#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40692	uniprotkb:P54278	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kondo et al. (2003)	imex:IM-27453|pubmed:12810663	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22119561|imex:IM-27453-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	-	-	-	figure legend:Fig. 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/15	2019/10/30	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rigid:V+h9QsGaEB7a1kNJz2tPPj4Yzzw	false	35s radiolabel:?-?|his tag:?-?|mutation disrupting interaction strength:166-756|mutation disrupting interaction strength:174-756|mutation decreasing interaction strength:181-756|mutation decreasing interaction strength:196-756|mutation decreasing interaction strength:197-756|mutation decreasing interaction strength:199-756|mutation decreasing interaction strength:212-756|mutation decreasing interaction strength:659-756|mutation decreasing interaction strength:712-756|mutation decreasing interaction strength:714-756|mutation disrupting interaction strength:242-756|mutation with no effect:245-756|mutation decreasing interaction strength:253-756|necessary binding region:166-756|v5 tag:?-?|mutation with no effect:28-28|mutation with no effect:35-35|mutation with no effect:44-44|mutation with no effect:67-67|mutation with no effect:68-68|mutation with no effect:77-77|mutation with no effect:107-107|mutation with no effect:117-117|mutation with no effect:117-117|mutation with no effect:128-128|mutation with no effect:185-185|mutation with no effect:244-244|mutation with no effect:326-326|mutation with no effect:492-492|mutation with no effect:506-506|mutation with no effect:542-542|mutation disrupting interaction strength:574-574|mutation with no effect:578-578|mutation with no effect:582-582|mutation decreasing interaction strength:618-618|mutation with no effect:618-618|mutation decreasing interaction strength:659-659|mutation decreasing interaction strength:681-681|mutation decreasing interaction strength:616-616	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P40692	uniprotkb:Q9UQ84	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-944667|uniprotkb:O60545|uniprotkb:O75214|uniprotkb:O75466|uniprotkb:Q5T396|uniprotkb:Q96IJ1|uniprotkb:Q9UG38|uniprotkb:Q9UNW0|ensembl:ENSP00000311873|ensembl:ENSP00000355506	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:exo1_human(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:EXOI(gene name synonym)|uniprotkb:HEX1(gene name synonym)|uniprotkb:Exonuclease I(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Kondo et al. (2003)	imex:IM-27453|pubmed:12810663	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22119686|imex:IM-27453-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	refseq:NP_003677.4|refseq:NP_006018.4|refseq:NP_569082.2|refseq:XP_006711903.1|refseq:XP_011542623.1|refseq:XP_011542624.1|dip:DIP-36701N|ensembl:ENSG00000174371(gene)|ensembl:ENST00000348581(transcript)|ensembl:ENST00000366548(transcript)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016604"(nuclear body)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0045145"(single-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048256"(flap endonuclease activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051908"(double-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:0090656"(t-circle formation)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:3QE9|rcsb pdb:3QEA|rcsb pdb:3QEB|rcsb pdb:5UZV|rcsb pdb:5V04|rcsb pdb:5V05|rcsb pdb:5V06|rcsb pdb:5V07|rcsb pdb:5V08|rcsb pdb:5V09|rcsb pdb:5V0A|rcsb pdb:5V0B|rcsb pdb:5V0C|rcsb pdb:5V0D|rcsb pdb:5V0E|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/10/15	2019/10/30	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:fvuFXVLS3mhyuaULAvHba1VPw8M9606	rigid:6T3Q5g3BbqTlGB6UG+wEnt7/DHY	false	mutation disrupting interaction strength:28-28|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:44-44|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:68-68|mutation disrupting interaction strength:77-77|mutation disrupting interaction strength:107-107|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:128-128|mutation disrupting interaction strength:185-185|mutation disrupting interaction strength:244-244|mutation with no effect:326-326|mutation with no effect:492-492|mutation decreasing interaction strength:506-506|mutation with no effect:542-542|mutation disrupting interaction strength:574-574|mutation with no effect:578-578|mutation with no effect:582-582|mutation decreasing interaction strength:618-618|mutation decreasing interaction strength:618-618|mutation disrupting interaction strength:659-659|mutation with no effect:681-681|mutation disrupting interaction strength:616-616|mutation with no effect:32-32|mutation with no effect:213-213|mutation with no effect:217-217|mutation with no effect:219-219|mutation with no effect:219-219|mutation with no effect:265-265|mutation with no effect:406-406|mutation with no effect:718-718|mutation with no effect:729-729	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:P54278	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Kondo et al. (2003)	imex:IM-27453|pubmed:12810663	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22119617|imex:IM-27453-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/10/15	2019/10/30	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rigid:V+h9QsGaEB7a1kNJz2tPPj4Yzzw	false	mutation disrupting interaction strength:28-28|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:44-44|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:68-68|mutation disrupting interaction strength:77-77|mutation disrupting interaction strength:107-107|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:128-128|mutation disrupting interaction strength:185-185|mutation disrupting interaction strength:244-244|mutation with no effect:326-326|mutation with no effect:492-492|mutation with no effect:506-506|mutation with no effect:542-542|mutation disrupting interaction strength:574-574|mutation with no effect:578-578|mutation with no effect:582-582|mutation with no effect:618-618|mutation with no effect:618-618|mutation disrupting interaction strength:659-659|mutation with no effect:681-681|mutation decreasing interaction strength:616-616|mutation with no effect:32-32|mutation with no effect:213-213|mutation with no effect:217-217|mutation with no effect:219-219|mutation with no effect:219-219|mutation with no effect:265-265|mutation with no effect:406-406|mutation with no effect:718-718|mutation with no effect:729-729	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40692	uniprotkb:P54278	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-1162561|uniprotkb:Q5FBW9|uniprotkb:Q5FBX1|uniprotkb:Q5FBX2|uniprotkb:Q52LH6|uniprotkb:Q75MR2|uniprotkb:B2R610|ensembl:ENSP00000265849	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:pms2_human(display_long)|uniprotkb:PMS1 protein homolog 2(gene name synonym)|uniprotkb:DNA mismatch repair protein PMS2(gene name synonym)|uniprotkb:PMS2(gene name)|psi-mi:PMS2(display_short)|uniprotkb:PMSL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Kondo et al. (2003)	imex:IM-27453|pubmed:12810663	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22119755|imex:IM-27453-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000122512(gene)|ensembl:ENST00000265849(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006298"(mismatch repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0032138"(single base insertion or deletion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|interpro:IPR042121|mint:P54278|rcsb pdb:1H7S|rcsb pdb:1H7U|rcsb pdb:5U5R|rcsb pdb:6MFQ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|rcsb pdb:1EA6|refseq:NP_000526.2|refseq:NP_001308932.1|refseq:NP_001308933.1|refseq:NP_001308934.1|refseq:NP_001308935.1|refseq:NP_001308936.1|refseq:NP_001308937.1|refseq:NP_001308938.1|refseq:NP_001308939.1|refseq:NP_001308940.1|refseq:NP_001308941.1|refseq:NP_001308942.1|refseq:NP_001308943.1|refseq:NP_001308944.1|refseq:XP_016885888.1|dip:DIP-46295N	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/10/15	2019/10/30	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:ZEPZOzJgtNSaYyRonkvr/+/30AE9606	rigid:V+h9QsGaEB7a1kNJz2tPPj4Yzzw	false	mutation disrupting interaction strength:659-756|necessary binding region:166-756|mutation disrupting interaction strength:712-756|mutation disrupting interaction strength:714-756|mutation disrupting interaction strength:166-756|mutation disrupting interaction strength:174-756|mutation disrupting interaction strength:181-756|mutation disrupting interaction strength:196-756|mutation disrupting interaction strength:197-756|mutation disrupting interaction strength:199-756|mutation disrupting interaction strength:212-756|mutation disrupting interaction strength:242-756|mutation disrupting interaction strength:245-756|mutation disrupting interaction strength:253-756|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:44-44|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:68-68|mutation decreasing interaction strength:77-77|mutation disrupting interaction strength:107-107|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:128-128|mutation disrupting interaction strength:185-185|mutation disrupting interaction strength:244-244|mutation with no effect:326-326|mutation with no effect:492-492|mutation with no effect:506-506|mutation with no effect:542-542|mutation disrupting interaction strength:574-574|mutation with no effect:578-578|mutation with no effect:582-582|mutation with no effect:618-618|mutation with no effect:618-618|mutation disrupting interaction strength:659-659|mutation with no effect:681-681|mutation decreasing interaction strength:616-616|mutation with no effect:32-32|mutation with no effect:213-213|mutation with no effect:217-217|mutation with no effect:219-219|mutation with no effect:219-219|mutation with no effect:265-265|mutation with no effect:406-406|mutation with no effect:718-718|mutation with no effect:729-729	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)