#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35348	uniprotkb:P35348	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uberti et al. (2003)	pubmed:14645668|imex:IM-26919	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282711|imex:IM-26919-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 2-1|comment:Monomers, dimers and oligomers  of all three subtypes were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/27	2019/03/27	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:WiqXIXNLJerV3vYsR0CHQxUrPdc	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35368	uniprotkb:P35368	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uberti et al. (2003)	pubmed:14645668|imex:IM-26919	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282722|imex:IM-26919-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	-	-	-	figure legend:Figure 2-2, 6B|comment:Monomers, dimers and oligomers  of all three subtypes were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/27	2019/03/27	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rigid:vWTebBjAIbDGXUV0EFKwS7a3bds	false	sufficient binding region:1-366|flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25100	uniprotkb:P25100	intact:EBI-489993|uniprotkb:Q9NPY0|ensembl:ENSP00000368766	intact:EBI-489993|uniprotkb:Q9NPY0|ensembl:ENSP00000368766	psi-mi:ada1d_human(display_long)|uniprotkb:Alpha-1D adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1A adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1a(gene name synonym)|uniprotkb:ADRA1D(gene name)|psi-mi:ADRA1D(display_short)|uniprotkb:ADRA1A(gene name synonym)	psi-mi:ada1d_human(display_long)|uniprotkb:Alpha-1D adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1A adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1a(gene name synonym)|uniprotkb:ADRA1D(gene name)|psi-mi:ADRA1D(display_short)|uniprotkb:ADRA1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uberti et al. (2003)	pubmed:14645668|imex:IM-26919	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282731|imex:IM-26919-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000669.1|ensembl:ENSG00000171873(gene)|ensembl:ENST00000379453(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000363(Adrenergic receptor, alpha-1A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482	refseq:NP_000669.1|ensembl:ENSG00000171873(gene)|ensembl:ENST00000379453(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000363(Adrenergic receptor, alpha-1A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482	-	-	-	figure legend:Figure 2-3|comment:Monomers, dimers and oligomers  of all three subtypes were detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/27	2019/03/27	rogid:jMKKmdeENCQ6B0ulSVJJECThmfE9606	rogid:jMKKmdeENCQ6B0ulSVJJECThmfE9606	rigid:c5JSGrdtgc+MEtxwUXqJxzRyUdY	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35348	uniprotkb:P35368	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uberti et al. (2003)	pubmed:14645668|imex:IM-26919	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282743|imex:IM-26919-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	-	-	-	figure legend:Figure 3-LHS, 4B,6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/27	2019/03/27	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rigid:JuAKgkqLMDsgMZZEEUB05uOelp0	false	flag tag:n-n|sufficient binding region:1-344	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25100	uniprotkb:P35368	intact:EBI-489993|uniprotkb:Q9NPY0|ensembl:ENSP00000368766	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	psi-mi:ada1d_human(display_long)|uniprotkb:Alpha-1D adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1A adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1a(gene name synonym)|uniprotkb:ADRA1D(gene name)|psi-mi:ADRA1D(display_short)|uniprotkb:ADRA1A(gene name synonym)	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uberti et al. (2003)	pubmed:14645668|imex:IM-26919	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282754|imex:IM-26919-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000669.1|ensembl:ENSG00000171873(gene)|ensembl:ENST00000379453(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000363(Adrenergic receptor, alpha-1A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	-	-	-	figure legend:Figure 3-Middle, 6B, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/27	2019/03/27	rogid:jMKKmdeENCQ6B0ulSVJJECThmfE9606	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rigid:XPkOgJ1HU5UG/6euLxDWFSuOGPY	false	flag tag:n-n|sufficient binding region:1-418|necessary binding region:80-418	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)