#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28335	uniprotkb:P28335	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399431|imex:IM-26995-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/05/08	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:e7qIeywCtDUUyB9rabQPcvcwFL8	false	yellow fluorescent protein tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08173	uniprotkb:P28335	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399439|imex:IM-26995-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 3|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/05/08	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:ysi1TMNG7kcoVrHhdVJaP0mP4OY	false	yellow fluorescent protein tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28335	uniprotkb:P28335	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399588|imex:IM-26995-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Figure 4-2|comment:"Pretreatment with CHEBI:28790 -serotonin/5-hydroxytryptamine (5-HT) did not produce a significant change in BRET ratio."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/07/15	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:e7qIeywCtDUUyB9rabQPcvcwFL8	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P08173	uniprotkb:P28335	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399597|imex:IM-26995-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Figure 4-1|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/07/15	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:ysi1TMNG7kcoVrHhdVJaP0mP4OY	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P28335	uniprotkb:P07550	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399607|imex:IM-26995-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 4-3|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/07/15	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:SOzMWtJpuxuitLDUqq4ylyFKwq0	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P07550	uniprotkb:P07550	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399617|imex:IM-26995-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 4-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/07/15	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:28aWl3vR3x8f7ElhSd6gCQK5Zeg	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P28335	uniprotkb:P28335	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Herrick-Davis et al. (2004)	pubmed:15518545|imex:IM-26995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21399633|imex:IM-26995-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/10	2019/05/08	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:e7qIeywCtDUUyB9rabQPcvcwFL8	false	yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)