#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35158	uniprotkb:Q13635	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396094|imex:IM-26979-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure 3a, 3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/30	2019/05/01	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:JYpDUJuyxfnU5W6KYmdeFghms0k	false	mutation decreasing interaction strength:777-777|mutation decreasing interaction strength:686-686|mutation decreasing interaction strength:787-787|mutation decreasing interaction strength:937-937|mutation decreasing interaction strength:688-688|mutation with no effect:681-681	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35158	uniprotkb:Q9BWV1	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396531|imex:IM-26979-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure 3c, 3d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/01	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rigid:WJ3Zb9TondLqe+TwTc9AnG25x48	false	mutation with no effect:681-681|mutation with no effect:777-777|mutation with no effect:937-937|mutation with no effect:688-688|mutation with no effect:787-787|mutation decreasing interaction strength:686-686	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:Q01721	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396573|imex:IM-26979-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure 3f, 3g|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/01	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:Iw1EBv2G66sMiXrnitsltCJjUQA	false	mutation with no effect:681-681|mutation with no effect:777-777|mutation with no effect:688-688|mutation decreasing interaction strength:686-686|mutation decreasing interaction strength:787-787|mutation decreasing interaction strength:937-937	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:Q01721	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397817|imex:IM-26979-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure S8e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/02	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:Iw1EBv2G66sMiXrnitsltCJjUQA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q32MD9	uniprotkb:Q01721	intact:EBI-7017034|ensembl:ENSMUSP00000045547|ensembl:ENSMUSP00000113977|uniprotkb:E9QKV9|intact:UNK-5400048|uniprotkb:O88971	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_mouse(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396556|imex:IM-26979-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006510570.1|refseq:XP_006510571.1|refseq:XP_006510572.1|refseq:XP_006510573.1|refseq:XP_006510574.1|refseq:XP_011240883.1|dip:DIP-57227N|ensembl:ENSMUSG00000038119(gene)|ensembl:ENSMUST00000042842(transcript)|ensembl:ENSMUST00000119129(transcript)|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q32MD9|reactome:R-MMU-525793|reactome:R-MMU-5632681|reactome:R-MMU-5635838|go:"GO:0043393"(regulation of protein binding)|refseq:NP_067314.2	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3	-	figure legend:Figure 3e, Figure S8c|comment:The amount of GAS1 that coprecipitated with CDON was not significantly altered by pretreatment of the cells with SHH-N|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c3h10t1_2)|taxid:10090(Mouse embryonic fibroblast C3H10T1_2)	-	2019/04/30	2019/05/01	rogid:GYx35GRWYwplerMIaopmyqHx6Jw10090	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:HEEU5jYixkb5zpQ1gcaqe/MvFGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01721	uniprotkb:Q6AZB0	intact:EBI-15729104|ensembl:ENSMUSP00000064555	intact:EBI-15610126|uniprotkb:Q6KAM5|uniprotkb:Q6P5H3|uniprotkb:Q7TMJ3|uniprotkb:Q8CE73|uniprotkb:Q8CE91|uniprotkb:Q8R377|uniprotkb:Q923W7	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:boc_mouse(display_long)|uniprotkb:Boc(gene name)|psi-mi:Boc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398210|imex:IM-26979-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0030424"(axon)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X4Y|rcsb pdb:1X4Z|reactome:R-MMU-525793|reactome:R-MMU-5635838|refseq:NP_766094.1|dip:DIP-60410N	-	-	-	figure legend:Figure S8b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c3h10t1_2)|taxid:10090(Mouse embryonic fibroblast C3H10T1_2)	-	2019/04/30	2019/05/03	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rogid:2VJdinzcmXH3y89o9dJ1PpSy2V010090	rigid:+A+aJwE35tx2fe2S3FHn+uhIvDc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q32MD9	uniprotkb:Q01721	intact:EBI-7017034|ensembl:ENSMUSP00000045547|ensembl:ENSMUSP00000113977|uniprotkb:E9QKV9|intact:UNK-5400048|uniprotkb:O88971	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_mouse(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396569|imex:IM-26979-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006510570.1|refseq:XP_006510571.1|refseq:XP_006510572.1|refseq:XP_006510573.1|refseq:XP_006510574.1|refseq:XP_011240883.1|dip:DIP-57227N|ensembl:ENSMUSG00000038119(gene)|ensembl:ENSMUST00000042842(transcript)|ensembl:ENSMUST00000119129(transcript)|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q32MD9|reactome:R-MMU-525793|reactome:R-MMU-5632681|reactome:R-MMU-5635838|go:"GO:0043393"(regulation of protein binding)|refseq:NP_067314.2	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3	-	figure legend:Figure 3e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2019/04/30	2019/05/01	rogid:GYx35GRWYwplerMIaopmyqHx6Jw10090	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:HEEU5jYixkb5zpQ1gcaqe/MvFGU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01721	uniprotkb:Q32MD9	intact:EBI-15729104|ensembl:ENSMUSP00000064555	intact:EBI-7017034|ensembl:ENSMUSP00000045547|ensembl:ENSMUSP00000113977|uniprotkb:E9QKV9|intact:UNK-5400048|uniprotkb:O88971	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:cdon_mouse(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398204|imex:IM-26979-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	refseq:XP_006510570.1|refseq:XP_006510571.1|refseq:XP_006510572.1|refseq:XP_006510573.1|refseq:XP_006510574.1|refseq:XP_011240883.1|dip:DIP-57227N|ensembl:ENSMUSG00000038119(gene)|ensembl:ENSMUST00000042842(transcript)|ensembl:ENSMUST00000119129(transcript)|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q32MD9|reactome:R-MMU-525793|reactome:R-MMU-5632681|reactome:R-MMU-5635838|go:"GO:0043393"(regulation of protein binding)|refseq:NP_067314.2	-	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3	figure legend:Figure S8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2019/04/30	2019/05/03	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rogid:GYx35GRWYwplerMIaopmyqHx6Jw10090	rigid:fE1FA4Mkk6E9/VLI0h81k6zXSh8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01721	uniprotkb:Q6AZB0	intact:EBI-15729104|ensembl:ENSMUSP00000064555	intact:EBI-15610126|uniprotkb:Q6KAM5|uniprotkb:Q6P5H3|uniprotkb:Q7TMJ3|uniprotkb:Q8CE73|uniprotkb:Q8CE91|uniprotkb:Q8R377|uniprotkb:Q923W7	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:boc_mouse(display_long)|uniprotkb:Boc(gene name)|psi-mi:Boc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398204|imex:IM-26979-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|go:"GO:0030424"(axon)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X4Y|rcsb pdb:1X4Z|reactome:R-MMU-525793|reactome:R-MMU-5635838|refseq:NP_766094.1|dip:DIP-60410N	-	-	-	figure legend:Figure S8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2019/04/30	2019/05/03	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rogid:2VJdinzcmXH3y89o9dJ1PpSy2V010090	rigid:fE1FA4Mkk6E9/VLI0h81k6zXSh8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4KMG0	uniprotkb:Q13635	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397243|imex:IM-26979-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure S6a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rd)|taxid:9606(Homo sapiens)	-	2019/04/30	2019/05/02	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:JaJTqgkaKOPy+qJZrxa49yaSRtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4KMG0	uniprotkb:Q13635	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397249|imex:IM-26979-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure S6b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rd)|taxid:9606(Homo sapiens)	-	2019/04/30	2019/05/02	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:JaJTqgkaKOPy+qJZrxa49yaSRtM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:Q01721	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397485|imex:IM-26979-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure 5a, 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/30	2019/05/03	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:Iw1EBv2G66sMiXrnitsltCJjUQA	false	fc-igg tag:?-?|sufficient binding region:718..718-815..815	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:Q9BWV1	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:"MI:0096"(pull down)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397654|imex:IM-26979-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure 5c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/07	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rigid:WJ3Zb9TondLqe+TwTc9AnG25x48	false	sufficient binding region:718..718-815..815|sufficient binding region:823..823-923..923|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:O35158	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-7016767|intact:MINT-5117456	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397778|imex:IM-26979-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	figure legend:Figure 5d, S7|comment:Participant was detected by Western blot, and by molecular weight both the bait and prey were distinguished|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/03	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rigid:cgSlu+REUIEfdScf/6mV50LN5Dg	false	-	sufficient binding region:823..823-923..923|sufficient binding region:718..718-815..815|fc-igg tag:?-?|mutation with no effect:681-681|mutation with no effect:686-686|mutation with no effect:688-688|mutation with no effect:777-777|mutation with no effect:787-787|mutation with no effect:937-937	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35158	uniprotkb:Q01721	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-15729104|ensembl:ENSMUSP00000064555	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21397798|imex:IM-26979-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure S8d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/03	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rigid:Iw1EBv2G66sMiXrnitsltCJjUQA	false	fc-igg tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01721	uniprotkb:Q9BWV1	intact:EBI-15729104|ensembl:ENSMUSP00000064555	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:"MI:0096"(pull down)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398242|imex:IM-26979-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	-	-	-	figure legend:Figure S8f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/03	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rigid:c121gDrZ5e4vI8ssvwrcgLp8vGQ	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01721	uniprotkb:Q9BWV1	intact:EBI-15729104|ensembl:ENSMUSP00000064555	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	psi-mi:gas1_mouse(display_long)|uniprotkb:Gas1(gene name)|psi-mi:Gas1(display_short)|uniprotkb:Gas-1(gene name synonym)	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398257|imex:IM-26979-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR016017(GDNF/GAS1)|interpro:IPR039596|reactome:R-MMU-5632681|reactome:R-MMU-5635838|ensembl:ENSMUSG00000052957(gene)|ensembl:ENSMUST00000065086(transcript)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|refseq:NP_032112.1|dip:DIP-59801N	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	-	-	-	figure legend:Figure S8g|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/03	rogid:Vvak9oDglyHbTXBLsNHsIyl7j3810090	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rigid:c121gDrZ5e4vI8ssvwrcgLp8vGQ	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35158	uniprotkb:Q13635	intact:EBI-7016767|intact:MINT-5117456	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:cdon_rat(display_long)|uniprotkb:Cdon(gene name)|psi-mi:Cdon(display_short)|uniprotkb:Cdo(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bae et al. (2011)	pubmed:21802063|imex:IM-26979	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21398270|imex:IM-26979-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O35158|interpro:IPR032983|go:"GO:0001708"(cell fate specification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-RNO-525793|reactome:R-RNO-5632681|reactome:R-RNO-5635838|go:"GO:0043393"(regulation of protein binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_059054.1|rgd:708433|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR036116|interpro:IPR036179	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Figure S6c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/30	2019/05/03	rogid:oe1E7rUyGntvgaJ79G30sTz6Pq410116	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:JYpDUJuyxfnU5W6KYmdeFghms0k	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)