#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51159	uniprotkb:Q70J99	intact:EBI-716881|uniprotkb:O00195|uniprotkb:Q6FI40|uniprotkb:Q9UIR9|uniprotkb:Q9Y5U3|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059	intact:EBI-11479429|uniprotkb:B4DWG9|uniprotkb:Q9H7K5|ensembl:ENSP00000207549	psi-mi:rb27a_human(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym)	psi-mi:un13d_human(display_long)|uniprotkb:UNC13D(gene name)|psi-mi:UNC13D(display_short)|uniprotkb:Munc13-4(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Zur et al. (2006)	pubmed:16278825|imex:IM-27395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055745|imex:IM-27395-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004571.2|refseq:NP_899057.1|refseq:NP_899058.1|refseq:NP_899059.1|refseq:XP_011520154.1|refseq:XP_011520156.1|refseq:XP_011520157.1|refseq:XP_011520158.1|refseq:XP_005254633.1|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|mint:P51159|rcsb pdb:6HUF|reactome:R-HSA-264876|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|dip:DIP-44244N	refseq:NP_954712.1|ensembl:ENSG00000092929(gene)|ensembl:ENST00000207549(transcript)|go:"GO:0002432"(granuloma formation)|go:"GO:0002467"(germinal center formation)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR035892|reactome:R-HSA-6798695	-	-	-	figure legend:Table 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 ebna)|taxid:9606(Homo sapiens)	-	2019/10/02	2019/10/02	rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606	rogid:caA8/VwktSz+pczqvN/tFLatKWo9606	rigid:ecjCFT5tlXSDQp/uAtLg/7FXI84	false	mutation disrupting interaction strength:23-23|mutation with no effect:78-78|mutation disrupting interaction strength:87-87	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51159	uniprotkb:Q70J99	intact:EBI-716881|uniprotkb:O00195|uniprotkb:Q6FI40|uniprotkb:Q9UIR9|uniprotkb:Q9Y5U3|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059	intact:EBI-11479429|uniprotkb:B4DWG9|uniprotkb:Q9H7K5|ensembl:ENSP00000207549	psi-mi:rb27a_human(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym)	psi-mi:un13d_human(display_long)|uniprotkb:UNC13D(gene name)|psi-mi:UNC13D(display_short)|uniprotkb:Munc13-4(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Zur et al. (2006)	pubmed:16278825|imex:IM-27395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055757|imex:IM-27395-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004571.2|refseq:NP_899057.1|refseq:NP_899058.1|refseq:NP_899059.1|refseq:XP_011520154.1|refseq:XP_011520156.1|refseq:XP_011520157.1|refseq:XP_011520158.1|refseq:XP_005254633.1|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|mint:P51159|rcsb pdb:6HUF|reactome:R-HSA-264876|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|dip:DIP-44244N	refseq:NP_954712.1|ensembl:ENSG00000092929(gene)|ensembl:ENST00000207549(transcript)|go:"GO:0002432"(granuloma formation)|go:"GO:0002467"(germinal center formation)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR035892|reactome:R-HSA-6798695	-	-	-	figure legend:Table 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 ebna)|taxid:9606(Homo sapiens)	-	2019/10/02	2019/10/02	rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606	rogid:caA8/VwktSz+pczqvN/tFLatKWo9606	rigid:ecjCFT5tlXSDQp/uAtLg/7FXI84	false	-	mutation disrupting interaction strength:403-403	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)