#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ES46	uniprotkb:Q64691	intact:EBI-6914996|ensembl:ENSMUSP00000023072	intact:EBI-21927513|uniprotkb:A2AVV3|uniprotkb:Q9WUC5|ensembl:ENSMUSP00000028749	psi-mi:parvb_mouse(display_long)|uniprotkb:Parvb(gene name)|psi-mi:Parvb(display_short)	psi-mi:can3_mouse(display_long)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:Capn3(gene name)|psi-mi:Capn3(display_short)	psi-mi:"MI:0096"(pull down)	van et al. (2008)	pubmed:19924298|imex:IM-27386	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21928632|imex:IM-27386-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022438(gene)|ensembl:ENSMUST00000023072(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|reactome:R-MMU-446353|reactome:R-MMU-446388|refseq:NP_573395.1|dip:DIP-57659N	refseq:NP_001171270.1|refseq:NP_031627.2|ensembl:ENSMUSG00000079110(gene)|ensembl:ENSMUST00000028749(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0012501"(programmed cell death)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990091"(sodium-dependent self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|reactome:R-MMU-1474228	-	-	-	figure legend:Figure S2C lane 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/24	2019/09/26	rogid:b14MEAShN/Fthf4wSniuRv1VJHM10090	rogid:1oVXdQNGI0bugnIPYdQpzWbzFxU10090	rigid:na1OSpF0GmXa1IvR4b1OLU8vdKo	false	his tag:n-n,c-c|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9ES46	uniprotkb:Q64691	intact:EBI-6914996|ensembl:ENSMUSP00000023072	intact:EBI-21927513|uniprotkb:A2AVV3|uniprotkb:Q9WUC5|ensembl:ENSMUSP00000028749	psi-mi:parvb_mouse(display_long)|uniprotkb:Parvb(gene name)|psi-mi:Parvb(display_short)	psi-mi:can3_mouse(display_long)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:Capn3(gene name)|psi-mi:Capn3(display_short)	psi-mi:"MI:0096"(pull down)	van et al. (2008)	pubmed:19924298|imex:IM-27386	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21984854|imex:IM-27386-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022438(gene)|ensembl:ENSMUST00000023072(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|reactome:R-MMU-446353|reactome:R-MMU-446388|refseq:NP_573395.1|dip:DIP-57659N	refseq:NP_001171270.1|refseq:NP_031627.2|ensembl:ENSMUSG00000079110(gene)|ensembl:ENSMUST00000028749(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0012501"(programmed cell death)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990091"(sodium-dependent self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|reactome:R-MMU-1474228	-	-	-	figure legend:Supplementary Figure 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/24	2019/09/26	rogid:b14MEAShN/Fthf4wSniuRv1VJHM10090	rogid:1oVXdQNGI0bugnIPYdQpzWbzFxU10090	rigid:na1OSpF0GmXa1IvR4b1OLU8vdKo	false	-	sufficient binding region:1-272..272,315..315-821|glutathione s tranferase tag:?-?|his tag:c-c,n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ES46	uniprotkb:Q64691	intact:EBI-6914996|ensembl:ENSMUSP00000023072	intact:EBI-21927513|uniprotkb:A2AVV3|uniprotkb:Q9WUC5|ensembl:ENSMUSP00000028749	psi-mi:parvb_mouse(display_long)|uniprotkb:Parvb(gene name)|psi-mi:Parvb(display_short)	psi-mi:can3_mouse(display_long)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:Capn3(gene name)|psi-mi:Capn3(display_short)	psi-mi:"MI:0096"(pull down)	van et al. (2008)	pubmed:19924298|imex:IM-27386	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22053277|imex:IM-27386-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022438(gene)|ensembl:ENSMUST00000023072(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|reactome:R-MMU-446353|reactome:R-MMU-446388|refseq:NP_573395.1|dip:DIP-57659N	refseq:NP_001171270.1|refseq:NP_031627.2|ensembl:ENSMUSG00000079110(gene)|ensembl:ENSMUST00000028749(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0012501"(programmed cell death)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990091"(sodium-dependent self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|reactome:R-MMU-1474228	-	-	-	figure legend:Figure S2A, Lane 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/24	2019/09/26	rogid:b14MEAShN/Fthf4wSniuRv1VJHM10090	rogid:1oVXdQNGI0bugnIPYdQpzWbzFxU10090	rigid:na1OSpF0GmXa1IvR4b1OLU8vdKo	false	his tag:c-c,n-n|glutathione s tranferase tag:?-?	his tag:c-c,n-n|t7 tag:n-n|mutation:129-129	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0113"(western blot)