#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08722	uniprotkb:P78324	intact:EBI-1268321|uniprotkb:Q53Y71|uniprotkb:Q96A60|uniprotkb:A8K198|uniprotkb:D3DN59|ensembl:ENSP00000355361	intact:EBI-745147|uniprotkb:O00683|uniprotkb:O43799|uniprotkb:Q8N517|uniprotkb:Q8TAL8|uniprotkb:Q9H0Z2|uniprotkb:Q9UDX2|uniprotkb:Q9UIJ6|uniprotkb:Q9Y4U9|uniprotkb:A8K411|uniprotkb:A2A2E1|ensembl:ENSP00000348307|ensembl:ENSP00000351621|ensembl:ENSP00000382941|uniprotkb:B2R6C3	psi-mi:cd47_human(display_long)|uniprotkb:CD47(gene name)|psi-mi:CD47(display_short)|uniprotkb:MER6(gene name synonym)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Antigenic surface determinant protein OA3(gene name synonym)|uniprotkb:Protein MER6(gene name synonym)	psi-mi:shps1_human(display_long)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-2(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-3(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:Macrophage fusion receptor(gene name synonym)|uniprotkb:p84(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:SIRPA(gene name)|psi-mi:SIRPA(display_short)|uniprotkb:BIT(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:MYD1(gene name synonym)|uniprotkb:SHPS1(gene name synonym)|uniprotkb:SIRP(gene name synonym)|uniprotkb:PTPNS1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Liu et al. (2007)	pubmed:17070842|imex:IM-27356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21228696|imex:IM-27356-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001768.1|refseq:NP_942088.1|dip:DIP-39948N|ensembl:ENSG00000196776(gene)|ensembl:ENST00000361309(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:2000439"(positive regulation of monocyte extravasation)|interpro:IPR006704(CD47 integrin associated protein)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037805|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2VSC|rcsb pdb:4CMM|rcsb pdb:4KJY|rcsb pdb:5IWL|rcsb pdb:5TZ2|rcsb pdb:5TZT|rcsb pdb:5TZU|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-391160|reactome:R-HSA-6798695|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)	refseq:NP_001035111.1|refseq:NP_001035112.1|refseq:NP_542970.1|ensembl:ENSG00000198053(gene)|ensembl:ENST00000356025(transcript)|ensembl:ENST00000358771(transcript)|ensembl:ENST00000400068(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0071641"(negative regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1903720"(negative regulation of I-kappaB phosphorylation)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2UV3|rcsb pdb:2WNG|rcsb pdb:4CMM|rcsb pdb:6BIT|rcsb pdb:6NMR|rcsb pdb:6NMS|rcsb pdb:6NMT|rcsb pdb:6NMU|rcsb pdb:6NMV|rcsb pdb:7KPG|reactome:R-HSA-202733|reactome:R-HSA-391160|reactome:R-HSA-6798695|refseq:XP_005260727.1|refseq:NP_001317657.1	-	-	-	figure legend:Figure 1b,Figure 2a, 2b, Figure 3, Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/04	2019/05/07	rogid:2hhmwvfeDFe7KHXzsBOJkjo2pjk9606	rogid:6Zacoq8Ycjy9+cn3gge8ZUZGGvE9606	rigid:BbiN+/J/lORtXGg0eDu0jUWLp7M	false	-	mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:67-67|mutation decreasing interaction strength:102-102|mutation decreasing interaction strength:67-67|mutation disrupting interaction strength:67-67|mutation decreasing interaction strength:67-67|mutation decreasing interaction strength:67-67|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation with no effect:57-57|mutation with no effect:57-57|mutation decreasing interaction strength:57-57|mutation decreasing interaction strength:57-57|mutation decreasing interaction strength:57-57	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P78324-4	uniprotkb:Q08722	intact:EBI-21280928	intact:EBI-1268321|uniprotkb:Q53Y71|uniprotkb:Q96A60|uniprotkb:A8K198|uniprotkb:D3DN59|ensembl:ENSP00000355361	psi-mi:p78324-4(display_long)|uniprotkb:SIRPA(gene name)|psi-mi:SIRPA(display_short)|uniprotkb:BIT(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:MYD1(gene name synonym)|uniprotkb:PTPNS1(gene name synonym)|uniprotkb:SHPS1(gene name synonym)|uniprotkb:SIRP(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:Macrophage fusion receptor(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-2(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-3(gene name synonym)|uniprotkb:p84(gene name synonym)	psi-mi:cd47_human(display_long)|uniprotkb:CD47(gene name)|psi-mi:CD47(display_short)|uniprotkb:MER6(gene name synonym)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Antigenic surface determinant protein OA3(gene name synonym)|uniprotkb:Protein MER6(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Liu et al. (2007)	pubmed:17070842|imex:IM-27356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279912|imex:IM-27356-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-745147(isoform-parent)	refseq:NP_001768.1|refseq:NP_942088.1|dip:DIP-39948N|ensembl:ENSG00000196776(gene)|ensembl:ENST00000361309(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:2000439"(positive regulation of monocyte extravasation)|interpro:IPR006704(CD47 integrin associated protein)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037805|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2VSC|rcsb pdb:4CMM|rcsb pdb:4KJY|rcsb pdb:5IWL|rcsb pdb:5TZ2|rcsb pdb:5TZT|rcsb pdb:5TZU|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-391160|reactome:R-HSA-6798695|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)	-	-	-	figure legend:Figure 1, Figure 2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/04	2019/05/07	rogid:acR2FycOUaz/Oj7tUpFY0F2Jqu89606	rogid:2hhmwvfeDFe7KHXzsBOJkjo2pjk9606	rigid:3H/rda5/mkNrji0oWuwbRP/r2eo	false	mutation disrupting interaction strength:57-57	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08722	uniprotkb:O00241	intact:EBI-1268321|uniprotkb:Q53Y71|uniprotkb:Q96A60|uniprotkb:A8K198|uniprotkb:D3DN59|ensembl:ENSP00000355361	intact:EBI-2615458|uniprotkb:Q9H1U5|uniprotkb:Q5TFR0|uniprotkb:Q8TB12|uniprotkb:Q5TFQ9|uniprotkb:Q9Y4V0|uniprotkb:B2R8V0|uniprotkb:A6NLM2|ensembl:ENSP00000371018	psi-mi:cd47_human(display_long)|uniprotkb:CD47(gene name)|psi-mi:CD47(display_short)|uniprotkb:MER6(gene name synonym)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Antigenic surface determinant protein OA3(gene name synonym)|uniprotkb:Protein MER6(gene name synonym)	psi-mi:sirb1_human(display_long)|uniprotkb:CD172 antigen-like family member B(gene name synonym)|uniprotkb:SIRPB1(gene name)|psi-mi:SIRPB1(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Liu et al. (2007)	pubmed:17070842|imex:IM-27356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280039|imex:IM-27356-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001768.1|refseq:NP_942088.1|dip:DIP-39948N|ensembl:ENSG00000196776(gene)|ensembl:ENST00000361309(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:2000439"(positive regulation of monocyte extravasation)|interpro:IPR006704(CD47 integrin associated protein)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037805|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2VSC|rcsb pdb:4CMM|rcsb pdb:4KJY|rcsb pdb:5IWL|rcsb pdb:5TZ2|rcsb pdb:5TZT|rcsb pdb:5TZU|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-391160|reactome:R-HSA-6798695|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)	refseq:NP_001077379.1|refseq:NP_006056.2|refseq:NP_001317568.1|refseq:XP_016883066.1|ensembl:ENSG00000101307(gene)|ensembl:ENST00000381605(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2D9C|rcsb pdb:2JJU|reactome:R-HSA-2172127|reactome:R-HSA-391160|reactome:R-HSA-6798695	-	-	-	figure legend:Figure 8|comment:p.Met56Val; p.Met66Gln mutations were not found to cause interaction between CD47 and SIRPB1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/04	2019/05/07	rogid:2hhmwvfeDFe7KHXzsBOJkjo2pjk9606	rogid:WChxqhoW8UPxaVrdQDYEL2zsN589606	rigid:3yfyCkiqqZ1ztDfWLAqfFVSt5uo	false	-	mutation causing an interaction:101-101,56-56,66-66|mutation causing an interaction:66-66,73-73,56-56|mutation causing an interaction:56-56,66-66	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)