#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10323	uniprotkb:Q12836	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280308|imex:IM-26910-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 3|antagonist:Heat treatment;rec-hZPs were incubated at 100°C for 10  minutes, after which they were used in the binding assay.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:BoD/oPBjoys09n/DavS6IJx/lu8	false	sufficient binding region:20-319(IPR009003)|his tag:c-c	sufficient binding region:19-463|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10323	uniprotkb:P21754	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280326|imex:IM-26910-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 3|agonist:Heat treatment;rec-hZPs were incubated at 100°C for 10  minutes, after which they were used in the binding assay.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:T0ea+zC/GoGNb76UkyyMzmrOnX0	false	sufficient binding region:20-319(IPR009003)|his tag:c-c	sufficient binding region:23-383|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:P10323	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280389|imex:IM-26910-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	-	-	-	figure legend:Figure 3,4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	-	false	sufficient binding region:39-638|his tag:c-c	sufficient binding region:20-319(IPR009003)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:34674"	uniprotkb:Q05996	intact:EBI-21280407	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:dextran sulfate(display_short)|psi-mi:"CHEBI:34674"(display_long)|intact:Dextran polysulfate(synonym)|intact:Dextran sulfate(synonym)|intact:Dextran sulfate 500(synonym)|intact:Dextran sulfuric acid(synonym)|intact:Dextran sulfuric acid ester(synonym)|intact:Dextran sulphate(synonym)|intact:Polydextran sulfate(synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280389|imex:IM-26910-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 3,4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	-	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	-	false	-	sufficient binding region:39-638|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:P10323	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280418|imex:IM-26910-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	-	-	-	figure legend:Figure 5|comment:"Binding carried out in the presence of BSA-fucose (Albumin-1-amido-1-deoxy-L-fucose). As binding of BSA alone gives results within the non-specific range, inhibition of binding can be attributed to the attached Fucose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	-	false	sufficient binding region:39-638|his tag:c-c	sufficient binding region:20-319(IPR009003)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18287"	uniprotkb:Q05996	intact:EBI-21280479|chebi:"CHEBI:13102"|chebi:"CHEBI:21293"	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:l-fucose(display_short)|psi-mi:"CHEBI:18287"(display_long)|intact:"(-)-fucose"(synonym)|intact:"(-)-L-fucose"(synonym)|intact:"L-(-)-fucose"(synonym)|intact:L-Fuc(synonym)|intact:L-galactomethylose(synonym)|intact:6-deoxy-L-galactose(iupac name)|intact:L-fucose(iupac name)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280418|imex:IM-26910-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 5|comment:"Binding carried out in the presence of BSA-fucose (Albumin-1-amido-1-deoxy-L-fucose). As binding of BSA alone gives results within the non-specific range, inhibition of binding can be attributed to the attached Fucose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	-	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	-	false	-	sufficient binding region:39-638|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q05996	uniprotkb:P10323	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280496|imex:IM-26910-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	-	-	-	figure legend:Figure 6|comment:As binding of BSA alone gives results within the non-specific range, inhibition of binding can be attributed to the attached Mannose residues.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	-	false	sufficient binding region:39-638|his tag:c-c	sufficient binding region:20-319(IPR009003)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:48042"	uniprotkb:Q05996	intact:EBI-21280527	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:aldehydo-d-mannose 6-phosphate(display_short)|psi-mi:"CHEBI:48042"(display_long)|intact:6-O-phosphono-D-mannose(synonym)|intact:"aldehydo-D-mannose 6-(dihydrogen phosphate)"(iupac name)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280496|imex:IM-26910-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 6|comment:As binding of BSA alone gives results within the non-specific range, inhibition of binding can be attributed to the attached Mannose residues.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	-	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	-	false	-	sufficient binding region:39-638|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21280562	uniprotkb:Q05996	-	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:pro_0000027518(display_short)|psi-mi:EBI-21280562(display_long)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280542|imex:IM-26910-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P10323(chain-parent)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 7|comment:"Full length (402aas) Acrosin showed higher binding activity than any of the C-terminally truncated fragments. A fragment from the N-terminus (aas 20-79) did not bind at all."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:YYM1fY+xPZEgB8eZkHdreEPMXLg9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:UR3rkK1Fjuw8h2DpflLGgcz9MDw	false	his tag:c-c	sufficient binding region:39-638|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21280562	uniprotkb:Q12836	-	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:pro_0000027518(display_short)|psi-mi:EBI-21280562(display_long)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280577|imex:IM-26910-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P10323(chain-parent)	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 7-2|comment:"Full length (402aas) Acrosin showed higher binding activity than any of the C-terminally truncated fragments. A fragment from the N-terminus (aas 20-79) did not bind at all."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:YYM1fY+xPZEgB8eZkHdreEPMXLg9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:3++7PRtM8UHspYIrJ4CAnc9EUNs	false	his tag:c-c	sufficient binding region:19-463|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21280562	uniprotkb:P21754	-	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:pro_0000027518(display_short)|psi-mi:EBI-21280562(display_long)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21280595|imex:IM-26910-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P10323(chain-parent)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 7-3|comment:"Full length (402aas) Acrosin showed higher binding activity than any of the C-terminally truncated fragments. A fragment from the N-terminus (aas 20-79) showed slight binding (30% of Rec30)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/03/22	rogid:YYM1fY+xPZEgB8eZkHdreEPMXLg9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:yLDBOPL64r8aQVrccq1NdsoeQIY	false	his tag:c-c	sufficient binding region:23-383|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10323	uniprotkb:Q05996	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21307824|imex:IM-26910-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/04/15	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:g0rLdK30qkku+aDPPytV9GOIAkM	false	sufficient binding region:20-319(IPR009003)|his tag:c-c	sufficient binding region:39-638|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10323	uniprotkb:Q12836	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21307985|imex:IM-26910-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/04/15	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:BoD/oPBjoys09n/DavS6IJx/lu8	false	sufficient binding region:20-319(IPR009003)|his tag:c-c	sufficient binding region:19-463|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10323	uniprotkb:P21754	intact:EBI-21280149|ensembl:ENSP00000216139|ensembl:ENSP00000490828|uniprotkb:Q6ICK2	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:acro_human(display_long)|uniprotkb:ACR(gene name)|psi-mi:ACR(display_short)|uniprotkb:ACRS(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Furlong et al. (2005)	pubmed:15950651|imex:IM-26910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21308008|imex:IM-26910-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100312(gene)|ensembl:ENSG00000283539(gene)|ensembl:ENST00000216139(transcript)|ensembl:ENST00000636109(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002077"(acrosome matrix dispersal)|go:"GO:0003677"(DNA binding)|go:"GO:0004040"(amidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007341"(penetration of zona pellucida)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0048545"(response to steroid hormone)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|reactome:R-HSA-1300645|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001088.2	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/15	2019/04/15	rogid:B2Zwwo6RCnvk7M3rA0bwuq7MI9c9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:T0ea+zC/GoGNb76UkyyMzmrOnX0	false	sufficient binding region:20-319(IPR009003)|his tag:c-c	sufficient binding region:23-383|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)