#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21202473|imex:IM-26820-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1a, Figure 3a, Figure S2a, S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:23-191(IPR001879)|his tag:c-c|maltose binding protein tag:n-n|biotin tag:n-n	sufficient binding region:38-65|biotin tag:n-n|amidated residue:65-65	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21202473|imex:IM-26820-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1a, Figure 3a, Figure S2a, S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:23-191(IPR001879)|his tag:c-c|maltose binding protein tag:n-n|biotin tag:n-n	carboxylated residue:65-65|sufficient binding region:32-65|mutation with no effect:62-62,54-54,58-59,64-65	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P12272	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-2372758|uniprotkb:Q15251|uniprotkb:Q6FH74|ensembl:ENSP00000379213|ensembl:ENSP00000441571|ensembl:ENSP00000441765	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthr_human(display_long)|uniprotkb:PTHLH(gene name)|psi-mi:PTHLH(display_short)|uniprotkb:PTHRP(gene name synonym)|uniprotkb:Parathyroid hormone-like protein(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21253844|imex:IM-26820-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:XP_011519076.1|refseq:XP_011519077.1|refseq:NP_002811.1|refseq:NP_945315.1|refseq:NP_945316.1|refseq:NP_945317.1|refseq:XP_016875163.1|refseq:XP_016875164.1|ensembl:ENSG00000087494(gene)|ensembl:ENST00000395872(transcript)|ensembl:ENST00000539239(transcript)|ensembl:ENST00000545234(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030282"(bone mineralization)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0061182"(negative regulation of chondrocyte development)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003626(Parathyroid hormone-related protein)|rcsb pdb:1BZG|rcsb pdb:1ET3|rcsb pdb:1M5N|rcsb pdb:3FFD|rcsb pdb:3H3G|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Figure 1b, Figure 3b, Figure S2c, S2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:xDgieq0IrFJamEASMichGJUQFbg9606	rigid:X+tvc5R9lBl0sngPAuOVzxWWj18	false	his tag:c-c|biotin tag:n-n|sufficient binding region:23-191(IPR001879)|maltose binding protein tag:n-n	sufficient binding region:48-70|carboxylated residue:70-70|mutation with no effect:59-59,63-64,67-67|mutation decreasing interaction strength:59-59,63-64,67-67,70-70	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21253844|imex:IM-26820-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1b, Figure 3b, Figure S2c, S2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:X+tvc5R9lBl0sngPAuOVzxWWj18	false	his tag:c-c|biotin tag:n-n|sufficient binding region:23-191(IPR001879)|maltose binding protein tag:n-n	sufficient binding region:38-65|amidated residue:65-65|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254874|imex:IM-26820-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1a, Figure 3a, Figure 2h, Figure S2a, S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:23-191(IPR001879)|his tag:c-c|maltose binding protein tag:n-n|biotin tag:n-n	sufficient binding region:38-65|amidated residue:65-65|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254874|imex:IM-26820-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1a, Figure 3a, Figure 2h, Figure S2a, S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:23-191(IPR001879)|his tag:c-c|maltose binding protein tag:n-n|biotin tag:n-n	mutation decreasing interaction strength:58-58|mutation with no effect:60-60|mutation with no effect:62-62|mutation with no effect:63-63|mutation decreasing interaction strength:65-65|mutation with no effect:50-50|mutation decreasing interaction strength:51-51|mutation decreasing interaction strength:52-52|mutation with no effect:54-54,59-59|amidated residue:65-65|sufficient binding region:32-65|mutation decreasing interaction strength:62-62,54-54,58-59|mutation decreasing interaction strength:54-54,62-62|mutation with no effect:58-59|mutation with no effect:62-62,58-58|mutation decreasing interaction strength:54-54|mutation with no effect:58-58|mutation decreasing interaction strength:59-59|mutation decreasing interaction strength:62-62|mutation with no effect:54-54,58-58|necessary binding region:43-65|mutation decreasing interaction strength:54-54|mutation decreasing interaction strength:55-55|mutation decreasing interaction strength:57-57|mutation with no effect:58-59,62-62,54-54,64-65|mutation decreasing interaction strength:59-59,62-62	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P12272	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-2372758|uniprotkb:Q15251|uniprotkb:Q6FH74|ensembl:ENSP00000379213|ensembl:ENSP00000441571|ensembl:ENSP00000441765	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthr_human(display_long)|uniprotkb:PTHLH(gene name)|psi-mi:PTHLH(display_short)|uniprotkb:PTHRP(gene name synonym)|uniprotkb:Parathyroid hormone-like protein(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254958|imex:IM-26820-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:XP_011519076.1|refseq:XP_011519077.1|refseq:NP_002811.1|refseq:NP_945315.1|refseq:NP_945316.1|refseq:NP_945317.1|refseq:XP_016875163.1|refseq:XP_016875164.1|ensembl:ENSG00000087494(gene)|ensembl:ENST00000395872(transcript)|ensembl:ENST00000539239(transcript)|ensembl:ENST00000545234(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030282"(bone mineralization)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0061182"(negative regulation of chondrocyte development)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003626(Parathyroid hormone-related protein)|rcsb pdb:1BZG|rcsb pdb:1ET3|rcsb pdb:1M5N|rcsb pdb:3FFD|rcsb pdb:3H3G|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Figure 1b, Figure 3b, Figure 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:xDgieq0IrFJamEASMichGJUQFbg9606	rigid:X+tvc5R9lBl0sngPAuOVzxWWj18	false	his tag:c-c|biotin tag:n-n|sufficient binding region:23-191(IPR001879)|maltose binding protein tag:n-n	mutation with no effect:59-59|mutation decreasing interaction strength:63-63|mutation with no effect:64-64|mutation with no effect:67-67|mutation with no effect:59-59,63-63|mutation with no effect:59-59,64-64|sufficient binding region:48-70|amidated residue:70-70|mutation with no effect:52-52|mutation decreasing interaction strength:56-56|mutation decreasing interaction strength:57-57|mutation decreasing interaction strength:59-59|mutation decreasing interaction strength:60-60|mutation decreasing interaction strength:63-63|mutation decreasing interaction strength:64-64|mutation with no effect:67-67|mutation decreasing interaction strength:68-68|mutation with no effect:69-69|mutation with no effect:59-59,63-64,67-67,70-70|mutation with no effect:55-55	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254958|imex:IM-26820-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:Figure 1b, Figure 3b, Figure 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-6(molar)	2019/02/19	2019/03/12	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:X+tvc5R9lBl0sngPAuOVzxWWj18	false	his tag:c-c|biotin tag:n-n|sufficient binding region:23-191(IPR001879)|maltose binding protein tag:n-n	sufficient binding region:38-65|amidated residue:65-65|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01270	uniprotkb:Q03431	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257906|imex:IM-26820-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Figure 1a, Figure 3a, Figure S2a, S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/03/14	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:38-65|biotin tag:n-n|amidated residue:65-65	sufficient binding region:23-191(IPR001879)|his tag:c-c|maltose binding protein tag:n-n|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12272	uniprotkb:Q03431	intact:EBI-2372758|uniprotkb:Q15251|uniprotkb:Q6FH74|ensembl:ENSP00000379213|ensembl:ENSP00000441571|ensembl:ENSP00000441765	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	psi-mi:pthr_human(display_long)|uniprotkb:PTHLH(gene name)|psi-mi:PTHLH(display_short)|uniprotkb:PTHRP(gene name synonym)|uniprotkb:Parathyroid hormone-like protein(gene name synonym)	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21237114|pdbe:3H3G|imex:IM-26820-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519076.1|refseq:XP_011519077.1|refseq:NP_002811.1|refseq:NP_945315.1|refseq:NP_945316.1|refseq:NP_945317.1|refseq:XP_016875163.1|refseq:XP_016875164.1|ensembl:ENSG00000087494(gene)|ensembl:ENST00000395872(transcript)|ensembl:ENST00000539239(transcript)|ensembl:ENST00000545234(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030282"(bone mineralization)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0061182"(negative regulation of chondrocyte development)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003626(Parathyroid hormone-related protein)|rcsb pdb:1BZG|rcsb pdb:1ET3|rcsb pdb:1M5N|rcsb pdb:3FFD|rcsb pdb:3H3G|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Table 1|3d-resolution:"50.00-1.94 (2.01-1.94)"|3d-r-factors:"Rwork/Rfree: 19.3/23.3"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/03/13	rogid:xDgieq0IrFJamEASMichGJUQFbg9606	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rigid:YkutNCZvo/JRZBPcciMPemnCnug	false	sufficient binding region:48-70|amidated residue:70-70	sufficient binding region:23-191|his tag:c-c|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03431	uniprotkb:P01270	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	intact:EBI-716817|uniprotkb:Q4VB48|uniprotkb:Q9UD38|ensembl:ENSP00000282091|ensembl:ENSP00000433208	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:pthy_human(display_long)|uniprotkb:PTH(gene name)|psi-mi:PTH(display_short)|uniprotkb:Parathyrin(gene name synonym)|uniprotkb:Parathormone(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21202996|imex:IM-26820-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000306.1|ensembl:ENST00000282091(transcript)|ensembl:ENST00000529816(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSG00000152266(gene)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031856"(parathyroid hormone receptor binding)|go:"GO:0031857"(type 1 parathyroid hormone receptor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0042493"|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003625(Parathyroid hormone subtype)|rcsb pdb:1BWX|rcsb pdb:1ET1|rcsb pdb:1ET2|rcsb pdb:1FVY|rcsb pdb:1HPH|rcsb pdb:1HPY|rcsb pdb:1HTH|rcsb pdb:1ZWA|rcsb pdb:1ZWB|rcsb pdb:1ZWD|rcsb pdb:1ZWE|rcsb pdb:1ZWF|rcsb pdb:1ZWG|rcsb pdb:2L1X|rcsb pdb:3C4M|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0047485"(protein N-terminus binding)	-	-	-	figure legend:supplemental Fig. S1a, Figure 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-6(molar)	2019/02/19	2019/03/14	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rogid:dXuZWgCWYCZUqtKebFmLH/7w93E9606	rigid:N8WhZFMp20EAcNKrHNl4wBL8oF4	false	sufficient binding region:23-191(IPR001879)|his tag:c-c|biotin tag:n-n	sufficient binding region:38-65|amidated residue:65-65|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12272	uniprotkb:Q03431	intact:EBI-2372758|uniprotkb:Q15251|uniprotkb:Q6FH74|ensembl:ENSP00000379213|ensembl:ENSP00000441571|ensembl:ENSP00000441765	intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774	psi-mi:pthr_human(display_long)|uniprotkb:PTHLH(gene name)|psi-mi:PTHLH(display_short)|uniprotkb:PTHRP(gene name synonym)|uniprotkb:Parathyroid hormone-like protein(gene name synonym)	psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Pioszak et al. (2009)	pubmed:19674967|imex:IM-26820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21203042|imex:IM-26820-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519076.1|refseq:XP_011519077.1|refseq:NP_002811.1|refseq:NP_945315.1|refseq:NP_945316.1|refseq:NP_945317.1|refseq:XP_016875163.1|refseq:XP_016875164.1|ensembl:ENSG00000087494(gene)|ensembl:ENST00000395872(transcript)|ensembl:ENST00000539239(transcript)|ensembl:ENST00000545234(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030282"(bone mineralization)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0061182"(negative regulation of chondrocyte development)|interpro:IPR001415(Parathyroid hormone)|interpro:IPR003626(Parathyroid hormone-related protein)|rcsb pdb:1BZG|rcsb pdb:1ET3|rcsb pdb:1M5N|rcsb pdb:3FFD|rcsb pdb:3H3G|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:supplemental Fig. S1b, Figure 1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.99x10^-6(molar)	2019/02/19	2019/03/14	rogid:xDgieq0IrFJamEASMichGJUQFbg9606	rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606	rigid:YkutNCZvo/JRZBPcciMPemnCnug	false	sufficient binding region:1-34|amidated residue:34-34|biotin tag:?-?	sufficient binding region:23-191(IPR001879)|his tag:c-c|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)