#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21294813|imex:IM-26941-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/29	2019/04/04	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:KZJSQYFy/EzS9XFFNc8Lk6nJ8AQ	false	flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21294836|imex:IM-26941-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	-	-	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/29	2019/04/04	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:KZJSQYFy/EzS9XFFNc8Lk6nJ8AQ	false	flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21294855|imex:IM-26941-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 1C|comment:Co-localization of the two receptors was observed on the cell surface as well as distinct puncta within the cell .|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2019/03/29	2019/04/04	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:KZJSQYFy/EzS9XFFNc8Lk6nJ8AQ	false	flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P25106	uniprotkb:P49407	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21298271|imex:IM-26941-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 2D|comment:Co-localization of the two receptors was observed on the cell surface as well as distinct puncta within the cell .|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2019/03/29	2019/04/05	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rigid:7u3Q/shOW4KweVIZhYs8E7PGLz0	false	flag tag:c-c	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21298271|imex:IM-26941-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 2D|comment:Co-localization of the two receptors was observed on the cell surface as well as distinct puncta within the cell .|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuro_2_a)|taxid:10090("Mus musculus albino neuroblastoma cell line neuro 2 a (N2a)")	-	2019/03/29	2019/04/05	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:7u3Q/shOW4KweVIZhYs8E7PGLz0	false	flag tag:c-c	tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P25106	uniprotkb:P49407	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Décaillot et al. (2011)	pubmed:21730065|imex:IM-26941	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21294877|imex:IM-26941-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N	-	-	-	figure legend:Figure 2A/B/C|comment:Co-expression of CXCR4 and CXCR7 resulted in a dramatic increase in both basal and SDF-1-induced beta-arrestin co-immunoprecipitation with CXCR7.|agonist:"CXCL12 (SDF-1) treatment in presence of transfected CXCR4."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/29	2019/04/04	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rigid:PGZeVTk84uUSMQJK/J2wMdg12Tg	false	flag tag:c-c	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)