#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N6Q3 uniprotkb:P62834 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P20701 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-961214|ensembl:ENSP00000349252|uniprotkb:O43746|uniprotkb:Q45H73|uniprotkb:Q9UBC8|intact:EBI-3962403|uniprotkb:Q96HB1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ital_human(display_long)|uniprotkb:ITGAL(gene name)|psi-mi:ITGAL(display_short)|uniprotkb:CD11A(gene name synonym)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002200.2|ensembl:ENSG00000005844(gene)|ensembl:ENST00000356798(transcript)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1CQP|rcsb pdb:1DGQ|rcsb pdb:1IJ4|rcsb pdb:1LFA|rcsb pdb:1MJN|rcsb pdb:1MQ8|rcsb pdb:1MQ9|rcsb pdb:1MQA|rcsb pdb:1RD4|rcsb pdb:1T0P|rcsb pdb:1XDD|rcsb pdb:1XDG|rcsb pdb:1XUO|rcsb pdb:1ZON|rcsb pdb:1ZOO|rcsb pdb:1ZOP|rcsb pdb:2ICA|rcsb pdb:2K8O|rcsb pdb:2M3E|rcsb pdb:2O7N|rcsb pdb:3BN3|rcsb pdb:3BQM|rcsb pdb:3BQN|rcsb pdb:3E2M|rcsb pdb:3EOA|rcsb pdb:3EOB|rcsb pdb:3F74|rcsb pdb:3HI6|rcsb pdb:3F78|rcsb pdb:3M6F|rcsb pdb:3TCX|rcsb pdb:4IXD|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6798695|reactome:R-HSA-8949275|refseq:NP_001107852.1|dip:DIP-623N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:JeiBJZbkw8mtrE7WrFlkepPiAOY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O75923 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2799016|uniprotkb:Q53QY3|uniprotkb:B1PZ70|uniprotkb:B1PZ72|uniprotkb:B1PZ76|uniprotkb:B1PZ79|uniprotkb:B1PZ71|uniprotkb:B1PZ73|uniprotkb:Q8TEL8|uniprotkb:Q09EX5|uniprotkb:Q0H395|uniprotkb:B3KQB9|uniprotkb:B1PZ77|uniprotkb:B1PZ80|uniprotkb:B1PZ81|uniprotkb:B1PZ74|uniprotkb:B1PZ75|uniprotkb:B1PZ78|uniprotkb:O75696|uniprotkb:Q9UEN7|uniprotkb:Q53TD2|uniprotkb:A0FK00|ensembl:ENSP00000258104 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:dysf_human(display_long)|uniprotkb:FER1L1(gene name synonym)|uniprotkb:Dystrophy-associated fer-1-like protein(gene name synonym)|uniprotkb:Fer-1-like protein 1(gene name synonym)|uniprotkb:DYSF(gene name)|psi-mi:DYSF(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001123927.1|refseq:NP_001124448.1|refseq:NP_001124449.1|refseq:NP_001124450.1|refseq:NP_001124451.1|refseq:NP_001124452.1|refseq:NP_001124453.1|refseq:NP_001124454.1|refseq:NP_001124455.1|refseq:NP_001124456.1|refseq:NP_001124457.1|refseq:NP_001124458.1|refseq:NP_001124459.1|refseq:NP_003485.1|ensembl:ENST00000258104(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002280"(monocyte activation involved in immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042383"(sarcolemma)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029998|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|rcsb pdb:4CAH|rcsb pdb:4CAI|rcsb pdb:4IHB|rcsb pdb:4IQH|rcsb pdb:7JOF|rcsb pdb:7K6B|rcsb pdb:7KRB|reactome:R-HSA-445355|ensembl:ENSG00000135636(gene) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:DOlOZvT68wMjkY4tQgaoT2hMQ7U9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P07948 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q92930 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1760095|uniprotkb:Q9P293|uniprotkb:Q5JPC4|ensembl:ENSP00000312734 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab8b_human(display_long)|uniprotkb:RAB8B(gene name)|psi-mi:RAB8B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_057614.1|ensembl:ENSG00000166128(gene)|ensembl:ENST00000321437(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016604"(nuclear body)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0150115"(cell-substrate junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q92930|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:1EzHoU6jEdli/t9gfwMBDjW3fNI9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P49748 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-727618|intact:EBI-10981570|uniprotkb:O76056|uniprotkb:Q8WUL0|uniprotkb:B4DEB6|uniprotkb:F5H2A9|ensembl:ENSP00000349297 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:acadv_human(display_long)|uniprotkb:ACADVL(gene name)|psi-mi:ACADVL(display_short)|uniprotkb:VLCAD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000009.1|refseq:NP_001029031.1|refseq:NP_001257376.1|ensembl:ENSG00000072778(gene)|ensembl:ENST00000356839(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:P49748|rcsb pdb:2UXW|rcsb pdb:3B96|reactome:R-HSA-381038|reactome:R-HSA-77305|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009409"(response to cold)|go:"GO:0015980"(energy derivation by oxidation of organic compounds)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0090181"(regulation of cholesterol metabolic process)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:3SR9FcNgkWFPGrRGTi8JaJtwiF49606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05164 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2556173|uniprotkb:Q14862|uniprotkb:Q9UCL7|uniprotkb:A1L4B8|uniprotkb:Q4PJH5|ensembl:ENSP00000225275 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:perm_human(display_long)|uniprotkb:MPO(gene name)|psi-mi:MPO(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000241.1|ensembl:ENSG00000005381(gene)|go:"GO:0002149"(hypochlorous acid biosynthetic process)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000225275(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042582"(azurophil granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1990268"(response to gold nanoparticle)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029609|interpro:IPR037120|mint:P05164|rcsb pdb:1CXP|rcsb pdb:1D2V|rcsb pdb:1D5L|rcsb pdb:1D7W|rcsb pdb:1DNU|rcsb pdb:1DNW|rcsb pdb:1MHL|rcsb pdb:1MYP|rcsb pdb:3F9P|rcsb pdb:3ZS0|rcsb pdb:3ZS1|rcsb pdb:4C1M|rcsb pdb:4DL1|rcsb pdb:4EJX|rcsb pdb:5FIW|rcsb pdb:5MFA|rcsb pdb:5UZU|rcsb pdb:6AZP|rcsb pdb:6BMT|reactome:R-HSA-6798695|reactome:R-HSA-8941413 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:SNoAXb3csr/iOyGWeyWcUyJTZLY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08670 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P46940 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P17213 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-21402203|ensembl:ENSP00000262865|uniprotkb:B2RCY2|uniprotkb:Q1ZZU8|uniprotkb:Q5JRW0|uniprotkb:Q8IW58|uniprotkb:Q9BYZ9|uniprotkb:Q9H1L2|uniprotkb:Q9H1M8|uniprotkb:Q9H203|uniprotkb:Q9UCT4|uniprotkb:Q9UD65 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:bpi_human(display_long)|uniprotkb:BPI(gene name)|psi-mi:BPI(display_short)|uniprotkb:CAP 57(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0045087"(innate immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001124(Lipid-binding serum glycoprotein)|interpro:IPR017942|interpro:IPR017943|interpro:IPR017954|interpro:IPR030181|interpro:IPR030675|interpro:IPR032942|rcsb pdb:1BP1|rcsb pdb:1EWF|reactome:R-HSA-166016|reactome:R-HSA-6798695|go:"GO:0043031"(negative regulation of macrophage activation)|reactome:R-HSA-6803157|ensembl:ENSG00000101425(gene)|ensembl:ENST00000262865(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|refseq:NP_001716.2 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Fij6bDpg2PwyQWVMHK28/rTiVt09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P22695 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1051424|uniprotkb:Q9BQ05|uniprotkb:B3KSN4|ensembl:ENSP00000268379 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:qcr2_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:UQCRC2(gene name)|psi-mi:UQCRC2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_003357.2|ensembl:ENSG00000140740(gene)|ensembl:ENST00000268379(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0009060"(aerobic respiration)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P22695|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:++DmwaVpqzRyxFl7mh62L4ku4P09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:B0I1T2 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2857637|uniprotkb:Q96RI5|uniprotkb:Q8TEI9|uniprotkb:Q96RI6|uniprotkb:Q8TES2|uniprotkb:Q96BE2|ensembl:ENSP00000258787 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:myo1g_human(display_long)|uniprotkb:MYO1G(gene name)|psi-mi:MYO1G(display_short)|uniprotkb:HA2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_149043.2|ensembl:ENSG00000136286(gene)|ensembl:ENST00000258787(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071976"(cell gliding)|go:"GO:0072678"(T cell migration)|go:"GO:0120117"(T cell meandering migration)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:B0I1T2|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030175"(filopodium) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:9VsQfp7AsKTN+3jpHkAWsSbNoxc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P21796 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9Y277 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O75955 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q14254 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-348613|ensembl:ENSP00000378368 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q00610 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P04899 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-353997|uniprotkb:Q8IZ71|intact:EBI-2563889|uniprotkb:B4DYA0|intact:EBI-4404691|uniprotkb:Q6B6N3|uniprotkb:B3KTZ0|uniprotkb:B4E2X5|ensembl:ENSP00000312999 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gnai2_human(display_long)|uniprotkb:GNAI2(gene name)|psi-mi:GNAI2(display_short)|uniprotkb:GNAI2B(gene name synonym)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002061.1|refseq:NP_001269546.1|refseq:NP_001269549.1|refseq:NP_001269547.1|refseq:NP_001269548.1|refseq:NP_001159897.1|dip:DIP-602N|ensembl:ENSG00000114353(gene)|ensembl:ENST00000313601(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:0030425"(dendrite)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:6D9H|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-400042|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-422356|reactome:R-HSA-9009391|reactome:R-HSA-9660821|mint:P04899 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Mi3PAXudkdPb375bOi7luNAmUaU9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P11215 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08631 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08754 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-357563|uniprotkb:Q5TZX1|uniprotkb:P17539|ensembl:ENSP00000358867 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gnai3_human(display_long)|uniprotkb:GNAI3(gene name)|psi-mi:GNAI3(display_short)|uniprotkb:"G(i) alpha-3"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_006487.1|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|ensembl:ENSG00000065135(gene)|ensembl:ENST00000369851(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:2IHB|rcsb pdb:2ODE|rcsb pdb:2V4Z|rcsb pdb:4G5O|rcsb pdb:4G5R|rcsb pdb:4G5S|rcsb pdb:7E9H|rcsb pdb:7KH0|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9009391|reactome:R-HSA-9660821 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:npLeIXVzrV8y0trCCII5rivIRYQ9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05186 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1054354|uniprotkb:A1A4E7|uniprotkb:O75090|uniprotkb:Q2TAI7|uniprotkb:Q59EJ7|uniprotkb:Q5BKZ5|uniprotkb:Q5VTG5|uniprotkb:Q6NZI8|uniprotkb:Q8WU32|uniprotkb:Q9UBK0|uniprotkb:B7Z387|uniprotkb:B2RMP8|uniprotkb:B7Z4Y6|ensembl:ENSP00000363965|ensembl:ENSP00000363973 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ppbt_human(display_long)|uniprotkb:Alkaline phosphatase liver/bone/kidney isozyme(gene name synonym)|uniprotkb:ALPL(gene name)|psi-mi:ALPL(display_short)|uniprotkb:Phosphoamidase(gene name synonym)|uniprotkb:Phosphocreatine phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000469.3|refseq:NP_001120973.2|refseq:NP_001170991.1|refseq:XP_005245875.1|refseq:XP_006710609.1|ensembl:ENSG00000162551(gene)|ensembl:ENST00000374832(transcript)|ensembl:ENST00000374840(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004035"(alkaline phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016462"(pyrophosphatase activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033280"(response to vitamin D)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071529"(cementum mineralization)|interpro:IPR001952(Alkaline phosphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR018299|reactome:R-HSA-163125 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:iO0/TZ5yjqLOEZWp673XGt02mnI9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P22748 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3906285|uniprotkb:Q6FHI7|ensembl:ENSP00000300900|uniprotkb:B4DQA4 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cah4_human(display_long)|uniprotkb:CA4(gene name)|psi-mi:CA4(display_short)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000708.1|ensembl:ENSG00000167434(gene)|ensembl:ENST00000300900(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018343|interpro:IPR023561|interpro:IPR036398|interpro:IPR041874|rcsb pdb:1ZNC|rcsb pdb:3F7B|rcsb pdb:3F7U|rcsb pdb:3FW3|rcsb pdb:5IPZ|rcsb pdb:5JN8|rcsb pdb:5JN9|rcsb pdb:5JNA|rcsb pdb:5JNC|rcsb pdb:5KU6|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-1475029|refseq:XP_016880501.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:BIoSJjPGq5xalERuqhZzBpsu7Dk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q08477 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2835626|uniprotkb:Q5U740|uniprotkb:O60634|ensembl:ENSP00000221307|uniprotkb:B7Z8Z3 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cp4f3_human(display_long)|uniprotkb:CYP4F3(gene name)|psi-mi:CYP4F3(display_short)|uniprotkb:LTB4H(gene name synonym)|uniprotkb:CYPIVF3(gene name synonym)|uniprotkb:Cytochrome P450-LTB-omega(gene name synonym)|uniprotkb:"Leukotriene-B(4) 20-monooxygenase 2"(gene name synonym)|uniprotkb:20-hydroxyeicosatetraenoic acid synthase(gene name synonym)|uniprotkb:"Leukotriene-B(4) omega-hydroxylase 2"(gene name synonym)|uniprotkb:Docosahexaenoic acid omega-hydroxylase CYP4F3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000887.2|refseq:NP_001186137.1|refseq:NP_001186138.1|ensembl:ENSG00000186529(gene)|ensembl:ENST00000221307(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006690"(icosanoid metabolic process)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0008391"(arachidonic acid monooxygenase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0036101"(leukotriene B4 catabolic process)|go:"GO:0042361"(menaquinone catabolic process)|go:"GO:0042376"(phylloquinone catabolic process)|go:"GO:0042377"(vitamin K catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050051"(leukotriene-B4 20-monooxygenase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0097258"(20-hydroxy-leukotriene B4 omega oxidase activity)|go:"GO:0097259"(20-aldehyde-leukotriene B4 20-monooxygenase activity)|go:"GO:0102207"(docosanoate omega-hydroxylase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|reactome:R-HSA-211935|reactome:R-HSA-211958|reactome:R-HSA-211979|reactome:R-HSA-2142691|refseq:XP_016882303.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:RyCsiksouEqqtFP4YUA5LuSqY+k9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P78329 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1752413|uniprotkb:Q16677|uniprotkb:Q6NWT4|uniprotkb:Q6NWT6|uniprotkb:Q9NNZ0|uniprotkb:Q9UIU8|uniprotkb:A8K425|uniprotkb:B4DV75|uniprotkb:A0A024R7K3|ensembl:ENSP00000221700 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cp4f2_human(display_long)|uniprotkb:20-hydroxyeicosatetraenoic acid synthase(gene name synonym)|uniprotkb:Arachidonic acid omega-hydroxylase(gene name synonym)|uniprotkb:"Leukotriene-B(4) omega-hydroxylase 1"(gene name synonym)|uniprotkb:CYP4F2(gene name)|psi-mi:CYP4F2(display_short)|uniprotkb:CYPIVF2(gene name synonym)|uniprotkb:"Leukotriene-B(4) 20-monooxygenase 1"(gene name synonym)|uniprotkb:Cytochrome P450-LTB-omega(gene name synonym)|uniprotkb:Docosahexaenoic acid omega-hydroxylase(gene name synonym)|uniprotkb:Phylloquinone omega-hydroxylase CYP4F2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001073.3|ensembl:ENSG00000186115(gene)|ensembl:ENST00000221700(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003095"(pressure natriuresis)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006690"(icosanoid metabolic process)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0007596"(blood coagulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008391"(arachidonic acid monooxygenase activity)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017144"|go:"GO:0018685"(alkane 1-monooxygenase activity)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0032304"(negative regulation of icosanoid secretion)|go:"GO:0032305"(positive regulation of icosanoid secretion)|go:"GO:0036101"(leukotriene B4 catabolic process)|go:"GO:0042360"(vitamin E metabolic process)|go:"GO:0042361"(menaquinone catabolic process)|go:"GO:0042376"(phylloquinone catabolic process)|go:"GO:0042377"(vitamin K catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050051"(leukotriene-B4 20-monooxygenase activity)|go:"GO:0052869"(arachidonic acid omega-hydroxylase activity)|go:"GO:0052871"(alpha-tocopherol omega-hydroxylase activity)|go:"GO:0052872"(tocotrienol omega-hydroxylase activity)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070330"(aromatase activity)|go:"GO:0097258"(20-hydroxy-leukotriene B4 omega oxidase activity)|go:"GO:0097259"(20-aldehyde-leukotriene B4 20-monooxygenase activity)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0102207"(docosanoate omega-hydroxylase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|reactome:R-HSA-211935|reactome:R-HSA-211958|reactome:R-HSA-211979|reactome:R-HSA-2142691|reactome:R-HSA-2142816 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:bYFSzH+jLWwgnxGurOFlIOX2mEw9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9H4M9 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9BSJ8 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-355956|ensembl:ENSP00000377612|uniprotkb:A0FGR7|uniprotkb:A8K2S2|uniprotkb:O94848|uniprotkb:Q6PJN4|uniprotkb:Q9H6J1|uniprotkb:Q9H6W2|uniprotkb:Q9Y416|intact:EBI-4399548 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:esyt1_human(display_long)|uniprotkb:KIAA0747(gene name synonym)|uniprotkb:MBC2(gene name synonym)|uniprotkb:ESYT1(gene name)|psi-mi:ESYT1(display_short)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:FAM62A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 interpro:IPR037752|interpro:IPR039010|mint:Q9BSJ8|reactome:R-HSA-1660662|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9035034|interpro:IPR037749|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|interpro:IPR037733|go:"GO:0005544"(calcium-dependent phospholipid binding)|ensembl:ENSG00000139641(gene)|ensembl:ENST00000394048(transcript)|go:"GO:0005509"(calcium ion binding)|refseq:NP_001171725.1|refseq:NP_056107.1|dip:DIP-57197N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:MYbYK3357LLH0TP1qU7CsvJenGk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P51149 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1056089|uniprotkb:A8K3V6|uniprotkb:Q9NWJ0|uniprotkb:Q9UPB0|ensembl:ENSP00000265062|ensembl:ENSP00000501618|ensembl:ENSP00000502000|ensembl:ENSP00000502088|ensembl:ENSP00000502486 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab7a_human(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004628.4|ensembl:ENSG00000075785(gene)|ensembl:ENST00000265062(transcript)|ensembl:ENST00000674589(transcript)|ensembl:ENST00000675342(transcript)|ensembl:ENST00000675497(transcript)|ensembl:ENST00000676214(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1902586"(obsolete multi-organism intercellular transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51149|rcsb pdb:1T91|rcsb pdb:1YHN|rcsb pdb:6IYB|rcsb pdb:6WCW|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9636383|reactome:R-HSA-9636569|rcsb pdb:3LAW|dip:DIP-39879N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61421 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-954063|ensembl:ENSP00000290949|uniprotkb:P12953|uniprotkb:Q02547 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:va0d1_human(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:32 kDa accessory protein(gene name synonym)|uniprotkb:ATP6V0D1(gene name)|psi-mi:ATP6V0D1(display_short)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VPATPD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000159720(gene)|ensembl:ENST00000290949(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P61421|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-381038|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016324"(apical plasma membrane)|refseq:NP_004682.2|dip:DIP-47435N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:3a/yIxEF9LMwAZUR3npGQrw8xNo9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P84095 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-446579|uniprotkb:P35238|uniprotkb:Q8NI04|ensembl:ENSP00000339467|ensembl:ENSP00000380175|ensembl:ENSP00000380176|ensembl:ENSP00000436932 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rhog_human(display_long)|uniprotkb:RHOG(gene name)|psi-mi:RHOG(display_short)|uniprotkb:ARHG(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001656.2|refseq:XP_005252973.1|refseq:XP_016873208.1|ensembl:ENST00000396978(transcript)|ensembl:ENST00000396979(transcript)|ensembl:ENST00000533217(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|ensembl:ENSG00000177105(gene)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|ensembl:ENST00000351018(transcript)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042734|mint:P84095|rcsb pdb:6UKA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5625970|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-9013408 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:9PItVl1k5j6JhIDqwqcov1E/N8w9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P68371 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q92673 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9HAV0 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P49795 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-874907|uniprotkb:Q53XN0|uniprotkb:Q8TD60|uniprotkb:A8K216|uniprotkb:E1P5G9|ensembl:ENSP00000333194|ensembl:ENSP00000378483 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rgs19_human(display_long)|uniprotkb:G-alpha-interacting protein(gene name synonym)|uniprotkb:RGS19(gene name)|psi-mi:RGS19(display_short)|uniprotkb:GAIP(gene name synonym)|uniprotkb:GNAI3IP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:XP_011526787.1|refseq:XP_011526788.1|refseq:NP_001034556.1|refseq:NP_005864.1|ensembl:ENSG00000171700(gene)|ensembl:ENST00000332298(transcript)|ensembl:ENST00000395042(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006914"(autophagy)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR036305|rcsb pdb:1CMZ|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-418597 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:lGw7GXTwMFo5aFKUn8B4tlkZ8rM9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P51148 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P04839 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-6253630|ensembl:ENSP00000367851|uniprotkb:A8K138|uniprotkb:Q2PP16 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cy24b_human(display_long)|uniprotkb:CYBB(gene name)|psi-mi:CYBB(display_short)|uniprotkb:NOX2(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:NADPH oxidase 2(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase heavy chain subunit(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR039261|rcsb pdb:3A1F|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|interpro:IPR017938|ensembl:ENSG00000165168(gene)|ensembl:ENST00000378588(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|refseq:NP_000388.2|dip:DIP-42005N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:+QJRbDhthdRaJRoQLhT4tS6nWfs9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05109 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q53GQ0 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P63092 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1047114|uniprotkb:P04895|uniprotkb:Q12927|uniprotkb:Q5JWD2|uniprotkb:Q5JWD4|uniprotkb:Q5JWD5|uniprotkb:Q6NR75|uniprotkb:Q6NXS0|uniprotkb:Q8TBC0|uniprotkb:Q96H70|uniprotkb:Q14433|uniprotkb:Q32P26|uniprotkb:E1P5G5|ensembl:ENSP00000360126|uniprotkb:A6NI00|intact:EBI-10977858 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gnas2_human(display_long)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:GSP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001070958.1|refseq:NP_001296769.1|refseq:NP_536350.2|refseq:NP_000507.1|refseq:NP_001070956.1|refseq:NP_001070957.1|ensembl:ENSG00000087460(gene)|ensembl:ENST00000371085(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0046907"(intracellular transport)|go:"GO:0048589"(developmental growth)|go:"GO:0050890"(cognition)|go:"GO:0060348"(bone development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P63092|rcsb pdb:5G53|rcsb pdb:5UZ7|rcsb pdb:5VAI|rcsb pdb:6AU6|rcsb pdb:6B3J|rcsb pdb:6E3Y|rcsb pdb:6E67|rcsb pdb:6EG8|rcsb pdb:6GDG|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LPB|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6ORV|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VN7|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XOX|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7BPH|rcsb pdb:7BW0|rcsb pdb:7BZ2|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX3|rcsb pdb:7CX4|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7D7M|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7KH0|rcsb pdb:7LCI|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|reactome:R-HSA-163359|reactome:R-HSA-164378|reactome:R-HSA-381676|reactome:R-HSA-392851|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-432040|reactome:R-HSA-5610787|reactome:R-HSA-9660821|refseq:NP_536351.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:fUnrdxwx4bBAqE3iO2cCB3UInyg9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08575 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1341|uniprotkb:A8K7W6|uniprotkb:Q16614|uniprotkb:Q9H0Y6|uniprotkb:A0A0A0MT22|uniprotkb:X6R433|ensembl:ENSP00000411355|ensembl:ENSP00000458322|ensembl:ENSP00000461074 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ptprc_human(display_long)|uniprotkb:PTPRC(gene name)|psi-mi:PTPRC(display_short)|uniprotkb:CD45(gene name synonym)|uniprotkb:T200(gene name synonym)|uniprotkb:Leukocyte common antigen(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002829.3|refseq:NP_563578.2|dip:DIP-224N|refseq:XP_006711535.1|refseq:XP_006711536.1|refseq:XP_006711537.1|ensembl:ENSG00000081237(gene)|ensembl:ENSG00000262418(gene)|ensembl:ENST00000442510(transcript)|ensembl:ENST00000573477(transcript)|ensembl:ENST00000573679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032059"(bleb)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0044855"(plasma membrane raft distribution)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048539"(bone marrow development)|go:"GO:0048864"(stem cell development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050857"(positive regulation of antigen receptor-mediated signaling pathway)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0098857"(membrane microdomain)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904155"(DN2 thymocyte differentiation)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000473"(positive regulation of hematopoietic stem cell migration)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016335(Leukocyte common antigen)|interpro:IPR024739|interpro:IPR029021|interpro:IPR036116|mint:P08575|rcsb pdb:1YGR|rcsb pdb:1YGU|rcsb pdb:5FMV|rcsb pdb:5FN6|rcsb pdb:5FN7|reactome:R-HSA-202427|reactome:R-HSA-416700|reactome:R-HSA-6798695 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:rrMiH60EcAzRWaaapYTjNU5+1IY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q13885 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-711595|ensembl:ENSP00000369703|uniprotkb:Q6FGZ8|uniprotkb:Q8IWR2 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:tbb2a_human(display_long)|uniprotkb:TUBB2A(gene name)|psi-mi:TUBB2A(display_short)|uniprotkb:TUBB2(gene name synonym)|uniprotkb:Tubulin beta class IIa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-389957|reactome:R-HSA-983189|reactome:R-HSA-9668328|ensembl:ENSG00000137267(gene)|ensembl:ENST00000333628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13885|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|refseq:NP_001060.1|refseq:NP_001297244.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61019 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-752037|uniprotkb:P08886|uniprotkb:B2R5W8|uniprotkb:B4DMQ5|ensembl:ENSP00000262646 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab2a_human(display_long)|uniprotkb:RAB2A(gene name)|psi-mi:RAB2A(display_short)|uniprotkb:RAB2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002856.1|refseq:NP_001229573.1|dip:DIP-316N|ensembl:ENSG00000104388(gene)|ensembl:ENST00000262646(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1Z0A|reactome:R-HSA-162658|reactome:R-HSA-8873719 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:MyG011KOkAtsvE2hU/fs21CEe/M9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05023 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-358778|uniprotkb:Q16689|uniprotkb:Q6LDM4|uniprotkb:Q9UJ20|uniprotkb:Q9UJ21|uniprotkb:B2RBR6|uniprotkb:Q9UCN1|ensembl:ENSP00000295598|uniprotkb:B7Z3U6|uniprotkb:B7Z2T5|uniprotkb:F5H3A1|intact:EBI-10963133 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:at1a1_human(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000692.2|refseq:NP_001153705.1|refseq:NP_001153706.1|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|ensembl:ENSG00000163399(gene)|ensembl:ENST00000295598(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P05023|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|refseq:XP_016856849.1|refseq:XP_016856850.1|dip:DIP-38196N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:uZf9iX38kcZh0Q+apz8uB17EtJw9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9H082 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3048549|ensembl:ENSP00000306496|uniprotkb:Q4W5B0|uniprotkb:B2R987 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rb33b_human(display_long)|uniprotkb:RAB33B(gene name)|psi-mi:RAB33B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000172007(gene)|ensembl:ENST00000305626(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903434"(negative regulation of constitutive secretory pathway)|go:"GO:2000156"(regulation of retrograde vesicle-mediated transport, Golgi to ER)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041822|rcsb pdb:6Y09|rcsb pdb:6ZAY|reactome:R-HSA-6811438|reactome:R-HSA-8854214|reactome:R-HSA-8873719|refseq:NP_112586.1|dip:DIP-61978N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:abTOfFzfOdw82bfp1EaZyJPjTDg9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q6IQ22 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-4289591|uniprotkb:A6NEF5|uniprotkb:Q4KMQ3 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab12_human(display_long)|uniprotkb:RAB12(gene name)|psi-mi:RAB12(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001020471.2|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|rcsb pdb:2IL1|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|reactome:R-HSA-8873719|interpro:IPR027417|reactome:R-HSA-8876198|interpro:IPR041830 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:g+NgQCwasQQEIrQJlkzs8EQh8449606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q15771 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3924277|uniprotkb:Q96CI8|uniprotkb:Q6FGK1|ensembl:ENSP00000260056|ensembl:ENSP00000435089|ensembl:ENSP00000435189|ensembl:ENSP00000478702|uniprotkb:Q6MZH2 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab30_human(display_long)|uniprotkb:RAB30(gene name)|psi-mi:RAB30(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001272988.1|refseq:NP_001272989.1|refseq:NP_001272990.1|refseq:NP_055303.2|ensembl:ENSG00000137502(gene)|ensembl:ENST00000260056(transcript)|ensembl:ENST00000527633(transcript)|ensembl:ENST00000533486(transcript)|ensembl:ENST00000612684(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007030"(Golgi organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041820|rcsb pdb:2EW1|reactome:R-HSA-6811438|reactome:R-HSA-8873719|dip:DIP-60519N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Qh3KHalGgosuTb+p7Oe39ix9/UM9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q14964 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3048577|ensembl:ENSP00000322594|uniprotkb:A8KAA4|uniprotkb:Q8N6W2 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rb39a_human(display_long)|uniprotkb:RAB39A(gene name)|psi-mi:RAB39A(display_short)|uniprotkb:RAB39(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000179331(gene)|ensembl:ENST00000320578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|reactome:R-HSA-6811438|reactome:R-HSA-8873719|reactome:R-HSA-8876198|refseq:NP_059986.1|dip:DIP-60521N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:jpkNU7VaaBLmc8P2kLuNq++1T2I9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P20338 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-722284|uniprotkb:Q9BQ44|uniprotkb:Q5T7P7|ensembl:ENSP00000355651 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab4a_human(display_long)|uniprotkb:RAB4A(gene name)|psi-mi:RAB4A(display_short)|uniprotkb:RAB4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004569.2|refseq:NP_001258927.1|dip:DIP-372N|ensembl:ENSG00000168118(gene)|ensembl:ENST00000366690(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041819|mint:P20338|rcsb pdb:1YU9|rcsb pdb:1Z0K|rcsb pdb:2BMD|rcsb pdb:2BME|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8875656 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:D2WXh1fcXRVjoim9QiqLpNdq2Gk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P11717 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P26038 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-528768|ensembl:ENSP00000353408 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P45880 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P30101 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q96E17 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-4287022|ensembl:ENSP00000282878 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab3c_human(display_long)|uniprotkb:RAB3C(gene name)|psi-mi:RAB3C(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_612462.1|refseq:NP_001304844.1|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|rcsb pdb:6Y7G|reactome:R-HSA-8873719|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|ensembl:ENSG00000152932(gene)|ensembl:ENST00000282878(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072659"(protein localization to plasma membrane) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:6wwv7VA89TJogvPAQsfBKLkk4Hc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P20336 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1045943|uniprotkb:Q9NYE1|uniprotkb:A8K0J4|ensembl:ENSP00000222256 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab3a_human(display_long)|uniprotkb:RAB3A(gene name)|psi-mi:RAB3A(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002857.1|ensembl:ENSG00000105649(gene)|ensembl:ENST00000222256(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003016"(respiratory system process)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030324"(lung development)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030424"(axon)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043195"(terminal bouton)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060201"(clathrin-sculpted acetylcholine transport vesicle membrane)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061670"(evoked neurotransmitter secretion)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR027417|interpro:IPR037872|mint:P20336|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|interpro:IPR005225(Small GTP-binding protein)|reactome:R-HSA-264642|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_011526466.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:mByWzDHvitYqJ1l4Fjjuq55Y9TA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08311 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-5462635|uniprotkb:Q6IBJ6|uniprotkb:Q9UCA5|uniprotkb:Q9UCU6|ensembl:ENSP00000216336 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:catg_human(display_long)|uniprotkb:CTSG(gene name)|psi-mi:CTSG(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001902.1|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|ensembl:ENSG00000100448(gene)|ensembl:ENST00000216336(transcript)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050832"(defense response to fungus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070946"(neutrophil-mediated killing of gram-positive bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08311|rcsb pdb:1AU8|reactome:R-HSA-448706|rcsb pdb:1CGH|rcsb pdb:1KYN|rcsb pdb:1T32|rcsb pdb:6VTM|reactome:R-HSA-6798695|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022377|reactome:R-HSA-381426|reactome:R-HSA-6803157|reactome:R-HSA-9635465|reactome:R-HSA-9660826 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Q3qTg9KcvP4oI+A/QOUqk7ahWMU9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P62879 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-356942|uniprotkb:P54312|uniprotkb:P11016|uniprotkb:B3KPU1|ensembl:ENSP00000305260|ensembl:ENSP00000377501|ensembl:ENSP00000377503 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gbb2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:Transducin beta chain 2(gene name synonym)|uniprotkb:G protein subunit beta-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_005264.2|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0031982"(vesicle)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62879|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|go:"GO:0016020"(membrane)|ensembl:ENSG00000172354(gene)|ensembl:ENST00000303210(transcript)|ensembl:ENST00000393924(transcript)|ensembl:ENST00000393926(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9Y490 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:C7FGaR2291KB6hBSloee5L8lYgA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P45880 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P59190 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3048571|ensembl:ENSP00000434103|uniprotkb:Q8IW89|uniprotkb:Q86TX7|uniprotkb:G5EMR7 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab15_human(display_long)|uniprotkb:RAB15(gene name)|psi-mi:RAB15(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000139998(gene)|ensembl:ENST00000533601(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041826|reactome:R-HSA-8873719|refseq:NP_001295083.1|refseq:NP_941959.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Bh4JGRoieQZbQGnXCvneLO13kEc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08473 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P15924 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08571 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3905196|uniprotkb:Q96L99|uniprotkb:Q53XT5|uniprotkb:Q9UNS3|uniprotkb:Q96FR6|ensembl:ENSP00000304236|ensembl:ENSP00000385519 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cd14_human(display_long)|uniprotkb:CD14(gene name)|psi-mi:CD14(display_short)|uniprotkb:Myeloid cell-specific leucine-rich glycoprotein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000582.1|refseq:NP_001035110.1|refseq:NP_001167575.1|refseq:NP_001167576.1|dip:DIP-1030N|ensembl:ENSG00000170458(gene)|ensembl:ENST00000302014(transcript)|ensembl:ENST00000401743(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001847"(opsonin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR016337(Monocyte differentiation antigen CD14)|interpro:IPR032675|rcsb pdb:4GLP|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:MpfQfOF+t0EMlzBio2kyYeJU3hE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O75558 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-714135|uniprotkb:O75378|uniprotkb:O95148|uniprotkb:Q5TCL6|ensembl:ENSP00000356540|uniprotkb:E1P598 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:stx11_human(display_long)|uniprotkb:STX11(gene name)|psi-mi:STX11(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028672|interpro:IPR042781|mint:O75558|ensembl:ENSG00000135604(gene)|ensembl:ENST00000367568(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0061025"(membrane fusion)|refseq:NP_003755.2|refseq:XP_016866889.1|refseq:XP_011534516.1|refseq:XP_011534519.1|refseq:XP_011534520.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:LckEg7WERVC628sZGjvi3qlYJ549606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61026 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61224 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P02788 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1058602|ensembl:ENSP00000231751|uniprotkb:O00756|uniprotkb:Q16780|uniprotkb:Q16785|uniprotkb:Q16786|uniprotkb:Q16789|uniprotkb:Q8IU92|uniprotkb:Q8IZH6|uniprotkb:Q8TCD2|uniprotkb:Q96KZ4|uniprotkb:Q96KZ5|uniprotkb:Q9H1Z3|uniprotkb:Q9UCY5|uniprotkb:B7Z4X2|uniprotkb:E7EQH5|uniprotkb:B2MV13|uniprotkb:Q5DSM0|uniprotkb:A8K9U8 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:trfl_human(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)|uniprotkb:LF(gene name synonym)|uniprotkb:Talalactoferrin(gene name synonym)|uniprotkb:GIG12(gene name synonym)|uniprotkb:Growth-inhibiting protein 12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001308050.1|ensembl:ENST00000231751(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006826"(iron ion transport)|go:"GO:0006959"(humoral immune response)|go:"GO:0008201"(heparin binding)|ensembl:ENSG00000012223(gene)|refseq:NP_001186078.1|refseq:NP_002334.2|go:"GO:0009986"(cell surface)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0030141"(secretory granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035580"(specific granule lumen)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1900159"(positive regulation of bone mineralization involved in bone maturation)|go:"GO:1900229"(negative regulation of single-species biofilm formation in or on host organism)|go:"GO:0042581"(specific granule)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000308"("negative regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:2001205"(negative regulation of osteoclast development)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0048525"(negative regulation of viral process)|interpro:IPR016357(Transferrin)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051673"(membrane disruption in another organism)|interpro:IPR018195|interpro:IPR030684|mint:P02788|rcsb pdb:1B0L|rcsb pdb:1BKA|rcsb pdb:1CB6|rcsb pdb:1DSN|rcsb pdb:1EH3|rcsb pdb:1FCK|rcsb pdb:1H43|rcsb pdb:1H44|rcsb pdb:1H45|rcsb pdb:1HSE|rcsb pdb:1L5T|rcsb pdb:1LCF|rcsb pdb:1LCT|rcsb pdb:1LFG|rcsb pdb:1LFH|rcsb pdb:1LFI|rcsb pdb:1LGB|rcsb pdb:1N76|rcsb pdb:1SQY|rcsb pdb:1VFD|rcsb pdb:1VFE|rcsb pdb:1XV4|rcsb pdb:1XV7|rcsb pdb:1Z6V|rcsb pdb:1Z6W|rcsb pdb:2BJJ|rcsb pdb:2DP4|rcsb pdb:2GMC|rcsb pdb:2GMD|rcsb pdb:2HD4|rcsb pdb:2PMS|reactome:R-HSA-1222449|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1U62|refseq:NP_001308051.1|dip:DIP-41354N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:OLhbdYXPaD10eAg3HyhCA5Akw8o9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P35232 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P14406 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2606666|uniprotkb:Q5TF59|uniprotkb:Q6FGI2|uniprotkb:Q3MIH5|uniprotkb:B2R5E1|ensembl:ENSP00000506727 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:cx7a2_human(display_long)|uniprotkb:COX7AL(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIIa-liver/heart(gene name synonym)|uniprotkb:COX7A2(gene name)|psi-mi:COX7A2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001856.2|ensembl:ENSG00000112695(gene)|ensembl:ENST00000684430(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR036539|interpro:IPR039297|mint:P14406|rcsb pdb:5Z62 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:krjTK658npBV4G6gH28GJhVqBkY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P35580 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P62873 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q15286 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-722275|uniprotkb:B4E390|uniprotkb:B2R6E0|ensembl:ENSP00000229340 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab35_human(display_long)|uniprotkb:Ras-related protein Rab-1C(gene name synonym)|uniprotkb:GTP-binding protein RAY(gene name synonym)|uniprotkb:RAB35(gene name)|psi-mi:RAB35(display_short)|uniprotkb:RAB1C(gene name synonym)|uniprotkb:RAY(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001161078.1|refseq:NP_006852.1|ensembl:ENSG00000111737(gene)|ensembl:ENST00000229340(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042470"(melanosome)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041815|mint:Q15286|rcsb pdb:3TW8|rcsb pdb:6EKK|rcsb pdb:6IF2|rcsb pdb:6IF3|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:95pH+DyDjv9FcxFeMmGYoJ0KyPo9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9Y394 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1387800|uniprotkb:Q9UKU2|uniprotkb:B2R896|ensembl:ENSP00000216500|ensembl:ENSP00000451882 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:dhrs7_human(display_long)|uniprotkb:DHRS7(gene name)|psi-mi:DHRS7(display_short)|uniprotkb:RETSDR4(gene name synonym)|uniprotkb:SDR34C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 34C member 1(gene name synonym)|uniprotkb:CGI-86(orf name)|uniprotkb:UNQ285/PRO3448(orf name)|uniprotkb:DHRS7A(gene name synonym)|uniprotkb:Retinal short-chain dehydrogenase/reductase 4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_057113.1|refseq:NP_001309209.1|ensembl:ENSG00000100612(gene)|ensembl:ENST00000216500(transcript)|ensembl:ENST00000557185(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:OcTvozRJMb/lmA0bzcIcNpWIbYE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P60660 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P06702 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1055001|uniprotkb:Q6FGA1|uniprotkb:Q9NYM0|uniprotkb:Q9UCJ1|uniprotkb:D3DV36|ensembl:ENSP00000357727 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:s10a9_human(display_long)|uniprotkb:S100 calcium-binding protein A9(gene name synonym)|uniprotkb:Calgranulin-B(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 14(gene name synonym)|uniprotkb:Leukocyte L1 complex heavy chain(gene name synonym)|uniprotkb:Calprotectin L1H subunit(gene name synonym)|uniprotkb:S100A9(gene name)|psi-mi:S100A9(display_short)|uniprotkb:CAGB(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:MRP14(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002956.1|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5I8N|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENSG00000163220(gene)|ensembl:ENST00000368738(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035821"(modulation of process of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045113"(regulation of integrin biosynthetic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|mint:P06702|rcsb pdb:1IRJ|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016209"(antioxidant activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|dip:DIP-1166N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:IGnX4DSnv8xMr5pY4T7X7vYos5A9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9NPA2 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-12346397|ensembl:ENSP00000337816|uniprotkb:D3DUA8|uniprotkb:Q9H3Q0 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:mmp25_human(display_long)|uniprotkb:MMP25(gene name)|psi-mi:MMP25(display_short)|uniprotkb:Leukolysin(gene name synonym)|uniprotkb:MMP20(gene name synonym)|uniprotkb:MMPL1(gene name synonym)|uniprotkb:MT6MMP(gene name synonym)|uniprotkb:Membrane-type matrix metalloproteinase 6(gene name synonym)|uniprotkb:Membrane-type-6 matrix metalloproteinase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000008516(gene)|ensembl:ENST00000336577(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0060022"(hard palate development)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018487|interpro:IPR021190|interpro:IPR024079|interpro:IPR033739|interpro:IPR036375|reactome:R-HSA-1592389|reactome:R-HSA-6798695|refseq:NP_071913.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:SE0WQPRMWbeDC9M8jirqfsT400E9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61106 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q8IYU8 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P53675 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-358826|uniprotkb:Q14017|uniprotkb:Q15808|uniprotkb:Q15809|uniprotkb:B7Z7U5|ensembl:ENSP00000441158 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:clh2_human(display_long)|uniprotkb:CLTCL1(gene name)|psi-mi:CLTCL1(display_short)|uniprotkb:CLH22(gene name synonym)|uniprotkb:CLTCL(gene name synonym)|uniprotkb:CLTD(gene name synonym)|uniprotkb:Clathrin heavy chain on chromosome 22(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001826.3|refseq:NP_009029.3|ensembl:ENSG00000070371(gene)|ensembl:ENST00000427926(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030135"(coated vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071439"(clathrin complex)|go:"GO:0097443"(sorting endosome)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-3928665|reactome:R-HSA-8856825|reactome:R-HSA-8856828 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:s+bmcNpUy0+PyN1d5eXCAvHBqus9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O95716 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-3386067|ensembl:ENSP00000222120|ensembl:ENSP00000466000 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab3d_human(display_long)|uniprotkb:RAB3D(gene name)|psi-mi:RAB3D(display_short)|uniprotkb:GOV(gene name synonym)|uniprotkb:RAB16(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000105514(gene)|ensembl:ENST00000222120(transcript)|ensembl:ENST00000589655(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045453"(bone resorption)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0099503"(secretory vesicle)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037872|rcsb pdb:2GF9|reactome:R-HSA-6798695|reactome:R-HSA-8873719|refseq:NP_004274.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:TqLXWDkAGuNeoR1b250i7GsNXVY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O75477 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P08514 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-702693|uniprotkb:O95366|uniprotkb:Q14443|uniprotkb:B2RCY8|uniprotkb:Q17R67|ensembl:ENSP00000262407 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ita2b_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIb(gene name synonym)|uniprotkb:GPalpha IIb(gene name synonym)|uniprotkb:ITGA2B(gene name)|psi-mi:ITGA2B(display_short)|uniprotkb:GP2B(gene name synonym)|uniprotkb:ITGAB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000410.2|refseq:XP_011523051.1|ensembl:ENSG00000005961(gene)|dip:DIP-68N|ensembl:ENST00000262407(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072562"(blood microparticle)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08514|rcsb pdb:1DPK|rcsb pdb:1DPQ|rcsb pdb:1JX5|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1M8O|rcsb pdb:1RN0|rcsb pdb:1S4W|rcsb pdb:1TYE|rcsb pdb:1UV9|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2K1A|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8936459|reactome:R-HSA-9649948|reactome:R-HSA-9656223 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:8JV9fiaPGQcRYp8HlTe0br3SrPg9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P20340 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P62820 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05141 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9H0U4 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1045214|ensembl:ENSP00000310226|uniprotkb:A8K7S1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab1b_human(display_long)|uniprotkb:RAB1B(gene name)|psi-mi:RAB1B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000174903(gene)|ensembl:ENST00000311481(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_112243.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9H0U4|rcsb pdb:3JZA|rcsb pdb:3NKV|rcsb pdb:4HLQ|rcsb pdb:4I1O|rcsb pdb:5O74|rcsb pdb:5SZH|rcsb pdb:5SZK|rcsb pdb:6SKU|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42462N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:EI6DHq7xCboSkoqGY5NmVY4Iqf09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q15907 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-722234|uniprotkb:Q2YDT2|uniprotkb:Q8NI07|uniprotkb:B2R7I4|uniprotkb:D6W671|uniprotkb:A5YM50|uniprotkb:Q5U0I1|uniprotkb:Q6FHR0|uniprotkb:Q6FI42|uniprotkb:B4DMK0|ensembl:ENSP00000333547 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rb11b_human(display_long)|uniprotkb:GTP-binding protein YPT3(gene name synonym)|uniprotkb:RAB11B(gene name)|psi-mi:RAB11B(display_short)|uniprotkb:YPT3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_004209.2|dip:DIP-50898N|ensembl:ENSG00000185236(gene)|ensembl:ENST00000328024(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q15907|rcsb pdb:2F9L|rcsb pdb:2F9M|rcsb pdb:4OJK|reactome:R-HSA-8854214|reactome:R-HSA-8873719 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:+fsu7NPmd5fgoe0TE67IcISlscA9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P06576 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P61006 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:O94905 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P12236 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P38405 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2512639|ensembl:ENSP00000269162|ensembl:ENSP00000408489|ensembl:ENSP00000439023|uniprotkb:Q86XU3|uniprotkb:B7ZA26 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gnal_human(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000141404(gene)|ensembl:ENST00000269162(transcript)|ensembl:ENST00000423027(transcript)|ensembl:ENST00000535121(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-170660|reactome:R-HSA-170670|reactome:R-HSA-381753|refseq:NP_001135811.1|refseq:NP_892023.1|refseq:NP_001248372.1|refseq:NP_001248373.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:IC+CI3TYQdbioxaPBNu/cSGn7TQ9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q03113 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2833081|uniprotkb:Q2T9L1|uniprotkb:Q8TD71|uniprotkb:Q86UM8|uniprotkb:Q9UDU9|uniprotkb:A4D204|ensembl:ENSP00000275364|uniprotkb:B3KXS2|uniprotkb:B7Z3F7|uniprotkb:Q5PPR5 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gna12_human(display_long)|uniprotkb:GNA12(gene name)|psi-mi:GNA12(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001280021.1|ensembl:ENSG00000146535(gene)|ensembl:ENST00000275364(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q03113|reactome:R-HSA-416482|reactome:R-HSA-456926|refseq:NP_031379.2|refseq:NP_001269370.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:iuIDldvBlG+r+jg59e3QSNbcvtY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q99623 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P15144 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2563898|uniprotkb:Q16728|uniprotkb:Q9UCE0|uniprotkb:Q8IVH3|uniprotkb:Q8IUK3|uniprotkb:Q6GT90|ensembl:ENSP00000300060|ensembl:ENSP00000452934|ensembl:ENSP00000453413|ensembl:ENSP00000502886 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ampn_human(display_long)|uniprotkb:APN(gene name synonym)|uniprotkb:CD13(gene name synonym)|uniprotkb:PEPN(gene name synonym)|uniprotkb:Alanyl aminopeptidase(gene name synonym)|uniprotkb:Microsomal aminopeptidase(gene name synonym)|uniprotkb:Aminopeptidase M(gene name synonym)|uniprotkb:gp150(gene name synonym)|uniprotkb:Myeloid plasma membrane glycoprotein CD13(gene name synonym)|uniprotkb:ANPEP(gene name)|psi-mi:ANPEP(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001141.2|refseq:XP_011519775.1|ensembl:ENSG00000166825(gene)|ensembl:ENST00000300060(transcript)|ensembl:ENST00000559874(transcript)|ensembl:ENST00000560137(transcript)|ensembl:ENST00000679248(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|rcsb pdb:4FYQ|rcsb pdb:4FYR|rcsb pdb:4FYS|rcsb pdb:4FYT|rcsb pdb:5LHD|rcsb pdb:6ATK|rcsb pdb:6U7E|rcsb pdb:6U7F|rcsb pdb:6U7G|rcsb pdb:6XWD|rcsb pdb:7AEW|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_005254949.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:rKOeK87j6V1zOyRYGR7v2CHuZn09606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P28331 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q14344 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P05107 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:Q9HDC9 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-723950|ensembl:ENSP00000217456|uniprotkb:Q6UVZ8|uniprotkb:Q9GZS8|uniprotkb:Q9NUB2|uniprotkb:A8K514|uniprotkb:B4DXG1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:apmap_human(display_long)|uniprotkb:Protein BSCv(gene name synonym)|uniprotkb:APMAP(gene name)|psi-mi:APMAP(display_short)|uniprotkb:C20orf3(gene name synonym)|uniprotkb:UNQ1869/PRO4305(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_065392.1|ensembl:ENSG00000101474(gene)|ensembl:ENST00000217456(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0009058"(biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016844"(strictosidine synthase activity)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018119|mint:Q9HDC9|refseq:XP_005260820.1 go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:IRPAV+sieIBDPYsV4ypu35eSrkQ9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P11488 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2562736|uniprotkb:Q4VBN2|ensembl:ENSP00000232461|ensembl:ENSP00000387555 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:gnat1_human(display_long)|uniprotkb:GNAT1(gene name)|psi-mi:GNAT1(display_short)|uniprotkb:GNATR(gene name synonym)|uniprotkb:Transducin alpha-1 chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21402192|imex:IM-27590-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000163.2|refseq:NP_653082.1|ensembl:ENSG00000114349(gene)|ensembl:ENST00000232461(transcript)|ensembl:ENST00000433068(transcript)|go:"GO:0000035"(acyl binding)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009642"(response to light intensity)|go:"GO:0016020"(membrane)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:3RBQ|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-418594|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding) go:"GO:0016020"(membrane) - - figure legend:Fig.2, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/28 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:N1vTXVCPunyeaYMi9E0pX4WhwTY9606 rigid:o1pA/hFEfTr9zGKM+6uZFSMe1wk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6Q3 uniprotkb:P11215 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21403890|imex:IM-27590-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695 go:"GO:0016020"(membrane) - - figure legend:Fig. 2E|comment:Trace amounts of CD11a were also observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/20 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606 rigid:a/JNC2T7YnOer1HuTalz43FuTsc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N6Q3 uniprotkb:P05107 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-21403890|imex:IM-27590-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N go:"GO:0016020"(membrane) - - figure legend:Fig. 2E|comment:Trace amounts of CD11a were also observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/20 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 rigid:a/JNC2T7YnOer1HuTalz43FuTsc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N6Q3 uniprotkb:P05107 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-21404769|imex:IM-27590-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N go:"GO:0016020"(membrane) - - figure legend:Fig. 4A|comment:Trace amounts of CD11a were also observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/20 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 rigid:S28N80cLZMxRNdOYtmfNGuGypGs false - - - - psi-mi:"MI:1198"(immunohistochemistry) psi-mi:"MI:1198"(immunohistochemistry) uniprotkb:Q8N6Q3 uniprotkb:P11215 intact:EBI-747170|uniprotkb:Q711Q2|uniprotkb:Q8NCV9|uniprotkb:Q96QH1|uniprotkb:Q9HDA5 intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1 psi-mi:cd177_human(display_long)|uniprotkb:Polycythemia rubra vera protein 1(gene name synonym)|uniprotkb:NB1 glycoprotein(gene name synonym)|uniprotkb:Human neutrophil alloantigen 2a(gene name synonym)|uniprotkb:CD177(gene name)|psi-mi:CD177(display_short)|uniprotkb:NB1(gene name synonym)|uniprotkb:PRV1(gene name synonym)|uniprotkb:UNQ595/PRO1181(orf name) psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Jerke et al. (2011) pubmed:21193407|imex:IM-27590 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-21404777|imex:IM-27590-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065139.2|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|reactome:R-HSA-140875|reactome:R-HSA-202733|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1990266"(neutrophil migration)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|reactome:R-HSA-6798695 refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695 go:"GO:0016020"(membrane) - - figure legend:Fig. 4A|comment:Trace amounts of CD11a were also observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil) - 2019/05/12 2019/05/20 rogid:uEXp4MCku095cvEhkd6wZyz5a/09606 rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606 rigid:yvZml/BHadsSviXi2Zb7S3e5BVQ false - - - - psi-mi:"MI:1198"(immunohistochemistry) psi-mi:"MI:1198"(immunohistochemistry)