpB4hQ10090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	rigid:FRAcVDBm9ULZj0EhaX7ZAMefyQQ	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3UU41	uniprotkb:Q60631	intact:EBI-21230112|uniprotkb:B2RVG2|uniprotkb:Q5SX69|ensembl:ENSMUSP00000104174	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:scimp_mouse(display_long)|uniprotkb:Scimp(gene name)|psi-mi:Scimp(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230130|imex:IM-27251-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001038991.1|ensembl:ENSMUSG00000057135(gene)|ensembl:ENSMUST00000108534(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	-	-	figure legend:Fig. 5G|comment:Cells were activated with anti-MHC-II antibody, lysed in laurylmaltoside|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-k46)|taxid:10090(Mouse B-cell K46)	-	2019/03/06	2019/03/06	rogid:g5OcKOZ++VnByDGD/kAhrnpB4hQ10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rigid:FRAcVDBm9ULZj0EhaX7ZAMefyQQ	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P07948	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230153|imex:IM-27251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	-	-	figure legend:Fig. 6B|comment:Cell were activated  with anti-CD25 antibody and lysed with a relatively stringent detergent, laurylmaltoside.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-raji)|taxid:9606(Homo sapiens RAJI Burkitt lymphoma cells)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:wTD7rmv0iKXrxW8e6qSrm2ziTXQ	false	myc tag:c-c|phosphorylated residue:?-?|fusion protein:n-n|sufficient binding region:13-145	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P41240	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-1380630|uniprotkb:Q2M3N2|uniprotkb:Q6FGZ6|ensembl:ENSP00000220003|ensembl:ENSP00000414764|ensembl:ENSP00000454906	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:csk_human(display_long)|uniprotkb:CSK(gene name)|psi-mi:CSK(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase CYL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230153|imex:IM-27251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001120662.1|refseq:NP_004374.1|refseq:XP_005254222.1|refseq:XP_016877414.1|ensembl:ENSG00000103653(gene)|ensembl:ENST00000220003(transcript)|ensembl:ENST00000439220(transcript)|ensembl:ENST00000567571(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|mint:P41240|rcsb pdb:1BYG|rcsb pdb:1CSK|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3EAC|rcsb pdb:3EAZ|reactome:R-HSA-180292|reactome:R-HSA-202427|reactome:R-HSA-354192|reactome:R-HSA-389948|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9013407|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9706369	-	-	-	figure legend:Fig. 6B|comment:Cell were activated  with anti-CD25 antibody and lysed with a relatively stringent detergent, laurylmaltoside.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-raji)|taxid:9606(Homo sapiens RAJI Burkitt lymphoma cells)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:9n6rgUUGjJ+e0fMPrB4A7JGyZqE9606	rigid:wTD7rmv0iKXrxW8e6qSrm2ziTXQ	false	myc tag:c-c|phosphorylated residue:?-?|fusion protein:n-n|sufficient binding region:13-145	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:P62993	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230153|imex:IM-27251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:Fig. 6B|comment:Cell were activated  with anti-CD25 antibody and lysed with a relatively stringent detergent, laurylmaltoside.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-raji)|taxid:9606(Homo sapiens RAJI Burkitt lymphoma cells)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rigid:wTD7rmv0iKXrxW8e6qSrm2ziTXQ	false	myc tag:c-c|phosphorylated residue:?-?|fusion protein:n-n|sufficient binding region:13-145	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UWF3	uniprotkb:Q8WV28	intact:EBI-2872510|intact:EBI-28974981|ensembl:ENSP00000461269|uniprotkb:Q96MD0|uniprotkb:B4DLK1|uniprotkb:A6XGL4	intact:EBI-2623522|uniprotkb:O75498|uniprotkb:O75499|ensembl:ENSP00000224337|uniprotkb:Q2MD49	psi-mi:scimp_human(display_long)|uniprotkb:SCIMP(gene name)|psi-mi:SCIMP(display_short)|uniprotkb:C17orf87(gene name synonym)|uniprotkb:SLP65/SLP76, Csk-interacting membrane protein(gene name synonym)|uniprotkb:UNQ5783/PRO16090(orf name)	psi-mi:blnk_human(display_long)|uniprotkb:BASH(gene name synonym)|uniprotkb:SLP65(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:BLNK(gene name)|psi-mi:BLNK(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draber et al. (2011)	pubmed:21930792|imex:IM-27251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21230153|imex:IM-27251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161929(gene)|ensembl:ENST00000574081(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030175"(filopodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031259"(uropod membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097197"(tetraspanin-enriched microdomain)|interpro:IPR028181|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|ensembl:ENST00000399600|ensembl:ENSP00000382509|ensembl:ENST00000571800|ensembl:ENSP00000459605|ensembl:ENSP00000461269|refseq:NP_996986.1|refseq:NP_001306119.1|refseq:NP_001258771.1	refseq:NP_001107566.1|refseq:NP_037446.1|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q8WV28|rcsb pdb:6YLU|reactome:R-HSA-912631|reactome:R-HSA-983695|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000095585(gene)|ensembl:ENST00000224337(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|refseq:NP_001245369.1	-	-	-	figure legend:Fig. 6B|comment:Cell were activated  with anti-CD25 antibody and lysed with a relatively stringent detergent, laurylmaltoside.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-raji)|taxid:9606(Homo sapiens RAJI Burkitt lymphoma cells)	-	2019/03/06	2019/03/06	rogid:bWQwbjlZLsf4iHC4GrgWP/LwBFs9606	rogid:befGiho6PlVSSMPyb84d31TT/So9606	rigid:wTD7rmv0iKXrxW8e6qSrm2ziTXQ	false	myc tag:c-c|phosphorylated residue:?-?|fusion protein:n-n|sufficient binding region:13-145	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)