#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75558	uniprotkb:Q15833	intact:EBI-714135|uniprotkb:O75378|uniprotkb:O95148|uniprotkb:Q5TCL6|ensembl:ENSP00000356540|uniprotkb:E1P598	intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283	psi-mi:stx11_human(display_long)|uniprotkb:STX11(gene name)|psi-mi:STX11(display_short)	psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	zur et al. (2009)	pubmed:19804848|imex:IM-27392	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055330|imex:IM-27392-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028672|interpro:IPR042781|mint:O75558|ensembl:ENSG00000135604(gene)|ensembl:ENST00000367568(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0061025"(membrane fusion)|refseq:NP_003755.2|refseq:XP_016866889.1|refseq:XP_011534516.1|refseq:XP_011534519.1|refseq:XP_011534520.1	refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836	-	-	-	figure legend:Figure 2c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/10/01	2019/10/01	rogid:LckEg7WERVC628sZGjvi3qlYJ549606	rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606	rigid:o/eEmTZo1JthYsRVVPS/YZD5Okg	false	flag tag:n-n	enhanced green fluorescent protein tag:n-n|mutation disrupting interaction strength:477-477|mutation disrupting interaction strength:405-405|mutation disrupting interaction strength:292-292|mutation disrupting interaction strength:232-232|mutation disrupting interaction strength:405-405	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75558	uniprotkb:Q15833	intact:EBI-714135|uniprotkb:O75378|uniprotkb:O95148|uniprotkb:Q5TCL6|ensembl:ENSP00000356540|uniprotkb:E1P598	intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283	psi-mi:stx11_human(display_long)|uniprotkb:STX11(gene name)|psi-mi:STX11(display_short)	psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	zur et al. (2009)	pubmed:19804848|imex:IM-27392	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055845|imex:IM-27392-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028672|interpro:IPR042781|mint:O75558|ensembl:ENSG00000135604(gene)|ensembl:ENST00000367568(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0061025"(membrane fusion)|refseq:NP_003755.2|refseq:XP_016866889.1|refseq:XP_011534516.1|refseq:XP_011534519.1|refseq:XP_011534520.1	refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836	-	-	-	figure legend:Figure S2|agonist:IL-2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2019/10/01	2019/10/02	rogid:LckEg7WERVC628sZGjvi3qlYJ549606	rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606	rigid:o/eEmTZo1JthYsRVVPS/YZD5Okg	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O75558	uniprotkb:Q15833	intact:EBI-714135|uniprotkb:O75378|uniprotkb:O95148|uniprotkb:Q5TCL6|ensembl:ENSP00000356540|uniprotkb:E1P598	intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283	psi-mi:stx11_human(display_long)|uniprotkb:STX11(gene name)|psi-mi:STX11(display_short)	psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	zur et al. (2009)	pubmed:19804848|imex:IM-27392	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055859|imex:IM-27392-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028672|interpro:IPR042781|mint:O75558|ensembl:ENSG00000135604(gene)|ensembl:ENST00000367568(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048278"(vesicle docking)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0061025"(membrane fusion)|refseq:NP_003755.2|refseq:XP_016866889.1|refseq:XP_011534516.1|refseq:XP_011534519.1|refseq:XP_011534520.1	refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836	-	-	-	figure legend:Figure S2|agonist:IL-2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell_cd8+)|taxid:9606(Homo sapiens CD8+ T lymphocytes)	-	2019/10/01	2019/10/02	rogid:LckEg7WERVC628sZGjvi3qlYJ549606	rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606	rigid:o/eEmTZo1JthYsRVVPS/YZD5Okg	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)