#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61645 uniprotkb:P37242-1 intact:EBI-21991144|uniprotkb:Q80Y47|ensembl:ENSMUSP00000022691|ensembl:ENSMUSP00000124816 intact:EBI-21991136|ensembl:ENSMUSP00000022303|ensembl:ENSMUSP00000089053 psi-mi:hair_mouse(display_long)|uniprotkb:Hr(gene name)|psi-mi:Hr(display_short)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase hairless"(gene name synonym) psi-mi:p37242-1(display_long)|uniprotkb:Thrb(gene name)|psi-mi:Thrb(display_short)|uniprotkb:Erba2(gene name synonym)|uniprotkb:Nr1a2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 2(gene name synonym)|uniprotkb:c-erbA-2(gene name synonym)|uniprotkb:c-erbA-beta(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Djabali et al. (2004) pubmed:15086341|imex:IM-27315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21991176|imex:IM-27315-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068677.2|refseq:XP_011243268.1|ensembl:ENSMUSG00000022096(gene)|ensembl:ENSMUST00000022691(transcript)|ensembl:ENSMUST00000161069(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase) ensembl:ENSMUSG00000021779(gene)|ensembl:ENSMUST00000022303(transcript)|ensembl:ENSMUST00000091471(transcript)|intact:EBI-6935043(isoform-parent) go:"GO:0005634"(nucleus) - - figure legend:Figure 3a|comment:"D1005N mutation in hairless gene (UniProt:Q61645) is mouse equivalent of human D1012N"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2019/08/27 2019/08/27 rogid:9/Ts7qpEFX5F+Sb7TT+I9aFeaPs10090 rogid:e8Wr18Fb02fPIadJyfhqv9l0WZs10090 rigid:VlOWcInA8Y9vnixQNhqSQ8DZs5A false enhanced green fluorescent protein tag:?-?|mutation with no effect:1005-1005 flag tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q61645 uniprotkb:P37242-1 intact:EBI-21991144|uniprotkb:Q80Y47|ensembl:ENSMUSP00000022691|ensembl:ENSMUSP00000124816 intact:EBI-21991136|ensembl:ENSMUSP00000022303|ensembl:ENSMUSP00000089053 psi-mi:hair_mouse(display_long)|uniprotkb:Hr(gene name)|psi-mi:Hr(display_short)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase hairless"(gene name synonym) psi-mi:p37242-1(display_long)|uniprotkb:Thrb(gene name)|psi-mi:Thrb(display_short)|uniprotkb:Erba2(gene name synonym)|uniprotkb:Nr1a2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 2(gene name synonym)|uniprotkb:c-erbA-2(gene name synonym)|uniprotkb:c-erbA-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Djabali et al. (2004) pubmed:15086341|imex:IM-27315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21991196|imex:IM-27315-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068677.2|refseq:XP_011243268.1|ensembl:ENSMUSG00000022096(gene)|ensembl:ENSMUST00000022691(transcript)|ensembl:ENSMUST00000161069(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase) ensembl:ENSMUSG00000021779(gene)|ensembl:ENSMUST00000022303(transcript)|ensembl:ENSMUST00000091471(transcript)|intact:EBI-6935043(isoform-parent) - - - figure legend:Figure 3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2019/08/27 2019/10/14 rogid:9/Ts7qpEFX5F+Sb7TT+I9aFeaPs10090 rogid:e8Wr18Fb02fPIadJyfhqv9l0WZs10090 rigid:VlOWcInA8Y9vnixQNhqSQ8DZs5A false green fluorescent protein tag:?-?|mutation with no effect:1005-1005 flag tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0705"(anti tag western blot)